scholarly journals The effectiveness of moxifloxacin in the treatment of community-acquired pneumonia

2021 ◽  
Vol 4 (2) ◽  
pp. 4-10
Author(s):  
Dmytro Dmytriiev ◽  
Oleksandr Nazarchuk ◽  
Yuliana Babina
Keyword(s):  
Respiratory Tract ◽  
High Efficiency ◽  
Community Acquired Pneumonia ◽  
Fourth Generation ◽  
Infusion Therapy ◽  
International Studies ◽  
Clinical Use ◽  
Cost Of Treatment ◽  
The Cost ◽  
Respiratory Tract Infec

The article presents the results of domestic and international studies of the use of the fourth-generation fluoroquinolone moxifloxacin in the treatment of commu-nity-acquired pneumonia and pneumonia caused by SARS-CoV-2. Analysis of the clinical use of moxifloxacin in the treatment of complications of the respiratory tract infec-tions indicates its high efficiency and bioavailability, a low risk of resistance, which makes it possible to recommend it for widespread use in the work of a practicing doctor. Ge-neric drug Maxicin (Yuria-Pharm), available as a 20 mg/ml concentrate in a 20 ml vial, can significantly reduce the cost of treatment and optimize infusion therapy by choosing both volume and solvent.

scholarly journals AMOXYCILLIN FOR COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN

2017 ◽  
pp. 52-55
Author(s):  
A. B. MALAKHOV ◽  
N. G. KOLOSOVA
Keyword(s):  
Respiratory Diseases ◽  
Adverse Reactions ◽  
Bacterial Pathogens ◽  
Community Acquired Pneumonia ◽  
Haemophilus Influenza ◽  
Cost Of Treatment ◽  
Global Challenge ◽  
Beta Hemolytic Streptococcus ◽  
Group A ◽  
The Cost

The majority of respiratory diseases have viral etiology, and they do not require antibacterial therapy since it does not affect the course of the disease, does not reduce the incidence of bacterial complications. The causes of tonsillitis, epiglottitis, pneumonia are bacterial pathogens, such as Streptococcus pyogenes (group A beta-hemolytic streptococcus), Streptococcus pneumoniae,Haemophilus influenza, S. aureus and Moraxella catarrhalis. Home treatment of children remains a global challenge, as it may be the cause of an unfavorable outcome in young children, and, therefore, the issues of diagnostics and rational antibiotic therapy are still relevant. Irrational use of antibiotics can promote growth of resistance of bacterial pathogens, increase the frequency of adverse reactions of therapy and increase the cost of treatment

scholarly journals Pharmaco-economic features of hospital treatment of acute community-acquired pneumonia in children

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 77-82
Author(s):  
Y. Nechytailo ◽  
N. Popelyuk ◽  
O. Dolzhenko
Keyword(s):  
Clinical Symptoms ◽  
Community Acquired Pneumonia ◽  
Point Of View ◽  
Fourth Generation ◽  
Hospital Treatment ◽  
Cost Of Treatment ◽  
Economic Point ◽  
Corticosteroid Hormones ◽  
Treatment Measures ◽  
Pathogenetic Therapy

The goal. Тo analyze the features of treatment and medical expenses in children hospitalized for acute community-acquired pneumonia. Materials and methods. The study analyzed medical records and examined 51 children aged 2 to 17 months hospitalized for pneumonia. In patients studied clinical symptoms, severity, structure and duration of basic treatment measures, their cost. Results. The duration of inpatient treatment was 13.3±0.62 days with subsequent outpatient treatment and rehabilitation. Antibiotics, antipyretics, antihistamines, mucolytics and corticosteroid hormones were used in the treatment. The total cost of treatment for one case averaged 2346.9±145.7 hryvnias. The most expensive were the costs of antibiotics, and the cheapest - the antipyretics. Given the community-acquired nature of the process, the initial use of third- and fourth-generation cephalosporins was irrational and significantly increased the cost of treatment. Conclusions. The introduction of a new model of medicine focuses on the optimization of treatment tactics and the rational choice of antibiotics for acute community-acquired pneumonia. In antibacterial therapy is still inadequate, from a clinical and economic point of view, the choice of drugs. In the treatment of this disease, the role of pathogenetic therapy to restore the processes of mucociliary clearance and prevention of dysbiosis on the background of the use of antibiotics has increased.

scholarly journals 9-YEAR EXPERIENCE OF LARGE JOINTS ARTHROPLASTY

2017 ◽  
Vol 8 (1) ◽  
pp. 35-39
Author(s):  
S G Chesnikov ◽  
M E Timoshenko ◽  
S I Dediaev ◽  
D V Rosenberg
Keyword(s):  
Joint Replacement ◽  
High Efficiency ◽  
Cost Of Treatment ◽  
Orthopedic Department ◽  
The Cost

Experience of small trauma and orthopedic Department shows the high efficiency of modern orthopedic technologies in major joint replacement. The application of the concept of FTS significantly reduces the cost of treatment and allows to accelerate the rehabilitation of patients.

scholarly journals Analysis of cots for children treatment pneumonia in Bach Mai Ha Noi hospital from 10/2018 to 3/2019

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Bui Thi Xuan ◽  
Pham Van Dem ◽  
Hoang Van Hung
Keyword(s):  
Direct Cost ◽  
Direct Costs ◽  
Community Acquired Pneumonia ◽  
Asia Pacific ◽  
Decompensated Cirrhosis ◽  
Viet Nam ◽  
Cost Of Treatment ◽  
Cross Sectional ◽  
Co Morbidity ◽  
The Cost

 A study of the direct costs of treating pneumonia of children at Bach Mai hospital from October 2018 to March 2019 that the costs of hospital beds accounts shows for the highest proportion, then comes the cost of medicines and diagnostics. The cost of antibiotics is the highest in the cost of drugs, while the cost of diagnosis is the cost of testing. The cost of treatment is significantly related to the number of days of treatment, in addition, the severity or co-morbidity factors are affected only when considered individually. The support of health insurance can be up to more than 70% of the direct cost. The research results show that the cost of treatment in Viet Nam is lower than some countries in the region, the cost distribution is similar to that of some other domestic studies, but the cost of antibiotics has decreased significantly. Although drugs used at Bach Mai hospital are prescribing mainly generic medicines. Keywords Direct costs, pneumonia, children, Bach Mai hospital. References [1] Ministry of pulic health, Decision on Guidelines for the Management of Community-Based Pneumonia in children 2014 (in Vietnamese).[2] UNICEF Viet Nam, The top two fatal diseases for children in the Asia-Pacific region and Viet Nam, 2012 (in Vietnamese).[3] Nguyen Van Quang, Analysis of the cost of treating decompensated cirrhosis due to hepatitis C at Ho Chi Minh Tropical Hospital and Bach Mai Hospital in Ha Noi 2015 University graduation thesis in pharmacy (2017) (in Vietnamese).[4] Duc Anh Dang, Kah Kee Tan, Ki Hwan Kim, Cissy Kartasasmita, et al, Burden of hospitalized childhood community-acquired pneumonia: A retrospective cross-sectional study in Vietnam, Malaysia, Indonesia and the Republic of Korea, Human vaccin Immunother 14 (1) (2018) 95-105. https://doi.org/10.1080/21645515.2017.1375073.[5] Philip Ayieko, Ulla Griffiths, Angela Oloo Akumu, Mike English, The economic burden of inpatient paediatric care in Kenya: household and provider costs for Treatment of pneumonia, malaria and meningitis.; Cost Effectiveness and Resource Allocation 7(3) (2009) 1-13. https://doi.org/10.1186/1478-7547-7-3.[6] Nguyen Ngoc Tu, Analyze the direct cost of treating community-acquired pneumonia at Thai Nguyen tuberculosis and lung disease year 2015, Master's thesis in pharmacy (2017) (in Vietnamese).[7] Bui Thi Quyen, Analyze the cost of treating community-acquired pneumonia at the children's hospital in Nam Dinh province 2015, Grade 1 specialized pharmacist thesis (2016) (in Vietnamese).[8] Hamidah Hussain, Hugh Waters, Aamir J Khan, Saad B Omer, et al, Economic analysis of childhood pneumonia in Northern Pakistan, Heatlh policy plan 23(6) (2008) 438-444. https://doi.org/10.1093/heapol/czn033.        

scholarly journals CURRENT STRATEGY FOR TREATMENT OF COMORBID STATES: COMPLICATED COMMUNITY-ACQUIRED PNEUMONIA WITH ARTERIAL HYPERTENSION

2020 ◽  
Vol 73 (6) ◽  
pp. 1257-1260
Author(s):  
Liliia V. Burya ◽  
Andrii V. Vakhnenko ◽  
Nataliia V. Moiseieva ◽  
Anna A. Kapustianska ◽  
Iryna M. Zviagolska
Keyword(s):  
Functional Limitations ◽  
Social Activity ◽  
Community Acquired Pneumonia ◽  
Cost Of Treatment ◽  
X Ray ◽  
Blood Biochemical ◽  
Combination Drugs ◽  
Prolonged Effect ◽  
The Cost

The aim: To optimize the treatment of CAP patients with hypertension, complicated by exudative pleuritis. Materials and methods: The study included 43 CAP patients, aged 46 to 65 years, with viral lesions along with hypertension. The average age of the patients was 52.5 ± 4.5 years. Verification of the CAP diagnosis and its formulation was performed in accordance with the order of the Ministry of Health of Ukraine No. 128 of 19.03.2007 “On the approval of clinical protocols of medical care in “Pulmonology” in all patients, pneumonia was complicated by exudative pleuritis, which was confirmed by X-ray examination. Results: The use of combination drugs, namely, torasemide with prolonged effect and tivortin aspartate in the treatment of patients with community-acquired pneumonia, complicated by exudative pleuritis, combined with hypertension led to more significant positive changes in the values of saturation, blood biochemical parameters, as well as accelerated recovery of patients, which was confirmed by the positive dynamics of X-ray examination. Conclusions: As a result of the treatment, all parameters of the quality of life of the patients were greatly improved, which resulted in a significant reduction in functional limitations and high social activity of the patients, which significantly reduced the cost of treatment.

Respiratory tract damage with bocavirus infection in children

2020 ◽  
Vol 19 (2) ◽  
pp. 14-18
Author(s):  
E. V. Sharipova ◽  
I. V. Babachenko ◽  
M. A. Shcherbatyh
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Clinical Manifestations ◽  
Respiratory Viruses ◽  
Community Acquired Pneumonia ◽  
Human Bocavirus ◽  
Long Time ◽  
Clinically Significant ◽  
Tract Infections ◽  
Tract Damage

Long time the main pathogens associated with the development of community-acquired pneumonia were bacteria. However, in recent years in the Russian Federation, like all over the world, the view of the damage of lower respiratory tract changed, including a unique approach to community-acquired pneumonia as a bacterial infection, and respiratory viruses have become seen as a direct cause of lower respiratory tract damage, or as part of a viral-bacterial co-infection. These studies became possible since the widespread introduction of PCR techniques in the clinical setting, identification of respiratory viruses has increased and new microorganisms such, one as human bocavirus have been discovered. Objective: to study the features of respiratory tract damage in acute bocavirus infection in children of different ages. Materials and methods: A retrospective analysis of 97 medical hospital documentation of children with acute bocavirus infection, detected confirmed by PCR in nasopharyngeal aspirate. Results: In this work, it was shown that human bocavirus spread throughout the year with an increase in the incidence of clinically significant forms in the autumnwinter period, including during the period of an increase in the incidence of influenza. HBoV infection requiring hospitals is most significant in the first three years of life. In 74.2% of hospitalized children, bocavirus infection occurs with lower respiratory tract infections in the form of bronchitis — 77.8%, pneumonia — 28.9% and rarely bronchiolitis and is complicated by the development of respiratory failure in 28.9% of cases. Changes in the blood test are non-specific, and the level of C-reactive protein in children with various clinical manifestations of HBoV infection generally does not exceed 50 mg / l. An x-ray of the chest organs does not objectively reflect the existing volume and nature of the inflammatory process in the lungs.

scholarly journals Optical spin-symmetry breaking for high-efficiency directional helicity-multiplexed metaholograms

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Muhammad Ashar Naveed ◽  
Muhammad Afnan Ansari ◽  
Inki Kim ◽  
Trevon Badloe ◽  
Joohoon Kim ◽  
...  
Keyword(s):  
High Efficiency ◽  
Spin Symmetry ◽  
Cost Effective ◽  
Dielectric Materials ◽  
Additional Degree ◽  
Cost Effective Alternative ◽  
Spin Orbit Interactions ◽  
Smart Mobile ◽  
The Cost ◽  
Hydrogenated Amorphous

AbstractHelicity-multiplexed metasurfaces based on symmetric spin–orbit interactions (SOIs) have practical limits because they cannot provide central-symmetric holographic imaging. Asymmetric SOIs can effectively address such limitations, with several exciting applications in various fields ranging from asymmetric data inscription in communications to dual side displays in smart mobile devices. Low-loss dielectric materials provide an excellent platform for realizing such exotic phenomena efficiently. In this paper, we demonstrate an asymmetric SOI-dependent transmission-type metasurface in the visible domain using hydrogenated amorphous silicon (a-Si:H) nanoresonators. The proposed design approach is equipped with an additional degree of freedom in designing bi-directional helicity-multiplexed metasurfaces by breaking the conventional limit imposed by the symmetric SOI in half employment of metasurfaces for one circular handedness. Two on-axis, distinct wavefronts are produced with high transmission efficiencies, demonstrating the concept of asymmetric wavefront generation in two antiparallel directions. Additionally, the CMOS compatibility of a-Si:H makes it a cost-effective alternative to gallium nitride (GaN) and titanium dioxide (TiO2) for visible light. The cost-effective fabrication and simplicity of the proposed design technique provide an excellent candidate for high-efficiency, multifunctional, and chip-integrated demonstration of various phenomena.

scholarly journals Cost of Management of Diabetes Mellitus: A Pan India Study

2021 ◽  
pp. 097275312199849
Author(s):  
Raghuram Nagarathna ◽  
M Madhava ◽  
Suchitra S Patil ◽  
Amit Singh ◽  
K. Perumal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Urban Areas ◽  
Noncommunicable Disease ◽  
Cost Of Treatment ◽  
Rural And Urban Areas ◽  
Cost Of Disease ◽  
Rural And Urban ◽  
Significant Difference ◽  
The Cost ◽  
Prevalence Of Diabetes Mellitus

Background: Diabetes mellitus is a major noncommunicable disease. While mortality rates are increasing, the costs of managing the disease are also increasing. The all-India average monthly expenditure per person (pppm) is reported to be ₹ 1,098.25, which translates to an annual expenditure of ₹13,179 per person. Purpose: While a number of studies have gone into the aspect of the cost of disease management, we do not find any study which has pan-India reach. We also do not find studies that focus on differences (if any) between rural and urban areas, age or on the basis of gender. We planned to report the cost of illness (COI) in diabetes individuals as compared to others from the data of a pan-India trial. Methods: Government of India commissioned the Indian Yoga Association to study the prevalence of diabetes mellitus in India in 2017. As part of the questionnaire, the cost of treatment was also captured. Data collected from 25 states and union territories were analyzed using the analysis of covriance (ANCOVA) test on SPSS version 21. Results: There was a significant difference ( P < .05) between the average expenses per person per month (pppm) of individuals with self-reported known diabetes (₹1,357.65 pppm) and others (unknown and/or nondiabetes individuals–₹ 999.91 pppm). Similarly, there was a significant difference between rural (₹2,893 pppm) and urban (₹4,162 pppm) participants and between those below (₹1,996 pppm) and above 40 years (₹5,059 pppm) of age. Conclusion: This preliminary report has shown that the COI because of diabetes is significantly higher than others pointing to an urgent need to promote disease-preventive measures.

scholarly journals Functional profiling of COVID-19 respiratory tract microbiomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Niina Haiminen ◽  
Filippo Utro ◽  
Ed Seabolt ◽  
Laxmi Parida
Keyword(s):  
Respiratory Tract ◽  
Carbohydrate Metabolism ◽  
Lower Respiratory Tract ◽  
Viral Infections ◽  
Lavage Fluid ◽  
Degradation Pathway ◽  
Community Acquired Pneumonia ◽  
The Body ◽  
Sequencing Data ◽  
Functional Profiling

AbstractIn response to the ongoing global pandemic, characterizing the molecular-level host interactions of the new coronavirus SARS-CoV-2 responsible for COVID-19 has been at the center of unprecedented scientific focus. However, when the virus enters the body it also interacts with the micro-organisms already inhabiting the host. Understanding the virus-host-microbiome interactions can yield additional insights into the biological processes perturbed by viral invasion. Alterations in the gut microbiome species and metabolites have been noted during respiratory viral infections, possibly impacting the lungs via gut-lung microbiome crosstalk. To better characterize microbial functions in the lower respiratory tract during COVID-19 infection, we carry out a functional analysis of previously published metatranscriptome sequencing data of bronchoalveolar lavage fluid from eight COVID-19 cases, twenty-five community-acquired pneumonia patients, and twenty healthy controls. The functional profiles resulting from comparing the sequences against annotated microbial protein domains clearly separate the cohorts. By examining the associated metabolic pathways, distinguishing functional signatures in COVID-19 respiratory tract microbiomes are identified, including decreased potential for lipid metabolism and glycan biosynthesis and metabolism pathways, and increased potential for carbohydrate metabolism pathways. The results include overlap between previous studies on COVID-19 microbiomes, including decrease in the glycosaminoglycan degradation pathway and increase in carbohydrate metabolism. The results also suggest novel connections to consider, possibly specific to the lower respiratory tract microbiome, calling for further research on microbial functions and host-microbiome interactions during SARS-CoV-2 infection.

A Determinant Elimination Method for Bottleneck Assignment and Generalized Assignment Problems

2012 ◽  
Vol 239-240 ◽  
pp. 1522-1527
Author(s):  
Wen Bo Wu ◽  
Yu Fu Jia ◽  
Hong Xing Sun
Keyword(s):  
Computational Complexity ◽  
Optimization Algorithm ◽  
Assignment Problem ◽  
Numerical Experiments ◽  
High Efficiency ◽  
Synthesis Method ◽  
Assignment Problems ◽  
Generalized Assignment ◽  
The Cost ◽  
Time And Space Complexity

The bottleneck assignment (BA) and the generalized assignment (GA) problems and their exact solutions are explored in this paper. Firstly, a determinant elimination (DE) method is proposed based on the discussion of the time and space complexity of the enumeration method for both BA and GA problems. The optimization algorithm to the pre-assignment problem is then discussed and the adjusting and transformation to the cost matrix is adopted to reduce the computational complexity of the DE method. Finally, a synthesis method for both BA and GA problems is presented. The numerical experiments are carried out and the results indicate that the proposed method is feasible and of high efficiency.

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