scholarly journals MORPHOLOGICAL AND BIOCHEMICAL BLOOD COMPOSITION IN FATTENING STEERS INDUSTRIAL AREA BY THE FEEDING OF THE ADSORBENT AND ENZYME PREPARATION

2019 ◽  
pp. 118-123
Author(s):  
C. R. Chamikoeva ◽  
P. B. Temiraev ◽  
R. S. Godgiev ◽  
V. V. Tedtova ◽  
L. V. Tsalieva ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Biochemical Composition ◽  
Enzyme Preparation ◽  
Live Weight ◽  
Industrial Area ◽  
Zinc Level ◽  
The Body ◽  
Enzyme Preparations ◽  
Lead And Cadmium ◽  
Experimental Group

To reduce the risk of accumulation of heavy metals in the meat of fattened young cattle successfully used adsorbents that bind toxins and removed from the digestive tract. The detoxification effect of adsorbents increases with the skillful selection of enzyme preparations due to the synergy of action. The aim of the research is to study the effect of toxfin adsorbent and the enzyme preparation celloviridin G20x in the diets with high content of heavy metals on the morphological and biochemical composition of the blood of fattened bulls. According to the principle of pairs-analogues (taking into account the origin, sex, age, live weight) were formed 4 groups of 10 heads each. The research material is processed statistically using the software package «Microsoft Excel». In the composition of the winter diet of animals of all groups there was an excess of maximum permissible concentrations (MPC) in zinc level by 67.3-67.5 %, lead -by 63.4-64.6 % and cadmium - by 62.9-63.1 %, in the summer diet - by 66.4-66.6 %, 61.4-61.6 % and 60.6-60.8 %. This article presents experimental material showing that to optimize the morphological and biochemical composition of blood and increase the detoxification effect in the body of bulls on fattening should be in the diet with high levels of heavy metals together to introduce IEC celloviridin G20h at a dose of 70 g/t feed and adsorbent toxfin at a dose of 1 kg/t feed. At the same time, animals of the 3rd experimental group showed improvement of morphological and biochemical composition of blood and optimization of protective properties of their organism. The highest detoxification effect was obtained by co-feeding the tested drugs, so that in the blood of bulls of the 3 experimental group there was a significant (P<0.05) decrease in the concentration of zinc by 2.23 times, lead by 2.43 and cadmium by 3.00 times. At the same time, in no case in animals of the 3 experimental group in the blood there was no excess of MPC in terms of zinc, lead and cadmium.

scholarly journals MORPHOLOGICAL AND BIOCHEMICAL BLOOD COMPOSITION IN FATTENING STEERS INDUSTRIAL AREA BY THE FEEDING OF THE ADSORBENT AND ENZYME PREPARATION

2020 ◽  
pp. 125-130
Author(s):  
S. R. Chamikoeva ◽  
R. B. Temiraev ◽  
R. S. Godgiev ◽  
V. V. Tedtova ◽  
L. V. Tsalieva ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Biochemical Composition ◽  
Enzyme Preparation ◽  
Live Weight ◽  
Industrial Area ◽  
Zinc Level ◽  
The Body ◽  
Enzyme Preparations ◽  
Lead And Cadmium ◽  
Experimental Group

To reduce the risk of accumulation of heavy metals in the meat of fattened young cattle successfully used adsorbents that bind toxins and removed from the digestive tract. The detoxification effect of adsorbents increases with the skillful selection of enzyme preparations due to the synergy of action. The aim of the research is to study the effect of toxfin adsorbent and the enzyme preparation celloviridin G20x in the diets with high content of heavy metals on the morphological and biochemical composition of the blood of fattened bulls. According to the principle of pairs-analogues (taking into account the origin, sex, age, live weight) were formed 4 groups of 10 heads each. The research material is processed statistically using the software package «Microsoft Excel». In the composition of the winter diet of animals of all groups there was an excess of maximum permissible concentrations (MPC) in zinc level by 67.3–67.5 %, lead –by 63.4–64.6 % and cadmium – by 62.9–63.1 %, in the summer diet – by 66.4–66.6 %, 61.4–61.6 % and 60.6–60.8 %. This article presents experimental material showing that to optimize the morphological and biochemical composition of blood and increase the detoxification effect in the body of bulls on fattening should be in the diet with high levels of heavy metals together to introduce IEC celloviridin G20h at a dose of 70 g/t feed and adsorbent toxfin at a dose of 1 kg/t feed. At the same time, animals of the 3rd experimental group showed improvement of morphological and biochemical composition of blood and optimization of protective properties of their organism. The highest detoxification effect was obtained by co-feeding the tested drugs, so that in the blood of bulls of the 3 experimental group there was a significant (P<0.05) decrease in the concentration of zinc by 2.23 times, lead by 2.43 and cadmium by 3.00 times. At the same time, in no case in animals of the 3 experimental group in the blood there was no excess of MPC in terms of zinc, lead and cadmium.

scholarly journals Use of water-alcohols treatment of medicinal plants under conditions modeling intoxication by lead and cadmium

2021 ◽  
pp. 80-88
Author(s):  
Yu. I. Koval ◽  
T. I. Bokova ◽  
A. F. Petrov
Keyword(s):  
Heavy Metals ◽  
Medicinal Plants ◽  
Blood Serum ◽  
Raw Materials ◽  
Antioxidant Properties ◽  
Live Weight ◽  
The Body ◽  
Laboratory Animals ◽  
Lead And Cadmium ◽  
Water Alcohol

The results of studying the effects of water-alcohol infusions of medicinal plants - rhizomes of thick-leafed incense (Bergenia crasslifolia L. Fritsch), dioica nettle leaves (Urtica dioca L.), burdock roots (Arctium lappa L.), and mother-and-leaf leaves - are presented. ordinary machichi (Tussilago farfara L.) on the organism of laboratory rats under conditions of short-term intoxication with heavy metals in doses of 25 mg of lead and 2.5 mg of cadmium per 1 kg of live weight. In the course of studies it was found that the effect of heavy metals on the body of laboratory animals is selective - the main “depot” of lead was bone tissue, and cadmium - the kidneys and liver. The addition of 1 ml of water-alcohol infusions from medicinal raw materials to the diet of rats as detoxicants caused a decrease in the level of lead in the animal organism to 6.32 times, cadmium to 3.46 times. The greatest detoxification ability was shown by infusions of the roots of burdock and leaves of nettle dioecious. Under the influence of elevated doses of lead and cadmium in laboratory animals there was an increase in heart mass by 40.34 % and spleen by 89.91 %, a decrease in the content of alkaline phosphatase in blood serum by 25.81 %. Water-alcohol infusions normalized the biochemical parameters of rat blood serum. Studies have shown that the infusions of rhizomes of thick-leafed frangipani, burdock roots, dioecious nettles and coltsfoot leaves with antioxidant properties can be the basis for the development of an effective herbal preparation used for the prevention and treatment of animals from intoxication with salts of heavy metals.

scholarly journals EFFECTS OF LEAD AND CADMIUM INTOXICATION ON ANTIOXIDANT STATUS OF BROILER CHICKENS AND ITS CORRECTION WITH SYNTHETIC PREPARATIONS

2022 ◽  
pp. 7-18
Author(s):  
Yu. I. Koval
Keyword(s):  
Heavy Metals ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Live Weight ◽  
The Body ◽  
Cadmium Content ◽  
Oxidation Reactions ◽  
Short Term ◽  
Lead And Cadmium

   The authors present the results of a study of the effects of long-term (1.5 MPa) and short-term (5, 10 and 15 MPa) intoxication with heavy metals on the antioxidant status of broiler chickens. The authors found that the addition of increased concentrations of toxicants to the diet leads to their accumulation in poultry’s muscle, fat tissues, and skin. According to the study, lead content increases by 2.25 times, cadmium content increases by 6.5 times. Lipophilic compounds Tiofan and Tiofan M have the most pronounced detoxifying effect in chronic intoxication. Fantox 11-1 is the most pronounced detoxifying effect among hydrophilic compounds, which are inferior to lipophilic ones. Accumulation of heavy metals in the body led to a decrease in the antioxidant status of poultry. There was an acceleration of oxidative processes in long-term experimental toxicosis up to 3.10, up to 21.00 times in the short-term. The addition of 100 mg of lipophilic antioxidants per 1 kg of live weight to the diet with 7.5 mg of lead and 0.75 mg of cadmium per 1 kg of feed resulted in a decrease in the rate of oxidation reactions. The presence of lead and cadmium ions in the tissues of poultry caused a reduction of induction periods in the temperature-stabilized samples to 90 %. Enrichment of the diet with Thiophan and Fantox 11-1 increased this indicator up to 12.40 times. The hydrophilic antioxidant Fantox 11-1 dosage of 15 mg per 1 kg of live weight had a pronounced effect. Its introduction into the diet will correct the lack of endogenous antioxidants and increase the body’s antioxidant status under the influence of heavy metals.

scholarly journals Effect of sodium selenite and feed additive “Metisevit plus” on morphological parameters of blood of rats at the intoxication of Cadmium and Lead

2020 ◽  
Vol 22 (97) ◽  
pp. 52-57
Author(s):  
S. О. Slobodian ◽  
B. V. Gutyj ◽  
S. D. Murska
Keyword(s):  
Heavy Metals ◽  
Sodium Selenite ◽  
Hemoglobin Level ◽  
The Body ◽  
Lead Intoxication ◽  
Feed Additive ◽  
Morphological Parameters ◽  
Lead And Cadmium ◽  
Cadmium And Lead ◽  
Experimental Group

Heavy metals, Lead and Cadmium, are hazardous environmental pollutants. In the body of mammals, Cadmium and Lead have a toxic effect on a number of organs and systems. The mechanism of action of these poisons is to inhibit the activity of enzyme systems by blocking carboxyl, amine and SH groups of protein molecules. The aim of the study was to investigate the effect of sodium selenite and feed additive “Metisevit plus” on the morphological parameters of rat blood by Cadmium and Lead intoxication. The experiments were carried out on 200–220 g male Wistar rats, out of which 3 groups of animals were formed: a control and two experimental animals. Rats in the control and experimental groups were administered 16.6 % aqueous lead acetate at a dose of 100 mg/kg and 0.029 % aqueous cadmium chloride at a dose of 2.0 mg/kg. The rats of the first experimental group additionally used sodium selenite. The rats of the second experimental group additionally used the feed additive “Metisevit plus”. Lead-cadmium loading in rats was accompanied by erythrocytopenia and leukopenia. The lowest erythrocyte count was in the blood of diseased rats at 21 days, where it decreased by 41.3 %, respectively, compared to the initial values. It was found that hemoglobin level decreased to 90.3 ± 2.63 g/l during Cadmium and Lead intoxication in control rats. At the same time as the decrease in hemoglobin level and the number of erythrocytes in intoxicated rats, an increase in the average hemoglobin content in one erythrocyte of blood was observed up to 20.57 ± 1.20 pg As a result of the development of lead-cadmium intoxication in ill rats, leukopenia was noted, which, in our opinion, is associated with systemic lesions of cadmium and lead in the blood-forming organs of animals that suppress leukopoiesis. It was found that the number of leukocytes in patients of rats of group C decreased by 36.1 % compared with the initial data. The use of sodium selenite and the feed additive “Metisevit plus” in rats under lead-cadmium loading contributed to the increase in the number of red blood cells and hemoglobin level, as well as the decrease in the number of leukocytes in their blood. The improvement of normalizing effect on the morphological parameters of blood of rats under conditions of loading with heavy metals was shown by the feed additive “Metisevit plus” in comparison with sodium selenite.

scholarly journals DOMESTIC ENZYMES IN PIG FODDER

2017 ◽  
Vol 12 (2) ◽  
pp. 26-29
Author(s):  
Надежда Данилова ◽  
Nadezhda Danilova ◽  
Анатолий Лаврентьев ◽  
Anatoliy Lavrentev
Keyword(s):  
Test Group ◽  
Live Weight ◽  
The Body ◽  
Control Group ◽  
Large White ◽  
Enzyme Preparations ◽  
Young Pigs ◽  
Economic Experience ◽  
Experimental Group ◽  
Feed Unit

One of the main promising areas in the technology of pigs feeding and the development of the industry is the use of enzyme preparations. Enzymes are specific proteins, that fulfill the role of biological catalysts in a living organism. Enzymes, unlike hormones and biostimulants, do not act on the animal organism, but on the components of the feed in the gastrointestinal tract, they do not accumulate in the body and products of animal husbandry. The scientific and economic experience was carried out on the basis of the CJSC “Progress” enterprise of the Yalchik district of the Chuvash Republic from May to October 2015. Studies were carried out on young pigs of large white breed at the age of 2 to 7 months. Three groups of clinically healthy gilts were formed according to the principle of analog groups of 12 heads in each one. The duration of scientific and economic experience was 150 days. The pigs of all groups were in the same conditions of feeding and maintenance, and they were fed mixed fodders in accordance with detailed feeding standards. Control samples are animals that received mixed feed, used in the farm when feeding young pigs. The feedstuff of the first experimental group was enriched additionally with a mixture of enzyme preparations №1 and №2, the second test group with mixture №1 and №3. At the beginning of the experiment in all groups, the average live weight of pigs was almost the same and amounted to 17.8 to 18.1 kg. At the end of the experiment, this parameter in the control group was 112.0 kg, in the first test group - 125.1 kg, in the second test group - 120.3 kg. Feed costs per 1 kg of gain were 4.82 energy feed unit in the control group, 4.25 energy feed unit in the first group and 4.44 energy feed unit in the second test group. The production was received for 1 ruble of additional costs in the first experimental group to 8.29 rubles and to 6.06 rubles in the second experimental group.

Polymorphism of p-450 cytochrome detoxication genes in adolescents depending on the degree of contamination of the organism by heavy metals

2020 ◽  
Vol 99 (5) ◽  
pp. 478-482
Author(s):  
N. P. Setko ◽  
A. G. Setko ◽  
Ekaterina V. Bulycheva ◽  
A. V. Tyurin ◽  
E. Yu. Kalinina
Keyword(s):  
Heavy Metals ◽  
Environmental Factors ◽  
Heavy Metal Contamination ◽  
Atomic Absorption Spectrophotometry ◽  
The Body ◽  
Lead And Cadmium ◽  
Cyp2b6 Gene ◽  
Cytochrome P 450 ◽  
Gene Cyp1a1 ◽  
Group 1

Introduction. Changes in the body of children and adolescents aimed at adapting to environmental factors are determined by genetic polymorphism in xenobiotic biotransformation genes, determining the degree of susceptibility of the child’s body to pollutants, which is the basis of modern personalized preventive medicine when managing risks to the health of the child population under the influence of environmental factors. Material and methods. Trace elements, including heavy metals, lead and cadmium, were determined in the hair of 256 practically healthy teenagers by atomic absorption spectrophotometry. Depending on the level of content of the latter, two groups of adolescents were formed to determine six genes of the cytochrome P-450 family. Group 1 consisted of adolescents whose cadmium lead content exceeded the average Russian indices. The second group included adolescents whose heavy metals were above the level of average Russian standards. Results. Studies have shown that in adolescents of the 1st group, compared with the data of adolescents of the 2nd group, an increase in the number of carriers of two mutant alleles at the locus rs 1048943 (gene CYP1A1) is 3.08 times, rs 464621 (gene CYP1A1) is 1. 8 times; locus rs 2069522 (CYP1A2 gene) 3.63 times; locus rs 1799853 (CYP2C9 * 2 gene) 4.5 times; locus rs 1057910 (gene CYP2C9 * 3) 3.8 times and locus rs 2279343 (gene CYP2B6) 4.25 times. Moreover, carriers of two normal alleles in adolescents of the first group at the locus rs 1048943 (gene CYP1A1) were 5.14 times; locus rs 2279343 (CYP2B6 gene) was 6.5 fold less than among adolescents of the 2nd group; and at the locus rs 464621 (gene CYP1A1), rs 2069522 (gene CYP1A2), rs 1799853 (gene CYP2C9 * 2), rs 1057910 (gene CYP2C9 * 3) there were no carriers of normal homozygotes. Conclusion. Group 1 adolescents with heavy metal contamination of the body are carriers significantly in a greater number of pathological mutations in the genes of the cytochrome P-450 detoxification system in comparison with data from group 2 adolescents.

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

Determination of Some Heavy Metals in Milk of Cow Grazing At Selected Areas, of Kaduna Metropolis

2017 ◽  
Vol 7 (7) ◽  
pp. 341 ◽  
Author(s):  
Mahmud Mohammed Imam ◽  
Zahra Muhammad ◽  
Amina Zakari
Keyword(s):  
Heavy Metals ◽  
Cadmium Toxicity ◽  
Research Work ◽  
The Body ◽  
Cow Milk ◽  
Scientific Model ◽  
Potential Health ◽  
Milk Samples ◽  
Lead And Cadmium ◽  
Digestion Technique

In this research work the concentration of zinc, copper, lead, chromium, cadmium, and nickel in cow milk samples obtained from four different grazing areas   (kakuri, kudendan, malali, kawo) of Kaduna metropolis. The samples were digested by wet digestion technique .The trace element were determined using bulk scientific model VPG 210 model  Atomic Absorption Spectrophotometer (AAS).. The concentration of the determined heavy metal were The result revealed that Cr,  Ni and Cd were not detected in milk samples from Kawo, Malali  and Kudendan whereas lead (Pb) is detected in all samples and found to be above  the stipulated limits of recommended dietary allowance (NRC,1989) given as 0.02mg/day. Cu and Zn are essential elements needed by the body for proper metabolism and as such their deficiency or excess is very dangerous for human health. However, they were found in all samples and are within the recommended limits while Cd (2.13 – 3.15 mg/kg) in milk samples from Kakuri was found to be above such limit (0.5mg/day). Cow milk samples analyzed for heavy metals in this research work pose a threat of lead and cadmium toxicity due to their exposure to direct sources of air, water and plants in these grazing areas, thereby, resulting to a potential health risk to the consumers.

Local mineral feed additives in the rations of steers of Hereford breed

2020 ◽  
pp. 28-39
Author(s):  
M. Grigoryev ◽  
N. Chernogradskaya
Keyword(s):  
Economic Effect ◽  
Live Weight ◽  
Negative Influence ◽  
Feed Additives ◽  
The Body ◽  
Control Group ◽  
Mineral Salts ◽  
Meat Productivity ◽  
Experimental Group ◽  
Mineral Feed Additives

Animals imported to Yakutia from other regions fall into feeding and housing conditions that differ from their usual agro-climatic conditions, which causes the problem of their adaptation. Yakutia is one of the areas where the feed of its own production has a lack of basic minerals, which affects the health and productivity of animals, which has an additional negative influence on the adaptation process of imported cattle. In order to replenish macro- and microelements in the body, it is necessary to introduce various local mineral feed additives, premixes, and use mineral salts into the ration. Under the conditions of Central Yakutia the influence of local mineral feed additives (zeolite of the Khonguruu Deposit in the Suntar district and sapropels of local lakes) containing macro- and microelements that increase the meat productivity of steers has been studied. As a result of the research the influence of local mineral feed additives on meat productivity and physiological condition of Hereford steers has been established. Influence of zeolite and sapropel in a complex with mineral salts on digestibility of nutrients of the ration and use of nitrogen, calcium and phosphorus by experimental animals has been defined. The influence of feed additives on the quality of meat products has been studied. The results have shown that the use of local mineral feed additives in the composition of ration of steers during the fattening period at a dose of 0,7 g zeolite per 1 kg of live weight of the animal and 200 g of sapropel in combination with 10 g of mineral salts contributed to the gain in live weight, carcass weight, carcass yield, yield of edible parts, and economic efficiency of fattening. For the entire period of the experiment the gain in live weight in groups was: in control group 2222,9 kg, in the 1st experimental group 2396,2 kg, in the 2nd experimental group 2471,1 kg. The total economic effect for the 1st experimental group for the period of experiment amounted to 44,3 thousand Rubles, for the 2nd experimental group 78,0 thousand Rubles or per 1 head/day 14,06 and 24,76 Rubles, respectively.

The effectiveness of use of enterosorbent Shelltic Es when rearing of young pigs

2020 ◽  
pp. 3-11
Author(s):  
S. Grikshas ◽  
N. Kulmakova ◽  
K. Spitsyna ◽  
A. Dar’in ◽  
T. Mittelshtein
Keyword(s):  
Average Daily Gain ◽  
Live Weight ◽  
Feed Additives ◽  
The Body ◽  
Control Group ◽  
Internal Organs ◽  
Feed Digestibility ◽  
Young Pigs ◽  
Carcinogenic Effects ◽  
Experimental Group

Mycotoxins have been formed in feed are secondary metabolites of fungi and are quite stable substances that have teratogenic, mutagenic and carcinogenic effects. An effective way to combat mycotoxins in feed is the use of feed additives that adsorb toxins, prevent their absorption in the gastrointestinal tract of the animal and are excreted from the body. The infl uence of coconut enterosorbent Shelltic Es on fattening and meat qualities of young pigs has been studied. It has been found in the process of fattening that the highest feed digestibility was in pigs of the experimental group, in the diet of which enterosorbent has been added. The results of studies of the chemical composition and technological properties of pork have been provided. The positive eff ect of enterosorbent on precocity, absolute average daily gain of live weight and reduction of feed expenditures per 1 kg of gain has been revealed. In pigs from the experimental group the average thickness of the fat was higher and the area of the “muscle eye” was lower compared with animals of the control group, which indicates that higher rates of carcass yield have been obtained due to faster accumulation of fat tissue. The weight of internal organs of pigs indicates the intensity of metabolic processes in the body. In experimental animals the weight of the lungs was 0,1 kg lower, and the liver and heart were higher by 0,13 and 0,01 kg, respectively. Enterosorbent had no effect on the content of vitamins in the liver of pigs of the compared groups. The content of impurities of organochlorine toxicants and toxic elements in the meat and liver of animals of the experimental group was lower than that of control analogues. Therefore, the use of enterosorbent Shelltic Es promotes more active excretion of them from the body.

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