6095 Background: Financial relationships with commercial interests (COI) are common in cancer research. There are few data examining the correlation between COI and research merit. Meeting placement prominence (MP) and peer review score (PRS) are indicators of research merit. We examined the association between ASCO AM abstracts whose authors disclose COI and both MP and PRS. Methods: We reviewed abstracts presented at the ASCO AM in 2006 and 2008-2011. We evaluated associations between COI disclosed by any author and PRS and MP (order of prominence: plenary session (PS), clinical science symposium (CSS), oral presentation (OP), poster discussion session (PDS), vs. general poster session (GPS)). Chi-square tests, T-tests, and logistic regressions of COI were used to assess associations with MP, PRS, and year. Results: Of 12,446 total abstracts accepted for presentation, 78% of PS, 59% of CSS, 54% of OP, 52% of PDS, and 39% of GPS report at least one COI. Abstracts selected for PS, CSS, OP, and PDS had more COI compared to those selected for GPS (p < 0.05). Stock ownership COI were more frequently disclosed in PS (30%), CSS (30%), OP (22%), and PDS (22%) compared to GPS (16%) (p < 0.05). Employment COI were more frequently reported among abstracts presented at PS (39%), CSS (37%), OP (27%), and PDS (27%) compared to GPS (21%) (p < 0.05). Consultant COI were more likely to have higher MP than GPS placement (OR for PS=5.5; CSS=2.4; OP=2.2; PDS=1.9). Similarly, honoraria COI were more likely to have higher MP than GPS placement (OR for PS=3.9; CSS=1.8; OP=2.1; PDS=1.7). Better PRS was associated with COI (OR 0.17; p < 0.05). The relationship of better PRS with any COI strengthened over time from 2006, 2008-2011 (PRS times year interaction OR=0.65, p<0.001). Conclusions: ASCO abstracts whose authors report COI have higher merit as measured by MP and PRS. This suggests a dependence on industry relationships for access to important data that will lead to prominent cancer research. These relationships will require further investigation and ongoing management. To our knowledge, this is the first study examining the scientific merit of research with relation to COI.