Lennart Heimer: concepts of the ventral striatum and extended amygdala

2008 ◽  
Vol 25 (1) ◽  
pp. E8 ◽  
Author(s):  
W. Jeff Elias ◽  
Dibyendu Kumar Ray ◽  
John A. Jane

Dr. Lennart Heimer, the famous neuroanatomist of Swedish descent, died last year but left a legacy that will impact the neurosciences and potentially psychosurgery for years to come. He developed an anatomical technique for demonstrating the terminal boutons that helped to delineate basal forebrain anatomy. During these studies, he realized the relationship of basal forebrain structures to the limbic system, thus initiating the concept of the ventral striatum and parallel basal ganglia circuitry. Heimer excelled as a teacher as well and honed his brain dissection technique to one of the most effective tools for understanding neuroanatomy. His legendary sessions with neurosurgical residents resulted in his recognition as one of the world’s leading fiber tract dissectors. His gentle, engaging manner has been documented in several media formats.

2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Agnes B. B. Mamiasa ◽  
Maya Pinkan Warouw ◽  
Jenny Hilda Pakasi

Contextual Teaching and Learning Approach (CTL) is one form of approach that can be said to be capable and very suitable to be a model of appropriate learning when applying the form of material in the classroom. Learning the form of CTL is closely related to the context, atmosphere or circumstances that can be interpreted also as learning related to a particular atmosphere. Talking about the atmosphere has to do with the use of the time form also known as tense. A little interesting about the Simple Future Tense that is raised to the core of learning because of this Tense became one of the important parts in the use of Grammar on learning English where we can express or declare actions in the future. This form uses the word 'will' and 'shall' (short form:’ll) plus infinitive. Besides using the form of 'going to' to be able to declare the time to come and the intention of the speaker to do something, for example I'm going to stop smoking '. CTL's role can make learning more effective and even create a fun and non-boring atmosphere, providing experiences that are closely related to the real world of learners and using a variety of learning resources; and therefore the method on CTL can provide understanding, development of science, the develop of knowledge and contextual understanding of learners about the relationship of subjects with what found learners in everyday life.Keywords : CTL, BE GOING TO vs WILL


2020 ◽  
Vol 60 (2-3) ◽  
pp. 205-234
Author(s):  
A. Sunarwoto

Abstract The focus of this article is on the Salafiyya-Madkhaliyya in Indonesia, which takes its name from Saudi scholar Rabīʿ al-Madkhalī. After an account of how they emerged and developed in Indonesia, the relationship of the Madkhalīs with the state, which is based on a “fiqh of obedience”, is analyzed. It is argued that, while this legal underpinning necessitates that they give total loyalty to the ruler (walī l-amr, or ūlū l-amr), the Indonesian Madkhalīs are unable to entirely follow this principle. The Madkhalīs have had to come to terms with the fact that Indonesia follows a democratic system, which, in fact, prevents the comprehensive accommodation of their Salafī principles. The resulting ambiguities prove difficult to solve. It is argued here that the negotiation between Madkhalī Salafīs and the Indonesian state is characterized by the constant efforts of the former to tackle those ambiguities.


1995 ◽  
Vol 105 (1) ◽  
pp. 1-19 ◽  
Author(s):  
P H Backx ◽  
W D Gao ◽  
M D Azan-Backx ◽  
E Marban

The control of force by [Ca2+] was investigated in rat cardiac trabeculae loaded with fura-2 salt. At sarcomere lengths of 2.1-2.3 microns, the steady state force-[Ca2+]i relationship during tetanization in the presence of ryanodine was half maximally activated at a [Ca2+]i of 0.65 +/- 0.19 microM with a Hill coefficient of 5.2 +/- 1.2 (mean +/- SD, n = 9), and the maximal stress produced at saturating [Ca2+]i equalled 121 +/- 35 mN/mm2 (n = 9). The dependence of steady state force on [Ca2+]i was identical in muscles tetanized in the presence of the Ca(2+)-ATPase inhibitor cyclopiazonic acid (CPA). The force-[Ca2+]i relationship during the relaxation of twitches in the presence of CPA coincided exactly to that measured at steady state during tetani, suggesting that CPA slows the decay rate of [Ca2+]i sufficiently to allow the force to come into a steady state with the [Ca2+]i. In contrast, the relationship of force to [Ca2+]i during the relaxation phase of control twitches was shifted leftward relative to the steady state relationship, establishing that relaxation is limited by the contractile system itself, not by Ca2+ removal from the cytosol. Under control conditions the force-[Ca2+]i relationship, quantified at the time of peak twitch force (i.e., dF/dt = 0), coincided fairly well with steady state measurements in some trabeculae (i.e., three of seven). However, the force-[Ca2+]i relationship at peak force did not correspond to the steady state measurements after the application of 5 mM 2,3-butanedione monoxime (BDM) (to accelerate cross-bridge kinetics) or 100 microM CPA (to slow the relaxation of the [Ca2+]i transient). Therefore, we conclude that the relationship of force to [Ca2+]i during physiological twitch contractions cannot be used to predict the steady state relationship.


2018 ◽  
Author(s):  
Richard Logsdon

While scholars have provided some insight into Penny Dreadful, no one has addressed the relationship of the piece’s overall design to the writer’s vision. Indeed, Penny Dreadful is offered as a warning of a darker age to come. Accordingly, writer John Logan sets his series in a late Victorian, Gothicized London that serves as a microcosm for a contemporary Western world experiencing a psychological and spiritual disintegration that touches the individual and the larger culture. Logan calls attention to the anxieties generated by this disintegration by incorporating into his series characters from late Victorian Gothic fiction: Frankenstein and his creature, Dracula, the Wolf Man, Dorian Gray, and Dr. Jekyll. The individual and cultural anxieties suggested by these characters’ “monstrous” behaviors have their basis not only in their sexual dysfunctions but in their despair over God’s absence. This crisis is centered in sexually adventurous Vanessa Ives, whose attempts to return to the Christ Who has rejected her hold the series together. In the series’ final episode, just before her death, Vanessa has a vision of Jesus. In response to Vanessa’s death, most of the remaining characters are seized by an ennui that has its counterpart in our own culture. The suggestion is that Logan uses Vanessa Ives as a symbolic representation of a dying world view, which, somewhat ironically, provided for her remaining friends a hope that sustained them.


2006 ◽  
Vol 5 (1) ◽  
Author(s):  
Jenu Widjaja Tandjung ◽  
Armanu Toyib ◽  
Multifiah .

A competition of 4T oil business is growing up. It can be seen from the increasing of a number of producers that have NPT (registered oil number). Customers will have more choices selecting many trademarks of 4T oil. To come out on top of this competition, the oil producers need to know oil attributes that influence customer choosing trademarks of 4T oil.This study wants to know the relationship between customer demography based on age, income, education level, sex and occupation with the choosing of 4T oil attributes. Besides, it is also to know the oil attributes that have strong relationship with characteristics of customer demography. The researcher also wants to know the relationship of customer demography of 4T oil with 4T oil post-hoc segmentation.This study focuses on 4T oil with motorcycle owners who change 4T oil in the garages in city area of Surabaya as samples. In taking sample, rescuer used accidental sampling with 168 people as respondents. Respondent characteristic is limited on demographically characteristic. Besides using primer data, it also used secondary data which taken from tabloid of Marketing, Jawa Pos, Badan Pusat Statistik, Indommercial and Bulletin Dirjen Migas. Scale and measurement that are used in this study is Likert Scale. Whereas, researcher used correlation of Rank Spearman and CHAID (Chi-Square Automatic Interaction Detection) as method of data analysis.The interesting result of this study is the choosing of 4T oil attributes in relation with characteristic of demography that is age, income, education, and occupation. Whereas, sex is not in relation with the choosing of 4T oil attributes. Besides, the customers of 4T oil tend to be rational that is taking more consideration on quality, acceleration of machine and oil endurance comparing with appearance and price.


2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Eka Wilani

Semiotics, as a study about a sign as part of social life, leans on the rule or social code in a society. A rose for Emily is a short story tells about the detail of the story that has in Emily’s life and an odd relationship with her father, her boy friend, Jefferson City, and her terrible secret that she was hiding. The objective of the article was to describe symbols used in the short story. The data was analyzed by using semiotics approach. It was found that there are some symbols in the short story illustrated by the author. They are “The Rose, The Move of her Hair, Ticking of Watch, The House and Black Color”. The Rose was symbolized as the relationship of Emily and her father. Emily grew up in luxurious. And The move of her hair was as a symbol of changing of her life. Moreover, ticking of watch was as a symbol to come to the new generation. Both of the House and Emily have changed after the death. Her house extinct as abandoned. Lastly, the black color was a symbol of death, depression, and darkness. The writer found that each symbols in A Rose for Emily illustrated the darkness and mysterious life of Miss Emily. Each of the symbols helps the author to create the story.


1990 ◽  
Author(s):  
Jerome D. Quinn

The Letter to Titus, one of the three "Pastoral Epistles" of the New Testament, has over the last twenty years become the ground of intense controversy-theologically, sociologically, even politically. For this letter (like its companions, I and II Timothy) dates to a time when the Apostles are gone and a new church leadership is evolving. In Titus we read instruction that is of continuing importance to the Christian faithful, touching on issues that are with us yet--leadership in the Church and qualifications for authority; propriety of worship; the roles of women; the demands of the Christian ethic upon individuals; the relationship of the new followers of Christ with their Jewish contemporaries. Monsignor Quinn guides us ably through the shoals of contemporary controversy among scholars, dealing definitively with issues of authorship, place of origin, original audience, and the purpose of the Pastorals. More than this, he sets before us his integrated vision of these letters as the earliest anthology on the subject of pastoral leadership. The crowning achievement of a lifetime of admirable work in biblical studies, these translations and commentaries will stand as Quinn's monument for generations to come.


Neuroanatomy ◽  
2017 ◽  
pp. 341-376
Author(s):  
Adam J Fisch

This chapter focuses on learning the anatomy of the diencephalon, basal ganglia, and limbic system. It provides instruction on how to draw the basal ganglia, the thalamus, the hypothalamus, diencephalon, limbic system, hippocampus, Papez circuit, parahippocampal gyrus, intrahippocampal circuitry, olfactory cortex, and basal forebrain. Also addressed is the neurocircuitry of sleep, including the anatomical location of the sleep center, the physiology of the thalamocortical circuits, the pathway for the generation of REM sleep, and the biology of sleep and wakefulness. The chapter concludes with key discoveries in the biology of sleep and wakefulness.


1977 ◽  
Vol 8 (2) ◽  
pp. 161-181 ◽  
Author(s):  
Robert L. Tignor

In the early months of 1920 a group of leading Egyptians founded Bank Misr. Destined to be the major financial arm of an emerging Egyptian bourgeoisie and the hub of a far-flung industrial and commercial empire, Bank Misr was established amidst the revolutionary turmoil of Egypt in 1919 and 1920. It reflected the nationalist and antiforeign sentiments of these troubled years. Its architect, Tal'at Harb, epitomized many of these characteristics. An ardent Muslim and a defender of Arab-Islamic civilization against its Western and Eastern detractors, he was a dedicated nationalist and a critic of rapacious and exploitative European capitalism. Bank Misr was founded as a supremely Egyptian institution and an expression of nationalist aspirations. Its founders hoped that the Bank might facilitate the emergence of an independent Egyptian bourgeoisie. They also wanted to use its resources to establish new commercial, industrial, and financial companies separate from European capital and working exclusively for the economic well-being of Egypt. But many questions immediately emerged. Could an institution founded in the furor of the revolution and headed by an inexperienced staff even survive, let alone spearhead, far-reaching industrial and commercial changes in the Egyptian economy? What would be its relations with foreigners and especially foreign capital? What role would foreign experts play in the life of the Bank? The purpose of this essay is to investigate how the Bank dealt with these problems by looking at the evolving relationship of the Bank with foreign capital. Put simply it can be said that as the Bank evolved and matured, it began to modify many of its original nationalist, populist, and antiforeign sentiments. It was forced to form alliances with the same groups it had so vigorously denounced at its birt. A close observation of the relationship between Bank Misr and foreign capital should cast light on the effort to create an autonomous Egyptian bourgeoisie. It will show the problems inherent in this vision and the compromises that had to be made as difficulties arose. It will also demonstrate the power of European capitalism in Egypt and its capacity to come to terms with even the most vigorous nationalist organizations.


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