scholarly journals PATTERNS IN WOUND HEALING PROCESS AFTER BRANCIAL CLEFT CYST EXCISION IN CHILDREN

2021 ◽  
pp. 68-72
Author(s):  
P.I. Tkachenko ◽  
S.A. Belokon ◽  
N.M. Lokhmatova ◽  
O.B. Dolenko ◽  
Yu.V. Popelo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
The Body ◽  
Local Temperature ◽  
Wound Healing Process ◽  
Wound Area ◽  
Cyst Excision ◽  
Skin Contact ◽  
Branchial Cleft ◽  
Cystic Masses

The course of the wound healing process after surgical intervention on brancial cleft cyst excision should be considered as a stereotyped inflammatory-reparative reaction of the body, characterized by staged aseptic inflammation, regeneration and fibrosis. Clinically and even morphologically, it is difficult to determine the stages of the wound healing process in the temporal aspect, since they are consistent and interconnected. Purpose. The paper is aimed at evaluation of the wound healing process according to clinical indicators in children after branchial cleft cyst excision. Methods and Material. 26 children aged from 5 to 17 years old with branchial cleft cysts have been examined and treated. In the postoperative period, the nature, amount of exudate and its cell composition has been determined; skin contact thermometry has been performed at 4 points around the wound at a distance of 1 cm. Results. The first manifestations of the disease coincided with the course of acute respiratory viral diseases in 8 children (30.8%); association with ENT pathology was observed in 3 (11.5%) children and the cystic masses emerged spontaneously in 15 cases (57.7%). They were localized with almost the same incidence on the left and right, but the vast majority (21 cases (80.7%)) was located anteriorly the sternocleidomastoid muscle and in 5 (19.3%) cases behind it. Ultrasound examination, made in 21 patients (80.8%), has revealed the presence of cystic masses with clear contours, hypoechoic structure and fine-grained inclusions, and the wall thickness varied from 1 to 3 mm. In 5 doubtful cases (19.2%) a puncture biopsy was performed. On 1st day after surgery, hyperemia around the wound was moderate in 15 children (57.7%); it was insignificant in 8 (30.8%) children and it was absent in 3 (11.5%) children. At the same time all children experienced collateral edema of various localization and painful modality. In the impression smears, a significant number of neutrophils, a moderate number of lymphocytes and erythrocytes was detected, which were prominent against the background of a loose substrate. The temperature of the wound area was 36.24 ± 0.07˚C, which was higher compared to the control group (34.71 ± 0.12˚C). On 3rd day, the corolla of hyperemia around the wound was not detected in 18 patients (69.2%), and its narrowing was recorded in 6 (23.1%) cases and it was persistent in 2 (7.7%) cases. On palpation, severe, moderate and weak pain on the wound area was experienced by 2 (7.7%), 15 (57.7%) and 9 (36.4%) children, respectively. The cytograms of the exudate showed a reduced quantity of neutrophils, erythrocytes and lymphocytes. Two children showed elevated quantity of destructured neutrophils and local temperature to 37.21 ± 0.16 ° C, which required medical adjustments. A narrow corolla of hyperemia around the wound, slight edema and moderate pain was detected on 7th day only in 2 children. In all patients, palpation revealed tissue compaction along the wound canal, onset of epithelialization, and the cytograms revealed the presence of sporadic neutrophils. The temperature of the skin around the wound reached 35.74 ± 0.11˚C, which was almost similar to controls (34.21 ± 0.08˚C). In all cases, the wounds healed with primary tension. Thus, the nature of the dynamics of wound healing after brancial cleft cyst extirpation in children can be successfully controlled by the prominence of the main clinical signs, the findings of the study of cellular composition of wound exudate and local temperature measuring. The perspectives of further research are associated with availability and simplicity of the methods in terms of their application in everyday clinical practice.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

scholarly journals Jatropha Neopauciflora Pax Latex Exhibits Wound-Healing Effect in Normal and Diabetic Mice

2021 ◽  
Vol 26 ◽  
pp. 2515690X2098676
Author(s):  
Ana Bertha Hernandez-Hernandez ◽  
Francisco Javier Alarcon-Aguilar ◽  
Mario Garcia-Lorenzana ◽  
Marco Aurelio Rodriguez-Monroy ◽  
Maria Margarita Canales-Martinez
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Diabetic Mice ◽  
Wound Area ◽  
Oral Infections ◽  
Patients With Diabetes ◽  
Exclusion Chromatography ◽  
Wound Healing Effect ◽  
Molecular Exclusion Chromatography

Jatropha neopauciflora is an endemic species of Mexico. Its latex is used to treat wounds, scarring, oral infections, and loose teeth. To date, there are no studies that validate at a morphological level a wound-healing use in diabetes. The present research aimed to evaluate the wound-healing capacity of the latex of J. neopauciflora in the skin of healthy and streptozotocin-induced diabetic mice. Also, a chemical analysis of the latex through molecular exclusion chromatography and HPLC were performed. Male mice ( Mus musculus) of 7-week-old CD1 strain were used. Groups of healthy and diabetic mice were formed. A longitudinal cut of 1 cm was performed on the depilated skin. All treatments were topically applied to the wound area twice a day for ten days. At the end of the experiments, the skin sections were obtained from the wound area and stained with Hematoxylin-Eosin. Then we counted the number of active fibroblasts in all the experimental groups. In normal mice, the latex accelerated the wound-healing process and decreased the number of active fibroblasts, similarly to Recoveron. In diabetic mice, the latex and Recoveron increased the number of active fibroblasts. In normal and diabetic mice, a thin and orderly epidermis was observed. Molecular exclusion chromatography exhibited 58 fractions, 14 of which were subjected to HPLC, to detect catechin, a flavonoid with antioxidant, antimicrobial, and anti-inflammatory properties. J. neopauciflora latex can be useful for wound treatment in patients with diabetes mellitus because it accelerates and promotes the wound-healing process.

scholarly journals Investigating the Wound Healing Potential of the Polyherbal Gels Prepared with Ficus Extract

2018 ◽  
Vol 8 (2) ◽  
pp. 13-16
Author(s):  
Mahender K ◽  
Ravi D ◽  
Chaitanya Kumar K ◽  
Mothilal K
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Human Body ◽  
Healing Process ◽  
The Body ◽  
Wound Healing Process ◽  
Aqueous Extracts ◽  
Standard Drug ◽  
Carbopol Gel ◽  
Ficus Benghalensis

Wounds are nothing but any damage to the tissue or skin that can be healed. The wound healing process is usually built in the human body to self heal many wounds. When there is an injury in the body, there is an inflammatory response that is generated in the body, and the cells begin to raise the collagen levels in the skin which enables to increase the healing process. Ficus species of plants are famous for their potency to treat diseases in various Indian systems of medicine and the tree is commonly called as a banyan. Especially the plant in the species benghalensis is used to treat rheumatism, wounds and other skin related problems like an ulcer. The herbal gels were prepared using the incorporation of the aqueous extracts of the plant Ficus benghalensis into carbopol gel. They were investigated for the wound healing potential compared to the betadine drug standard. The gels at a concentration 200mg/g of the gel showed better activity compared to the gel at 100mg/g and the standard drug, betadine.

Pulse Voltage Electrical Stimulation for Bacterial Inactivation and Wound Healing in Mice with Diabetes

2022 ◽  
Author(s):  
Mokhamad Tirono ◽  
Farid Samsu Hananto ◽  
Ahmad Abtokhi
Keyword(s):  
Wound Healing ◽  
Electrical Stimulation ◽  
Treatment Time ◽  
Healing Process ◽  
Anaerobic Bacteria ◽  
Pulse Voltage ◽  
Wound Healing Process ◽  
Bacterial Inactivation ◽  
Wound Area ◽  
Treatment Of Wounds

Background: Treatment of wounds in diabetes often gets less than perfect healing. One of the reasons for the difficulty in treating wounds in diabetes is the growth of aerobic and anaerobic bacteria. This study aims to determine the pulse voltage and treatment time that can optimally inactivate bacteria, and their effect on wound healing in mice suffering from diabetes. Methods: The study used electrical stimulation with a direct voltage of 10 volts given a pulse voltage of 50-80 volts, a width of 50 µs, and the number of pulses of 65 per second. The research samples were Staphylococcus aureus (S. aureus) and Pseudo-monas aeruginosa (P. aeruginosa) bacteria that grew on beef and mice (Mus musculus) with diabetes. The treatment for S. aureus and P. aeruginosa bacteria was carried out using a pulse voltage of 50-80 volts for 5-15 min/day and repeated for 3 days. Meanwhile, treatment of mice wounds was carried out with a pulse voltage of 80 volts for 15 min/day and repeated for 7 days. Results: The results showed that treatment with a pulse voltage of 50-80 volts and a treatment time of 5-15 min significantly reduced the number of S. aureus and P. aeruginosa bacteria in beef (p£0.05). Treatment with a pulse voltage of 80 volts for 15 min made beef free from bacteria. Meanwhile, treatment with a pulse voltage of 80 volts for 15 min per day for seven days resulted in the wound state of three mice in the maturation phase and two mice in the proliferation phase on day 8 with an average wound area of 0.108 cm 2. Conclusion: The treatment with a pulse voltage of 80 volts for 15 min made the beef sterile, the mice wounds healed quickly, and the mice not stressed. The higher the blood glucose level, the slower the wound healing process.  

scholarly journals Effect of Carica papaya Extract toward Incised Wound Healing Process in Mice (Mus musculus) Clinically and Histologically

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Rachmi Fanani Hakim ◽  
Fakhrurrazi ◽  
Dinni
Keyword(s):  
Wound Healing ◽  
Mus Musculus ◽  
Carica Papaya ◽  
Healing Process ◽  
Antibacterial Properties ◽  
The Body ◽  
Wound Healing Process ◽  
Protective Function ◽  
Incised Wound ◽  
Anterior Teeth

Wound healing entails a sequence of complex biological processes, which is a protective function of the body that focuses on a quick recovery. Reducing wound healing time is crucial in a wound as it lowers the chance of infection and decreases complications and costs. Papaya extract was obtained by a maceration method. It contains papain enzyme, flavonoid, saponin, and alkaloid, which act as an anti-inflammatory, astringent substance, vasodilator, antioxidant, analgesic, with antifungal, and antibacterial properties, and increase the collagen synthesis. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice (Mus musculus) clinically and histologically. This experimental laboratory study was performed using 24 mice weighing between 30 and 40 grams and 12 and 14 weeks of age as experimental animals. Each group was incised along 5 mm at the labial gingiva under both of mandible anterior teeth with a depth reaching alveolar bone. Papaya extract was applied topically in the morning and evening for 14 days. The clinical result was obtained by assessing the length of wound closure measured every day for 14 days. Based on the statistic test result, it showed that the papaya extract has a significant effect (p≤0.05) toward the healing process of an incised oral wound in mice. Histologically at day 14, 75% concentration papaya extract showed perfect epithelial layer and fibrillation.

Use of bromelain in cutaneous wound healing in streptozocin-induced diabetic rats: an experimental model

2020 ◽  
Vol 29 (9) ◽  
pp. 488-495
Author(s):  
Amene Nikgoftar Fathi ◽  
Mohammad Hassan Sakhaie ◽  
Sepehr Babaei ◽  
Soroush Babaei ◽  
Fateme Slimabad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Diabetic Rats ◽  
Wound Healing Process ◽  
Wound Area ◽  
Small Vessels ◽  
Histological Sections ◽  
Therapeutic Benefits ◽  
Wide Range

Objective: To assess the effect of bromelain on different aspects of the wound healing process in type 1 diabetic rats. Method: In this study, 112 streptozocin-diabetic (type 1) male Wistar rats were euthanised; 28 each on days three, five, seven and 15, after a wound incision had been made. To estimate changes in a number of different cellular and tissue elements, histological sections were provided from all wound areas and stained with haematoxylin and eosin. Some 1.056mm2 of total wound area from all specimens were evaluated, by assessment of 4200 microscope photos provided from all histological sections, by stereological methods. A biomechanical test of each wound area was performed with an extensometer to evaluate the work-up to maximum force and maximum stress of the healed wound on day 15. Results: In the experimental groups, bromleain caused significant wound contraction and reduced granulation tissue formation by day 7 (p=0.003); increased neovasculars (new small vessels that appear in the wound area during wound healing) on days three, five and seven (p=0.001); significantly increased fibroblasts on day five but decreased by day seven (p=0.002); and significantly decreased macrophage numbers and epithelium thickness on all days of study (p=0.005). Wound strength significantly increased in experimental groups by day 15. Conclusion: Bromelain has a wide range of therapeutic benefits, but in most studies the mode of its action is not properly understood. It has been proved that bromelain has no major side effects, even after prolonged use. According to the results of this study, bromelain can be used as an effective health supplement to promote and accelerate wound healing indices, reduce inflammation and improve biomechanical parameters in diabetic wounds.

scholarly journals Investigation of Wound Healing Potential of Azadirachta indica Seed Extract using Wistar Rats

2020 ◽  
Vol 45 (6) ◽  
Author(s):  
I. A. Ajayi ◽  
O. B. Omolere
Keyword(s):  
Wound Healing ◽  
Azadirachta Indica ◽  
Wistar Rats ◽  
Wound Closure ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Treatment ◽  
Phytochemical Screening ◽  
Wound Area ◽  
Seed Extracts

This study investigated the wound healing potential of hexane and methanolic seed extracts of Azadirachta indica using 35 wistar rats that were divided into 5 groups of 7 rats each. Phytochemical screening and antimicrobial activity of the extracts were carried out while the wound healing potential was evaluated by treating the test rats with 5 % and 10 % hexane and methanol extracts in an experiment that lasted for 21 days. Wound area and percentage of wound closure of the rats were noted at four-day intervals and at 21 days, the blood and organs of the rats were subjected to haematological and histopathological analyses respectively. The extracts were found to contain tannins, glycosides and phenols and they inhibited the growth of tested organisms. All the test rats displayed better and faster healing than the control ones but there were no significant differences between their haematological and histophatological results. The seed extracts quickened the wound healing process of the rats and might therefore be useful in wound treatment.

scholarly journals Features of the Dynamics of Infected and Septic Wounds Microcirculation in Children

2016 ◽  
Vol 23 (3) ◽  
Author(s):  
O. V. Spahiu ◽  
A. P. Paholchuk
Keyword(s):  
Wound Healing ◽  
Blood Flow ◽  
Healing Process ◽  
Wound Healing Process ◽  
Doppler Flowmetry ◽  
Wound Area ◽  
Average Value ◽  
Process Dynamics ◽  
Area Monitoring ◽  
Microcirculation Parameter

Treatment of infected and septic wounds remains one of the most important problems of pediatric surgery. According to the authors, the wound process monitoring affects the treatment outcome not less than operative technique.The objective of the research was to examine the dynamics of microcirculation of the infected and septic wounds in children.Materials and methods. The analysis of the study of infected and septic wounds microcirculation in 178 children was performed. Blood flow laser analyzer (“LAKК-02” RPE “Lazma”, Russia) was used to study the blood flow in the wound area. Monitoring of wound healing process dynamics was conducted by studying the wound healing cytogram.Results. On the first day the average parameter of microcirculation was markedly increased in the area of wound edges in comparison with the contralateral area. The subsequent study of a blood flow during 5 days showed that average value of microcirculation parameter in the wound area decreased by more than 2 times in comparison with the figures on the first day. Microcirculation parameters of in the wound area further decreased.Conclusions. Dynamics of microcirculation changes in wound healing process significantly corresponds to cytogram of impression smears obtained from infected and septic wounds in children. Laser Doppler flowmetry is an effective method microcirculation control and minimally invasive diagnostic method of wound healing process.

scholarly journals Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

2019 ◽  
Vol 2 (2) ◽  
pp. 80-88
Author(s):  
Haryanto Haryanto ◽  
Kanae Mukai ◽  
Nakajima Yukari ◽  
Mayumi Okuwa ◽  
Cau Kim Jiu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Control Group ◽  
Wound Healing Process ◽  
Wound Area ◽  
Hydrocolloid Dressing ◽  
Thickness Skin ◽  
Microscopic Evaluation ◽  
Acacia Honey ◽  
Macroscopic Findings

The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of Japanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.

scholarly journals Hydrogels for management of chronic wound healing

2021 ◽  
Vol 5 (3) ◽  
pp. 095-104
Author(s):  
IM Cardoso-Daodu ◽  
CP Azubuike ◽  
MO Ilomuanya
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Three Dimensional ◽  
Scar Tissue ◽  
The Body ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Dimensional Network ◽  
Healing Wound

Chronic wounds occur when one wound healing process or a sequence of wound healing events are affected resulting in slow healing of the wound thereby placing the patient in deep pain. Various diseases and conditions can delay the process of wound healing. Wound healing can be classified into four main stages: hemostasis, inflammation, remodeling, and scar tissue formation with each phase overlapping one another. The skin is the largest organ in the body. It protects the entire external surface of the human body and is the primary site of interaction with the outside environment. There is therefore a need to fabricate an ideal dressing through scientific research and investigations. Hydrogels are a three-dimensional network of hydrophilic polymers that can swell in water and absorb copious amounts of water while maintaining their structure because of their chemical or physical crosslinking of individual polymer chains. A hydrogel must be composed of at least 10% water. Hydrogels possess the flexibility and water percentage which is remarkably like tissues. They are biocompatible and biodegradable which makes them ideal for dermal wound healing.

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