The expression of programmed death-ligand 1 and its association with histopathological grade, stage of disease, and occurrence of metastasis in breast cancer

2021 ◽  
pp. 1-6
Author(s):  
Agung Sindu Pranoto ◽  
Haryasena Haryasena ◽  
Prihantono Prihantono ◽  
Septiman Rahman ◽  
Daniel Sampepajung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Tumor Escape ◽  
Cross Sectional ◽  
Programmed Death Ligand 1 ◽  
Histopathological Grade ◽  
Stage Of Disease ◽  
Programmed Death ◽  
The Relationship

INTRODUCTION: Programmed death ligand 1 (PD-L1) plays a role in tumor escape and progression by inactivating T lymphocytes. The aim of the study reported here was to determine the relationship between the expression of PD-L1 and histopathological grade, stage of disease, and the occurrence of metastasis in breast cancer. METHODS: The observational cross-sectional study involved analyzing the expression of PD-L1 by immunohistochemistry. RESULTS: PD-LI was expressed in 43 of 60 patients with breast cancer (71.6%), mostly with a moderate histopathological grade (58.3%) and at an advanced stage (50%). Associations between the expression of PD-L1 and histopathological grade (p = 0.011), stage of disease (p = 0.009), and the occurrence of metastasis (p = 0.01) were significant, with an odds ratio of 5. CONCLUSION: The associations between the expression of PD-L1 and histopathological grade, disease stage, and occurrence of metastasis were all significant in cases of breast cancer in the sample. Those findings suggest that the expression of PD-L1 increases the progression of breast cancer.

scholarly journals The Relationship between Breast Self-examination and the Disease Stage in Detection Time among Patients with Breast Cancer in Yazd

2019 ◽  
Author(s):  
Mohammad Ali Morowatisharifabad ◽  
Masumeh Seifi ◽  
Arefe Dehghani ◽  
Saeid Kargar ◽  
Seyed Mohammad Reza Mortazavizadeh
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Detection Time ◽  
Cross Sectional ◽  
Simple Method ◽  
Breast Self Examination ◽  
Self Examination ◽  
The Relationship

Introduction: breast cancer, as the most common cancer among women, is controllable if it is diagnosed at the early stages. Breast self- examination is a simple method for early detection. One of the most important effective factors on the cancer-related mortality is the defection stage. This study was conducted to determine the relationship between breast self-examination and the disease stage with regard to the detection time among patients with breast cancer in Yazd. Method: this cross-sectional study was carried out on 159 women with breast cancer, who referred to medical centers in Yazd. Data collection tool was a questionnaire with two parts. The first part was the demographic information and the second part dealt with the patients' breast self-examination before the detection of their disease. The disease stage in the detection time was determined based on the results of the pathology test. Data were analyzed using χ2 and other description tests by SPSS. Result: A statistically signification relationship was observed between disease stage at the defection time and breast self-examination. The disease was detected earlier in individuals who reported a higher frequency of breast self-examination in comparison with those who did not. Conclusion: Breast self-examination affects the early detection of breast cancer and those who were educated had better practice. So, the results show the importance of educational programs in this regard.

scholarly journals The Relationship Between Sexual Self-concept and Mental Body Image in Women With Breast Cancer

2020 ◽  
Vol 8 (4) ◽  
pp. 383-388
Author(s):  
Safieh Gooran ◽  
Masoumeh Simbar ◽  
Sepideh Hajian ◽  
Soheila Nazarpour ◽  
Malihe Nasiri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Image ◽  
Mental Image ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Sexual Problem ◽  
The Body ◽  
Self Concept ◽  
Cross Sectional ◽  
The Relationship

Objectives: Breast cancer is the most common malignancy in women. In addition, it is the most mentally powerful cancer in women due to affecting the most important female sexual part. Patients with breast cancer experience problems in their marital relationship because of their disrupted mental image and sexual relations. In this regard, this study was conducted to investigate the relationship between sexual self-concept and mental body image in women with breast cancer. Materials and Methods: This descriptive cross-sectional study was conducted on a sample of 120 women with breast cancer. Using a convenience sampling technique, patients were selected from among those hospitalized in the selected hospitals of Tehran in 2018. Data were collected using demographic details, the Multidimensional Sexual Self-Concept Questionnaire (MSSCQ), and the Fisher’s Body Focus questionnaire. Finally, the data were statistically analyzed in SPSS-21. Results: According to the descriptive and analytical statistics, women with breast cancer obtained the highest scores in avoiding risky sex and sexual problem prevention while the lowest scores in terms of sexual preoccupation. Based on the results, there was no disruption in the body image of any of the examined women. Eventually, a significant correlation was observed between sexual self-concept and body image (P<0.001, r=0.4). Conclusions: In general, body image has a positive relationship with sexual self-concept in women with breast cancer and is considered an important predictor of sexual health and behaviors of this group. Accordingly, psychological interventions, along with midwifery and sexual consultations offered by trained personnel can help empower these patients.

scholarly journals Surgery and Financial Toxicity are Risk Factors for Distress in Cancer Survivors: A Cross-sectional Study

2020 ◽  
Author(s):  
Huihui Yu ◽  
Tingting Zuo ◽  
Xue Bi ◽  
Hui Li ◽  
Haiyang Xing ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psychological Distress ◽  
Cancer Survivors ◽  
Cross Sectional Study ◽  
Disease Stage ◽  
Financial Toxicity ◽  
Sectional Study ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
The Relationship

Abstract Background: Patients with cancer often face some level of distress, regardless of disease stage. Distress in cancer survivors has a negative impact on their quality of life. The goal of this study was to identify risk factors for distress, under­stand how treatment associated with distress and reveal the relationship between the psychological and financial distress. Methods: This was a multi-center cross-sectional study of patients with cancer requiring surgery or chemotherapy. Patients completed questionnaires regarding their demographics, disease characteristics, psychological distress, and financial toxicity. A multivariable logistic regression model was used to examine factors associated with distress in surgical versus chemotherapy treatment groups.Results: A total of 409 patients participated in the study. Patients treated with surgery (n = 172) were more likely to be female, unemployed, early stage compared with patients undergoing chemotherapy (n = 237). Multivariable analysis revealed that surgical patients tended to have a higher risk of distress compared with patients receiving chemotherapy (OR, 95% CI: 3.086, 1.854–5.137) due to higher rates of nervousness, pain, and difficulty with bathing/dressing, and patients with high financial toxicity had a higher risk of distress compared with those with low financial toxicity (OR, 95% CI: 2.000, 1.278–3.130). The relationship between financial toxicity and psychological distress was stronger in the chemotherapy group, with the correction coefficient -0.294 and slope -1.196. Conclusion: Patients who underwent surgery and reported higher financial toxicity were more likely to experience distress. Multidimensional distress screening and psychosocial interventions should be provided pre- and post-operatively for patients.

Justification for deployment of peripherally inserted central catheter (PICC).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18257-e18257
Author(s):  
João Raphael Maia ◽  
Flavia Torrecillas ◽  
Marcio Borella
Keyword(s):  
Breast Cancer ◽  
Central Venous Access ◽  
Venous Access ◽  
Cross Sectional Study ◽  
Peripheral Vein ◽  
Central Venous ◽  
Cross Sectional ◽  
Peripheral Venous Access ◽  
Fast Start ◽  
The Relationship

e18257 Background: Is not practical in countries of Latin America the use of Central Venous Catheters - CL in Oncology due the difficulty of financing of this procedure. The PICC is a vascular access device inserted in peripheral vein infusion drugs with Center for a cost of no more than 20% when compared to use of a catheter fully deployed. Methods: We conducted a cross-sectional study, retrospective and quantitative data were collected from complication and pharmacovigilance of a private oncology outpatient clinic in Rio de Janeiro, in the care of patients undergoing treatment for breast cancer with Paclitaxel weekly in the Jan 2016 period the Dec 2016. Results: The study were performed with 98 patients, peripheral venous access 75.5% and 24.5% central venous access. Of patients with peripheral venous access, 47.3% had exclusive member to puncture. Of this group, 21.6% of patients achieved success on first CL in all infusions performed in the period and 78.4% needed more than one CL for Administration of paclitaxel in at least an infusion. 182 Pharmacovigilance notifications were made, being 38.5% for the flebogênicidade symptoms after use of paclitaxel. Conclusions: The study highlights the relationship between venous access safe and successful outpatient antineoplasic therapy. The data observed in analyzed period justifies the creation of deployment Protocol of PICC for patients with breast cancer to treatment with Paclitaxel weekly. It is hoped with this Protocol added convenience and safety for the patient, ensuring fast start of infusional therapy often delayed by the difficulty in accessing the patient's venous network, reducing and avoiding delays in cycles, with low rates of complications for the same and lower costs.

Lipocalin 2 could predict circulating MMP9 levels in patients with breast cancer

2021 ◽  
pp. 1-3
Author(s):  
Uleng Bahrun ◽  
Wildana Wildana ◽  
Hegaria Rahmawati ◽  
Liong Boy Kurniawan ◽  
William Hamdani
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Lipocalin 2 ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Patients ◽  
The Relationship ◽  
Metalloproteinase 9

OBJECTIVES: Breast cancer is the most prevalent carcinoma found in Indonesian women, and its incidence remains high worldwide. Lipocalin 2 has been linked with the progression of breast cancer. Matrix metalloproteinase 9 (MMP9) is an enzyme that has an important role in angiogenesis. We investigated the relationship between lipocalin 2 and MMP9 and the ability of lipocalin 2 for predicting MMP9 levels in female patients with breast cancer. METHOD: A total of 55 female patients with breast cancer were enrolled in this cross-sectional study. Lipocalin 2 and MMP9 were measured by enzyme-linked immunosorbent assay. RESULTS: Lipocalin 2 was significantly correlated with MMP9 levels (r = 0.756, p < 0.001). Lipocalin 2 levels could describe the MMP9 levels (𝛽 = 0.76, p < 0.001, R2 = 56.9%). CONCLUSION: Higher lipocalin 2 levels in female patients with breast cancer indicate higher MMP9 levels. Lipocalin 2 can be used to predict MMP9 levels.

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