Genetic susceptibility of CYP1A1 gene and risk of pesticide exposure in prostate cancer

2020 ◽  
Vol 29 (4) ◽  
pp. 429-440
Author(s):  
Amar Abhishek ◽  
Nasreen Ghaji Ansari ◽  
Vishwajeet Singh ◽  
Rahul Janak Sinha ◽  
Prabhakar Mishra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stress Level ◽  
Genetic Factors ◽  
Pesticide Exposure ◽  
High Stress ◽  
P Value ◽  
Specific Pcr ◽  
Cyp1a1 Gene ◽  
High Stress Level ◽  
High Level

BACKGROUND: The etiology of prostate cancer (PCa) is multi-factorial including environmental and genetic factors. Present study evaluates the association between level of pesticides, stress level and CYP1A1 gene polymorphism with PCa patients. METHODS: A case control study was conducted with 102 PCa patients and age match symptomatic (n= 107) and asymptomatic benign prostatic hyperplasia (BPH, n= 70) patients. Pesticide level was characterized by Gas Chromatography. The oxidative stress and scavenging mechanisms were determined by biochemical method. Two polymorphisms of CYP1A1 gene, rs4646903 and rs1048943, were analyzed by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism and allele specific PCR method. RESULTS: Higher level of pesticide namely beta-hexachlorocyclohexane (β-HCH), Malathion, Chlorpyrifos and Fenvalerate were found in PCa group (all p value: < 0.05). Kruskal Wallis H test depicted that level of β-HCH and Malathion significantly correlated with higher grade of PCa (all p< 0.05). The PCa Patients with simultaneously low antioxidant activity and high stress level tended to suffer worst clinical outcomes. Dominant model of rs4646903 and rs1048943 suggested that substitution is associated with a higher risk of PCa (OR: 2.2, CI: 1.6–3.8, p: 0.009 and OR: 1.95, CI: 1.1–3.4, p: 0.026; respectively) and this risk was also influenced by smoking and pesticide exposure. CONCLUSION: Environmental and genetic factors are reported to raise risk; person with high level of these pesticides especially in high risk genotype might be more susceptible to PCa.

HUBUNGAN ROTASI KERJA TERHADAP TINGKAT STRES PERAWAT

2019 ◽  
Vol 11 (1) ◽  
pp. 73-78
Author(s):  
Maria Ledy Tania ◽  
Eni Hidayati
Keyword(s):  
Stress Level ◽  
High Stress ◽  
Sampling Technique ◽  
Stratified Sampling ◽  
Bivariate Analysis ◽  
P Value ◽  
Depression Anxiety Stress Scale ◽  
Chi Square ◽  
Negative Effect ◽  
High Stress Level

Rotasi kerja erawat dilakukan berdasarkan kebutuhan tenaga perawat masing-masing instalasi. Di Instalasi Paviliun Garuda RSUP Dr. Kariadi sendiri, sudah dilakukan sebanyak 5 kali rotasi terhadap para perawat dalam satu tahun terakhir ini. Rotasi bisa memberikan dampak yang negatif pada perawat diantaranya menimbulkan gangguan cemas dan stress. Tujuan penelitian untuk menganalisis hubungan rotasi kerja terhadap tingkat stress pada perawat di Instalasi Paviliun Garuda RSUP Dr. Kariadi Semarang. Desain penelitian menggunakan rancangan korelasional. Proses penelitian dilaksanakan di Instalasi Paviliun Garuda RSUP Dr. Kariadi Semarang yang dilakukan terhadap 146 perawat dengan tehnik pengambilan sampel stratified sampling berdasarkan kriteria inklusi dan eksklusi. Instrumen penelitian menggunakan kuisioner DASS (Depression Anxiety Stress Scales) serta 5 pertanyaan terbuka untuk mengkaji tingkat stress perawat. Hasil penelitian menunjukkan nilai median umur responden 29 tahun, sebagian besar berjenis kelamin perempuan sebesar 84,2%, pendidikan responden sebagian besar D-3 Keperawatan sebanyak 60,3%, nilai tengah masa kerja adalah 5 tahun, sebagian besar jabatan perawat adalah perawat pelaksana (PA) sebanyak 84,9%, perawat yang dilakukan rotasi sebanyak 35,6%. Kategori stres berat dan sangat berat pada perawat masing-masing 2,1%. Hasil analisis bivariat menggunakan Pearson Chi-Square didapatkan nilai X2 sebesar 11,480 dengan nilai p sebesar 0,004 < α (0,05), artinya terdapat hubungan yang bermakna antara rotasi ruangan dengan tingkat stress pada perawat di Instalasi Paviliun Garuda RSUP Dr. Kariadi Semarang. Pihak rumah sakit diharapkan sebelum melakukan rotasi terlebih dahulu melakukan sosialisasi kepada para perawat dan untuk para perawat diharapkan dapat mempersiapkan diri jika sewaktu-waktu dilakukan rotasi ruangan.   Kata kunci: rotasi kerja, tingkat stres   THE CORRELATION BETWEEN WORKING ROTATION TOWARD NURSES’ STRESS LEVEL   ABSTRACT Work rotation among nurses is determined based on the need of each installation. At Garuda Pavilion Installation of RSUP Dr. Kariadi, the rotation has been carried five times within a year. The rotation may bring negative effect to the nurses in a form of anxiety and stress. Analyzing the correlation between working rotation toward nurses’ stress level at Garuda Pavilion Installation of RSUP Dr. Kariadi. The correlational design was used in the research. The research was conducted at Garuda Pavilion Installation of RSUP Dr. Kariadi involving 146 nurses using stratified sampling technique based inclusion and exclusion criteria. DASS (Depression Anxiety Stress Scale) was used as the instrument to collect the data added with 5 open questions to review the nurses’ stress level. The result showed that the median value of respondents’ age was 29 years old, with female majority at 84.2%, D-3 Nursing program qualified was 60.3%, median of the working period was 5 years, Nurse Executive majority with 84.9%, the nurse rotation was 35.6%. High stress level and very high stress level were 2.1% for each category. The bivariate analysis using Pearson Chi-square showed that X2 was 11.480 with p value 0.004 < α (0.05) which means that there was significant correlation between room rotation with the stress level of the nurses at Garuda Pavilion Installation of RSUP Dr. Kariadi. The hospital representative should conduct socialization for nurses before the rotation so that the nurses are able to prepare for the upcoming rotation.   Keywords : working rotation, stress level  

scholarly journals Effectiveness of Affirmation Stress Management on The Stress level Among Caregivers of Shizophrenia Patient

2020 ◽  
Vol 8 (2) ◽  
pp. 82
Author(s):  
Mulyanti Ners ◽  
Brune Indah Yulitasari ◽  
Tri Paryati
Keyword(s):  
Stress Management ◽  
Stress Level ◽  
Family Relationships ◽  
Negative Impact ◽  
Severe Disease ◽  
High Stress ◽  
Measuring Instruments ◽  
P Value ◽  
Management Intervention ◽  
High Stress Level

<p><em>Schizophrenia is a chronic and severe disease so they need caregivers to help their daily activities. Caregivers of patients with schizophrenia have experienced chronic stress in their daily lives. The effects of caregiver of Schizophrenia with high stress level are the disruption of family relationships, constraints in social, leisure and work activities, financial difficulties, and negative impact on their own physical health. Affirmation stress management one of the intervention to reduce the level stress on caregiver of patients with Schizophrenia.This study aimed to prove effect affirmation stress management on the stress level among caregivers of Schizophrenia people.This research was quasi-experimental with one group pretest-postest without control. Subjects of this study were 29 caregivers of schizophrenia patients. Subjects selection technique used purposive sampling. Measuring instruments used perceived stress scale. The technique of data analysis used correlation of paired t-test</em><em>. </em><em>The results showed that the average level of stress caregiver before the stress management action was 15.17 (SD: 6.54) and the average stress level after the action was 13.59 (5.39). Statistical test results showed that there were significant differences between the stress level values before and after the affirmative stress management intervention was given (p. Value = 0.015).</em><em> </em><em>The conclusion of this research is there was an influence of affirmation stress management on stress level on caregivers of Schizophrenia patient.</em><em></em></p>

Implementation of K-Modes Algorithm for Clustering of Stress Causes in University Students

2021 ◽  
Vol 9 (3) ◽  
pp. 419
Author(s):  
Ni Putu Mira Novita Dewi ◽  
Ida Bagus Gede Dwidasmara
Keyword(s):  
Stress Level ◽  
Clustering Algorithm ◽  
High Stress ◽  
Optimal Number ◽  
Mild Stress ◽  
Student Groups ◽  
High Stress Level ◽  
Internal And External Factors ◽  
Python Programming ◽  
Cluster 2

Stress is an inevitable part of life in a college environment. The variety of factors that cause stress in students, it is necessary to cluster the factors that cause stress in students to see the description of the characteristics of each cluster of students. The clustering process is carried out to identify the causes of stress in student groups and their relationship to these internal and external factors. Cluster analysis can be used as a reference to decide on efforts to handle and prevent increased stress in students. The clustering process is carried out using the Python programming language. The algorithm used is the k-modes clustering algorithm. This algorithm is suitable for clustering categorical data. The optimal number of clusters obtained from the implementation of the elbow method is three clusters. Cluster 1 is a cluster with a mild stress level, the main cause of stress is academic issues. Cluster 1 is the only group where the majority of the cause of stress is not financial. Cluster 2 is a cluster with a high stress level which causes various stressors. However, cluster 2 is the only cluster where the cause of stress is on careers and on involvement in hostels, clubs, and society. Cluster 3 is a cluster with a medium stress level. This cluster is the only cluster dominated by male gender. The main cause of stress in this cluster is academic and financial.

scholarly journals Study on the Effect of Laser Quenching on Fretting Fatigue Life

Metals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 566 ◽  
Author(s):  
Hongjian Zhang ◽  
Xufeng Yang ◽  
Haitao Cui ◽  
Weidong Wen
Keyword(s):  
Fatigue Life ◽  
Stress Level ◽  
High Stress ◽  
Fretting Fatigue ◽  
Test System ◽  
Experimental Results ◽  
Laser Quenching ◽  
Error Band ◽  
Hydraulic Servo ◽  
High Stress Level

Laser quenching hardening is one of the most used surface treated technologies. In order to study the effect of laser quenching on the fretting fatigue life, fretting fatigue experiments of TC11 (Ti-6.5Al-1.5Zr-3.5Mo-0.3Si) titanium alloy specimens with different surface conditions were carried out on a special hydraulic servo fatigue test system. The experimental results showed that laser quenching hardening has a good performance in increasing the fretting fatigue lives of the TC11 alloy. However, the effects of laser quenching on fretting fatigue are more obviously at low stress level than at high stress level, the fretting fatigue life was increased by 110.78% at low stress level and 17.56% at high stress level, respectively. Based on the critical plane approach, the traditional SWT (Smith–Watson–Topper) parameter was modified and used to describe the fretting fatigue life of the TC11 alloy after hardening by the consideration of the variations of the hardening layer’s elastic modulus. Compared with the experimental results, all the errors of the predicted results lied in the error band of two.

Distress screening in patients with urogenital malignancies.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 412-412
Author(s):  
Pia Paffenholz ◽  
Maria Angerer-Shpilenya ◽  
Johannes Salem ◽  
David Pfister ◽  
Axel Heidenreich
Keyword(s):  
Psychological Distress ◽  
Stress Level ◽  
Malignant Tumors ◽  
High Stress ◽  
Salvage Treatment ◽  
Distress Screening ◽  
Prospective Longitudinal Study ◽  
Psychological Burden ◽  
High Stress Level ◽  
Prospective Longitudinal

412 Background: Malignant tumors do not only have a somatic but also a psychological impact on patients. To date, only a few studies are available which evaluated the potential psychological burden of patients suffering from urogenital cancers. In this prospective, longitudinal study we examine the baseline psychological distress of patients treated for urogenital malignancies focussing on testicular cancer (TC) and prostate cancer (PCA). Methods: Psychological distress of 192 inpatients treated for urogenital malignancies was evaluated using the distress thermometer (DT), an established tool for the detection of distress, prior to any surgical or systemic therapy. The DT consists of a visual analogue scale ranging from 0 to 10 resulting in a low (0-3), moderate (4-6) or high (7-10) stress level. Furthermore, it contains a 36-item list of problems subdivided into 5 categories (practical, family, emotional, spiritual/religious, physical). Results: The mean DT score was 5 (interquartile range (IQR) 3-7) with the most common stressors being of emotional origin, namely fear (50%), worry (44%), nervousness (42%), sleep disorders (39%) and fatigue (32%). DT analysis did not reveal any difference between the tumor entities but 64% of all patients displayed a moderate to high stress level requiring psycho-oncological support. The comparison of PCA and TC demonstrated a higher distress level in PCA patients in the subgroups of metastatic disease (median 5.5, IQR 4-8 vs. median 4, IQR 2-6; p = 0.018), secondary therapy (median 6, IQR 5-8 vs. median 4.5, IQR 2.75-6; p = 0.023) and salvage treatment (median 7, IQR 4.5-9 vs. 5, IQR 2.75-6; p = 0.021). PCA patients receiving salvage treatment displayed significantly higher distress levels compared to non-salvage treated patients (median 7, IQR 4.5-9 vs. median 5, IQR 2-7; p 0.028). Conclusions: Our study shows that 64% of urological tumor patients should be offered psycho-oncological support. Especially patients suffering from advanced stage PCA seem to have a high stress level. Thus, physicians in the field of urologic oncology should be aware of their patients’ psychological distress in order to identify high-risk patients and provide them with an appropriate psycho-oncological support.

scholarly journals The Differences in Stress Levels of Male and Female Nurses at Hospitals

2020 ◽  
Author(s):  
Sendhi Tristanti Puspitasari ◽  
Samsul Arifin ◽  
Anggaunitakiranantika . ◽  
Farah Farida Tantiani ◽  
Ludi Wishnu Wardhana
Keyword(s):  
Work Stress ◽  
Stress Level ◽  
High Stress ◽  
Male Nurses ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Male And Female ◽  
Stress Levels ◽  
Female Nurses

A study conducted by Northwestern National Life stated that around 40% of workers experienced work-related stress. One of the professions who has a high risk of stress is nursing. This research aims to analyze the differences in stress levels of male and female nurses, employing a quantitative method and a cross sectional approach. There were 73 respondents, all of whom were nurses at X Hospital. Random sampling was used in this research. Chi Square test was carried out to determine the relationship between gender and work stress levels. The results showed that the majority of nurses were women (78.1% or 57 people) and male nurses accounted for the remaining 21.9% (16 people). A higher number of female nurses experience high stress (15.8%) compared to male nurses (12.5%). The result of the analysis of the gender effect on stress levels in X Hospital nurses generated p-value of 0.745 indicating that p value > 0.05. This result shows that there is no significant effect of gender on the stress level of nurses in Hospital X. Accordingly, from the hypothesis tested, it is proven that there is no significant relationship between the gender of nurses and work stress experienced. Keywords: Stress Level, Nurse, Hospital

Clinical and Biochemical Considerations Regarding Stress and Arrhythmic Risk in Patients with Chronic Viral Liver Diseases

2018 ◽  
Vol 69 (4) ◽  
pp. 881-885
Author(s):  
Victor Gheorman ◽  
Felicia Militaru ◽  
Veronica Calborean ◽  
Lavinia Maria Gheorman ◽  
Anca Livia Chirita ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Stress Level ◽  
Subjective Evaluation ◽  
High Stress ◽  
Objective Evaluation ◽  
Point Of View ◽  
Chronic Liver ◽  
Depression And Anxiety ◽  
High Stress Level

The prevalance of depression and anxiety is higher at the patients diagnosticated with viral liver disease. The corelation between stress and chronic liver disease is a natural, implicit one, but still insufficiently studied. The study has the objective of finding out the clinical and also biochemical correlations between stress and chronic viral diseases. Our research was realised on a group of 78 patients with chronic viral liver disease, who underwent an evaluation of the stress level, both from a subjective point of view and based on concrete methods like questionnaires. The patients were asked to espress their state more or less affected by stress, and, subsequently, they were subjected to a questionnaire that was analyzed, followed by establishing the necessary correlations. Our patients were also evaluated by cardiologicaly, psychologicaly and psyhiatricaly examinations. After the first evaluation we had these results :38 patients (49.19%) consider that they have an average stress level, 18 patients (22.58%) have a high stress level. Only 22 patients (28.22%) declared stress was at a low level. We divided the pacients in two groups, function of Qt (questionare total score) results and we observed that a number of 38 patients ( 49.19%) registered �Qt 20 and 40 patients (50.81%) had Qt � 20, 63 patients (50.81%).We found a strong correlation between the patients� subjective evaluation of the stress level and the objective evaluation of stress level according to the used questionnaire, which confirms the objectivity of our study. We found a direct corelation, with a morphological, biochemical and functional support between stress and the arrhythmia risk in the evolution of chronic liver disease. We consider very important a complex examination psychiatricaly, psychologicaly and cardiological of the pacients diagnosticated with viral liver disease in order to help them and to prevent arrhythmic events, depression, anxiety and other mood disorders.

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