The comparison of IL-17 levels in patients with unstable angina before and after medical treatment

2021 ◽  
pp. 1-5
Author(s):  
Ahmad Boluri ◽  
Hosseinali Khazaei ◽  
Narjes Sargolzaei ◽  
Hanie Olfat Miri ◽  
Bahman Khazaei
Keyword(s):  
Serum Level ◽  
Unstable Angina ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Interleukin 17 ◽  
Cross Sectional ◽  
Clinical Instability ◽  
Before And After

BACKGROUND: Interleukin (IL)-17 plays a central role in orchestrating the cytokine cascade and accelerates atherosclerosis and plaque vulnerability in animal models. However, epidemiological data evaluating the role of IL-17 levels in unstable angina are lacking. The aim of our study is to evaluate and compare the IL-17 levels in unstable angina (UA) cases before and after treatment. METHODS: This cross-sectional study was performed from July to October 2018 in Ali Iben-abitaleb heart center, Zahedan, Iran. 48 patients with UA in the age range of below 50 years entered the study. All demographic, past medical history, physical examination, electrocardiogram (EKG or ECG), and transthoracic echocardiogram (TTE) data were collected. Serum level of IL-17 was measured using enzyme-linked immunosorbent assay (ELISA) method. In all the tests, P< 0.05 was considered as statistically significant. All data analyses were performed using the SPSS 13.0 software (SPSS Inc., Chicago, Illinois, USA). RESULTS: In this study, 48 UA patients, including 34 women and 16 men with a mean age of 56.60 years were included in the study. The mean serum level of interleukin 17 after treatment (65.13 ± 53.29 pg/dl) was significantly lower than Its level before treatment (94.89 ± 51.25 pg/dL) (P< 0/05). CONCLUSION: Our findings point towards a role of inflammation in the form of increased activity of IL-17 in UA patients and thus suggest that IL-17-driven inflammation may play a role in the promotion of clinical instability in patients with coronary artery disease.

scholarly journals Role of Physiotherapy in Hospitalised Patients of COVID-19 disease

2021 ◽  
Vol 9 (3) ◽  
pp. 154-159
Author(s):  
Dr. Sanjay Kumar Bharty ◽  
◽  
Dr. Jitendra Kishore Bhargava ◽  
Dr. Brahma Prakash ◽  
Dr. Vikas Patel ◽  
...  
Keyword(s):  
Severity Index ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Medical College ◽  
Breathing Exercises ◽  
Hospitalised Patients ◽  
Before And After ◽  
Respiratory Physiotherapy

Introduction: Respiratory physiotherapy is one of the therapeutic methods in various respiratoryviral infections. Breathing exercises with other interventions, could enhance the total lung capacityand symptom alleviation in patients with virus-related acute respiratory distress syndrome (ARDS).Aim: To study the clinical evaluation of the role of physiotherapy in hospitalised patients of covid-19diseases. Method: This was an Observational (prospective, cross-sectional) study. 187 patientswere recruited and diagnosed as COVID-19 as per RTPCR at NSCB Medical College, Jabalpur (MP).Patients were randomised into the physiotherapy group and controlled group. Patients in thephysiotherapy group were undergone positional changes, prone ventilation, Breathing exercise,Resistive training, Passive joint motion, Muscle stretching, Bedside standing training, enduranceexercise by a specialized physiotherapist. Mean cough severity index, MMRC grade, respiration rateand peripheral blood saturation were recorded before and after intervention and compared with thecontrolled group. Result: There was significant improvement found in MMRC grade and respirationrate after physical therapy in the physiotherapy group (p-value < 0.05). Exertional dyspnoea andcough severity index significant deceased in physiotherapy group. The positive change was found inperipheral blood saturation. There was decreased in hospitalization stay in the physiotherapy groupas compared to the controlled group. Conclusion: Our study revealed the positive effect ofphysiotherapy on covid-19 disease in terms of symptoms and hospitalization duration among thephysiotherapy group. Physiotherapy exerts a beneficial role in the management of the covid-19disease.

scholarly journals Osteoprotegerin Serum Level is Associated with Severity of Coronary Artery Calcification in Non Diabetic Centrally Obese Men

2012 ◽  
Vol 4 (1) ◽  
pp. 24
Author(s):  
Trilis Yulianti ◽  
Antonia Anna Lukito ◽  
Andi Wijaya ◽  
Gatot Susilo Lawrence ◽  
Syakib Bakri
Keyword(s):  
Coronary Artery ◽  
Serum Level ◽  
Coronary Artery Calcification ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Alpha Level ◽  
Dual Source ◽  
Spearman Correlation Test ◽  
Maximum Minimum

BACKGROUND: Osteoprotegerin (OPG) is produced by a variety of tissues including those of the cardiovascular system. Recent clinical studies have suggested a significant correlation between elevated OPG serum level and cardiovascular mortality. Since coronary artery calcification (CAC) is positively associated with cardiovascular disease (CVD) events, we carried out a study to investigate whether OPG serum level is associated with the severity of CAC in non diabetic centrally obese men.METHODS: A cross sectional study was done on seventy non diabetic centrally obese men. CAC score was determined by using dual source computed tomography (DSCT). OPG serum level was measured by enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was done with SPSS for windows ver 16. ANOVA was performed to analyze mean, maximum, minimum value, and standard deviation. Spearman correlation test was performed to determine the correlation between OPG serum level and CAC score. Significance value was defined as alpha level=0.05 based on two-tailed tests.RESULTS: OPG serum level was significantly correlated with CAC score. The severity of CAC increased with the increase of OPG level. Age was significantly correlated with OPG serum level and CAC score.CONCLUSIONS: Our data show that serum OPG level was associated with the severity of CAC, which highlights that OPG could be involved in the progression of CAC in non diabetic obese men.KEYWORDS: obesity, vascular calcification, osteoprotegerin, coronary artery calcification

scholarly journals Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 143
Author(s):  
Florentia Kanakoudi-Tsakalidou ◽  
Evangelia Farmaki ◽  
Eleni Papadimitriou ◽  
Anna Taparkou ◽  
Eleni Agakidou ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Epidemiological Data ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Humoral Immune ◽  
Measles Antibodies ◽  
Measles Outbreaks ◽  
First Year Of Life ◽  
Antibody Levels

Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants’ antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions.

scholarly journals The Role of Parathyroid Hormone in Alveolar Bone Resorption on Postmenopausal Women

2020 ◽  
Vol 14 (1) ◽  
pp. 82-87
Author(s):  
Susi R. Puspitadewi ◽  
Lindawati S. Kusdhany ◽  
Sri Lelyati C. Masulili ◽  
Pitu Wulandari ◽  
Hanna B. Iskandar ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Postmenopausal Women ◽  
Alveolar Bone ◽  
Bone Mineralization ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Collection ◽  
Cross Sectional

Background: Postmenopausal women exhibit reduced bone mineralization, which causes bone resorption, including that of alveolar bone. Parathyroid hormone has been shown to play a role in alveolar bone resorption. Objective: This study aims to analyze relationships between parathyroid hormone and other factors that may contribute to alveolar bone resorption in postmenopausal women. Methods: This cross-sectional study included 82 postmenopausal women aged 50–74 years, who resided in Central and East Jakarta, Indonesia. Subjects' data were obtained through questionnaires, dental examinations, and blood collection for the examination of parathyroid hormone levels by enzyme-linked immunosorbent assay and using panoramic radiography to measure bone resorption. Results: Spearman correlation analysis showed a significant correlation between parathyroid hormone level (p = 0.005) and extent of alveolar bone resorption, but age (p = 0.292), menopausal duration (p = 0.244), and number of missing teeth (p = 0.517) were not significantly correlated with the extent of alveolar bone resorption. Conclusion: Various factors play a role in the mechanism of bone resorption, so knowing the role of each factor is expected to reduce the effects of alveolar bone resorption that occurs in postmenopause. Among the factors investigated in this study, the parathyroid hormone was the sole factor correlated with postmenopausal alveolar bone resorption.

scholarly journals Vancomycin dosing in low-flux hemodialysis; is adjustment of drug dosage necessary?

2018 ◽  
Vol 8 (2) ◽  
pp. 112-115
Author(s):  
Niloofar Khodabandehloo ◽  
Arash Fourodi ◽  
Aria Jenabi
Keyword(s):  
Serum Level ◽  
Drug Dosage ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Dialysis Session ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gram Positive Bacteria ◽  
Before And After ◽  
The Mean

Introduction: Vancomycin is a wide useable antibiotic against gram-positive bacteria species in different clinical setting particularly in hemodialysis patients. Objectives: The present study aimed to assess the serum level of vancomycin before and after hemodialysis. Patients and Methods: This cross-sectional study was performed on patients who were hospitalized and medicated by vancomycin with the loading dose of 1000 mg followed by the maintenance dose of 500 mg after each dialysis session every other day. All patients were dialyzed with a low-flux dialyzer membrane. Half an hour before and immediately after dialysis, 2 mL blood sample was taken and stored at -20°C until assaying the level of vancomycin. Results: The average reduction in the serum level of vancomycin was totally 17.65 ± 1.69%. The mean reduction in the serum level of vancomycin was significantly higher in the patients aged higher than 60 years, as compared to other ones. But the level of drug was independent to gender or body mass index. Conclusion: Using low-flux dialyzer membranes, the average reduction in the serum level of vancomycin is expected to be in the range of 12.43% to 21.56% that age was directly associated with the average reduction of the level of vancomycin. Therefore, adjusting and monitoring the serum level of drug in old ages even in the cases of using low-flux dialyzer membranes is recommended.

scholarly journals Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels during Normal Pregnancy

2011 ◽  
Vol 6 ◽  
pp. BMI.S6150 ◽  
Author(s):  
Abdolreza Sotoodeh Jahromi ◽  
Parvin Zareian ◽  
Abdolhossein Madani
Keyword(s):  
Insulin Resistance ◽  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Tnf Α ◽  
Factor Α

Overview The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy. Approach This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Results There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women. Conclusion In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.

scholarly journals The serum level of anti-phospholipase A2 receptor antibody does not predict severity of proteinuria in primary membranous glomerulonephritis

2020 ◽  
Vol 10 (2) ◽  
pp. e15-e15
Author(s):  
Sepideh Hajian ◽  
Ali Sarbazi-Golezari ◽  
Nazanin Samandari
Keyword(s):  
Serum Level ◽  
Phospholipase A2 ◽  
Membranous Glomerulonephritis ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Medical Treatments ◽  
Phospholipase A2 Receptor ◽  
Before And After ◽  
The Relationship

Introduction: Anti-phospholipase A2 receptor (anti-PLA2r) antibody is a marker in blood and has been recently reported that it is increased in patients with primary membranous glomerulonephritis (MGN). Objectives: To investigate the role of this receptor in severity of proteinuria in pMGN, we evaluated the relationship between serum levels of this receptor and proteinuria in patients with primary MGN. Patients and Methods: This study was conducted on patients with primary MGN referring to the nephrology clinic in Qazvin province during 2016-2017. Serum level of anti-PLA2r and level of proteinuria before and after medical treatments were measured. anti-PLA2r was measured using the enzyme-linked immunosorbent assay (ELISA) kits. Results: Anti-PLA2r was positive and negative in 42.3% and 57.7% of the patients with primary MGN, respectively. There was no significant relationship between serum level of anti-PLA2r and level of proteinuria before and after the medical treatments. Conclusion: Our data show that anti-PLA2r could not predict the severity of proteinuria in patients with primary MGN.

scholarly journals Immunological evaluation of the crevicular fluid in patients with gingivitis, periodontitis, and peri-implantitis: a 1-year cross-sectional study

2021 ◽  
Vol 10 (13) ◽  
pp. e41101320756
Author(s):  
Juliana Barbosa de Faria ◽  
Taíssa Cássia de Souza Furtado ◽  
Thaís Soares Farnesi de Assunção ◽  
Douglas Reis Abdalla ◽  
Fabiane Minin Andrade ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Cross Sectional ◽  
Implant Placement ◽  
Before And After ◽  
One Year ◽  
Crevicular Fluid ◽  
Immunological Evaluation

Objective:  To assess the levels of IL-12, IL-15, IL-18, and IL-32 in the gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) in patients with gingivitis, periodontitis, and peri-implantitis before and one year after implant installation. Material and Methods: Forty-nine samples of GCF and PICF were collected from March 2018 to March 2019. The patients were classified: patients with gingivitis (n=7), patients with periodontitis (n=14), patients with peri-implantitis (n=4) and healthy patients (n=24). The crevicular fluid from the 49 patients was collected before implant installation (n=8) and one year after implant placement (n=8). The Enzyme-Linked Immunosorbent Assay (ELISA) was used to evaluate the levels of cytokines in crevicular fluid. Results: Patients with gingivitis, periodontitis, and peri-implantitis showed higher concentrations of IL-12, IL-15, IL-18, and IL-32 when compared with control group. In general, the levels of IL-12 and IL-15 increased when compared to the moments before and after implant installation. There was also an increase in the concentration of IL-18 in the control group volunteers after implant installation. Conclusion: The results and methodology of this study showed that there was no difference in the synthesis of IL-12, IL-15, IL-18, and IL-32 in healthy individuals or in those with periodontal injuries. However, there was an increase in the cytokines IL-12, IL-15, and IL-18 one year after implant installation, which would be increasing the inflammatory activity in peri-implantitis.

scholarly journals The Role of Angiopoietin-2 Gene Mutation on Clinical Severity of Dengue Disease in Children

2020 ◽  
Vol 8 (B) ◽  
pp. 1110-1115
Author(s):  
Mayetti Akmal ◽  
Amirah Zatil Izzah ◽  
Jamsari ◽  
Eriyati Darwin ◽  
Dadang Hudaya Somasetia
Keyword(s):  
Dengue Shock Syndrome ◽  
Cross Sectional Study ◽  
Clinical Severity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Chain Reaction ◽  
Cross Sectional ◽  
Dengue Disease ◽  
Polymerase Chain ◽  
Angiopoietin 2

BACKGROUND: In general, angiopoietin-2 levels are increased concomitantly with dengue clinical severity. AIM: This research aims to determine the role of mutation on angiopoietin-2 on dengue clinical severity. METHODS: A cross-sectional study of 108 children with dengue disease grouped by severity. Angiopoietin-2 level was examined by enzyme-linked immunosorbent assay. Polymerase chain reaction and double nucleic acid sequencing are using 2 Exon 4-F primers. RESULTS: Angiopoietin-2 levels on rs7834131 mutant are higher in dengue fever (p < 0.05) and dengue hemorrhage fever group than non-mutant, while on dengue shock syndrome, it is lower than non-mutant. CONCLUSION: Angiopoietin-2 mutation on rs7834131 might have a protective effect on dengue disease severity.

Role of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of Newborn (PPHN) - Should it Be Withdrawn from Market of Bangladesh due to Threat of being Misuses

2020 ◽  
Vol 35 (2) ◽  
pp. 100-104
Author(s):  
Maksudur Rahman ◽  
Mohammad Abdullah Al Mamun ◽  
MAK Azad Chowdhury ◽  
Abu Sayeed Munsi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cardiac Intensive Care Unit ◽  
Cross Sectional ◽  
Cardiac Intensive Care ◽  
Hospital Protocol

Background: Recently it has been apprehended that sildenafil, a drug which has been successfully using in the treatment of PPHN and erectile dysfunction in adult, is going to be withdrawn from the market of Bangladesh due to threat of its misuses. Objective: The aim of this study was to see the extent of uses of sildenafil in the treatment of PPHN and importance of availability of this drugs in the market inspite of its probable misuses. Methods: This cross sectional study was conducted in neonatal intensive care unit (NICU), special baby care unit (SCABU) and cardiac intensive care unit (CICU) of Dhaka Shishu (Children) Hospital from June, 2017 to May 2018. Neonates with PPHN were enrolled in the study. All cases were treated with oral sildenefil for PPHN along with others management according to hospital protocol. Data along with other parameters were collected and analyzed. Results: Total 320 patients with suspected PPHN were admitted during the study period. Among them 92 (29%) cases had PPHN. Male were 49(53 %) cases and female were 43(47%) cases. Mean age at hospital admission was 29.7±13.4 hours. Based on echocardiography,13(14%) cases had mild, 38 (41%) cases moderate and 41(45%) cases severe PPHN. Mean duration of sildenafil therapy was 11.9±7.1 days. Improved from PPHN were 83 (90%) cases. Mortality was 10% (9). Conclusion: In this study it was found that the incidence of PPHN is 29% among the suspected newborns. Sildenafil is successfull in improving the oxygenation of PPHN and to decrease the mortality of neonates. DS (Child) H J 2019; 35(2) : 100-104

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