Role of annular pentameric molecule: C-Reactive protein in periodontal disease and its association with systemic health

2021 ◽  
pp. 1-5
Author(s):  
Preeti Prakash Kale ◽  
Amit Mani ◽  
Raju Anarthe ◽  
Rachita Mustilwar
Keyword(s):  
Periodontal Disease ◽  
Adverse Pregnancy Outcome ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Inflammatory Stimuli ◽  
Adverse Pregnancy ◽  
Clinical Conditions ◽  
Systemic Health

Various acute phase reactants are produced in response to inflammatory stimuli, one of them is C-reactive protein which is. Serum levels of C-Reactive protein are useful to monitor and diagnose inflammatory process associated with disease as it being one of the valuable biomarkers in various clinical conditions, increase in level of C-Reactive protein is found in subjects with periodontal disease, which in turn can act as useful biomarker to diagnose cardiovascular disease, adverse pregnancy outcome as they being associated with periodontal disease. This manuscript is brief overview of C-Reactive protein and its relation with periodontal disease and systemic health.

scholarly journals Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

2011 ◽  
Vol 50 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Takumi Yoshino ◽  
Natsuko Kusunoki ◽  
Nahoko Tanaka ◽  
Kaichi Kaneko ◽  
Yoshie Kusunoki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinical Conditions

scholarly journals C-reactive protein and cytokines in the diagnosis of neonatal sepsis

2006 ◽  
Vol 59 (11-12) ◽  
pp. 545-549 ◽  
Author(s):  
Borisav Jankovic ◽  
Dobrila Veljkovic ◽  
Srdjan Pasic ◽  
Zorica Rakonjac ◽  
Dragana Jevtic ◽  
...  
Keyword(s):  
Acute Phase ◽  
Neonatal Sepsis ◽  
Current Knowledge ◽  
Systemic Infection ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Correct Treatment ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Serum Crp

Introduction. Accurate evaluation and correct treatment of neonates for possible sepsis still represent the most challenging clinical tasks. Early diagnosis of neonatal sepsis is largely based on the measurement of serum concentrations of different mediators of systemic inflammation, as well as, on a group of proteins named acute phase reactants. Among acute phase reactants, C-reactive protein (CRP) has been the most extensively used and investigated so far. Synthesis and biological role of CRP. This article reviews current knowledge on the synthesis, structure and biologic roles of CRP. Also, we present our original results in regard to the kinetics of serum CRP concentration during the first 24 hours of systemic infection, as well as different patterns of CRP dynamics associated with the initial choice of antibiotics, complications and the final outcome of systemic infection. Interleukins and procalcitonin in diagnosis of sepsis. Because CRP is specific, but somewhat late marker of neonatal sepsis, possible diagnostic use of other indicators of inflammation, i.e. interleukins 6 and 8, and procalcitonin during neonatal sepsis is also considered. The theoretical advantage of these early indicators is discussed in comparative analysis of the time of their activation after initial infectious stimuli. Conclusion. In conclusion, we point to the diagnostic accuracy of serial measurements of serum CRP levels. As an alternative, simultaneous measurement of CRP and serum levels using a faster marker, such as procalcitonin, is recommended.

A STUDY TO ASSESS PREDICTIVE ROLE OF C-REACTIVE PROTEIN IN EARLY PREGNANCY AMONG WOMEN

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Asmita Nayak ◽  
Ruchi Saxena ◽  
Gajendra Saxena
Keyword(s):  
Early Pregnancy ◽  
Quantitative Estimation ◽  
Adverse Pregnancy Outcome ◽  
First Trimester ◽  
Normal Pregnancy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Predictive Role ◽  
High Concentrations ◽  
Adverse Pregnancy

Background: High concentrations of maternal C-reactive protein have been associated with adverse pregnancy outcome, and premature uterine contraction may be predicted by elevated levels of C-reactive protein. Methods: Hospital based comparative analysis was conducted on women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Results: The mean c-reactive protein level in cases 2.23 with min-max value ranging from 0.82-3.94 mg/dl while in controls mean c-reactive protein value came to be 9.15 with min-max range from 3.11-24.9mg/dl. Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies. Keywords: Diagnostic, CRP, Pregnancy, Women.

COVID-19 and pregnancy: are they friends or enemies?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tamara Gulic ◽  
Gordana Blagojevic Zagorac
Keyword(s):  
Immune System ◽  
Cell Activation ◽  
Adverse Pregnancy Outcome ◽  
Severe Disease ◽  
Late Pregnancy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Adverse Pregnancy ◽  
Novel Coronavirus ◽  
Control Work

Abstract Objectives Novel coronavirus disease (COVID-19) is rapidly spreading all over the world. Although in many cases the infection causes very weak symptoms, it can be severe in patient with diverse chronical diseases and immunological compromising patients. Pregnancy is a unique condition in which mother and fetus peacefully collaborate. Diverse endocrine-immune mechanisms, mostly under progesterone control work together to protect the fetus from maternal immunocompetent cell activation driven rejection. The physiological shift to Th2 dominant environment, while favourable for fetus, it makes mothers susceptible to infective pathogens, making pregnancy during COVID-19 pandemic challenging. Materials and methods Studies involving COVID-19 in pregnancy and those analysing changes of immune system induced by COVID-19 were searched in databases such as PubMed, Scopus, Google Scholar and ScienceDirect. Databases were searched using a keyword COVID-19/coronavirus, that was combined with following terms: immune system, pregnancy, oestrogen, or progesterone. Search included studies published up to 01.07.2020. Almost 1,500 articles were found, but only 18 met criteria. Results Most frequent symptoms of COVID-19 in mothers infected in the late pregnancy were fever and cough accompanied with lymphopenia and elevated C-reactive protein. Mothers reported to have severe disease had comorbidities and were obese. Low rate of neonatal complications of maternal Sars-Coc-2 infection without neonatal mortality was observed. Conclusions Currently available data didn’t show significant relationship between COVID-19 severity and pregnancy and there is no strong evidence that mother’s infection can lead to adverse pregnancy outcome, but further studies are needed to determinate the possible effects of COVID-19 gained during earlier pregnancy.

Brain-derived neurotrophic factor is associated with coronary macrophage infiltrates in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R.A Montone ◽  
M Camilli ◽  
M Russo ◽  
M Del Buono ◽  
F Gurguglione ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
C Reactive Protein ◽  
St Segment Elevation ◽  
Protein Levels ◽  
Reactive Protein ◽  
Coronary Syndrome ◽  
St Segment

Abstract Background Brain-derived neurotrophic factor (BDNF) is a neurotrophine that plays a key role in the regulation of both central and peripheral nervous system. Moreover, BDNF is secreted in multiple tissues and exerts systemic, autocrine, and paracrine effects in the cardiovascular system. Of importance, BDNF expression was enhanced in macrophages and smooth muscle cells in atherosclerotic coronary arteries and may be involved in thrombus formation. Thus, BDNF has been suggested as an important link between inflammation and thrombosis, potentially involved in the pathogenesis of acute coronary syndrome (ACS). Purpose In our study we aimed at assessing serum levels of BDNF in patients with ACS, evaluating differences according to clinical presentation [ST-segment elevation myocardial infarction (STEMI) vs. Non-ST-segment elevation ACS (NSTE-ACS)]. Moreover, we assessed the presence of optical coherence (OCT)-defined macrophage infiltrates (MØI) in the culprit vessel of ACS patients and evaluated their relationship with BDNF levels. Methods ACS patients were prospectively selected. Blood samples were collected at admission and serum levels of BDNF were subsequently assessed. Presence of OCT-defined MØI along the culprit vessel was assessed. Results 166 ACS patients were enrolled [mean age 65.3±11.9 years, 125 (75.3%) male, 109 STEMI, 57 NSTE-ACS]. Serum levels of BDNF were higher among STEMI patients compared with NSTE-ACS [median (IQR) 2.48 pg/mL (1.54–3.34) vs. 2.12 pg/mL (1.34–2.47), p=0.007], while C-reactive protein levels did not differ between the two groups. OCT assessment was performed in 53 patients and MØI were detected in 27 patients. Of importance, patients with MØI in the culprit vessel had higher levels of BDNF compared with patients without MØI [median (IQR) 2.23 pg/mL (1.38–2.53) vs. 1.41 pg/mL (0.93–2.07), p=0.023], while C-reactive protein levels did not differ between the two groups. Of note, at multivariate regression analysis BDNF levels were independent predictor of MØI [OR: 2.20; 95% CI (1.02–4.74), p=0.043]. Conclusions Serum levels of BDNF may reliable identify the presence of local macrophage inflammatory infiltrates in patients with ACS. Moreover, BDNF levels are higher in patients with STEMI compared with NSTE-ACS. Taken together, these data suggest that BDNF may represent an interesting link between local inflammatory activation and enhanced thrombosis in ACS. BDNF serum levels Funding Acknowledgement Type of funding source: None

scholarly journals EXPRESS: Serum biomarkers for prediction of mortality in patients with COVID-19

2021 ◽  
pp. 000456322110142
Author(s):  
Rohit S Loomba ◽  
Enrique G Villarreal ◽  
Juan S Farias ◽  
Gaurav Aggarwal ◽  
Saurabh Aggarwal ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Hepatic Function ◽  
Pooled Analysis ◽  
Cardiac Biomarkers ◽  
Limited Information ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Prediction Of Mortality ◽  
Novel Coronavirus

Background There is limited information regarding the role of biomarker levels at predicting mortality in patients with the novel coronavirus pandemic (Covid-19). The purpose of this study is to determine the differences in serum biomarker levels in adults with Covid-19 who survived hospitalization from those who did not. Methods A comprehensive search was completed on PubMed, EMBASE, and Cochrane libraries to identify studies of interest. Endpoints of interest were blood counts, hepatic function test, acute phase reactants, cytokines and cardiac biomarkers. Results A total of 10 studies with 1,584 patients were included in the pooled analyses. Biomarkers that were noted to be significantly higher in those who died from Covid-19 (coronavirus disease 2019) included: white blood cell count, neutrophil count, C-reactive protein, high sensitivity C-reactive protein, procalcitonin, ferritin, D-dimer, interleukins 6, lactate dehydrogenase, creatine kinase, prothrombin time, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and creatinine. Lymphocyte count, platelet count, and albumin were significantly lower in patients who died. Conclusion This pooled analysis of 10 studies including 1,584 patients identified significant differences in biomarkers on admission in patients who survived from those who did not. Further research is needed to develop risk stratification models to help with judicious use of limited healthcare resources.

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