Relationship between calcium metabolism and benign paroxysmal positional vertigo in north Sardinia population

BACKGROUND: Benign paroxysmal positional vertigo (BPPV) has a reported recurrence ranging from 26.8 to 50%. Osteoporosis and Vitamin D deficiency seems to have an impact on recurrence of BPPV. OBJECTIVE: to evaluate the impact of osteoporosis and Vitamin D deficiency on recurrence of BPPV. METHODS: 73 consecutive patients were divided in two groups according to the presence (group 1) or absence (group 0) of a recurrent episode. BMD, femoral and lumbar T-scores and Vitamin D levels were recorded. Statistical analysis was performed to investigate correlations. RESULTS: patients in group 1 had statistically significant lower values of both femoral (–1,62±1,06 vs. –0,53±1,51; p = 0,001), lumbar T-score (–2,10±1,19 vs –0, 53±1.51, p = 0.001) and Vitamin D (19.53±15.33). The values of femoral T-score and Vitamin D could be combined in a model able to properly classify 65.8% of the cases (p = 0.002) as isolated or recurrent BPPV, with high accuracy (AUC 0.710 [0.590 –0.830]). CONCLUSION: present data show a probable correlation between osteoporosis and Vitamin D with recurrent BPPV.

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The impact of COVID-19 preventive lockdowns on the prevalence of benign paroxysmal positional vertigo

Medwave ◽

10.5867/medwave.2021.03.8174 ◽

2021 ◽

Vol 21 (03) ◽

pp. e8174-e8174

Author(s):

Sofia Waissbluth ◽

Francisco García-Huidobro ◽

Macarena Araya-Céspedes

Keyword(s):

Vitamin D ◽

Medical History ◽

Benign Paroxysmal Positional Vertigo ◽

Demographic Data ◽

Daily Lives ◽

Positional Vertigo ◽

Vitamin D Levels ◽

High Prevalence ◽

The Impact ◽

Paroxysmal Positional Vertigo

Introduction The implementation of preventive lockdowns worldwide due to the COVID-19 pandemic has radically altered our daily lives. We have observed an increase in vertigo consultations during this period, mainly benign paroxysmal positional vertigo. Objective To determine the impact of preventive lockdown on the prevalence and characteristics of benign paroxysmal positional vertigo. Methods We did a retrospective study. All patients with benign paroxysmal positional vertigo during July and August 2020 who visited the clinic in Red de Salud UC Christus, Santiago, Chile, were included. Demographic data, clinical characteristics, need for repositioning maneuvers, and medical history was compared with patients seen in July and August 2019. Cases secondary to trauma and with incomplete records were excluded. Results During July and August 2020, 99 patients consulted with a medical history compatible with benign paroxysmal positional vertigo, average age 54.5 years, 68.9% were female. Repositioning maneuvers were required in 40.2% of cases. Of 28 patients with vitamin D levels, 27 showed deficiency/insufficiency. In 2019, for July and August, 54 patients were seen in the clinic with an average age of 61.7 years, and 83.3% were female. Repositioning maneuvers were required in 79.6%, and of the nine patients with vitamin D levels, seven presented deficiency/insufficiency. Statistically significant differences were observed regarding age, sex, and need for repositioning maneuvers. Conclusions A high prevalence of benign paroxysmal positional vertigo was observed during preventive lockdown for COVID-19 in our clinic. Patients were generally younger, and although it was more frequent in women, the incidence by sex was not as striking as in the previous year.

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The Role of Comorbidities in Benign Paroxysmal Positional Vertigo

Ear Nose & Throat Journal ◽

10.1177/0145561319878546 ◽

2019 ◽

pp. 014556131987854 ◽

Cited By ~ 1

Author(s):

V. Sreenivas ◽

Natashya H. Sima ◽

Sumy Philip

Keyword(s):

Vitamin D ◽

Hearing Loss ◽

Vitamin D Deficiency ◽

Blood Sugar ◽

Benign Paroxysmal Positional Vertigo ◽

Significant Risk ◽

Positional Vertigo ◽

Increased Risk ◽

Vitamin D Levels ◽

Paroxysmal Positional Vertigo

Purpose: To assess the correlation between the comorbidities, such as hypertension, diabetes, thyroid disorders, hearing loss, hyperlipidemia, and vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) and to determine the high-risk groups for recurrence of symptoms. Design: Descriptive analytical study. Materials and Methods: Patients who met the inclusion criteria underwent complete ear, nose, and throat examination, including Dix-Hallpike test and roll-over test and blood pressure recording. Investigations included pure tone audiometry, random blood sugar/fasting blood sugar, serum thyroid-stimulating hormone, fasting serum total cholesterol, and serum vitamin D levels. Patients were followed up for a period of 6 months to 1 year. Results: Older age-group has an increased risk of BPPV and recurrence of symptoms. About 45.1% of the patients with BPPV who were detected to have symptoms of hypertension were also more common with hypertensive. Diabetes mellitus was found to have an increased risk of BPPV and its recurrence. The presence of other comorbidities, such as abnormal thyroid function test (9%), sensorineural hearing loss (14%), hypercholesterolemia (46%), and vitamin D deficiency (79%) didn’t show any significant risk for recurrence. Conclusion: The presence of comorbidities worsens the status of BPPV, causing more frequent otolith detachment. Hence, it increases the risk of recurrence even after successful repositioning maneuver. Patients presenting with BPPV should therefore be evaluated and treated for these comorbidities along with the repositioning maneuvers.

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Investigating the Association Between Serum Vitamin D Deficiency and Idiopathic Benign Paroxysmal Positional Vertigo

International Clinical Neuroscience Journal ◽

10.34172/icnj.2020.12 ◽

2020 ◽

Vol 7 (3) ◽

pp. 122-126

Author(s):

Jignesh Dhirubhai Dhameliya ◽

Umesh Kumar Chandra ◽

Sumit Kumar Vishwakarma ◽

Dattaprasad Ganganpalli ◽

Archana Verma

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Benign Paroxysmal Positional Vertigo ◽

Positive Association ◽

Posterior Canal ◽

Positional Vertigo ◽

Vitamin D Levels ◽

Vitamin D3 Deficiency ◽

Paroxysmal Positional Vertigo

Background: It is suggested that there is a positive association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV). We suggest, as a hypothesis, there is a positive association between vitamin D deficiency and BPPV. The current study aimed to investigate the association between vitamin D levels and BPPV. Methods: The present observational case-control study was planned and conducted on 100 participants (50 cases and 50 controls) in the Department of Neurology, Choithram Hospital & Research Center (CHRC), Indore, MP, India, from January 2018 to December 2018. All consecutive patients with diagnosis of idiopathic BPPV who were above the age of 18 years with a negative neurological status were included. Analyses were performed using SPSS software version 10. Results: BPPV was more common among those aged 50 to 70 years (64%). Out of 100 participants, 72 (72%) had vitamin D deficiency, in which 40 (80%) were cases and 32 (64%) were controls. 32 (64%) patients had posterior canal involved, out of them 20 (40%) were females and 12 (24%) were males, and in both groups posterior canal was more involved. Canal involvement according to gender was not statistically significant (P value=0.45). Mean vitamin D level for cases and controls was 34.9 and 46.5 nmol/L, respectively, and this difference was statically very significant with a p-value of 0.01 (P value < 0.05). Conclusion: According to the findings, there is a statistically significant association between vitamin D3 deficiency and Idiopathic BPPV. It can be noted that vitamin D3 deficiency may be a risk factor for the BPPV.

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Seasonal variation of idiopathic benign paroxysmal positional vertigo correlates with serum 25-hydroxyvitamin D levels: a six-year registry study in Shanghai, China

Scientific Reports ◽

10.1038/s41598-019-52803-4 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Liang Shu ◽

Jing Wu ◽

Chun-Yan Jiang ◽

Xu-Hong Sun ◽

Hui Pan ◽

...

Keyword(s):

Vitamin D ◽

Benign Paroxysmal Positional Vertigo ◽

Serum Vitamin ◽

Chinese Patients ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Positional Vertigo ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

Paroxysmal Positional Vertigo

Abstract Seasonal variation of benign paroxysmal positional vertigo (BPPV) occurrence has been reported in recent years. Whether the seasonality of BPPV also exists in Chinese patients and whether it correlates with serum vitamin D levels is unexplored. We retrospectively analyzed the data of 1269 new-onset idiopathic BPPV patients registered in our vertigo outpatient clinic over a six-year period. Additionally, serum 25-hydroxyvitamin D levels during this period were measured in 877 patients by chemiluminescence immunoassay. We delineated the changing trend of the monthly BPPV patient numbers and serum 25-hydroxyvitamin D levels, and the correlation between them was explored. December to next March is the top 4 months with higher BPPV patient numbers. The median BPPV patient numbers in winter group were higher than those in summer group (20 vs. 16 patients, p < 0.05). Median 25-hydroxyvitamin D levels in winter group were much lower than those in summer group (16.3 vs. 20.8 ng/ml, p < 0.001) and autumn group (16.3 vs. 19.3 ng/ml, p < 0.05). A moderate negative correlation was observed between median serum 25-hydroxyvitamin D levels and BPPV patient numbers each month. The onset of BPPV also shows a seasonal fluctuation in Chinese patients. This phenomenon may be related to serum vitamin D levels.

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Evaluation of bone mineral density and 25-(OH) vitamin D levels in middle-aged and elderly women with recurrent benign paroxysmal positional vertigo

Acta Oto-Laryngologica ◽

10.1080/00016489.2019.1692146 ◽

2019 ◽

Vol 140 (2) ◽

pp. 89-93 ◽

Cited By ~ 2

Author(s):

Zhibin Wang ◽

Guanghui Yao ◽

Xiangming Tao ◽

Jincui Zhang ◽

Ting Zhang ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Bone Mineral ◽

Benign Paroxysmal Positional Vertigo ◽

Elderly Women ◽

Mineral Density ◽

Positional Vertigo ◽

Vitamin D Levels ◽

25 Oh Vitamin D ◽

Paroxysmal Positional Vertigo

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Effect of vitamin D levels in benign paroxysmal positional vertigo

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20212355 ◽

2021 ◽

Author(s):

Shweta Sawant ◽

Taranath Nandini ◽

Rajashree Partabad

Keyword(s):

Vitamin D ◽

Benign Paroxysmal Positional Vertigo ◽

Semicircular Canals ◽

Vitamin D Supplementation ◽

High Rate ◽

Common Cause ◽

Rehabilitation Therapy ◽

Positional Vertigo ◽

Vitamin D Levels ◽

Paroxysmal Positional Vertigo

Background: Benign paroxysmal positional vertigo (BPPV) is a common cause of disabling vertigo with a high rate of recurrence. BPPV is the most common cause of neurotological disorder. It is caused by dislodged otoconia which fall from the utricular macula and float into the semicircular canals there by making them sensitive to gravity. It has been shown that elderly people may suffer from unrecognized, chronic BPPV. Patients with unrecognized BPPV were more likely to have reduced activity of daily living scores, to have sustained a fall in the previous 3 months and to have depression.Methods: A prospective study of 100 patients with clinical diagnosis of BPPV visiting Navodaya medical college and hospital between June 2019 to May 2020 were included in the study.Results: Patients taking both vitamin D supplementation and rehabilitation therapy improved better than patients taking rehabilitation therapy alone.Conclusions: Both rehabilitation therapy and supplementation of vitamin D is helpful in patients with vitamin D deficient BPPV patients.

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Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo

Bioscience Reports ◽

10.1042/bsr20190142 ◽

2019 ◽

Vol 39 (4) ◽

Cited By ~ 9

Author(s):

Jing Ding ◽

Lei Liu ◽

Wei-Kuan Kong ◽

Xiao-Bing Chen ◽

Xudong Liu

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Benign Paroxysmal Positional Vertigo ◽

Serum Levels ◽

Chinese Patients ◽

Control Group ◽

Binary Logistic Regression Analysis ◽

Positional Vertigo ◽

25 Hydroxy Vitamin D ◽

Paroxysmal Positional Vertigo

Abstract Background: The present study aimed to evaluate serum 25-hydroxy vitamin D (25(OH) D) levels in Chinese patients with idiopathic benign paroxysmal positional vertigo (BPPV) and to investigate the possible relationship between the occurrence and recurrence of idiopathic BPPV and low 25(OH) D levels. Methods: Between 1 January 2017 and 31 May, 2018, consecutively older patients (age, older than 50 years) with idiopathic BPPV were recruited in the present study. For each patient, 2:1 sex and age matched healthy people were assigned as the control group. The influence of 25(OH) D levels on BPPV and recurrent BPPV were performed by binary logistic regression analysis. Results: In the present study, 174 patients with BPPV and 348 controls were included. The serum levels of 25(OH) D in those patients were lower than in those controls (P<0.001). One hundred eight patients were found to have vitamin D deficiency; thus, the prevalence was 62.1%, which was higher than that in the controls (42.8%). The data showed that patients with recurrent BPPV (N = 31) had lower serum levels of 25(OH) D compared with those who were not (11.2 ng/ml [interquartile range, 7.2–20.8 ng/ml] vs 18.7 ng/ml [14.2–24.8 ng/ml]). The regression analyses demonstrated that vitamin D deficiency was associated with BPPV and recurrent BPPV with an odds ratio of 2.15 (95% confidence interval [CI], 1.30–4.32; P=0.006) and 5.16 (95% CI, 1.00–34.12; P=0.05). Conclusion: Decreased serum levels of 25(OH)D were associated with the occurrence and recurrence of BPPV in a Chinese population, independent of other baseline markers.

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