scholarly journals Research of medicinal products of the nsaid of the pharmaceutical market in Ukraine for the period 2014–2018

2019 ◽  
pp. 41-51
Author(s):  
L. V. Iakovlieva ◽  
A. A. Titova
Keyword(s):  
Generic Drugs ◽  
Low Cost ◽  
Pharmaceutical Market ◽  
Chemical Structures ◽  
Wide Range ◽  
Retail Prices ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Trade Names ◽  
Target Characteristics

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are groups of different chemical structures of drugs (derivatives of acids) that are widely used in clinical practice. More than three million people in the world take NSAIDs every day. The aim of the study – аnalysis of the range and target characteristics of nonsteroidal anti-inflammatory drugs in the Ukrainian pharmaceutical market during 2014–2018. Nonsteroidal anti-inflammatory drugs, presented on the pharmaceutical market of Ukraine for 2014–2017, were selected as research objects. The research used retail prices, according to the «Pharmstandard» system of the «Morion» company. NSAIDs in Ukraine during 2014–2018 were represented from 302 to 419 TN based on 32 INN. Diclofenac was also represented by the largest number of trade names, due to its distinct efficacy, less toxicity among the most effective drugs and the low cost of domestic generic drugs. Fewer TN than Diclofenac but more than the bulk of NSAIDs in the market were presented by the following INNs – meloxicam, ibuprofen, nimesulide and a combination of glucosamine with chondroitin sulfate. A large selection of NSAIDs has been identified in the pharmaceutical market of Ukraine. Imported Nonsteroidal anti-inflammatory drugs are more represented. These drugs have a wide range of prices that allow you to optimize your treatment costs. The prices of NSAIDs for researched period had increase. The reason can be in conditions of political and socio-economic crisis in the country

Adverse reactions with the use of non-steroidal anti-inflammatory drugs

2020 ◽  
pp. 35-50
Author(s):  
M. L. Maksimov ◽  
N. M. Kiseleva ◽  
D. G. Semenikhin ◽  
B. K. Romanov
Keyword(s):  
Risk Factors ◽  
Adverse Reactions ◽  
Effective Prevention ◽  
Chemical Structures ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Prevention Method ◽  
Effective Medication ◽  
Upper Gastrointestinal

Non-steroidal anti-inflammatory drugs (NSAIDs) are included in a pharmacological group of drugs with different chemical structures providing anti-inflammatory, analgesic and antipyretic actions, as well as antiplatelet action to a certain degree. Unfortunately, NSAIDs can cause a wide range of adverse reactions (AR) posing a serious risk to the health and life of patients. Therefore, the rational use of NSAIDs should include methods for effective prevention of drug complications. Many NSAIDs have a pronounced therapeutic effect, simultaneously causing many undesirable effects, so the drug shall be chosen considering the development of predicted side effects and modern algorithms. According to clinical recommendations, risk factors and administration of safer NSAIDs shall be considered as the main prevention method. Besides, it is possible to protect the patient from the upper gastrointestinal tract complications using proton pump inhibitors. It should be noted that there are no effective medication methods for kidney and liver protection to reduce the risk of NSAID-associated complications.

scholarly journals CONTENT-ANALYSIS OF THE PHARMACEUTICAL MARKET OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN GROUPS OF ACETIC ACID DERIVATIVES IN THE KYRGYZ REPUBLIC

2020 ◽  
Vol 22 (1) ◽  
pp. 74-81
Author(s):  
Dinara Ermekova ◽  
◽  
Isabek Ismailov ◽  
Keyword(s):  
Acetic Acid ◽  
Medical Engineering ◽  
Pharmaceutical Market ◽  
High Price ◽  
Kyrgyz Republic ◽  
Foreign Countries ◽  
Price Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Trade Names

Objective: To segment the pharmaceutical market of non-steroidal anti-inflammatory drugs (NSAIDs) of the derivatives groups of acetic acid in the Kyrgyz Republic. Methods: The database of the State Registry of Medicines registered and approved for Medical use in Kyrgyzstan, the Department of Drugs Security and Medical Engineering of the Ministry of Health of the Kyrgyz Republic is used for analysis. Results: Analysis showed that the leaders of the pharmaceutical market in Kyrgyzstan the number of registered medicines (M) under the trade names are Medical Drugs (MD) with international generic name: diclofenac, ketorolac, indomethacin. It has been established that there are 99 trade names of NSAIDs of the groups of acetic acid derivatives in the Kyrgyz pharmaceutical market. The largest part of the range consists of diclofenac (M01AB05), represented by 62 trade names MD (62.6%), and ketorolac (M01AB15), represented by 20 trade names MD (20.2%). In the pharmaceutical market of Kyrgyzstan are NSAIDs from the groups of acetic acid derivatives from 15 countries, of which 21.1% of MDs are produced by neighboring countries, and 73.3% – in far countries. Conducted studies have revealed that the structure of the range of NSAIDs groups of acetic acid derivatives is dominated by soft medicinal forms, which making up 37.4%. A comparative analysis of the composition of MD by the number of active substances revealed that 92.9% of NSAIDs of the groups of acetic acid derivatives are monodrugs. Based on the analysis of the price segmentation of NSAIDs of the groups of acetic acid derivatives, most of the drugs are in the low-price segment. Conclusions: A sufficient assortment saturation of the pharmaceutical market of Kyrgyzstan NSAIDs groups of acetic acid derivatives has been revealed. The pharmaceutical market of the Kyrgyz Republic is dominated by monocomponent NSAIDs in the form of soft medicinal forms produced in foreign countries. Only 7 MDs from this group are in the high-price range, making the remaining drugs financially available to consumers. Keywords: NSAIDs, indomethacin, diclofenac, etodolac, ketorolac, aceclophenac.

scholarly journals Analysis of the assortment and economic affordability of noоtropic drugs

2021 ◽  
Vol 7 (1) ◽  
pp. 80-86
Author(s):  
O. Ya. Mishchenko ◽  
N. Yu. Palagina ◽  
O. L. Khaleeva ◽  
Yu. I. Greshko
Keyword(s):  
Cerebrovascular Diseases ◽  
Dosage Forms ◽  
Pharmaceutical Market ◽  
Oral Dosage ◽  
Nootropic Drugs ◽  
Gamma Aminobutyric Acid ◽  
Wide Range ◽  
Retail Prices ◽  
Trade Names ◽  
Ischemic Attack

Aim. To analyze the range and assess the economic availability of nootropic drugs at the Ukrainian pharmaceutical market in 2018. Materials and methods. The study object was information about nootropic drugs available at the pharmaceutical market of Ukraine in 2018 based on the data of the “PharmXplorer” analytical system of the information retrieval company “Morion”. The study included drugs used for the treatment of cerebrovascular diseases from the N06B X pharmacotherapeutic group (according to the ATC classification) – “Other psychostimulative and nootropic drugs”. An indicator of the adequacy of solvency (Ca.s.) was calculated using the data taken on the prices of drugs and the average level of wages for 2018. Results. At the Ukrainian pharmaceutical market in 2018 a wide range of nootropic drugs was presented. The range of retail prices per drug pack was significant, indicating the possibility of a doctor and a patient to choose the drug taking into account its efficacy, safety and affordability. Most trade names of nootropics (52 %) were registered as oral dosage forms, being compliant for patients with chronic cerebral circulatory disorders. 48 % were injectable and infusion drugs, which were topical for acute ischemic attack. Conclusions. It was found that in 2018 drugs containing piracetam, vinpocetine, gamma-aminobutyric acid (GABA) and its derivatives, most drugs based Phenibut (84.6 % of TN) and citicoline (68 % of TN) were highly available to the consumer. Most of the injectable dosage forms of nootropics based on hydrolyzates and tissue derivatives were readily available (50 % of TH) for the average consumer in Ukraine. Considering a fairly wide range of nootropic drugs and the economic availability of most of them the principle of superiority of clinical efficacy, safety and affordability should be the basis for creating and developing new nootropic drugs. Key words: nootropic drugs; assortment; economic affordability; Ukrainian pharmaceutical market.

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Immune modulations and immunotherapies for Alzheimer’s disease: a comprehensive review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sara Mahdiabadi ◽  
Sara Momtazmanesh ◽  
George Perry ◽  
Nima Rezaei
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Cognitive Outcomes ◽  
Tau Proteins ◽  
Causal Role ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Immune Related Genes

Abstract Alzheimer’s disease (AD), the most common cause of dementia, is characterized by progressive cognitive and memory impairment ensued from neuronal dysfunction and eventual death. Intraneuronal deposition of tau proteins and extracellular senile amyloid-β plaques have ruled as the supreme postulations of AD for a relatively long time, and accordingly, a wide range of therapeutics, especially immunotherapies have been implemented. However, none of them resulted in significant positive cognitive outcomes. Especially, the repetitive failure of anti-amyloid therapies proves the inefficiency of the amyloid cascade hypothesis, suggesting that it is time to reconsider this hypothesis. Thus, for the time being, the focus is being shifted to neuroinflammation as a third core pathology in AD. Neuroinflammation was previously considered a result of the two aforementioned phenomena, but new studies suggest that it might play a causal role in the pathogenesis of AD. Neuroinflammation can act as a double-edged sword in the pathogenesis of AD, and the activation of glial cells is indispensable for mediating such attenuating or detrimental effects. The association of immune-related genes polymorphisms with the clinical phenotype of AD as well as the protective effect of anti-inflammatory drugs like nonsteroidal anti-inflammatory drugs supports the possible causal role of neuroinflammation in AD. Here, we comprehensively review immune-based therapeutic approaches toward AD, including monoclonal antibodies and vaccines. We also discuss their efficacy and underlying reasons for shortcomings. Lastly, we highlight the capacity of modulating the neuroimmune interactions and targeting neuroinflammation as a promising opportunity for finding optimal treatments for AD.

Non-steroidal anti-flammatory drugs in domestic animals: I. Their classification, mechanism of action and pharmacological effects

1991 ◽  
Vol 62 (1) ◽  
pp. 35-38 ◽  
Author(s):  
G. E. Swan
Keyword(s):  
Mechanism Of Action ◽  
Domestic Animals ◽  
Pharmacological Effects ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chemical Groups

A large number of non-steroidal anti-inflammatory drugs, of different chemical groups are available for veterinary use. These drugs act mainly by inhibiting the. formation of endoperoxides (prostaglandins and thromboxanes) through the inhibition of cyclo-oxygenase in the eicosanoid pathway. A wide range of pharmacological effects, including analgesic, antipyretic and anti-inflammatory effects occur as a result of this inhibition. The classification, mechanism of action and pharmacological effects of these drugs are reviewed.

On the use of carbon blacks as potential low-cost adsorbents for the removal of non-steroidal anti-inflammatory drugs from river water

2010 ◽  
Vol 177 (1-3) ◽  
pp. 1046-1053 ◽  
Author(s):  
Eduardo M. Cuerda-Correa ◽  
Joaquín R. Domínguez-Vargas ◽  
Francisco J. Olivares-Marín ◽  
Jesús Beltrán de Heredia
Keyword(s):  
River Water ◽  
Low Cost ◽  
Carbon Blacks ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals The estimation of competitive positions of non-steroid anti-inflammatory drugs on pharmaceutical market of Ukraine

2018 ◽  
Vol 65 (1) ◽  
pp. 10-14
Author(s):  
A. A. Kotvitska ◽  
V. H. Kostiuk
Keyword(s):  
Market Share ◽  
Pharmaceutical Manufacturing ◽  
Competitive Strategies ◽  
Competitive Position ◽  
Manufacturing Enterprises ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Trade Names ◽  
Level Calculation ◽  
Selective Nsaid

Abstract The aim of our analysis is the estimation of non-steroid anti-inflammatory drugs (NSAID) competitiveness level, calculation of capacity, share and saturation of studied segment of market that allow to improve the competitive strategies of pharmaceutical manufacturing enterprises. MATERIALS AND METHODS: According to the results of content-analysis of foreign and native economic literature, we elaborated the methodology of estimation of NSAID competitive positions that consists of six main stages. The offered model of estimation of competitiveness of the studied group of medicines is based on the construction of competition map of medicines on the example of non-selective NSAID as the largest group by the number of presented trade names (TN) using the calculation of market share of medicines for 2015-2016 and dynamics of its growth. RESULTS: The results of NSAID TN distribution in groups according to the market share volume testify that only 8 TN of medicines among 74 are the leaders of market and 10 TN are characterized with strong competitive position. At the same time 51 NSAID TN are outsiders and 5 TN have weak competitive position. The results of NSAID TN distribution in groups according to the change of their competitive position allow state that 16 TN among 74 have fast worsening competitive position, 43 TN belong to the group with worsening competitive position and only 5 TN has competitive position, characterized by fast improvement. CONCLUSION: The analysis of position, occupied by NSAID TN in matrix, demonstrated that 8 TM of medicines are the leaders of the market. At the same time 51 medicines TN are outsiders. The results of research demonstrated that 59 NSAID TN are characterized with worsening and fast worsening competitive positions.

scholarly journals Predictive Modeling of Henry’s Law Constant in Chemical Structures Using LSSVM and ANFIS Algorithms

2020 ◽  
Author(s):  
Qikai Wang ◽  
Aiqin Yao ◽  
Manouchehr Shokri ◽  
Adrienn A. Dineva
Keyword(s):  
Chemical Structure ◽  
Fuzzy Inference ◽  
Low Cost ◽  
Support Vector ◽  
Inference System ◽  
Chemical Structures ◽  
Neuro Fuzzy ◽  
Wide Range ◽  
Accuracy Of Measurement

Henry’s constants for different existing compounds in water have great importance in transfer calculations. Measurement of these constants face different difficulties including high costs of experiment and low accuracy of measurement apparatus. Due to these facts, proposing a low cost and accurate approach becomes highlighted. To this end, adaptive neuro-fuzzy inference system (ANFIS) and least squares support vector machine (LSSVM) have been used as Henry’s constant predictor tools. The molecular structure of compounds has been used as inputs of models. After training the models, the visual and mathematical studies of outputs have been done. The coefficients of determination of LSSVM and ANFIS algorithms are 0.999 and 0.990 respectively. According to the comprehensiveness of databank and accurate prediction of algorithms, it can be concluded that LSSVM and ANFIS algorithms are accurate methods for prediction of Henry’s constant in wide range of chemical structure of compounds in water.

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