scholarly journals Trazodone succinate — new opportunities for pharmacological correction of situational behavioral abnormalities in dogs and cats

2021 ◽  
Vol 2021 (4) ◽  
pp. 5-13
Author(s):  
Denis Beloglazov ◽  
Sergey Mukaseev ◽  
Orhan Zeynalov
Keyword(s):  
Dosage Form ◽  
High Efficiency ◽  
Deviant Behavior ◽  
Companion Animals ◽  
Abnormal Behavior ◽  
Behavioral Abnormalities ◽  
Target Action ◽  
History Of ◽  
Pharmacological Correction ◽  
Trazodone Hydrochloride

Currently, the interest of veterinarians and owners in the pharmacological correction of situational behavioral disorders in companion animals has increased significantly. To quickly correct deviant behavior in dogs and cats, veterinarians use some of the psychotropic drugs used in humane medicine, in particular, trazodone, an antidepressant antagonist / serotonin reuptake inhibitor. Based on the analysis of literature sources, data on the history of creation and pharmacological properties, assessment of the safety and efficacy of drugs based on trazodone hydrochloride in behavioral medicine of small pets are provided. The data on the prerequisites for the development, pharmaco-toxicological and clinical evaluation of a new drug for the modification of abnormal behavior in dogs and cats, Express Uspokoin® tablets based on trazodone succinate, which, with a high efficiency of the target action, made it possible to achieve the absence of side effects and significantly increase the tolerance of the dosage form by animals, are analyzed. compared with preparations based on trazodone hydrochloride.

scholarly journals TRAINING TEACHERS TO INTERACT WITH STUDENTS SHOWING DEVIANT BEHAVIOR: ANALYSIS OF DIFFERENT APPROACHES

2019 ◽  
pp. 27-36
Author(s):  
O. I Istrofilova
Keyword(s):  
Children And Adolescents ◽  
Behavior Analysis ◽  
Deviant Behavior ◽  
Current Situation ◽  
Future Prospects ◽  
History Of Research ◽  
Behavioral Abnormalities ◽  
The Future ◽  
History Of ◽  
Pedagogical Research

The paper analyzes various approaches to training teachers to interact with students demonstrating deviations in behavior. The complexity and inconsistency of the current situation with personality socialization exacerbates the problem of deviant behavior in children and adolescents. The aim of this research was to consider urgent issues of preparing teachers for working with children showing deviant behavior. The works of leading experts and psychologists were reviewed; the history of research in this area was analyzed; and the main problems and the proposed solutions were noted. The theoretical and practical achievements of educators were closely considered. The findings indicate the future prospects of psychological and pedagogical research on the topic and support the idea to improve the training of educators who teach children with behavioral abnormalities.

scholarly journals L2HGDH Missense Variant in a Cat with L-2-Hydroxyglutaric Aciduria

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 682
Author(s):  
Matthias Christen ◽  
Nils Janzen ◽  
Anne Fraser ◽  
Adrian C. Sewell ◽  
Vidhya Jagannathan ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Genetic Defect ◽  
Clinical Signs ◽  
Missense Variant ◽  
Microcytic Anemia ◽  
Abnormal Behavior ◽  
Functional Candidate Gene ◽  
History Of ◽  
The Brain ◽  
Hydroxyglutaric Acid

A 7-month-old, spayed female, domestic longhair cat with L-2-hydroxyglutaric aciduria (L-2-HGA) was investigated. The aim of this study was to investigate the clinical signs, metabolic changes and underlying genetic defect. The owner of the cat reported a 4-month history of multiple paroxysmal seizure-like episodes, characterized by running around the house, often in circles, with abnormal behavior, bumping into obstacles, salivating and often urinating. The episodes were followed by a period of disorientation and inappetence. Neurological examination revealed an absent bilateral menace response. Routine blood work revealed mild microcytic anemia but biochemistry, ammonia, lactate and pre- and post-prandial bile acids were unremarkable. MRI of the brain identified multifocal, bilaterally symmetrical and T2-weighted hyperintensities within the prosencephalon, mesencephalon and metencephalon, primarily affecting the grey matter. Urinary organic acids identified highly increased levels of L-2-hydroxyglutaric acid. The cat was treated with the anticonvulsants levetiracetam and phenobarbitone and has been seizure-free for 16 months. We sequenced the genome of the affected cat and compared the data to 48 control genomes. L2HGDH, coding for L-2-hydroxyglutarate dehydrogenase, was investigated as the top functional candidate gene. This search revealed a single private protein-changing variant in the affected cat. The identified homozygous variant, XM_023255678.1:c.1301A>G, is predicted to result in an amino acid change in the L2HGDH protein, XP_023111446.1:p.His434Arg. The available clinical and biochemical data together with current knowledge about L2HGDH variants and their functional impact in humans and dogs allow us to classify the p.His434Arg variant as a causative variant for the observed neurological signs in this cat.

A New Prediction Model on the Luminance of OLEDs Subjected to Different Reverse Biases for Alleviating Degradation in AMOLED Displays

2014 ◽  
Author(s):  
Paul C.-P. Chao ◽  
Yen-Ping Hsu ◽  
Yung-Hua Kao ◽  
Kuei-Yu Lee
Keyword(s):  
Reverse Bias ◽  
High Efficiency ◽  
Life Time ◽  
Density Currents ◽  
High Brightness ◽  
Light Emitting ◽  
Wide Viewing Angle ◽  
Time Operation ◽  
Long Time ◽  
History Of

Organic light-emitting diodes (OLEDs) have drawn much attention in areas of displays and varied illumination devices due to multiple advantages, such as high brightness, high efficiency, wide viewing angle, and simple structure. However, the long-time degradation of OLED emission is a serious drawback. This degradation was investigated by past works, which pointed out that the degradation was induced by high-density currents through OLED component under the long-time operation [1][2]. Proposed by a past work [3], different reverse biases was imposed on OLED components in display frames to alleviate the long-time degradation on OLEDs. Most recently, along with the reverse bias, new pixel circuits [4][5] for AMOLED displays are designed to alleviate OLED degradation, thus successfully extending OLED life time. However, since emission luminances in different frame times during AMOLED displaying differs significantly for displaying varied images, the OLED degradation evolves in a highly unpredictable fashion. In this study, based on valid theories, the voltage across the OLED is first used as indicator for OLED degradation. Then the relation between the level of OLED degradation, in terms of OLED’s cross voltage, and the history of imposing reverse biases are precisely modeled. With the model, the degradation of the OLED under reverse bias to extend lifetime can be successfully predicted. Based on this model, engineers can then optimize the applied reverse bias on OLEDs to maximize the OLED lifetime for varied display requirement.

scholarly journals Subacute Sclerosing Panencephalitis

2019 ◽  
Vol 37 (4) ◽  
pp. 205-208
Author(s):  
Gobinda Chandra Banik ◽  
Sakib Aman ◽  
Farhana Sultana ◽  
Syed Mohammad Arif
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Antibody Titer ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Abnormal Behavior ◽  
Short History ◽  
Altered Consciousness ◽  
History Of ◽  
Metachromatic Leucodystrophy

  Subacute sclerosing panencephalitis (SSPE) is chronic progressive encephalitis of childhood and young adoloscent due to persistent measles virus infection. This case illustrates a 14 year old girl presented with short history of intellectual decline, abnormal behavior, myoclonus and altered consciousness with suggestive neuroimaging mimicking metachromatic leucodystrophy. Subsequently she was diagnosed to be a case of Subacute sclerosing panencephalitis (SSPE) on the basis of Electroencephalography (EEG) and Cerebrospinal fluid(CSF) measles antibody titer. J Bangladesh Coll Phys Surg 2019; 37(4): 205-208

scholarly journals First Isolation and Multilocus Sequence Typing of Brucella canis from a Subclinically Infected Pet Dog in China

2022 ◽  
Vol 9 (1) ◽  
pp. 22
Author(s):  
Guangwen Yan ◽  
Zidong Pang ◽  
Yan Hu ◽  
Ziyao Zhou ◽  
Haifeng Liu ◽  
...  
Keyword(s):  
Multilocus Sequence Typing ◽  
Companion Animals ◽  
Human Brucellosis ◽  
Potential Threat ◽  
Brucella Strain ◽  
Pet Dogs ◽  
Brucella Canis ◽  
Biological Tests ◽  
History Of ◽  
Canine Brucellosis

Canine brucellosis, a worldwide zoonotic disease, is mainly caused by Brucella canis. In the present study, we isolated a Brucella strain (CD3) from a subclinically infected pet dog in Sichuan Province, Southwestern China. Classical biotyping methods and molecular biological tests (BCSP31 and BcSS PCR) proved that the strain belonged to B. canis. Furthermore, B. canis CD3 and another two B. canis strains (WJ5 and YA4), which were all isolated from pet dogs in Sichuan, were genotyped using multilocus sequence typing (MLST). Our results showed that the three B. canis strains were identified as the same sequence type (ST21). The present study is the first to report B. canis strain from a subclinically infected pet dog in China, indicating a potential threat to public health posed by subclinical infections in pet dogs. We suggest that screening for B. canis should be incorporated into routine medical examination of pet dogs and other companion animals in areas with a history of animal or human brucellosis.

Gender and Sexuality in Colonial Brazil

2021 ◽  
Author(s):  
Ronaldo Vainfas
Keyword(s):  
Turning Point ◽  
Deviant Behavior ◽  
Moral Theology ◽  
Gender And Sexuality ◽  
Historical Research ◽  
Early 20Th Century ◽  
Marital Relations ◽  
Sexual Imagery ◽  
History Of ◽  
Brazilian History

The topics of gender and sexuality in Brazilian historiography, though available from colonial chroniclers to the present, were notably absent in 19th-century historiography, which was constrained by the moral taboos and racial prejudices of that age. This was true until the early 20th-century turning point represented by the works of Paulo Prado with regard to language, and of Gilberto Freyre with regard to content, in their pioneering attempts to address the issue, emphasizing how interracial procreation and sexual desires shaped Brazilian history. Historical research at universities began in the 1980s, based on unpublished sources and international scholarship on new topics. This resulted in studies on marital relations, misogynist patriarchalism, accepted models of licit sexuality, and various other transgressions such as adultery, concubinage, male and female homosexuality, sexual imagery, libidinous behavior by members of the clergy, and acts considered deviant behavior or associated with heresy. Recently, sources have come into use from the Ecclesiastical Court and the Portuguese Inquisition, which assumed jurisdiction over accusations of bigamy, sodomy, priests who took advantage of the confessional to molest their parishioners, and declarations that contradicted Catholic moral theology with regard to chastity, celibacy, and fornication or were suspected of being heretical due to their association with Protestant doctrines. Additionally, there are important works inspired by French scholarship on the history of mentalities and the historical and philosophical contributions of Michel Foucault.

scholarly journals The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 859 ◽  
Author(s):  
Huiling Chen ◽  
Qing Huang ◽  
Shunjia Zhang ◽  
Kaiqiang Hu ◽  
Wenxiang Xiong ◽  
...  
Keyword(s):  
Protein Expression ◽  
Therapeutic Effects ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
Hippocampal Tissue ◽  
Behavioral Abnormalities ◽  
Antidepressant Effects ◽  
Polygala Tenuifolia ◽  
History Of

Major depressive disorder (MDD) is a chronic mental disorder characterized by mixed symptoms and complex pathogenesis. With long history of practical application, traditional Chinese medicine (TCM) offers many herbs for the treatment and rehabilitation of chronic disease. In this study, we developed a modified Chinese herbal formula using Panax ginseng, Angelica Sinensis, Polygala tenuifolia Willd, and Ziziphi spinosae Semen (PAPZ), based on an ancient TCM prescription. The antidepressant effects of PAPZ were investigated with a corticosterone (CORT) model of depression in mice. Our results showed that administration of PAPZ ameliorated depression-like phenotypes in the CORT model. An anatomic study showed that chronic PAPZ administration upregulated the protein expression of brain-derived neurotrophic factor (BDNF) in hippocampal tissue. The enzyme activity of superoxide dismutase was enhanced in hippocampal tissue, in line with a decreased malondialdehyde level. Taken together, these findings suggested that PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain.

scholarly journals Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy: A Long-Term Follow-Up Study

2015 ◽  
Vol 29 (4) ◽  
pp. 1081-1087 ◽  
Author(s):  
T.S. Jokinen ◽  
K. Tiira ◽  
L. Metsähonkala ◽  
E.H. Seppälä ◽  
A. Hielm-Björkman ◽  
...  
Keyword(s):  
Follow Up Study ◽  
Behavioral Abnormalities ◽  
Long Term Follow Up ◽  
History Of

Caring about Blood, Flesh, and Pain:Women's Standing in the Animal Protection Movement

2001 ◽  
Vol 9 (1) ◽  
pp. 43-61 ◽  
Author(s):  
Lyle Munro
Keyword(s):  
Animal Rights ◽  
Companion Animals ◽  
Drunk Driving ◽  
Women's Movements ◽  
Animal Abuse ◽  
Men And Women ◽  
Male And Female ◽  
Animal Protection ◽  
Mothers Against Drunk Driving ◽  
History Of

AbstractUsing the results of a survey of animal rights activists, advocates, and supporters, the paper reveals much more convergence (80%) than divergence (20%) of attitudes and actions by male and female animal protectionists. Analysis of the divergence suggests that the differences between men and women in the movement are contingent upon such things as early socialization, gendered work and leisure patterns, affinity with companion animals, ambivalence about science, and a history of opposition to nonhuman animal abuse by generations of female activists and animal advocates. Aside from the feminist and women's movements and groups like Mothers Against Drunk Driving, it is rare to find a social movement in which the standing of women eclipses those of their male colleagues. The paper suggests that animal protection remains a bastion of female activism and advocacy because women care about blood, flesh, and pain and, unlike earlier generations of animal activists, no longer are seen as a liability to the success of the movement.

Instruction Clustering Analysis for Unknown Network Protocol's Abnormal Behavior

2015 ◽  
Vol 15 (03n04) ◽  
pp. 1540002
Author(s):  
YANJING HU ◽  
QINGQI PEI ◽  
LIAOJUN PANG
Keyword(s):  
Clustering Analysis ◽  
Clustering Algorithm ◽  
High Efficiency ◽  
Abnormal Behavior ◽  
Automatic Clustering ◽  
Reverse Analysis ◽  
Message Format ◽  
Instruction Sequences ◽  
Analysis Platform ◽  
Abnormal Behaviors

Protocol's abnormal behavior analysis is an important task in protocol reverse analysis. Traditional protocol reverse analysis focus on the protocol message format, but protocol behavior especially the abnormal behavior is rare studied. In this paper, protocol behavior is represented by the labeled behavior instruction sequences. Similar behavior instruction sequences mean the similar protocol behavior. Using our developed virtual analysis platform HiddenDisc, we can capture a variety of known or unknown protocols' behavior instruction sequences. All kinds of executed or unexecuted instruction sequences can automatic clustering by our designed instruction clustering algorithm. Thereby we can distinguish and mine the unknown protocols' potential abnormal behavior. The mined potential abnormal behavior instruction sequences are executed, monitored and analyzed on HiddenDisc to determine whether it is an abnormal behavior and what is the behavior's nature. Using the instruction clustering algorithm, we have analyzed 1297 protocol samples, mined 193 potential abnormal instruction sequences, and determined 187 malicious abnormal behaviors by regression testing. Experimental results show that our proposed instruction clustering algorithm has high efficiency and accuracy, can mine unknown protocols' abnormal behaviors effectively, and enhance the initiative defense capability of network security.

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