EFFICACY AND SAFETY OF LUBRICATING JELLY INSTILLATION TO PREVENT RETROPULSION DURING URETEROLITHOTRIPSY FOR URETERAL STONES

Objective: We studied the efficacy and safety of lubricating jelly instillation before ureterolithotripsy for prevention of retropulsion and improvement in stone-free rate. Material & methods: We enrolled 22 subjects with ureteral stone in this prospective, randomized, single-blind and controlled clinical trial. Each subject was randomly assigned to the lubricating jelly instillation group (n=11) and control group (n=11). Ureteroscopy and lithotripsy was performed according the standard protocol, using 9.8 F semirigid ureteroscope and pneumatic lithotripter. A 6 F ureteral catheter was advanced beyond the stone, and lubricating jelly was instilled through the catheter lumen. Retropulsion and the presence of residual fragments were evaluated with plain kidneys, ureters and bladder x-ray and ultrasonography, or Non Contrast-enhanced Computed Tomography. Any complication was reported and graded using the Modified Clavien Classification System.Results: The 2 groups had comparable preoperative characteristics. There were no statistically significant difference between the lubricating jelly instillation group and control group regarding the retropulsion rate (54.5% vs 72.7%, ρ=0.375), the stone-free rate (54.5% vs 36.4%, ρ=0.392), and the complication rate (45.5% vs 54.5%, ρ=0.670). Conclusion: Lubricating jelly instillation during ureterolithotripsy has limited value for prevention of retropulsion and improvement in stone-free rate.

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Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial

Nutrients ◽

10.3390/nu13082604 ◽

2021 ◽

Vol 13 (8) ◽

pp. 2604

Author(s):

Jin-Young Park ◽

Kyung-A Ko ◽

Ji-Yeong Lee ◽

Jae-Woon Oh ◽

Hyun-Chang Lim ◽

...

Keyword(s):

Patient Reported Outcomes ◽

Daily Intake ◽

Test Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Immunological Parameters ◽

Significant Difference ◽

Patient Reported ◽

And Control

Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis. Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. At baseline, the participants were randomly allocated to either the test group, with daily intake of a single capsule containing 194 mg of MAEC for eight weeks, or control group, with placebo. Clinical periodontal evaluation and immunological parameters from saliva and gingival sulcular fluid were assessed at baseline, four, and eight weeks. Individual PROMs were assessed by OHIP-14 questionnaires. Results: There was a significant difference of modified gingival index at four and eight weeks between the test and control groups. In the test group, crevicular interleukin (IL)-6 was reduced, and the salivary matrix metalloproteinase (MMP)-9 was increased after eight weeks. PROMs were improved up to four weeks compared to placebo. Conclusion: Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.

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The effect of delivery ball and warm shower on the childbirth experience of nulliparous women: A randomized controlled clinical trial

10.21203/rs.3.rs-903099/v1 ◽

2021 ◽

Author(s):

parvaneh sharifipour ◽

Masoomeh Kheirkhah ◽

Mojgan Rajati ◽

hamid haghani

Keyword(s):

Clinical Trial ◽

Pregnant Women ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Childbirth Experience ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Childbirth is a unique experience that affects women’s life. Therefore, this study was performed to determine the effect of delivery ball and warm shower on the childbirth experience of primiparous women. Methods This study is a clinical trial that was carried out on primiparous pregnant women referred to Motazedi Hospital in Kermanshah, Iran. Sampling was done by continuous method and pregnant women were divided into three groups of delivery ball-warm shower (n = 33), delivery ball (n = 33) and control (n = 33). Exercise with ball at the dilation of 4 cm was similar in the two groups of delivery ball-warm shower and delivery ball, but the first group also used warm shower at the dilatation of 7 cm. The control group only received the routine delivery care. Demographic information form consisting of pregnancy history and information about the mother and infant were completed and the childbirth experience questionnaire (CEQ) were completed by the women two hours after the childbirth. Results There was a statistically significant difference in the mean score of childbirth experience after the intervention between the two groups of delivery ball-warm shower and control (P = 0.001), and also between the delivery ball and control groups (P = 0.001). There was a statistically significant difference in the mean scores of professional support between the two groups of delivery ball-warm shower and control (P = 0.02) and also between the delivery ball and control groups (p = 0.02). There was a statistically significant difference in the mean scores of participation between the two groups of delivery ball-warm shower and control (P = 0.003) and also between the delivery ball and control groups (P = 0.01). There was also a statistically significant difference in the mean scores of sense of security between the two groups of delivery ball-warm shower and control (P = 0.01). Conclusion Delivery ball and warm shower were effective interventions to create a positive childbirth experience. This method was more effective than using delivery ball alone in childbirth experience. To achieve a positive experience of childbirth in mothers, the use of both intervention (delivery ball and warm shower) is recommended.

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Efecto del ejercicio cardiovascular sobre el autoconcepto en adultos mayores: ensayo clínico

Enfermería Global ◽

10.6018/eglobal.403851 ◽

2020 ◽

Vol 19 (4) ◽

pp. 145-169

Author(s):

Erick Landeros-Olvera ◽

Joaquín Gil-Benitez ◽

Claudia Sosa-Rodríguez ◽

Rosa María Galicia-Aguilar ◽

Natalia Ramírez-Girón

Keyword(s):

Self Concept ◽

Control Group ◽

Controlled Clinical Trial ◽

Significant Difference ◽

Las Mujeres ◽

Musculoskeletal Function ◽

And Control ◽

Los Grupos ◽

Experimental Group ◽

Ensayo Clínico

Objetivo: Describir el efecto de una dosis de ejercicio gradual y progresiva de bajo impacto cardiovascular sobre el autoconcepto físico en un grupo de adultos mayores.Métodos: Ensayo Clínico Aleatorizado y Controlado con intervención simple ciego en dos grupos equivalentes (experimental y control), bajo un modelo de mediciones repetidas. La muestra estuvo compuesta por 20 sujetos por grupo. Se seleccionaron adultos mayores de 60 a 70 años, de ambos sexos, sin riesgo cardiaco; se excluyeron adultos mayores con patologías que pudieran causar limitaciones en la funcionalidad músculo-esquelética o cardiopulmonar. La intervención consistió en la realización de ejercicio de forma gradual y progresiva, 3 veces por semana durante 10 semanas. El indicador para evaluar el autoconcepto físico fue el Instrumento de Auto descripción (SDQ), con un patrón de respuesta tipo Likert.Resultados: Ingresaron 45 sujetos, grupo control 22 adultos (edad 66.6±6.14) y grupo experimental 23 adultos (edad 67.0±7.19); completaron el programa 38 adultos. En ambos grupos predominaron las mujeres (66.7%), nivel socioeconómico medio (73.3%) y escolaridad básica (44.6%). No existió diferencia significativa entre los grupos antes de la intervención, en contraste, después de la intervención existió diferencia significativa entre grupos, lo que resultó en un incremento del autoconcepto físico en el grupo experimental y un descenso del autoconcepto físico en el grupo control.Conclusión: La intervención de ejercicio controlado, gradual, progresivo y de bajo impacto cardiovascular, de tres sesiones por semana durante 10 semanas probó ser efectiva para aumentar el autoconcepto físico en el grupo experimental de adultos. Objective: To describe the effect of a dose of gradual and progressive exercise of low cardiovascular impact on physical self- concept in a group of seniors. Methods: Randomized, controlled clinical trial with a blinded experiment in two equivalent groups (experimental one and control one), under a repeated model of measures. The sample consisted of 20 individuals per group. Male and female seniors from 60 to 70 years old with no heart risk, were selected. Seniors with pathologies that could cause limitations on the musculoskeletal function cardiopulmonary functionality were excluded. The intervention consisted of performing exercise gradually and progressively, 3 times a week for 10 weeks. The indicator for assessing physical self-concept was the Self-Description Questionnaire (SDQ), with a Likert response pattern.Results: 45 individuals were taken; control group 22 adults (age 66.6 ± 6.14) and experimental group 23 adults (age 67.0 ± 7.19); 38 adults completed the program. In both groups, women predominated (66.7%), medium socioeconomic level (73.3%) and basic schooling (44.6%). There was no significant difference between the groups before the intervention, in contrast, after the intervention there was a significant difference between them, which resulted in an increase in physical self-concept in the experimental group and a decrease in physical self-concept in the control group.Conclusion: The intervention of controlled, gradual, progressive and low cardiovascular impact exercise of three sessions per week for 10 weeks proved to be effective in increasing physical self-concept in the experimental group of adults.

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The effect of distraction techniques on pain and stress during labor: a randomized controlled clinical trial

BMC Pregnancy and Childbirth ◽

10.1186/s12884-019-2683-y ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA. Results The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: − 0.8 to − 6.0; P = 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P < 0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to − 6.0; P = − 2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P = 0.504), second stage of delivery (P = 0.928), total length of delivery (P = 0.520), Apgar score (P = 1.000) and frequency of oxytocin consumption (P = 0.622). Conclusion According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion. Trial registration IRCT2017042910324N39; Name of registry: Iranian Registry of Clinical Trials; Registered 11 September 2017. URL of registry: https://fa.irct.ir/user/trial/10814/view. Date of enrolment of the first participant to the trial: September 2017.

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RANDOMIZED CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF VIDANGADI GUGGULU IN DUSHTA VRANA

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj2808102020 ◽

2020 ◽

Vol 8 (10) ◽

pp. 4753-4760

Author(s):

Preeti G. Verma ◽

Sandip Bhosale

Keyword(s):

Educational Status ◽

Control Group ◽

Controlled Clinical Trial ◽

Trial Group ◽

Intense Pain ◽

Randomized Controlled ◽

Significant Difference ◽

And Control ◽

Controlled Clinical Study ◽

Written Informed Consent

Introduction: Agantu Vranas are shudha at initial stages but due to contamination at the time of accident, poor hygiene and lack of proper care by persons, these get vitiated by Tridosha frequently & convert into Dushta Vrana. The presence of Dushta Vrana worsens the condition of the patient and when associated with complications may become fatal. Objectives: To Study the Efficacy of Vidangadi Guggul in Dushta Vrana. To study the efficacy of Triphala Guggulu Orally in Dushta Vrana. Methodology: Randomized Controlled Clinical Trial, Total 67 patients of Dushta Vrana were enrolled in this study selected of age 18 to 60 year irrespective of sex, religion, occupation, economic and educational status. This study was ap-proved by IEC of institute and written informed consent were taken before enrolment in the study. Trial group of 30 patients were given Vidangadi Guggulu 500 mg orally and Control group patients were given. Triphala Guggulu 500 mg orally were given for 30 days. Discussion: Dushta is one in which there is local-ization of three all the Doshas. Dushta Vrana, which had a bad odor, has abnormal color, irregular in size, with plentiful discharge, intense pain and takes a long period to heal. Dushta Vrana is a long-standing ulcer where removing debris enabling drug to reach healthy tissue is more important. In Ayurveda Dushta Vrana are treated effectively by Guggulu preparations like Triphala Guggulu and Vidangadi Guggulu. Results & Conclusion: In trial group as well as control, there is significant difference observed on Day 0 and Day 30 in Size of Vrana, Vedana(pain) Srava (Discharge), Gandha (Smell), Edge of Vrana and Granulation tissue within group.

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The Effect of Distraction Techniques on Pain and Stress during Labor: A Randomized Controlled Clinical Trial

10.21203/rs.2.13303/v2 ◽

2019 ◽

Author(s):

Paria Amiri ◽

Mojgan Mirghafourvand ◽

Khalil Esmaeilpour ◽

Mahin Kamalifard ◽

Reyhaneh Ivanbagha

Keyword(s):

Intervention Group ◽

Active Phase ◽

Labor Pain ◽

Control Group ◽

Controlled Clinical Trial ◽

Fear Of Childbirth ◽

Control Groups ◽

Significant Difference ◽

The Mean ◽

And Control

Abstract Background: Pain control and the stress associated with labor and delivery are among the most important issues of health care system. Use of distraction techniques during childbirth is reported to reduce pain and stress of labor. However, there is a limited publication that looked on the effect of distraction techniques on labor pain and stress. Thus, the aim of this study was to determine the effect of distraction techniques on labor pain and stress (primary outcomes), fear of childbirth, length of delivery stages, first minute Apgar score and oxytocin consumption (secondary outcomes). Methods: A randomized controlled clinical trial was conducted on 68 pregnant women. Participants were allocated into two groups (intervention and control groups) by blocked randomization. Participants in the intervention group received distraction techniques in four sessions. Questionnaires of Fear of Childbirth (W-DEQ version A) and PSS once were completed before intervention and again at the 36th week for the W-DEQ and in the active phase for the PSS through interviews. The pain was assessed through VAS during active phase per hour. The length of delivery stages was recorded in the partograph chart. Data were analyzed by independent t-test and ANCOVA . Results: The mean of perceived stress during labor in the intervention group was significantly less than that of the control group (AMD: -3.2; 95% CI: -0.8 to -6.0; P= 0.01). The mean (SD) of pain intensity during labor was less than in the intervention and control groups compare to the control group (6.2 vs 7.5; P<0.001). There was no significant difference between the two groups in terms of fear of childbirth score (AMD: 5.3; 95% CI: 13.0 to -6.0; P= -2.3). Moreover, there was no statistically significant difference between the two groups in terms of the active phase of labor (P= 0.504), second stage of delivery (P= 0.928), total length of delivery (P= 0.520), Apgar score (P= 1.000) and frequency of oxytocin consumption (P= 0.622). Conclusion: According to the results, distraction techniques can reduce the pain and stress of labor, but further studies by using the distraction techniques are needed to reach a decisive conclusion .

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Open Randomized Clinical Trial on JWSJZ Decoction for the Treatment of ALS Patients

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/347525 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 6

Author(s):

Weidong Pan ◽

Xiaojing Su ◽

Jie Bao ◽

Jun Wang ◽

Jin Zhu ◽

...

Keyword(s):

Clinical Trial ◽

Amyotrophic Lateral Sclerosis ◽

Rating Scale ◽

Control Group ◽

Efficacy And Safety ◽

Significant Difference ◽

Als Patients ◽

And Control ◽

Lateral Sclerosis ◽

Basic Treatment

Objective. To investigate the efficacy and safety of the traditional Chinese medicine Jiawei Sijunzi (JWSJZ) decoction for the treatment of patients with amyotrophic lateral sclerosis (ALS).Methods. Forty-eight patients with ALS were divided into a JWSJZ group (n=24) and a control group (n=24) using a randomized number method. Together with the basic treatment for ALS, JWSJZ decoction was added to the treatment regimen of patients in the JWSJZ group or Riluzole was administered to the control group for 6 months. Neurologists evaluated the treated and control patients using the ALS functional rating scale (ALSFRS) before, 3 and 6 months after starting the additional treatments.Results. The ALSFRS scores in both groups were lower 3 and 6 months after treatment than before. There was a significant difference at 6 months after treatment between the subgroups of patients with ALS whose limbs were the initial site of attack. No serious adverse effects were observed in the JWSJZ group.Conclusion. JWSJZ decoction may be a safe treatment for ALS, and may have delayed the development of ALS, especially in the subgroup of patients in whom the limbs were attacked first when compared with Riluzole treatment.

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Retrospective Comparison of Intramuscular Admixtures of Ketamine and Dexmedetomidine Versus Ketamine and Midazolam for Preoperative Sedation

Anesthesia Progress ◽

10.2344/anpr-67-04-02 ◽

2020 ◽

Vol 68 (1) ◽

pp. 3-9

Author(s):

David B. Guthrie ◽

Martin R. Boorin ◽

Andrew R. Sisti ◽

Ralph H. Epstein ◽

Jamie L. Romeiser ◽

...

Keyword(s):

Chart Review ◽

Control Group ◽

Time Interval ◽

Efficacy And Safety ◽

Control Groups ◽

Retrospective Comparison ◽

Significant Difference ◽

Dental Rehabilitation ◽

Intraoperative Period ◽

And Control

Precooperative children and patients with intellectual disabilities often require intramuscular (IM) sedation prior to the induction of general anesthesia (GA). Ketamine is an effective preinduction sedative but can produce significant adverse side effects. Dexmedetomidine, a sedative with sympatholytic and analgesic properties, may provide advantages when used in combination with ketamine. This retrospective study evaluated the efficacy and safety of IM ketamine with dexmedetomidine for preoperative sedation. We conducted a chart review of all patients (n = 105) treated for dental rehabilitation who received either IM ketamine and dexmedetomidine (study group, n = 74) or IM ketamine and midazolam (control group, n = 31) prior to induction of GA. No significant difference (p = .14) was observed in the time interval from IM administration to operating room entry (median [interquartile range]) between the study and control groups (5 [4–8] vs 5 [2–7] minutes). Patients who received IM dexmedetomidine exhibited significantly lower mean arterial pressures throughout the induction (p = .004) and had lower heart rates (p = .01) throughout the intraoperative period compared with patients who did not receive dexmedetomidine. The combination of dexmedetomidine and ketamine may provide effective and safe IM sedation prior to the induction of GA.

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USAGE OF SUPPORTING PAD FOR SUPINE PCNL: A SINGLE CENTER EXPERIENCE

Indonesian Journal of Urology ◽

10.32421/juri.v29i1.720 ◽

2022 ◽

Vol 29 (1) ◽

Author(s):

Rizky Lukman Hakim ◽

Ponco Birowo

Keyword(s):

Pediatric Patients ◽

Renal Stones ◽

Ureteral Stones ◽

Inclusion Criteria ◽

Single Center Experience ◽

Stone Free Rate ◽

Significant Difference ◽

Effective Choice ◽

A Prospective Study ◽

Free Rate

Objective: This study aims to compare the safety, efficacy, and other surgical outcomes of supine PCNLs performed with and without the use of supporting pad. Material & Methods: We enrolled 27 patients who undergone PCNL procedure with supine position for renal stones with all sizes between January - December 2019. Divided into two groups, operated with and without supporting pad, with 13 and 14 patients respectively. Inclusion criteria are patients with renal stones, including staghorn, multiple calyx, and proximal ureteral stones. Meanwhile, pediatric patients under 12 years old, uncorrectable bleeding disorders, active urinary infection, and pregnancy are excluded. Results: Our observation showed no statistically significant difference between the two groups, although blood loss and length of stay in supporting pad showed better results. A statistically significant difference was found in stone-free-rate (P = 0.006) favoring in supine PCNL with supporting pad. Conclusion: Supine PCNL with support padding may be a safe and more effective choice to treat renal stones. Nevertheless, the patient’s anatomic variations may influence this. Thus, a prospective study with a larger population is needed to verify our outcomes.

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Comparing the Effect of Aromatherapy with Peppermint and Lavender Essential Oils on Fatigue of Cardiac Patients: A Randomized Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/9925945 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Somayeh Mahdavikian ◽

Masoud Fallahi ◽

Alireza Khatony

Keyword(s):

Essential Oil ◽

Essential Oils ◽

Intervention Group ◽

Cardiac Patients ◽

Control Group ◽

Controlled Clinical Trial ◽

Control Groups ◽

Randomized Controlled ◽

Significant Difference ◽

And Control

Background and Objectives. There is limited and contradictory evidence about the effect of aromatherapy with peppermint and lavender essential oils on the fatigue of cardiac patients. Therefore, the present study was aimed to compare the effect of aromatherapy with peppermint and lavender essential oils on fatigue in cardiac patients. Methods. This randomized controlled clinical trial was conducted on 105 cardiac patients. They were randomly divided into three groups: peppermint essential oil (n = 35), lavender essential oil (n = 35), and control (n = 35). Fatigue Severity Scale (FSS) was used to collect data. The intervention was performed for 7 nights. Before and after the intervention, the questionnaire was completed by all patients. In each intervention group, patients inhaled 3 drops of lavender or peppermint essential oils. In the control group, patients inhaled 3 drops of aromatic placebo. Results. The results showed the average fatigue decreased in the study groups. There was no statistically significant difference between the two groups of lavender and peppermint in terms of mean fatigue after the intervention. However, there was a statistically significant difference between lavender and control groups ( P < 0.001 ), as well as peppermint and control groups ( P < 0.001 ). Conclusion. Aromatherapy with peppermint and lavender essential oils can reduce the fatigue of cardiac patients, so the use of these fragrances is recommended.

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