Evalution of anti Diabetic Activity for ethanolic extract Syzygium cumini leaf in Alloxan induced diabetic rat

2015 ◽  
Vol 1 (1) ◽  
pp. 27-31
Author(s):  
Maheswararao Chattu ◽  
Guptha Attyam
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hypoglycemic Agents ◽  
Syzygium Cumini ◽  
Test Drug ◽  
Standard Drug

The available drugs for the treatment of diabetes, such as Insulin or Oral hypoglycemic agents have one or more side effects. So the search for newer anti-diabetic drugs with minimum or no side effects from herbal plants is a challenge as per world health organization (WHO) recommendations. Diabetes mellitus is a metabolic disorder of carbohydrate, protein and fat which are characterized by hyperglycemia, polyuria, polydipsia, and polyphagia which is deficient insulin production or ineffectiveness in insulin actions. The present study was aimed to evaluate the anti diabetic potency of syzygium cumini leaf on the blood glucose level in alloxan induced diabetic rats. Diabetic Wistar strain rats were treated with standard drug Glibenclamide and test drug syzygium cumini at 100mg, 200mg. The hypoglycemic effect was determined in the rats and the efficacy of the test drug was compared to the standard drug Glibenclamide. Syzygium cumini leaf was orally administered for 14 days in alloxan induced diabetic rats. At the end of the study duration blood glucose level and Biochemical parameters were statistically analyzed. Based on these results of the study this syzygium cumini produced a significant reduction in blood glucose levels when compared with diabetic control rats and hence the present research work proved that the syzygium cumini possess hypoglycemic effect.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

scholarly journals ANTIDIABETIC EVALUATION OF ISOLATED COMPOUNDS FROM TINOSPORA CORDIFOLIA IN ALLOXON INDUCED DIABETIC RAT MODEL

2020 ◽  
Vol 8 (6) ◽  
Author(s):  
Ram Bindurani L G P ◽  
Anoop Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Drug Formulation ◽  
Hypoglycemic Effect ◽  
Tinospora Cordifolia ◽  
Albino Rats ◽  
Standard Drug

Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to synthetic drugs. Tinospora cordifolia commonly named as “Guduchi” is known for its immense application in the treatment of various diseases in the traditional Ayurveda literature. The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Tinospora cordifolia (Guduchi) in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug formulation in two different doses 250 mg and 500 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated compounds produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly.

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 759-764
Author(s):  
Murtaza Haidari ◽  
Kawsar Alami ◽  
Arefa Hossaini ◽  
Sayed Yousof Mousavi
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Body Weight Loss ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hibiscus Sabdariffa ◽  
Carum Carvi

Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.

scholarly journals Effect of L-tryptophan on intestinal glucagon like peptide-1(GLP-1) in streptozotocin (stz) induced diabetic rat model

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 194-198
Author(s):  
K. K. Vineetha ◽  
Gayathri M. Rao ◽  
K. Ashok Prabhu ◽  
Vinodchandran Vinodchandran ◽  
Kavyashree . ◽  
...  
Keyword(s):  
Amino Acids ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Diabetic Patients ◽  
Intestinal Histology ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Introduction and Aim: The management of diabetes is a great challenge in this era due to several factors. The financial burden of the medications and the complications of diabetes create management demanding especially in the Indian population. A high protein-rich diet is beneficial in controlling hyperglycemia in diabetic patients. Different amino acids play roles in reducing blood glucose levels in diabetes. Certain amino acids trigger hypoglycemia in diabetes by inducing the gut hormone, Glucagon-like peptide -1(GLP-1) secretion. L-tryptophan is one among them and is present in many of the food items like poultry, beans, seeds, nuts, etc., This study using albino rats focuses on the effect of L-tryptophan on intestinal GLP-1 secretion in diabetic rats by evaluating the blood glucose level, intestinal GLP-1, and intestinal histology of diabetic rats after tryptophan administration.Materials and Methods: Single dose of intraperitoneal injection of STZ (50mg/kg) used to develop diabetic model and orogastric gavage of tryptophan (50mg/kg) was done. Intestinal GLP-1 and blood glucose assay and intestinal histology were the parameters studied.Results: The results showed a significant reduction in blood glucose level and an increased secretion of intestinal GLP-1(p=0.001) in diabetic rats by tryptophan administration and recovery was seen in intestinal histology. In conclusion, in our study, the administration of L- tryptophan in diabetic rats induced a hypoglycemic effect by GLP-1 secretion and restored normal histology.Conclusion: Tryptophan administration showed hypoglycemic effect on diabetic rats as the blood glucose level was reverted to normal and the hypoglycemic effect of L-tryptophan in diabetic rats could be due to increased GLP-1 secretion.

scholarly journals Antidiabetic effect of Pterocarpus marsupium seed extract in gabapentin induced diabetic rats

2020 ◽  
Vol 9 (3) ◽  
pp. 371
Author(s):  
Sivanageswararao Mekala ◽  
Salum Seif Salum Mchenga ◽  
Saravanan R.
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Disease Control ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Albino Rats ◽  
Pterocarpus Marsupium ◽  
Standard Drug

Background: Type 2 diabetes mellitus is the most common type of diabetes. Diabetes mellitus is a leading cause of morbidity and mortality among Indian population and all over the world with more than hundreds of millions of patients worldwide. Pterocarpus marsupium is a medicinal plant used in Ayurvedic system of medicine to control blood sugar and strong antidiabetic. The purpose of this study was to assess the hypoglycemic effect of the ethanolic extract of Pterocarpus marsupium seeds in diabetic rats.Methods: The present work was designed to evaluate the anti-hyperglycaemic activity of Pterocarpus marsupium seed extract (100 mg/kg and 200 mg/kg) on gabapentin induced hyperglycaemia in wistar albino rats. Blood glucose level, serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were evaluated in gabapentin induced diabetic rats. The results of the test drug were compared with the standard drug.Results: Ethanolic seed extract of Pterocarpus marsupium at 100 mg/kg and 200 mg/kg had significantly reduced the blood glucose level compared to disease control rats on day 1, 7, 14 and 21. Pterocarpus marsupium shows significant decrease in triglycerides levels, serum cholesterol levels, LDL levels and increased HDL levels, total protein levels compared to the disease control group.Conclusions: In conclusion, the present study shows that the ethanolic seed extract of Pterocarpus marsupium has potential antidiabetic action in gabapentin induced diabetic rats and the effect was found to be more similar to the standard drug metformin.

PENGENDALIAN KADAR GLUKOSA DARAH OLEH TEH HIJAU DAN ATAU TEH DAUN MURBEI PADA TIKUS DIABETES

2010 ◽  
Vol 5 (2) ◽  
pp. 87
Author(s):  
Rusman Efendi ◽  
Evy Damayanthi ◽  
Lilik Kustiyah ◽  
Nastiti Kusumorini
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Green Tea ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Feed Consumption ◽  
Font Size ◽  
High Prevalence ◽  
The Difference ◽  
Control Diabetes

<p class="MsoNormal" style="margin: 0cm 7.1pt 6pt 14.2pt; text-align: justify; text-indent: 1cm;"><span style="font-size: 10pt;">Diabetes mellitus is degeneratif disease with high prevalence that happens in many countries. Several studies had been done to control diabetes by using green tea, mullberry leaf  tea, and their mixture. The aim of this research was to analyze the influence of the administration green tea, mullbery leaf tea, and their mixtures to blood glucose level of diabetic rats both during 120 minutes after administration. This research had four phases, first to determine the best mullberry leaf tea, second to fourth phases respectively, determine turnover of blood glucose level on normal rats; attempt during 120 minutes on diabetic rats.  The result of research during 120 minutes have showed that blood glucose level on diabetic rats which were administered by green tea, mullberry leaf tea and their mixture is significantly difference with diabetic rats which were administered by water. Blood glucose level at baseline increased at 30<sup>th </sup>minutes and showed the difference significantly and then until 60<sup>th</sup> and 120<sup>th</sup> minutes and relatively stable. During 120 minutes after feed consumption, inhibition of blood glucose level occured increasingly on diabetic rats which were administered by green tea, mullberry leaf tea, and their mixture compared to diabetic rats which were administered by water.</span></p>

Anti-diabetic activity of diphenhydramine in diabetic rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5067-5070
Author(s):  
Pang Jyh Chayng ◽  
Nurul Ain ◽  
Kaswandi Md Ambia ◽  
Rahim Md Noah
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Insulin Level ◽  
Diabetic Rats ◽  
Group Iv ◽  
Diabetic Rat ◽  
Control Group ◽  
Group I

The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p&lt;0.05) and group IV (11.34 ±3.67, p&lt;0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p&lt;0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

scholarly journals Effect of nicorandil, on blood glucose level in alloxan induced diabetic rats and its pharmacodynamic interaction with glibenclamide

2018 ◽  
Vol 7 (12) ◽  
pp. 2378
Author(s):  
Soni .
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Potassium Channel ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Potassium Channel Opener ◽  
Pharmacodynamic Interaction

Background: Diabetes increases the risk of macrovascular complications and is often associated with angina in patient. Currently nicorandil, a potassium channel opener is being frequently used for the prevention and long-term treatment of angina pectoris. Glibenclamide exerts its antidiabetic action by closing the ATP sensitive potassium channels. Simultaneous use of nicorandil may antagonizes this action and may worsens the existing diabetes. To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide.Methods: Albino rats, weighing 150-200gm of male sex were used for the study. Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. Animal with Fasting Blood Sugar level between 250-300g/dl was selected for study and they were divided into 4 groups of 5 animals each. Group I- serving as control received 0.5ml normal saline orally for 28 days. Group II was given glibenclamide (0.5mg/kg body wt) for 28 days. Group III was treated orally with nicorandil (0.3mg/kg body wt) for 28 days. Group IV was given glibenclamide (0.5mg/kg) and nicorandil (0.3mg/kg) for 28 days. Fasting Blood Sugar level was recorded in all rats on 1st,3rd,7th,14th,21st and 28th day of the treatments.Results: results showed that glibenclamide significantly reduce blood sugar level (p <0.05) Wherase nicorandil showed rise in blood glucose level (p <0.05) While the combination (glibenclamide + nicorandil) showed rise in blood glucose (p <0.05) overall.Conclusions: Nicorandil worsen the existing diabetes and to be avoided or replaced with alternative drug in case of diabetes being treated with sulfonyl urease group of drugs.

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