scholarly journals Antidiabetic effect of Pterocarpus marsupium seed extract in gabapentin induced diabetic rats

2020 ◽  
Vol 9 (3) ◽  
pp. 371
Author(s):  
Sivanageswararao Mekala ◽  
Salum Seif Salum Mchenga ◽  
Saravanan R.
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Disease Control ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Albino Rats ◽  
Pterocarpus Marsupium ◽  
Standard Drug

Background: Type 2 diabetes mellitus is the most common type of diabetes. Diabetes mellitus is a leading cause of morbidity and mortality among Indian population and all over the world with more than hundreds of millions of patients worldwide. Pterocarpus marsupium is a medicinal plant used in Ayurvedic system of medicine to control blood sugar and strong antidiabetic. The purpose of this study was to assess the hypoglycemic effect of the ethanolic extract of Pterocarpus marsupium seeds in diabetic rats.Methods: The present work was designed to evaluate the anti-hyperglycaemic activity of Pterocarpus marsupium seed extract (100 mg/kg and 200 mg/kg) on gabapentin induced hyperglycaemia in wistar albino rats. Blood glucose level, serum triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol were evaluated in gabapentin induced diabetic rats. The results of the test drug were compared with the standard drug.Results: Ethanolic seed extract of Pterocarpus marsupium at 100 mg/kg and 200 mg/kg had significantly reduced the blood glucose level compared to disease control rats on day 1, 7, 14 and 21. Pterocarpus marsupium shows significant decrease in triglycerides levels, serum cholesterol levels, LDL levels and increased HDL levels, total protein levels compared to the disease control group.Conclusions: In conclusion, the present study shows that the ethanolic seed extract of Pterocarpus marsupium has potential antidiabetic action in gabapentin induced diabetic rats and the effect was found to be more similar to the standard drug metformin.

scholarly journals EVALUATION OF ANTI-DIABETIC ACTIVITY OF FICUS BENGALENSIS LINN IN ALLOXAN INDUCED RATS

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Fegade Sachin A ◽  
Siddaiah M
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Albino Rats ◽  
Standard Drug ◽  
Wistar Albino Rats ◽  
Ficus Bengalensis

The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Ficus bengalensis in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug extract in 150 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated fractions produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly. Keywords: Ficus begalensis, antidiabetic, allaxon induced, Diabetes mellitus.

scholarly journals ANTIDIABETIC EVALUATION OF ISOLATED COMPOUNDS FROM TINOSPORA CORDIFOLIA IN ALLOXON INDUCED DIABETIC RAT MODEL

2020 ◽  
Vol 8 (6) ◽  
Author(s):  
Ram Bindurani L G P ◽  
Anoop Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Research Work ◽  
Diabetic Rats ◽  
Drug Formulation ◽  
Hypoglycemic Effect ◽  
Tinospora Cordifolia ◽  
Albino Rats ◽  
Standard Drug

Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to synthetic drugs. Tinospora cordifolia commonly named as “Guduchi” is known for its immense application in the treatment of various diseases in the traditional Ayurveda literature. The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Tinospora cordifolia (Guduchi) in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug formulation in two different doses 250 mg and 500 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated compounds produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

scholarly journals Ekstrak air daun ceplikan (Ruellia tuberosa L.) serta pengaruhnya terhadap kadar glukosa darah dan gambaran histologis pankreas tikus putih (Rattus norvegicus) diabetes mellitus

2009 ◽  
Vol 6 (2) ◽  
pp. 64
Author(s):  
Taufan Hendra Tandri ◽  
Wiryatun Lestariana ◽  
Fatma Zuhrotun Nisa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rattus Norvegicus ◽  
Diabetic Rats ◽  
Effective Control ◽  
White Rats ◽  
Group I ◽  
Significant Difference

Background: Effective control of blood glucose and activities of antioxidant are key factors that prevent diabetes mellitus (DM) and its complications. There are lots of herbal plants that have those both effects. Ceplikan leaves (Ruellia tuberosa L.) is a traditional medicine which is empirically used to lower blood glucose level. Instead of antioxidant compound, there is assumed other compound in ceplikan leaves that has side effect to pancreatic beta cells.Objective: To identify the effect of ceplikan leaves extract to blood glucose level and pancreas histology description in white diabetic rats (Rattus norvegicus).Method: Thirty subjects of Wistar strain male white rats of 2-3 months old and of 150-200 grams weight were made diabetic with aloxan and randomly divided into 5 groups. Group I consisted of diabetic rats with aquadest, group II with glibenclamide, and Group III-V were given extract of ceplikan leaves in different concentrations that were 1.6 mg, 3.2 mg, and 6.4mg, respectively. Treatment was given orally per day within 30 days. Level of blood glucose was measured in the day of 0, 3, 4, and 30. Statistical analysis used repeated measures and t-test.Result: The supply of ceplikan leaves extract could reduce level of blood glucose of diabetic rats, although the decrease was insignificant. Average diameter of wider Langerhans island occurred to the group of diabetic rats that were given extract of ceplikan leaves dosage 6.4 mg. There was no significant difference (p > 0.05) in changes of blood glucose level before and after experiment in diabetic rats. Pancreas histological description of rats showed that there was improvement as indicated by greater quantity of Langerhans Island and wider diameter of Langerhans Island.Conclusion: Ceplikan leaves was safe and efficacious, so that self-medication of DM using ceplikan leaves could be sustained through formal approach.

scholarly journals Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients

2020 ◽  
Vol 11 (3) ◽  
pp. 2879-2883
Author(s):  
Sheela R ◽  
Merlin Shiny Sheeba ◽  
Poornima ◽  
Priya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Low Income ◽  
Seed Extract ◽  
Medical Expenditure ◽  
Diabetic Patients ◽  
Treatment Of Diabetes ◽  
Coriander Seed

Diabetes Mellitus (DM) belongs to a group of metabolic disorders. It is characterised by Chronic Hyperglycemia and disturbance of carbohydrate, lipid and protein metabolism. The cause for this condition arises from a disease in insulin secretion. The International Diabetes Federation (IDF) expresses that worldwide 415 million individuals have Diabetes Mellitus. It also predicts that by 2040 this will ascend to 642 billion. The other prediction is that 77% of individuals with Diabetes live in middle and low-income countries. 12% of the worldwide population spend on the treatment of Diabetes. With the escalating medical expenditure in treating Diabetes, a person from middle or low income may find it challenging to meet the expenses. It is an expected tendency for an individual from this category to opt for a more straightforward treatment that suits their pocket. In the recent past, all over the world, people from all walks of life know essential things about natural remedies. A lot of researches are going on in support of using natural products per se. One such study is this – on the Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients.Coriandrum Sativum is a plant that has been utilised in the administration of Diabetes. It is a herbaceous plant originally from the Mediterranean and Middle Eastern locales, having a place in the family Apiaceae. It is known to have antifungal, antibacterial, free radical searching, and lipid peroxidation activities. The study was conducted to assess the level of pretest and posttest blood glucose level. And, also to evaluate the effect of coriander seed extract in the treatment of Diabetes Mellitus. An experimental study was chosen to assess the effectiveness of coriander seed extract among diabetic clients. The present study was conducted at Mappedu. 60 male and female who come under inclusion criteria were selected by purposive sampling technique. Data was collected by using a socio-demographic variable, and random blood glucose was assessed by CBG machine. The results revealed that coriander seed extract has a significant effect on decreasing blood glucose level among diabetic patients.

scholarly journals Impact of Momordica Charantia (Karela) on the Fasting Blood Glucose level in the Streptozotocin-Induced Diabetic Rats

1970 ◽  
Vol 9 (1) ◽  
pp. 45-48
Author(s):  
S Mohal ◽  
DK Mondal ◽  
PK Chowdhury ◽  
A Khanom ◽  
KM Shamim
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
Key Words Diabetes ◽  
Fasting Blood Glucose Level ◽  
The Mean

Context: Scientific studies revealed the hypoglycaemic properties of momordica charantia. The present study was carried out to find out microscopically whether Momordica charantia (karela) has got any impact lowering of FBG (Fasting Blood Glucose) level in diabetes mellitus. Study type: an experiemental study. Setting: Anatomy department of the then IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders). Subjects: Sixty five healthy young Long Evans rats of male sex weighing 150 to 280gm aged between 10 to 12 weeks were used in this study. Methods: The rats were divided into four equal groups depending on their different sorts of dietry feeding and drug treatment. Main outcome measures: variation of differential FBG level in different groups of rat. Result: Mean 'initial' and 'final' (on day 7 and day 51 from Streptozotocin/vehicle injection) fasting blood glucose (FBG) level in the control group (Group-A) was 7.872 ± 0.60 and 8.55 ± 0.82 respectively. Therefore the mean (FBG) increased by about 13% (P = 0.022*) which is higher than that of the initial value. In untreated diabetic group the mean initial (FBG) level was 25.95 ± 8.90 and the mean final was 24.02 ± 4.08. So here, the (FBG) level decreased by about 13% (P = 0.557). On the other hand, in the insulintreated diabetic rats the mean initial (FBG) level was 24.35 ± 6.81 and the mean final was 8.38 ± 5.02, which is lower (P = 0.000*) & in the karela–treated diabetic rats, the initial (FBG) level was 23.03 ± 5.70 and the mean final was 5.65 ± 1.29 which is lower* (P = 0.000*). The value in the insulin-treated diabetic rats & in the karela-treated diabetic rats were significantly lower than that of the untreated diabetic rats (P = 0.007) & (P= 0.005) respectively. But there was no significant difference between the insulin-treated diabetic rats & the karela-treated diabetic rats (P = 0.605) in this regard. Conclusion: Karela showed a tendency of acting against hyperglycemic effects of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing karela as a safe, useful effective anti- hyperglycemic agent as well as antidiabetogenic agent. Key words: Diabetes mellitus; Hyperglycemia; Momordica charantia (karela) DOI: http://dx.doi.org/ 10.3329/bja.v9i1.8148 Bangladesh Journal of Anatomy January 2011, Vol. 9 No. 1 pp 45-48  

scholarly journals Hypoglycemic Activity of Ethanol Extract of Jasminum Grandiflorum Flowers in Vivo and Cytotoxicity of Its Chloroform Isolate in Vitro

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Albino Rats ◽  
Chloroform Fraction ◽  
Dependent Manner ◽  
Flower Extract

Ethno pharmacological relevance: Traditionally different parts of Jasminum grandiflorum have been used to treat various ailments, including diabetes. However, antidiabetic potential of Jasminum grandiflorum on animal models of diabetes have not been evaluated. Aim of the study: The objective of this study was to determine antidiabetic potential of ethanol extract of leaves and flowers of Jasminum grandiflorum, and different fractions of the flower extract in rodent model of streptozotocin-induced diabetes. Materials and methods: Ethanol extract of both leaves and flowers of Jasminum grandiflorum were screened for the presence of various phytochemicals followed by acute and sub-acute toxicity in rats. Effect of Jasminum grandiflorum leaf and flower extracts on blood glucose level in normal albino rats, in glucose-overloaded healthy albino rats, and in streptozotocininduced diabetic rats was evaluated. Furthermore, based on preliminary results, fractionalization of the flower extract was carried out using petroleum ether, ethyl acetate, methanol, and chloroform. Different fractions were further tested for hypoglycemic activity in streptozotocin-induced diabetic rats. Results: Preliminary phytochemical evaluation suggested presence of various antidiabetic metabolites in both the extracts and were found to safe up to 5000 mg/kg dose. Flower extract (500 mg/kg, p.o.) demonstrated significant hypoglycemic effect than leaf extract (500 mg/kg, p.o.) in normal rats, glucose-overloaded rats, and streptozotocin-induced diabetic rats when compared to control. Long-term effect of different fractions of ethanol extract of Jasminum grandiflorum flowers in streptozotocin model suggested that all four fractions were able to reduce blood glucose level in a time-dependent manner at 200 mg/kg dose with chloroform fraction being highly significant (p<0.001) amongst all when compared to diabetic untreated rats. Chloroform isolate from Jasminum grandiflorum flowers demonstrated enhanced glucose uptake and dosedependent cytotoxicity in L6 cell line. Conclusion: The ethanol extract of Jasminum grandiflorum flowers as well as its various fractions have potential therapeutic value in treating diabetes, which may be due to the presence of various antidiabetic metabolites, by enhancing insulin secretion and antioxidant defense. These observations rationalize its use as ethnomedicine and hence can be considered in treating diabetes.

scholarly journals Antimicrobial and antidiabetic potentials of processed finger millet (Eleusine coracana)

2018 ◽  
Vol 6 (1) ◽  
pp. 18
Author(s):  
Japhet Erasmus Aisoni ◽  
Muhammad Yusha’u ◽  
Olukayode Olugbenga Orole
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Finger Millet ◽  
Islet Cells ◽  
Salmonella Typhi ◽  
Glycaemic Index ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Methanolic Extracts

Finger millet is a food crop with energy value, phytochemical constituents, and minerals, hence its use as whole flour for traditional food preparation among traditional people. The study was designed to determine the glycaemic index and blood glucose level in albino rats, and the antimicrobial potential of processed finger millets. Finger millets were processed by fermentation and roasting, and methanolic extracts obtained used to test antimicrobial activity. Albino rats (18) divided into three groups were fed fermented, roasted, and unprocessed millet (control), and glycaemic index and blood glucose level determined. Another 25 rat were treated into 5 groups of diabetic rats without treatment, diabetic rats treated daily with Metformin, diabetic rats fed 20% millet, diabetic rats fed 40% millet, and untreated group (control). At 100% concentration, roasted and fermented millet obtained inhibition of 15mm and 14mm against Salmonella typhi, while the control drug 25mg/ml streptomycin had 17mm inhibition. While values obtained for the glycemic indexes were close though significantly different from each other (roasted - 36.83±1.23; fermented - 38.73±1.87), roasted millet brought about the highest reduction in blood glucose level 90.9 and 65.1mg/dl at 60 and 120min respectively compared with fermented millet with 125.1 and 100.2mg/dl respectively at the same time. Animals administered finger millet in Groups 3 and 4-showed regeneration of the islet cells. The millet had the capacity to bring about healing of necrotic cells while also restoring and maintaining glucose levels in blood of subjects. 

Evalution of anti Diabetic Activity for ethanolic extract Syzygium cumini leaf in Alloxan induced diabetic rat

2015 ◽  
Vol 1 (1) ◽  
pp. 27-31
Author(s):  
Maheswararao Chattu ◽  
Guptha Attyam
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hypoglycemic Agents ◽  
Syzygium Cumini ◽  
Test Drug ◽  
Standard Drug

The available drugs for the treatment of diabetes, such as Insulin or Oral hypoglycemic agents have one or more side effects. So the search for newer anti-diabetic drugs with minimum or no side effects from herbal plants is a challenge as per world health organization (WHO) recommendations. Diabetes mellitus is a metabolic disorder of carbohydrate, protein and fat which are characterized by hyperglycemia, polyuria, polydipsia, and polyphagia which is deficient insulin production or ineffectiveness in insulin actions. The present study was aimed to evaluate the anti diabetic potency of syzygium cumini leaf on the blood glucose level in alloxan induced diabetic rats. Diabetic Wistar strain rats were treated with standard drug Glibenclamide and test drug syzygium cumini at 100mg, 200mg. The hypoglycemic effect was determined in the rats and the efficacy of the test drug was compared to the standard drug Glibenclamide. Syzygium cumini leaf was orally administered for 14 days in alloxan induced diabetic rats. At the end of the study duration blood glucose level and Biochemical parameters were statistically analyzed. Based on these results of the study this syzygium cumini produced a significant reduction in blood glucose levels when compared with diabetic control rats and hence the present research work proved that the syzygium cumini possess hypoglycemic effect.

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