Aromatherapy in the treatment of psychiatric disorders: A review

2016 ◽  
Vol 2 (1) ◽  
pp. 12-20
Author(s):  
Maria Ayub ◽  
Amna Islam
Keyword(s):  
Side Effects ◽  
Essential Oils ◽  
Psychiatric Disorders ◽  
Selection Criteria ◽  
Clinical Effects ◽  
Clinical Endpoints ◽  
Cochrane Database ◽  
Computer Based ◽  
Eligibility Requirements ◽  
Quality Evidence

Aromatherapy is most commonly used therapy for the relaxation purpose to overcome the symptoms associated with psychiatric disorders. Essential oils are most commonly used substances for this purpose. These are obtained from various plant species including lavender, rosemary, sage, and salvia. The objective of this study was to evaluate aromatherapy in the treatment of psychiatric disorders. A computer-based search of Pubmed, Medline, Embase, Cinahl, PsycINFO, AMED, and the Cochrane Database of Systematic Reviews was performed. Trials were included if they were potential human trials assessing aromatherapy in the treatment of psychiatric disorders and utilized validated instruments to assess participant eligibility and clinical endpoints. Selection criteria of the study was decided and taken into consideration. Trials were identified that met all eligibility requirements. Individual trials investigating botanical sources and clinical effects of essential oils used in aromatherapy. Results of the trials are discussed to form the basis of a recommendation. No good quality evidence was identified on which to base a recommendation. However, no serious side effects were reported in any of the studies on the use of aromatherapy. Further studies are recommended to reach at any conclusion.

scholarly journals Interest of Fluvoxamine as an Add-on to Clozapine in Children With Severe Psychiatric Disorder According to CYPs Polymorphisms: Experience From a Case Series

2021 ◽  
Author(s):  
Camille BEREL ◽  
Ulysse RIOT MOSSE ◽  
Julien Wils ◽  
Lauriane Cousin ◽  
Laurent Imbert ◽  
...  
Keyword(s):  
Side Effects ◽  
Plasma Level ◽  
Psychiatric Disorder ◽  
Psychiatric Disorders ◽  
Neurodevelopmental Disorders ◽  
Case Series ◽  
Clinical Effects ◽  
A Minor ◽  
Enzymatic Inhibitor ◽  
Cyp Inhibitors

Abstract BackgroundDespite its drastic efficacy in resistant psychiatric disorders, clozapine remains rarely used in youth due to its side effects. Clozapine plasma level is determined through its metabolism involving several isoforms of cytochromes 450 (CYP450) family. Isoform CYP1A2 appears as a limiting enzyme involved in the metabolism of clozapine while isoforms 2C19, 2D6, 3A4 and 3A5 also contribute in a minor way. Clozapine efficacy is limited by a significant inter-patient variability in exposure according to CYP’s polymorphisms. Clozapine plasma levels may be increased with CYP inhibitors such as fluvoxamine. This drug is a potent enzymatic inhibitor of CYP1A2 and to a lesser extent of CYP3A4 and CYP2D6. Hence, in case of CYPs polymorphisms in youth, the use of fluvoxamine as add on to clozapine could help reaching clinical and biological efficacy and allowing lower clozapine dosage and a better tolerance profile, as it has already been described in adults.Case ReportWe report four pediatric cases with severe psychiatric disorders underlying our experience with CYPs polymorphism explorations and the use of fluvoxamine as add on to clozapine. Our four patients clinically improved after the introduction of fluvoxamine, enhancing clozapine metabolism and therefore clozapine plasma level within therapeutic range. Despite the interesting results of fluvoxamine, we report a severe issue of tolerance for one patient, emphasizing the need for caution regarding possible drugs interactions when fluvoxamine is considered. Hence, we propose a detailed step by step multidisciplinary protocol.ConlusionThe results pointed out the positive clinical effects of fluvoxamine as add-on to clozapine in youth with severe neurodevelopmental disorders but stresses the need for caution regarding drugs interactions.

scholarly journals Effects of non-invasive brain stimulation in children and young people with psychiatric disorders: a protocol for a systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yael D. Lewis ◽  
Lucy Gallop ◽  
Iain C. Campbell ◽  
Ulrike Schmidt
Keyword(s):  
Systematic Review ◽  
Young People ◽  
Psychiatric Disorders ◽  
Brain Stimulation ◽  
Grey Literature ◽  
Significant Proportion ◽  
Clinical Effects ◽  
Children And Young People ◽  
Non Invasive ◽  
Specific Symptoms

Abstract Background Most psychiatric disorders have their onset in childhood or adolescence, and if not fully treated have the potential for causing life-long psycho-social and physical sequelae. Effective psychotherapeutic and medication treatments exist, but a significant proportion of children and young people do not make a full recovery. Thus, novel, safe, brain-based alternatives or adjuncts to conventional treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation (NIBS) techniques which have shown clinical benefits in adult psychiatric conditions. However, in children and young people their efficacy is not well established. The objective of this study will be to systematically evaluate the evidence on clinical effects of NIBS in children and young people with psychiatric disorders, assessing disorder-specific symptoms, mood and neurocognitive functions. Methods We designed and registered a study protocol for a systematic review. We will include randomised and non-randomised controlled trials and observational studies (e.g. cohort, case-control, case series) assessing the effects of NIBS in children and young people (aged ≤ 24 years old) for psychiatric disorders. The primary outcome will be reduction of disorder-specific symptoms. Secondary outcomes will include effects on mood and cognition. A comprehensive search from database inception onwards will be conducted in MEDLINE, EMBASE and PsycINFO. Grey literature will be identified through searching multiple clinical trial registries. Two reviewers will independently screen all citations, full-text articles and abstract data. The methodological quality of the studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence and according to heterogeneity will conduct an appropriate meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity. Discussion This systematic review will provide a broad and comprehensive evaluation of the evidence on clinical effects of NIBS in children and young people with psychiatric disorders. Our findings will be reported according to the PRISMA guidelines and will be of interest to multiple audiences (including patients, researchers, healthcare professionals and policy-makers). Results will be published in a peer-reviewed journal. Systematic review registration PROSPERO CRD42019158957

Analysis Of Factors Influencing Acupuncture Clinical Effects: A Systematic Review

2021 ◽  
Author(s):  
Yali Liu ◽  
Honglin Jiang ◽  
Xiaotong Li ◽  
Xingyue Yang
Keyword(s):  
Systematic Review ◽  
Individual Difference ◽  
Current Status ◽  
Clinical Effects ◽  
High Quality ◽  
Psychological States ◽  
Factors Influencing ◽  
High Quality Evidence ◽  
Stimulus Parameters ◽  
Quality Evidence

Background: Acupuncture therapy has been widely applied all around the world. But there still lacks high-quality evidence to evaluate its clinical effects, safety and cost-effectiveness, which seriously restricts its further promotion and development. Acupuncture, as an operational intervention, is more complex than drug therapy. Factors involved in the acupuncture operation process, such as individual and interventional factors, may affect clinical effects. Purpose:s Through this systematic review, we attempt to analyze the current status of studies about the key factors influencing clinical effects, so as to provide evidence for the design of acupuncture studies. Methods: A literature research was conducted in six databases until May, 2020. Studies were screened and assessed by two authors independently. Data extraction was made after screening. We extracted the basic information of these studies, including publishing years and countries, population and factors influencing clinical effects.Results: Through the initial search in these six database, 6404 records were retrieved. After duplication and screening, a total of 355 studies were finally included in the qualitative analysis. About 88.5% of these studies were conducted in China with increasing number in the past decades, covering neurological disorders, orthopedic disorders, obstetrical and gynecological diseases, digestive diseases and so on; 239 studies focused on stimulus parameters which may influence effects, accounting for 67.3%, and 128, 44, 39, 32, 15, 11 studies discussed acupoints, patients’ pathological states, individual difference, psychological states, deqi, and other factors separately. Conclusion: There are more and more studies focusing on factors influencing acupuncture clinical effects, including stimulus parameters, acupoints, individual difference, patient pathological and psychological states. Based on this systematic review, several ignored factors should be considered for future researches, and more scientifically and objectively high quality evidence should also be proved.

EXACT LASER FLUENCE FOR SUCCESSFUL TREATMENT OF FACE AND LEG TELANGIECTASIA

2021 ◽  
Vol 74 (9) ◽  
pp. 2340-2344
Author(s):  
Muna B. Mustafa ◽  
Wailed K. Hamoudi ◽  
Ghufran. S. Jaber ◽  
Mohammed Y. Abbas ◽  
Noor R. Abdulhameed
Keyword(s):  
Side Effects ◽  
Lower Extremity ◽  
Laser Treatment ◽  
Laser Fluence ◽  
Clinical Effects ◽  
Safe Procedure ◽  
Laser Materials ◽  
Yag Laser ◽  
Laser Parameters ◽  
Long Pulse

The aim: Facial and leg telangiectasia are usual cosmetic concern for females who have different skin phototypes and ages. Until now, the various treatments for these problem have frequently failed or led to unwanted side-effects. Based on approved pre-calculated doses, the present study highlights the clinical effects and safety of treatment after using the exact laser parameters from 1064-nm Nd: YAG laser. Materials and methods: Twenty people with facial and leg telangiectasia underwent a single laser treatment, based on pre-calculated laser parameters for each case. Results: All subjects showed visible improvement, with 95–100% clearance of face telangiectasia directly after the first treatment, and 50–100% clearance of the lower extremity vessels after one to three days; with minimal side-effects. Conclusions: Treatment of facial and leg telangiectasia by using true, exact, and mathematically pre-calculated parameters of long pulse 1064 nm Nd: YAG laser was an effective and safe procedure of clearing face and leg telangiectasia.

scholarly journals Essential Oil-Based Bioherbicides: Human Health Risks Analysis

2021 ◽  
Vol 22 (17) ◽  
pp. 9396
Author(s):  
Chloë Maes ◽  
Jeroen Meersmans ◽  
Laurence Lins ◽  
Sandrine Bouquillon ◽  
Marie-Laure Fauconnier
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Essential Oils ◽  
Health Risks ◽  
Good Alternative ◽  
Aquatic Systems ◽  
Air Transport ◽  
Human Health Risks ◽  
Potential Risks ◽  
Negative Side Effects

In recent years, the development of new bio-based products for biocontrol has been gaining importance as it contributes to reducing the use of synthetic herbicides in agriculture. Conventional herbicides (i.e., the ones with synthetic molecules) can lead to adverse effects such as human diseases (cancers, neurodegenerative diseases, reproductive perturbations, etc.) but also to disturbing the environment because of their drift in the air, transport throughout aquatic systems and persistence across different environments. The use of natural molecules seems to be a very good alternative for maintaining productive agriculture but without the negative side effects of synthetic herbicides. In this context, essential oils and their components are increasingly studied in order to produce several categories of biopesticides thanks to their well-known biocidal activities. However, these molecules can also be potentially hazardous to humans and the environment. This article reviews the state of the literature and regulations with regard to the potential risks related to the use of essential oils as bioherbicides in agricultural and horticultural applications.

Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations

1985 ◽  
Vol 147 (3) ◽  
pp. 283-288 ◽  
Author(s):  
Jes Gerlach ◽  
Kirsten Behnke ◽  
Jon Heltberg ◽  
Ebbe Munk-Andersen ◽  
Henrik Nielsen
Keyword(s):  
Side Effects ◽  
Plasma Concentrations ◽  
Clinical Effects ◽  
Median Dose ◽  
Double Blind ◽  
Day Range ◽  
Daily Dose ◽  
Schizophrenic Patients ◽  
High Doses ◽  
Therapeutic Profile

SummaryIn a double-blind cross-over trial, 20 chronic schizophrenic patients were treated with sulpiride and haloperidol in two 12-week periods. The final median dose of sulpiride was 2000 mg/day (range 800–3200) and of haloperidol 12 mg/day (range 6–24). Sulpiride had an antipsychotic effect and therapeutic profile not significantly different from that of haloperidol. In spite of the high doses of sulpiride, extrapyramidal side-effects were seen less frequently during the first four weeks of the sulpiride period than during the corresponding haloperidol period (P < 0.05), whereas autonomic side-effects were equally rare for both drugs. A positive correlation was found between daily dose and plasma concentration of both sulpiride (P < 0.001) and haloperidol (P < 0.05), but no correlation could be established between clinical effects and plasma levels of either neuroleptic.

scholarly journals Evaluation of Automatic Segmentation of Thalamic Nuclei through Clinical Effects Using Directional Deep Brain Stimulation Leads: A Technical Note

2020 ◽  
Vol 10 (9) ◽  
pp. 642
Author(s):  
Marie T. Krüger ◽  
Rebecca Kurtev-Rittstieg ◽  
Georg Kägi ◽  
Yashar Naseri ◽  
Stefan Hägele-Link ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Side Effects ◽  
Brain Stimulation ◽  
Technical Note ◽  
Patient Specific ◽  
Brain Anatomy ◽  
Clinical Effects ◽  
Thalamic Nuclei ◽  
Lead Placement ◽  
Deep Brain

Automatic anatomical segmentation of patients’ anatomical structures and modeling of the volume of tissue activated (VTA) can potentially facilitate trajectory planning and post-operative programming in deep brain stimulation (DBS). We demonstrate an approach to evaluate the accuracy of such software for the ventral intermediate nucleus (VIM) using directional leads. In an essential tremor patient with asymmetrical brain anatomy, lead placement was adjusted according to the suggested segmentation made by the software (Brainlab). Postoperatively, we used directionality to assess lead placement using side effect testing (internal capsule and sensory thalamus). Clinical effects were then compared to the patient-specific visualization and VTA simulation in the GUIDE™ XT software (Boston Scientific). The patient’s asymmetrical anatomy was correctly recognized by the software and matched the clinical results. VTA models matched best for dysarthria (6 out of 6 cases) and sensory hand side effects (5/6), but least for facial side effects (1/6). Best concordance was observed for the modeled current anterior and back spread of the VTA, worst for the current side spread. Automatic anatomical segmentation and VTA models can be valuable tools for DBS planning and programming. Directional DBS leads allow detailed postoperative assessment of the concordance of such image-based simulation and visualization with clinical effects.

scholarly journals Dentists' knowledge regarding signs and symptoms of the systemic toxicity of local anesthetic solutions

2015 ◽  
Vol 63 (1) ◽  
pp. 41-46
Author(s):  
Ana Carolina PINHEIRO ◽  
Jayne França MARQUES ◽  
Mayana Soares VIEIRA ◽  
Luciana Salles BRANCO-DE-ALMEIDA
Keyword(s):  
Side Effects ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Selection Criteria ◽  
Signs And Symptoms ◽  
Individual Characteristics ◽  
Systemic Toxicity ◽  
Dental Clinics ◽  
General Dentists ◽  
Toxic Concentrations

OBJECTIVE: To evaluate the knowledge of dentists about signs and symptoms that may be indicative of systemic toxicity associated with the use of local anesthetic solutions. METHODS: One hundred and twenty-four (124) dentists from private clinics in São Luís (Maranhão, Brazil) answered a questionnaire regarding the choice of solutions, selection criteria for local anesthetics and vasoconstrictors, and side effects associated with these substances. Results were analyzed by using descriptive statistics. RESULTS: Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. The main selection criteria of anesthetic solutions reported were the duration of procedures and patients' individual characteristics. In general, dentists demonstrated being aware of some side effects associated with vasoconstrictors; however, they showed a lack of knowledge regarding signs and symptoms related to an overdose of local anesthetics. CONCLUSION: The group of dentists involved in this study showed limited knowledge about the toxicity of local anesthetics, as well as some inconsistent background over the choice of vasoconstrictors. Thus, strategies are required towards improving the knowledge of professionals from private dental clinics regarding local anesthetics and/or vasoconstrictors.

A Comparison of Two Butyrophenones with Trifluoperazine

1966 ◽  
Vol 11 (1) ◽  
pp. 26-30 ◽  
Author(s):  
G. Marjerrison ◽  
W. Hrychuk ◽  
E.I. Varsanyi
Keyword(s):  
Side Effects ◽  
Rating Scale ◽  
Drug Action ◽  
Small Study ◽  
Clinical Effects ◽  
Double Blind ◽  
Morbidity Score ◽  
Closed Ward

A small study was carried out to compare the clinical effects of the two butyrophenone compounds, triperidol and haloanisone to those of trifluoperazine, in a population of chronically hospitalized long-term schizophrenics in a closed ward setting. Twenty-seven patients were randomly assigned to one of the three compounds, and treated for a twelve-week period under double-blind conditions. Observations with a modified PRP rating scale, based on ward nurses' monthly ratings, revealed an over-all improvement after one month of treatment, but differences between the three drugs were not apparent and the over-all decrease of this PRP morbidity score was not sustained in subsequent ratings. Psychiatrist's ratings on the IMPS revealed several symptom-factor differences with treatment. Between-drug differences on these factors were apparent. They are discussed in terms of the possible differences in type of drug action which they may reflect. The incidence of parkinsonistic side effects with each drug is presented. In no case did the side effects prevent continued treatment with the compound.

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