scholarly journals SOME PHENOLIC COMPOUNDS OF LICHEN PARMOTREMA PLANATILOBATUM (HALE) HALE (PARMELIACEAE)

2011 ◽  
Vol 14 (4) ◽  
pp. 5-10
Author(s):  
Huy Thuc Duong ◽  
Chi Bui Linh Huynh ◽  
Phong Xuan Ha ◽  
Quang That Ton ◽  
Phung Kim Phi Nguyen
Keyword(s):  
Phenolic Compounds ◽  
Spectroscopic Data ◽  
Usnic Acid ◽  
Viet Nam ◽  
Orsellinic Acid

Parmotrema planatilobatum (Hale) Hale is a lichen which has not been chemically and biologically studied. From the lichen collected in Viet Nam, seven compounds were isolated, including methyl β-orsellinate (1), methyl orsellinate (2), orsellinic acid (3), methyl haematommate (4), atranorin (5), lecanoric acid (6) and (+)-(12R)-usnic acid (7). The structures of these compounds were elucidated by spectroscopic data and compared with those in references. This is the fisrt time that these compounds are known in Parmotrema planatilobatum (Hale) Hale.

Chemical Constituents of the Lichen Cladina macaronesica

1991 ◽  
Vol 46 (1-2) ◽  
pp. 12-18 ◽  
Author(s):  
Antonio G . González ◽  
Jaime Bermejo Barrera ◽  
Elsa Ma Rodríguez Pérez ◽  
Consuelo E. Hernández Padrón
Keyword(s):  
Natural Products ◽  
Phenolic Compounds ◽  
Silver Nitrate ◽  
Silica Gel ◽  
Column Chromatography ◽  
Chemical Constituents ◽  
Usnic Acid ◽  
Acetone Extract ◽  
First Time

Column chromatography of the acetone extract of the lichen Cladina macaronesica (Sephadex LH-20, silica gel and silver nitrate-im pregnated silica gel) afforded eight triterpenes identified by chemical and spectral m eans. α-Amyrenone, lupenone, taraxerol, taraxerone and /so-arborinol acetate were isolated for the first time from lichens and (-)-usnic acid and five mononuclear phenolic compounds were also obtained, four for the first time as natural products. The possible transformation of perlatolic acid into these phenolic compounds is briefly outlined.

scholarly journals A New Ursane-type Triterpenoid and Other Constituents from the Leaves of Crataegus azarolus var. aronia

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Sarbast A. Mahmud ◽  
Omar A.M Al-Habib ◽  
Serena Bugoni ◽  
Marco Clericuzio ◽  
Giovanni Vidari
Keyword(s):  
Cardiovascular Disease ◽  
Phenolic Compounds ◽  
Medicinal Plant ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Triterpene Acid ◽  
Etoac Extract ◽  
Triterpene Acids

A new ursane-type triterpene acid, named azarolic acid (1), along with four known phenolic compounds and four known triterpene acids, was isolated from the crude EtOAc extract of the leaves of Crataegus azarolus var. aronia L. The structure of 1 was determined from 1D and 2D NMR spectroscopic data. Euscaphic acid showed high anti-vasoconstriction effects on aortic rings, supporting the use of this medicinal plant in cardiovascular disease.

scholarly journals Bioactive Phenolic Compounds from Aerial Parts of Plinia glomerata

2007 ◽  
Vol 62 (3-4) ◽  
pp. 196-200 ◽  
Author(s):  
Claúdia Serafin ◽  
Viviane Nart ◽  
Angela Malheiros ◽  
Márcia Maria de Souza ◽  
Luiz Fischer ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Spectroscopic Data ◽  
P Values ◽  
Analgesic Drugs ◽  
Antinociceptive Action ◽  
Chromatographic Techniques ◽  
Aerial Parts

Abstract The present work describes the antinociceptive properties and chemical composition of the aerial parts of Plinia glomerata (Myrtaceae). Both of the extracts evaluated, acetonic and methanolic, showed potent antinociceptive action, when analyzed against acetic acid-induced abdominal constrictions in mice, with calculated ID50 (mg/kg, i. p.) values of 24.8 and 3.3, respectively. Through usual chromatographic techniques with an acetonic extract, the following compounds were obtained: 3,4,3′-trimethoxy flavellagic acid (1), 3,4,3′-trimethoxy flavellagic acid 4′-O-glucoside (3) and quercitrin (4), which were identified based on spectroscopic data. Compounds 1 (ID50 = 3.9 mg/kg, i. p., or 10.8 μmol/kg) and 3 (ID50 = 1.3 mg/kg or 2.5 μmol/kg) were notably more active than some well-known analgesic drugs used here for comparison.

scholarly journals HPLC determination of phenolic compounds content in Parmelia sulcata and Parmelia vagans thalli

Pharmacia ◽  
2019 ◽  
Vol 66 (4) ◽  
pp. 161-164
Author(s):  
O. A. Kyslychenko ◽  
Viktoriia V. Protska ◽  
Iryna O. Zhuravel
Keyword(s):  
Phenolic Compounds ◽  
Inflammatory Diseases ◽  
Raw Materials ◽  
Folk Medicine ◽  
Usnic Acid ◽  
Total Content ◽  
Raw Material ◽  
Parmelia Sulcata ◽  
Quantitative Content

The species of Parmelia genus have long been used in Indian folk medicine for the treatment of bronchitis, ulcers, furunculosis, cardiovascular diseases, urolithiasis, amenorrhea, and also at infectious and inflammatory diseases. In Ukraine, the most common lichens of the Parmelia genus are Parmelia sulcata Tailor and Parmelia vagans Nyl. At the same time, thalli of Parmelia genus lichens belong to the non-officinal and poorly studied types of raw material. The qualitative composition and the quantitative content of phenolic compounds in Parmelia sulcata and Parmelia vagans thalli was studied by HPLC. According to the results of the chromatographic analysis, salazinic, fumaroprotocetraric, usnic acids, chloratranorin and atranorin were identified in both types of raw material studied. In addition, protocetraric acid was identified in Parmelia sulcata thalli. According to the results of the experiment, the total content of identified phenolic compounds in Parmelia sulcata thalli was 2019.71±40.39 g/mol, and in Parmelia vagans thalli it comprised 1754.18±34.77 g/mol. In the thalli of both studied species of Parmelia genus, fumaroprotocetraric acid dominanted by the quantity. This substance was present in Parmelia sulcata thalli in the amount of 474.00±9.00 g/mol, and in Parmelia vagans thalli – 456.21±8.67 g/mol. In addition, a significant amount of chloratranorin (408.79±8.99 g/mol) was present in Parmelia sulcata thalli. Quite a high content of atranorin (393.34±8.65 g/mol) and usnic acid (375.31±7.53 g/mol) were defined in Parmelia vagans thalli. The results obtained can be used in the development of quality control methods for Parmelia sulcata and Parmelia vagans thalli, as well as medicines based on these types of raw materials.

scholarly journals Saponin Composition Analysis of the Aerial Part of Panax Bipinnatifidus Seem. Collected in Sa Pa, Lao Cai

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Dang Thi Ngan ◽  
Bui Thi Thanh Van ◽  
Tran Thi Ngoc Ha ◽  
Nong My Hoa ◽  
Cao Thi Phuong Thao ◽  
...  
Keyword(s):  
Spectroscopic Data ◽  
Aerial Part ◽  
Chemical Diversity ◽  
Composition Analysis ◽  
Viet Nam ◽  
Anticancer Activities ◽  
Pentacyclic Triterpenoids ◽  
Chromatographic Techniques ◽  
Lao Cai ◽  
Stem Leaf

Panax bipinnatifidus Seem. is a precious medicinal plant belonging to the Araliaceae family. This study qualitatively analyzed saponins of the stem, leaf and rhizome of P. bipinnatifidus by HPLC. Subsequently, by using chromatographic techniques, a major saponin from the leaf of P.bipinnatifidius Seem. was isolated. On the basis of NMR and MS spectroscopic data as well as comparison with those reported in the literature, the isolated saponin’s structure was identified as stipuleanoside R2. To the best our knowledge, this is the first report of saponin from the aerial part of P. bipinnatifidius Seem. Keywords Panax bipinnatifidus, Araliaceae, Stipuleanosid R2, HPLC.. [1] Nguyễn Văn Tập, Các loài thuộc chi Panax L. ở Việt Nam, Tạp chí Dược liệu. 10(3) (2005) 71-76. [2] Nguyễn Văn Tập, Phạm Thanh Huyền, Kết quả nghiên cứu về phân bố, sinh thái sâm vũ diệp và Tam thất hoang ở Việt Nam, Tạp chí Dược liệu. 11(5) (2006) 177-180. [3] Nguyen Huu Tung, Tran Hong Quang, Nguyen Thị Thanh Ngan, Chau Van Minh, Bui Kim Anh, Pham Quoc Long, Nguyen Manh Cuong, Young Ho Kim, Oleanolic triterpenesaponins from the roots of Panax bipinnatifidus, Chem Pharm Bull (Tokyo). 59(11) (2011) 1417-1420. [4] Đỗ Văn Hào, Nguyễn Thị Huệ, Nguyễn Thị Thu Thủy, Đặng Thị Ngần, Đào Thị Hồng Bích, Nguyễn Thị Hoàng Anh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần hóa học của phân đoạn ethyl acetat từ rễ cây sâm vũ diệp (Panax bipinnatifidus Seem.) thu hái ở Sa Pa, Lào Cai, Tạp chí Khoa học ĐHQGHN - Khoa học Y Dược. 33(2) (2017) 50-55. [5] Nguyễn Thị Thu Thủy, Nguyễn Thị Huệ, Đặng Thị Thùy, Nguyễn Thị Hoàng Anh, Dương Thị Phượng, Phạm Thị Tuyết Nhung, Hà Vân Oanh, Dương Thị Ly Hương, Nguyễn Hữu Tùng, Thành phần saponin của thân rễ sâm vũ diệp thu hái ở Sa Pa, Lào Cai, Tạp chí Dược liệu. 23(2) (2018) 82-88.[6] Wen-zhi Yang, Ying Hu, Wan-ying Wu, Min Ye, De-an Guo, Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity, Phytochemistry. 106 (2014) 7-14. [7] Shashi B. Mahato, Asish P. Kundu, 13C NMR spectra of pentacyclic triterpenoids - a complication and some salient features, Phytochemistry. 37 (1994) 1517-1575. [8] Pawan K. Agrawal, NMR spectroscopy in the structural elucidation of oligossacharides and glycosides, Phytochemistry. 31 (1992) 1307-1330. [9] Chun Liang, Yan Ding, Huu Tung Nguyen, Jeong-Ah Kim, Hye-Jin Boo, Hee-Kyoung Kang, Mahn Cuong Nguyen, Young Ho Kim, Oleanane –type triterpenoids from Panax stipuleannatus and their anticancer activities, Bioorg Med Chem Lett. 20 (2010) 7110-7115.  

Studies in the usnic acid series. I. The condensation of (+)-usnic acid with aliphatic and aromatic amines

1976 ◽  
Vol 54 (17) ◽  
pp. 2795-2803 ◽  
Author(s):  
James P. Kutney ◽  
Ignacio H. Sanchez
Keyword(s):  
Aromatic Amines ◽  
Spectroscopic Data ◽  
Usnic Acid ◽  
X Ray

Detailed investigations concerned with the reaction of usnic acid (1) and dihydrousnic acid (14) with a variety of aliphatic and aromatic amines are described. Extensive analyses of the characteristic spectroscopic data allow structural assignments for all the isolated products. The correctness of these assignments is established by an X-ray analysis of one of the products resulting from the reaction of usnic acid with ammonia.

Antimicrobial, Antiviral and Cytotoxic Activity of New Zealand Lichens

1999 ◽  
Vol 31 (6) ◽  
pp. 627-636 ◽  
Author(s):  
Nigel B. Perry ◽  
Michael H. Benn ◽  
Nerida J. Brennan ◽  
Elaine J. Burgess ◽  
Gill Ellis ◽  
...  
Keyword(s):  
Biological Activity ◽  
New Zealand ◽  
Phenolic Compounds ◽  
Cytotoxic Activity ◽  
Usnic Acid

AbstractA total of 69 species of lichens have been collected from various locations around New Zealand. Screening of extracts of these species for antimicrobial, antiviral and cytotoxic activity showed a high proportion with biological activity. Active extracts were generally from species known to contain phenolic compounds. Bioactivity-directed isolation work on Cladia retipora, Pseudocyphellaria glabra and P. homoeophylla led to the identification of usnic acid as the main antimicrobial, cytotoxic and antiviral component in these three species.

scholarly journals Phenolic Compounds, Including Novel C-glycosylflavone, from the Flowers of the Tall Bearded Iris Cultivar ‘Victoria Falls’

2012 ◽  
Vol 7 (12) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Takayuki Mizuno ◽  
Tsutomu Yabuya ◽  
Nobuhiro Sasaki ◽  
Tsukasa Iwashina
Keyword(s):  
Phenolic Compounds ◽  
Methyl Ether ◽  
Spectroscopic Data ◽  
Victoria Falls ◽  
Hybrid Cultivar ◽  
First Time

A new C-glycosylflavone, luteolin 7-methyl ether 6-C-[β-arabinopyranosyl-(1→2)–5-glucopyranoside] (swertiajaponin 2″- O-arabinoside) (1) was isolated and identified from the violet blue colored flowers of the tall bearded iris (Iris hybrid) cultivar ‘Victoria Falls’, together with five known flavonoids, swertisin 2″- O-arabinoside (2), schaftoside (3), isoschaftoside (4), swertiajaponin (5), swertisin 2″- O-glucoside (6) and a C-glycosylxanthone, mangiferin (7). Of these compounds, 1 and 2 were elucidated from NMR spectroscopic data, which revealed the rotameric pairs. C-Glycosylflavone O-arabinosides were isolated from the genus Iris for the first time.

scholarly journals Structural Elucidation and Free Radical Scavenging Activity of a new o-Orsellinic Acid Derivative Isolated from the Lichen Cladonia rappii

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100
Author(s):  
Tiago C.A. Lage ◽  
Lívia P. Horta ◽  
Ricardo M. Montanari ◽  
Jefferson G. Silva ◽  
Ângelo de Fátima ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Reactive Nitrogen Species ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Usnic Acid ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Oxygen Species ◽  
Orsellinic Acid ◽  
Ros Scavenger

Rappiidic acid, a new o-orsellinic acid derivative, was isolated from the lichen Cladonia rappii. Its capability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) was investigated and compared with resveratrol and (+)-usnic acid. Usnic acid at 100 μM was the most efficient ROS scavenger, exhibiting activity 3-fold higher than that of resveratrol. At the same concentration, rappidic acid scavenged 23.1% of ROS formed, demonstrating that this compound is twice as active as resveratrol. Both compounds were shown to be poor RNS scavengers.

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