ROLE OF AYURVEDA MEDICINE WITH RELEVANCE OF LIVER CANCER

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Sonia Kukreti Bhatt
Keyword(s):  
Nervous System ◽  
Liver Cancer ◽  
Malignant Tumors ◽  
Arterial System ◽  
Herbal Drugs ◽  
Indigenous Medicine ◽  
Key Words Cancer ◽  
Plant Drugs ◽  
Natural Drugs

Ayurveda, the oldest Indian indigenous medicine system of plant drugs is known from very early times for preventing or suppressing various tumors using these natural drugs. And nowadays scientists are keener to researches on complementary and alternative medicine for the management of cancer. In Ayurvedic concept, according to ‘Charaka’ and ‘SushrutaSamhitas’ cancer is described as inflammatory or non-inflammatory swelling and mentioned either as ‘Granthi’ (minor neoplasm) or ‘Arbuda‘ (major neoplasm). The nervous system (Vata or air), the venous system (Pitta or fire) and the arterial system (Kapha or water) are three basics of Ayurveda and very important for normal body function. In malignant tumors all three systems get out of control (Tridoshas) and lose mutual coordination that causes tissue damage, resulting critical condition. Tridoshas cause excessive metabolic crisis resulting in proliferation. Key words: Cancer, Charaka, Arbuda, Herbal drugs, TCM.  

Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System

2020 ◽  
Vol 27 (12) ◽  
pp. 1878-1900 ◽  
Author(s):  
Vasco Branco ◽  
José Pimentel ◽  
Maria Alexandra Brito ◽  
Cristina Carvalho
Keyword(s):  
Nervous System ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Malignant Tumors ◽  
Tumor Biology ◽  
Antioxidant Systems ◽  
Ros Scavenging ◽  
Survival Prognosis ◽  
Primary Tumors

Background: Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments. Objective: In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e., gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors. We review the role of antioxidant systems, namely the thioredoxin and glutathione systems, in the genesis and/or progression of brain tumors. Methods: Although overexpression of Thioredoxin Reductase (TrxR) and Thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of Glutathione (GSH) and Glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of Peroxiredoxins (Prx), and Glutaredoxins (Grx). Conclusion: Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment are discussed.

scholarly journals Nuclear PHGDH promotes neutrophil recruitment to drive liver cancer progression

2021 ◽  
Author(s):  
Hongwen Zhu ◽  
Hua Yu ◽  
Hu Zhou ◽  
Wencheng Zhu ◽  
Xiongjun Wang
Keyword(s):  
Liver Cancer ◽  
Cancer Progression ◽  
Malignant Tumors ◽  
Metabolic Dysregulation ◽  
Metabolic Role ◽  
Act Domain ◽  
Advanced Stages ◽  
Nuclear Location ◽  
Phosphoglycerate Dehydrogenase

Metabolic dysregulation and the communications between cancer and immune cells are emerging as two essential features of malignant tumors. In this study, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) associates with poor prognosis of liver cancer patients, and Phgdh is required for liver cancer progression in a mouse model. Unexpectedly, the impairment of Phgdh enzyme activity exerts a slight effect on liver cancer model, indicating PHGDH contributes to liver cancer progression mainly depending on its non-metabolic roles with nuclear location. PHGDH uses its ACT domain to bind cMyc in nuclear and forms a transactivation axis PHGDH/p300/cMyc/AF9 which drives CXCL1/8 gene expression. Chemokines CXCL1/8 promotes neutrophils recruitment and then supports tumor associated macrophages (TAMs) filtration in liver, thereby urging liver cancer into advanced stages. Forced cytosolic location of PHGDH or destruction of the PHGDH/cMyc interaction abolishes the oncogenic function of nuclear PHGDH. Collectively, this study reveals a non-metabolic role of PHGDH with altered cellular location in liver cancer, and suggests a promising drug target for liver cancer therapy by targeting the interaction between PHGDH and undruggable cMyc.

Current management approach of Cancer in Ayurveda

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Archana Kashid
Keyword(s):  
Malignant Tumors ◽  
Integrated Approach ◽  
Normal Function ◽  
The Body ◽  
Arterial System ◽  
Management Approach ◽  
Drug Induced ◽  
Health Maintenance ◽  
Organ Systems ◽  
Natural Drugs

Ayurveda, the oldest Indian indigenous medicine system of plant drugs is known from very early times for preventing or suppressing various tumors using these natural drugs. In Ayurvedic concept, according to Charaka and Sushruta Samhitas, Cancer is described as inflammatory or non-inflammatory swelling and mentioned either as Granthi (minor neoplasm) or Arbuda (major neoplasm). The nervous system (Vata), the venous system (Pitta) and the arterial system (Kapha) are three basics of Ayurveda and very important for normal body function. In malignant tumors all three systems get out of control (Tridoshas) and lose mutual coordination that causes tissue damage, resulting critical condition. Tridoshas cause excessive metabolic crisis resulting in proliferation. The modern cancer therapy which is known to burdened by drug-induced toxic side effects hoping perfect cure of disease form the complementary and alternative medicine system. The main goal of Ayurvedic therapy is to find the ultimate cause of an illness while the therapeutic approach of Ayurveda is divided into four categories as Prakrutisthapana Chikitsa (health maintenance), Rasayana Chikitsa, (restoration of normal function), Roganashani Chikitsa (disease cure) and Naishthiki Chikitsa (spiritual approach). Commonly used herbal decoctions reported in Ayurveda are made of multiple herbs possessing great potential for a cancer cure; scientifically these formulations work on multiple biochemical pathways and influence different organ systems all together and nourish the body as a whole by supporting body‘s deference systems. Now it is important to raise awareness and encourage implementation of Ayurvedic therapies for combating cancer and suggest an integrated approach in tumor management and treatment.

The role of the sympathetic and sensory nervous system in peritoneal endometriotic lesions

2011 ◽  
Vol 71 (10) ◽  
Author(s):  
J Arnold ◽  
ML Barcena de Arellano ◽  
C Rüster ◽  
A Schneider ◽  
S Mechsner
Keyword(s):  
Nervous System ◽  
Sensory Nervous System

Role of p38gamma-delta in liver cancer

2012 ◽  
Vol 120 (10) ◽  
Author(s):  
A Tomas Loba ◽  
E Manieri ◽  
G Sabio
Keyword(s):  
Liver Cancer

Role of the IQGAP1/IQGAP2 imbalance in Liver Cancer

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
F Pinna ◽  
R Pellegrino ◽  
O Neumann ◽  
J Baues ◽  
A Eberhardt ◽  
...  
Keyword(s):  
Liver Cancer

Thyroid hormone-catecholamine interrelationships during exposure to cold

1981 ◽  
Vol 97 (1) ◽  
pp. 91-97 ◽  
Author(s):  
H. Storm ◽  
C. van Hardeveld ◽  
A. A. H. Kassenaar
Keyword(s):  
Nervous System ◽  
Plasma Concentration ◽  
Thyroid Hormone ◽  
Sympathetic Nervous System ◽  
Plasma Levels ◽  
Surgical Procedure ◽  
Exposure To Cold ◽  
Basal Plasma ◽  
Sympathetic Nervous

Abstract. Basal plasma levels for adrenalin (A), noradrenalin (NA), l-triiodothyronine (T3), and l-thyroxine (T4) were determined in rats with a chronically inserted catheter. The experiments described in this report were started 3 days after the surgical procedure when T3 and T4 levels had returned to normal. Basal levels for the catecholamines were reached already 4 h after the operation. The T3/T4 ratio in plasma was significantly increased after 3, 7, and 14 days in rats kept at 4°C and the same holds for the iodide in the 24-h urine after 7 and 14 days at 4°C. The venous NA plasma concentration was increased 6- to 12-fold during the same period of exposure to cold, whereas the A concentration remained at the basal level. During infusion of NA at 23°C the T3/T4 ratio in plasma was significantly increased after 7 days compared to pair-fed controls, and the same holds for the iodide excretion in the 24-h urine. This paper presents further evidence for a role of the sympathetic nervous system on T4 metabolism in rats at resting conditions.

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