Improving on nature:The role of nanomedicine in the development of clinical natural drugs

In 2019, a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), aroused the attention of the entire world. It causes an acute respiratory disease, by involving the same receptor, i.e. the angiotensin-converting enzyme 2, as that for severe acute respiratory syndrome coronavirus (SARS-CoV), mainly spreads through the respiratory tract. The clinical symptoms in patients with of SARS-CoV-2 include fever, cough, dyspnea, fatigue and in a small percentage of patients also gastrointestinal symptoms have been reported...

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The Role of Biologically Active Ingredients from Natural Drug Treatments for Arrhythmias in Different Mechanisms

BioMed Research International ◽

10.1155/2017/4615727 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Jie Li ◽

Dan Hu ◽

Xiaoli Song ◽

Tao Han ◽

Yonghong Gao ◽

...

Keyword(s):

Antiarrhythmic Drugs ◽

Theoretical Foundation ◽

Biologically Active ◽

Active Ingredients ◽

Cardiovascular Morbidity And Mortality ◽

Drug Treatments ◽

Primary Focus ◽

Natural Drugs ◽

Antiarrhythmic Effects

Arrhythmia is a disease that is caused by abnormal electrical activity in the heart rate or rhythm. It is the major cause of cardiovascular morbidity and mortality. Although several antiarrhythmic drugs have been used in clinic for decades, their application is often limited by their adverse effects. As a result, natural drugs, which have fewer side effects, are now being used to treat arrhythmias. We searched for all articles on the role of biologically active ingredients from natural drug treatments for arrhythmias in different mechanisms in PubMed. This study reviews 19 natural drug therapies, with 18 active ingredient therapies, such as alkaloids, flavonoids, saponins, quinones, and terpenes, and two kinds of traditional Chinese medicine compound (Wenxin-Keli and Shensongyangxin), all of which have been studied and reported as having antiarrhythmic effects. The primary focus is the proposed antiarrhythmic mechanism of each natural drug agent.Conclusion. We stress persistent vigilance on the part of the provider in discussing the use of natural drug agents to provide a solid theoretical foundation for further research on antiarrhythmia drugs.

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ROLE OF AYURVEDA MEDICINE WITH RELEVANCE OF LIVER CANCER

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i3.1067 ◽

2020 ◽

Vol 4 (3) ◽

Author(s):

Sonia Kukreti Bhatt

Keyword(s):

Nervous System ◽

Liver Cancer ◽

Malignant Tumors ◽

Arterial System ◽

Herbal Drugs ◽

Indigenous Medicine ◽

Key Words Cancer ◽

Plant Drugs ◽

Natural Drugs

Ayurveda, the oldest Indian indigenous medicine system of plant drugs is known from very early times for preventing or suppressing various tumors using these natural drugs. And nowadays scientists are keener to researches on complementary and alternative medicine for the management of cancer. In Ayurvedic concept, according to ‘Charaka’ and ‘SushrutaSamhitas’ cancer is described as inflammatory or non-inflammatory swelling and mentioned either as ‘Granthi’ (minor neoplasm) or ‘Arbuda‘ (major neoplasm). The nervous system (Vata or air), the venous system (Pitta or fire) and the arterial system (Kapha or water) are three basics of Ayurveda and very important for normal body function. In malignant tumors all three systems get out of control (Tridoshas) and lose mutual coordination that causes tissue damage, resulting critical condition. Tridoshas cause excessive metabolic crisis resulting in proliferation. Key words: Cancer, Charaka, Arbuda, Herbal drugs, TCM.

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Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00877 ◽

2021 ◽

pp. 5029-5033

Author(s):

Safeeq Ahamed ◽

Sumitra M. ◽

Chitra V.

Keyword(s):

Wide Spectrum ◽

Aloe Vera ◽

Vital Role ◽

Female Reproduction ◽

Herbal Products ◽

Ayurvedic Drugs ◽

Clinical Phenomenon ◽

Natural Drugs ◽

Clinical Error

The polycystic ovarian syndrome is a convoluted endocrine disorder of the reproductive system which influences several girls with puberty and 6-8% of germinating women in endemic populations and displays a wide spectrum of clinical phenomenon. This disorder was first reported in 1935 as a synthetic clinical error for its associations with high androgen levels, hyperinsulinemia, and PCOS. The pineal hormone melatonin is known to regulate a mixture of central and peripheral actions related to circadian rhythms. It is a pleiotropic fragment, which plays a vital role in female reproduction as a capable free radical hunter and involves many gynecological and obstetrical pathology. PCOS is a compound condition for which the symptoms are irregular, and the cause is anonymous. Herbal products like Yastimadhu (Glycyrrhiza glabra), Kumari (Aloe vera), Tvaka (Cinnamomum Zeylanicum), Mostly the Ayurvedic drugs used for the PCOS, all are Vata-kapha shamaka. Neurological associated in pcos is still in the platform of research, no drugs melatonin an important modulator in pcos can be concentrated to cure pcos. Melatonin might be effective against neurological associate pcos. In ayurvedic way of treatment it can be cured with several natural drugs.

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Role of Glucose Transporters in Drug Membrane Transport

Current Drug Metabolism ◽

10.2174/1389200221666200810125924 ◽

2020 ◽

Vol 21 (12) ◽

pp. 947-958

Author(s):

Xin Wang ◽

Kunkun Guo ◽

Baolin Huang ◽

Zimin Lin ◽

Zheng Cai

Keyword(s):

Membrane Transport ◽

Chemical Structure ◽

Biological Membrane ◽

Glucose Transporters ◽

Phospholipid Bilayer ◽

Design Strategies ◽

Similar Chemical ◽

Pass Through ◽

Natural Drugs

Background: Glucose is the main energy component of cellular activities. However, as a polar molecule, glucose cannot freely pass through the phospholipid bilayer structure of the cell membrane. Thus, glucose must rely on specific transporters in the membrane. Drugs with a similar chemical structure to glucose may also be transported through this pathway. Methods: This review describes the structure, distribution, action mechanism and influencing factors of glucose transporters and introduces the natural drugs mediated by these transporters and drug design strategies on the basis of this pathway. Results: The glucose transporters involved in glucose transport are of two major types, namely, Na+-dependent and Na+-independent transporters. Glucose transporters can help some glycoside drugs cross the biological membrane. The transmembrane potential is influenced by the chemical structure of drugs. Glucose can be used to modify drugs and improve their ability to cross biological barriers. Conclusion: The membrane transport mechanism of some glycoside drugs may be related to glucose transporters. Glucose modification may improve the oral bioavailability of drugs or achieve targeted drug delivery.

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Wound Healing Management: A Systematic Approach Of Existing Treatment

Current Drug Therapy ◽

10.2174/1574885514666191211120229 ◽

2019 ◽

Vol 14 ◽

Author(s):

Azmi Khan ◽

Manupriya Chaudhary ◽

Madhu Gupta

Keyword(s):

Wound Healing ◽

Cell Types ◽

Research Area ◽

Negative Pressure Therapy ◽

Pressure Therapy ◽

Know How ◽

Technical Advances ◽

Extracellular Microenvironment ◽

Natural Drugs

: Wound healing is an elaborated and vastly synchronized process that requires intricate coordination between many cell types with an appropriate extracellular microenvironment. The management of wounds represents a key research area due to the vital functional and aesthetic role of this tissue. An auspicious approach in the currently available treatment is the growth factors that imitate the micro environs and active vital regenerative pathways conducive to wound healing. An organized methodology to study, a multi-expert methodology to treatment and enthusiasm to study the patient’s perceptions are some of the principal amendments that have paralleled technical advances and know-how such as debridement, Negative Pressure Therapy, natural drugs etc. These methodologies may be seen as co-operative in wound healing. This article will review pathophysiology, discuss currently available treatment and novel approaches for treating a wound.

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Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽

10.1001/jama.195.12.1005 ◽

1966 ◽

Vol 195 (12) ◽

pp. 1005-1009 ◽

Cited By ~ 18

Author(s):

D. J. Fernbach

Keyword(s):

Wilms Tumor

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Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽

10.1001/jama.195.3.167 ◽

1966 ◽

Vol 195 (3) ◽

pp. 167-172 ◽

Cited By ~ 2

Author(s):

T. E. Van Metre

Keyword(s):

Diagnosis And Management

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The power of norms to sway fused group members

Behavioral and Brain Sciences ◽

10.1017/s0140525x18001644 ◽

2018 ◽

Vol 41 ◽

Cited By ~ 1

Author(s):

Winnifred R. Louis ◽

Craig McGarty ◽

Emma F. Thomas ◽

Catherine E. Amiot ◽

Fathali M. Moghaddam

Keyword(s):

Evolutionary Anthropology ◽

Normative Systems ◽

Violent Extremism ◽

Identity Fusion ◽

Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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