scholarly journals Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects

Acta Naturae ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 40-47 ◽  
Author(s):  
M. V. Shepelev ◽  
S. V. Kalinichenko ◽  
A. V. Deykin ◽  
I. V. Korobko

The use of transgenic animals as bioreactors for the synthesis of the recombinant proteins secreted into milk is a current trend in the development of biotechnologies. Advances in genetic engineering, in particular the emergence of targeted genome editing technologies, have provided new opportunities and significantly improved efficiency in the generation of animals that produce recombinant proteins in milk, including economically important animals. Here, we present a retrospective review of technologies for generating transgenic animals, with emphasis on the creation of animals that produce recombinant proteins in milk. The current state and prospects for the development of this area of biotechnology are discussed in relation to the emergence of novel genome editing technologies. Experimental and practical techniques are briefly discussed.

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Corina Iannaggi ◽  
Kiersten Latham

This article provides an overview of the creation and installation of the Document Academy (DOCAM) 2014 Instantiation, an experimental exhibition intended to develop a three dimensional representation of the DOCAM 2014 participants’ spoken presentations. During the installation process, it was evident that the Instantiation resembled a current trend in the museum profession known as “The Pop-Up Museum.” An evaluation of the Instantiation in the context of the Pop-Up Museum uncovered a similar core objective, the ability to create meaningful conversations centered around the participants’ documents on display. This objective was supported by participants’ responses to follow-up questions about their experience participating in and conversing about the Instantiation while attending the conference. It is believed that other academic conferences could benefit from a project similar to the Instantiation and the process outlined in this article can be used as a model for its creation.


2019 ◽  
Author(s):  
Andrew Sidwell ◽  
Michael Perry

The purpose of this article was to examine the current state of self-leadership training. The authors analyzed all published, publicly available studies (in English) pertaining to self-leadership training methods, offering a current state of self-leadership training, and implications for future research.


Biomics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 422-429
Author(s):  
N.A. Rozhnova ◽  
G.A. Gerashchenkov ◽  
A.V. Chemeris

Catalysts ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 812
Author(s):  
Hoang Chinh Nguyen ◽  
My-Linh Nguyen ◽  
Chia-Hung Su ◽  
Hwai Chyuan Ong ◽  
Horng-Yi Juan ◽  
...  

Biodiesel is a promising alternative to fossil fuels and mainly produced from oils/fat through the (trans)esterification process. To enhance the reaction efficiency and simplify the production process, various catalysts have been introduced for biodiesel synthesis. Recently, the use of bio-derived catalysts has attracted more interest due to their high catalytic activity and ecofriendly properties. These catalysts include alkali catalysts, acid catalysts, and enzymes (biocatalysts), which are (bio)synthesized from various natural sources. This review summarizes the latest findings on these bio-derived catalysts, as well as their source and catalytic activity. The advantages and disadvantages of these catalysts are also discussed. These bio-based catalysts show a promising future and can be further used as a renewable catalyst for sustainable biodiesel production.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Gema Ramírez-Guerrero ◽  
Javier García-Onetti ◽  
Juan Adolfo Chica-Ruiz ◽  
Manuel Arcíla-Garrido

Purpose This paper attempts to fill the gap that exists in research regarding 20th-century heritage and its social appreciation. The purpose of this paper is to explore different ways of evaluating the heritage value and tourism potential and to propose an innovative model validated in the Zarzuela Hippodrome as an example of cultural asset from 20th century with important economic, social, cultural, aesthetic and architectural aspects. Design/methodology/approach This study opted for an interpretation of heritage from an ecosystem, integrating and global paradigm, understanding the asset as a set of resources that interact with each other, generating a common and enriched tourist experience among all the elements that make it up. From this perspective, it is conceived that by modifying one of the elements, the whole (tourist) ecosystem will be equally influenced. On the other side, it was incorporated non-parametric techniques based on the implementation of surveys for the validation of the tool to the case study of the Zarzuela hippodrome. Findings The results suggest that the hippodrome's internal values have been evaluated very positively, while its external values are low. Through this study, the paper has identified several weaknesses that impede its functioning as a viable “tourist product.” The distance from the city center, the lack of available information and the scarce diffusion and tourism promotion are its main weaknesses. The proposed analysis tool reveals the importance of the active participation of visitors to evaluate cultural assets through the combination of aspects related to the conservation of cultural assets and, in turn, elements that encourage their commodification as tourist products, break down barriers between these two disciplines. Research limitations/implications The management tool proposed in this study can be used to underpin the creation of tourism experiences in cultural or heritage assets by diagnosing the current state of its tourist potential, quantifying its value in relation to the visitors’ perception and making visible those problematic aspects to develop actions to solve them. Although the present study is support for future research, as well as for improving the marketing of heritage in tourist settings, an in-depth analysis of the technical elements of heritage, as well as of its intervention (if applicable), will be necessary for the managers who want to use the tool. Social implications One of the most differentiating characteristics between the construction typology of 20th-century historical buildings is perhaps the scarcity of decorative ornamentation, with exposed concrete being the main surface coating. Many of these constructions have an important cultural and historical relevance, however, the social perception, as regards its consideration as architectural and artistic heritage seems to reflect discordant aspects. This study provides support as a decision-making tool to determine the existing valuation of a building and how to enhance it. Originality/value This study takes steps toward the creation of a model that supports decision-makers and owners of cultural assets through a measurement system that makes it possible to quantify and determine the current state of tourism use through the social evaluation of heritage criteria. It defines which are the elements that favor the resilience of the property or, on the contrary, which are those that undermine its enhancement.


2018 ◽  
Vol 108 (05) ◽  
pp. 319-324
Author(s):  
I. Bogdanov ◽  
A. Nuffer ◽  
A. Sauer

Der vorliegende Beitrag behandelt den Themenkomplex Ressourcen-effizienz und digitale Transformation im verarbeitenden Gewerbe sowie die dabei entstehenden Wechselwirkungen. Neben dem aktuellen Stand der Technik werden die im Rahmen einer aktuellen Studie durchgeführte Fallbeispielanalyse und die entwickelte Methodik zur Ermittlung der Ressourceneffizienzpotenziale vorgestellt. Diese Potenziale und die eingesetzten digitalen Maßnahmen sind zentrale Bausteine des vorliegenden Beitrags.   This article deals with the topic complex of resource efficiency and digital transformation in the manufacturing sector as well as the resulting interactions. In addition to the current state of the art and perspectives, the case study analysis carried out as part of a current study, as well as the developed method for establishing the resource efficiency potentials will be presented. The resultant potential and the digital measures are central components of this article.


2021 ◽  
Vol 48 (2) ◽  
pp. 119-129
Author(s):  
Lilyana Lesnichkova ◽  

The article focuses on the presentation of the Hungarian-Bulgarian valence dictionary, which is currently in preparation, against the background of an extremely actual task – the creation of an academic English-Bulgarian dictionary, adequately reflecting the current state of vocabulary in both languages. The author substantiates the need for such a dictionary, given the lack of general and specialized Hungarian-Bulgarian dictionaries, based on the theoretical foundations and principles of modern lexicography. Outlined are the main features of the dictionary, the specificities and approaches in the work of its compilation. The selection of material and the methods of its presentation are in accordance with the practical needs of learners of Hungarian as a foreign language.


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