Comparison of Traditional Versus Computer-Based Cognitive Training on Cognition in Elderly with Mild Cognitive Impairment

Normal ageing cause alterations in the prefrontal cortex, medial temporal lobe system, hippocampus and cerebellum. These changes are the cause of mild cognitive impairment in terms of decreased memory function, reduced speed and executive functions, personality and behavioral disturbances. Computer-based cognitive training is a new tool used for cognitive rehabilitation. This randomized control trial includes 50 subjects, Group A received computer-based cognitive training (n=25) by using BrainHQ app and Group B received Tradition cognitive training (n=25) for 3 weeks. Montreal cognitive assessment (MOCA) was taken as outcome measure. The comparison of difference of pre and post MOCA score between Group A and Group B shows p=0.002. Also comparison of MOCA score between male and female of group A shows statistically significant difference with respect to MALE P=0.008 and FEMALE P=0.000.This study provides a strong evidence that Computer Based Cognitive Training showed added improvements in cognition function compared to traditional training.

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Effects of Structured Resisted Exercises on Cognition Level Among Patients with Mild Cognitive Impairment

10.53350/pjmhs211561876 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1876-1878

Author(s):

Muhammad Hassan ◽

Sajid Rashid ◽

Rehan Ramzan Khan ◽

Muhammad Usman Khalid ◽

Haroon Mansha ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Pharmacological Treatment ◽

Total Sample ◽

Post Intervention ◽

Significant Difference ◽

Resistance Exercises ◽

Group A ◽

Group B ◽

Trial Making Test

Objective: To evaluate the effects of structured resistance exercises on cognition level among patients with mild cognitive impairment. Methods: A quasi experimental trial was conducted on thirty patients with mild cognitive impairment (MCI) from September 2020 to February 2021 at Ibn e Siena hospital, Multan. The total sample was randomly divided into two equal groups containing fifteen patients each; Group-A (Conventional pharmacological treatment) and Group-B (Resisted exercises). Group-A participants were treated with conventional pharmacological treatment cholinesterase inhibitors along with regular physical exercise while Group-B participants were treated with resistance exercises along with conventional pharmacological treatment. The standardized tools were used for data collection including Standardized mini mental state examination (SMMSE), Montreal cognitive assessment (MOCA), Trial making test A (TMT-A) and Trial making test B (TMT-B). Data was entered and analyzed by using SPSS 21. Results: Independent samples T-test showed statistically significant difference after intervention for measures of cognitive performance. There was significant difference (p<0.01) between pre and post intervention score of SMMSE (20.60 ± 1.75 and 23.20 ± 1.69) and MOCA (17.60 ± 1.35 and 21.93 ± 1.57). There was also significant difference between (p<0.01) pre and post intervention score of TMT-A (1.47 ± 0.34 & 1.23 ± 0.04) and TMT-B (2.51 ± 0.04 and 2.08 ± 0.04). Conclusion: Resistance exercises increases the cognitive levels of Mild Cognitive impairment patients. Key Words: Cognitive dysfunction, Exercises, Dementia.

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A computer-based cognitive training in Mild Cognitive Impairment in Parkinson’s Disease

Neurorehabilitation ◽

10.3233/nre-192714 ◽

2019 ◽

Vol 44 (4) ◽

pp. 555-567 ◽

Cited By ~ 3

Author(s):

Sara Bernini ◽

Anna Alloni ◽

Silvia Panzarasa ◽

Marta Picascia ◽

Silvana Quaglini ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Training ◽

Computer Based

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Beneficial effect of computer-based multidomain cognitive training in patients with mild cognitive impairment

Applied Neuropsychology Adult ◽

10.1080/23279095.2019.1692842 ◽

2019 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Anastasia Nousia ◽

Maria Martzoukou ◽

Vasileios Siokas ◽

Eleni Aretouli ◽

Athina-Maria Aloizou ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Beneficial Effect ◽

Cognitive Training ◽

Computer Based

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Computer-based cognitive rehabilitation program GRADIOR for mild dementia and mild cognitive impairment: new features

BMC Medical Informatics and Decision Making ◽

10.1186/s12911-020-01293-w ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Manuel A. Franco-Martín ◽

Angie A. Diaz-Baquero ◽

Yolanda Bueno-Aguado ◽

María T. Cid-Bartolomé ◽

Esther Parra Vidales ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Older People ◽

Cognitive Rehabilitation ◽

Clinical History ◽

Rehabilitation Program ◽

Mild Dementia ◽

Cognitive Evaluation ◽

People With Dementia ◽

Computer Based

Abstract Background The growing number of older people and, with it, the increase of neurological impairments such as dementia has led to the implementation of the use of computer programs for cognitive rehabilitation in people with dementia. For 20 years, we have been developing the GRADIOR cognitive rehabilitation program and conducted several studies associated with its usability and effectiveness. This paper describes the development of the latest version of the GRADIOR computer-based cognitive rehabilitation program for people with different neurological etiologies, especially mild cognitive impairment and mild dementia. Results GRADIOR is a program that allows cognitive evaluation and rehabilitation of people affected by cognitive impairment. The new version of GRADIOR is characterized by a structure that is dynamic and flexible for both user and therapist, consisting of: Clinical Manager, Clinical History Manager, Treatment Manager and Report Manager. As a structure based on specific requirements, GRADIOR includes a series of modalities and sub-modalities, each modality comprising a series of exercises with different difficulty levels. Discussion Previous studies associated with earlier versions of GRADIOR have allowed the development of a new version of GRADIOR. Taking into account aspects associated with user experience, usability and effectiveness. Aspects that have made it possible to achieve a program that can meet the needs of older people with dementia.

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Cognitive function and fatigue in cancer patients after chemotherapy: A longitudinal cohort study in patients with colorectal cancer (CRC)

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.9099 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 9099-9099

Author(s):

J. L. Vardy ◽

S. Rourke ◽

G. R. Pond ◽

J. Galica ◽

A. Park ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Healthy Volunteers ◽

Clotting Factors ◽

Related Factors ◽

Post Surgery ◽

Significant Difference ◽

Cytokine Levels ◽

Group A ◽

Group B

9099 Background: There is growing evidence that fatigue and cognitive dysfunction can affect cancer survivors. Here we evaluated these symptoms in patients with CRC in a longitudinal prospective study. Methods: Patients with localized CRC were evaluated for cognitive function and fatigue at baseline (mean 8 weeks post-surgery or before neoadjuvant therapy), 6 & 12 months. Group A (Stage III/high risk II) received chemotherapy (CT) and group B (Stage I/II) received no CT. Pts had neuropsychological (NP) assessment with traditional tests and CANTAB, a computerized NP battery. They completed concurrent questionnaires for fatigue & QOL (FACT-F), anxiety/depression (GHQ), and perception of cognitive function (FACT-COG). Blood tests evaluated cytokine levels, blood clotting factors, sex hormones and apolipoprotein genotyping as potential causal factors. Primary endpoints were cognitive function (traditional NP tests) and fatigue. Associations between test results, demographic and disease-related factors were sought. Results: Baseline data are available for 182 pts: 127 group A, and 55 group B, with follow-up at 6 and 12 months for 71 and 39 pts. Mean age was 57 years and 62% were male. At baseline (pre CT): 30% had cognitive impairment on traditional NP tests & 20% on CANTAB; 25% reported moderate fatigue and 10% extreme fatigue. At 6 months there was no significant difference on objective NP testing between the groups or in perceived cognitive impairment (median FACT- COG 82 vs 88, p=0.34). CT pts had more fatigue (median FACT-F 75 vs 91, p<0.001). At 12 months CT pts tend to have more cognitive impairment on traditional NP tests (26% vs 0%, p=.09), more perceived cognitive impairment (13.5% vs 0%, p=.57) & greater fatigue (16% vs 0%). Cytokine levels were elevated in all groups at all time points compared to healthy volunteers. There was a trend to higher cytokine levels with greater fatigue and worse cognitive impairment. Fatigue, QOL and anxiety and depression were highly correlated. Conclusions: Cognitive impairment is present in some pts prior to CT and there is a trend for CT pts to have worse cognitive impairment at 12 but not at 6 months. Fatigue is associated with CT. Cytokine levels remained elevated in all groups compared to healthy volunteers. No significant financial relationships to disclose.

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Comparison of changes in cognitive functions of post-stroke patients with the computer-based cognitive intervention (PABLO system) and conventional cognitive intervention (Paper-Pencil method)

Current Psychiatry Research and Reviews ◽

10.2174/2666082217666210408122228 ◽

2021 ◽

Vol 17 ◽

Author(s):

Sudhi Kulshrestha ◽

Manju Agrawal ◽

Ajai K Singh ◽

Akash Ved

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Research Work ◽

Cognitive Intervention ◽

Stroke Patients ◽

Post Stroke ◽

Group A ◽

Computer Based ◽

Attention Memory ◽

Group B

Background: Cognitive functions are mental series of activities that allow us to carry out any activity. The most important cognitive functions are orientation, attention, memory, executive functions, language, and visuospatial skills. Cognitive impairment is a prevalent consequence of stroke. Prognosis of stroke recovery can be estimated through the severity of cognitive impairment. The objective of this research work was to compare the changes in cognitive functions of post-stroke patients with the computer-based cognitive intervention (CBCI) using PABLO system and conventional cognitive intervention (CCI) using paper-pencil method. Methods: Total 80 stroke patients with cognitive impairment were selected and divided into two groups. The Group A received intervention through PABLO System (CBCI) and the Group B received the cognitive intervention through Paper Pencil method (CCI). Pre and post-assessment of cognitive functions like verbal fluency, language, orientation and attention, memory, visuospatial and mini mental state examination for both the groups were done by Addenbrooke Cognitive Examination-Revised (ACE-R) scale. Result: After the intervention of 4 weeks, patients of both groups showed improvement in cognitive functions. However, the group A scored higher in comparison to group B. Conclusion: Data suggest that both the interventions will bring the changes in cognitive functions post-stroke patients but CBCI may be much more effective in improving cognitive functions of stroke patients.

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Meta-Analysis on the Effectiveness of Virtual Reality Cognitive Training (VRCT) and Computer-Based Cognitive Training (CBCT) for Individuals with Mild Cognitive Impairment (MCI)

Electronics ◽

10.3390/electronics9122185 ◽

2020 ◽

Vol 9 (12) ◽

pp. 2185

Author(s):

Sarah Chui-wai Hung ◽

Annie Yin-ni Ho ◽

Idy Hiu-wai Lai ◽

Carol Sze-wing Lee ◽

Angela Shuk-kwan Pong ◽

...

Keyword(s):

Virtual Reality ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Training ◽

Effect Size ◽

Meta Analysis ◽

Random Effect Model ◽

Real Life ◽

Cognitive Domains ◽

Computer Based

This meta-analysis aims to assess the effectiveness of virtual reality cognitive training (VRCT) and conventional computer-based cognitive training (CBCT) in five specific cognitive domains (i.e., global cognitive function (GCF), memory (Mem), executive function (EF), language (Lang) and visuospatial skills (VS)) of individuals with mild cognitive impairment. A total of 320 studies were yielded from five electronic databases. Eighteen randomized controlled trials met the PRISMA criteria, with 10 related to VRCT and 8 related to CBCT. A random-effect model was used in determining the main effect of cognitive training in five specific cognitive domains. VRCT provided the largest effect size on VS and Lang while the smallest on EF. CBCT provided the largest effect size on Mem and Lang while the smallest on EF. VRCT and CBCT generate an opposite effect on VS. VRCT outweighs CBCT in treatment effectiveness of GCF, EF, Lang and VS. More immersive and interactive experiences in VRCT may help individuals with MCI better engage in real-life experiences, which supports skill generalization and reduces external distractions. CBCT tends to improve Mem but no definite conclusions can be made. Further investigation with more stringent research design and specific protocol are required to reach consensus about the optimum intervention regime.

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Effects of combined physical and cognitive training on fall prevention and risk reduction in older persons with mild cognitive impairment: a randomized controlled study

Clinical Rehabilitation ◽

10.1177/0269215520918352 ◽

2020 ◽

Vol 34 (6) ◽

pp. 773-782 ◽

Cited By ~ 1

Author(s):

Donald S Lipardo ◽

William WN Tsang

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Training ◽

Older Persons ◽

Dynamic Balance ◽

Community Dwelling ◽

Controlled Study ◽

Fall Rate ◽

Randomized Controlled ◽

Significant Difference

Objective: The aim of this study is to investigate the effects of combined physical and cognitive training on fall rate and risks of falling in older adults with mild cognitive impairment. Design: The design of this study was an assessor-blinded, randomized controlled trial. Setting: The setting for this study is the community from Manila, Philippines. Subjects: In total, 92 community-dwelling older persons with mild cognitive impairment (aged 60–83) were randomly allocated to three intervention groups and one waitlist control group. Interventions: The physical training, cognitive training, and combined physical and cognitive training intervention programs were delivered for 60 to 90 minutes, one to three times per week for 12 weeks with six-month follow-up. Main measures: Participants were assessed at baseline, 12 weeks after baseline, and 36 weeks after baseline for fall incidence, overall fall risk, dynamic balance, walking speed, and lower limb strength. Results: No significant difference was observed across time and groups on fall incidence rate at 12 weeks ( P = 0.152) and at 36 weeks ( P = 0.954). The groups did not statistically differ in other measures except for a significant improvement in dynamic balance based on Timed Up and Go Test in the combined physical and cognitive training group (9.0 seconds with P = 0.001) and in the cognitive training alone group (8.6 seconds with P = 0.012) compared to waitlist group (11.1 seconds) at 36 weeks. Conclusion: There was no significant difference among groups on fall rate and risks of falling post-intervention. Dynamic balance was improved with combined physical and cognitive training and cognitive training alone. Further research with a larger sample size is needed to establish whether or not the interventions are effective.

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Tempeh Consumption and Cognitive Improvement in Mild Cognitive Impairment

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000510563 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Yvonne Suzy Handajani ◽

Yuda Turana ◽

Yogiara Yogiara ◽

Nelly Tina Widjaja ◽

Tara Puspitarini Sani ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Older People ◽

Fermented Food ◽

Cognitive Improvement ◽

Before And After ◽

Number Of Microorganisms ◽

Group A ◽

Group B

Introduction: Tempeh consumption has been linked to the improvement of cognitive function in older people. However, to what extent the amount of microorganism or the size of tempeh serving consumed per day influences the benefit to cognitive functions has not yet been studied. Methods: This experimental study involved a total of 90 respondents, who were divided into 3 groups: group A (consuming 100 g of Tempeh A/day), group B (consuming 100 g of Tempeh B/day), and group C (control). Intervention was given for 6 months. Cognitive assessments were done before and after the intervention. Blood uric acid level was checked at the end of intervention to examine the effect of tempeh consumption on this. The inclusion criteria were respondents aged 60 years or over with mild cognitive impairment (MCI) who agreed not to consume other fermented food during the study period. Respondents with diabetes were excluded. Results: There were 84 subjects at the end of the study, majority being female (71.4%) and aged over 65 years (72.6%). An increase in global cognitive scores was found in both groups A and B. The increase in language domain scores was found only in group A. Conclusion: Both Tempeh A or Tempeh B consumption for 6 months appeared to be beneficial in improving global cognitive function of older people with MCI. Consuming Tempeh A, which had a lower number of microorganisms, was also associated with an improvement in the language domain.

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