scholarly journals Analysis of innovative technologies of hydrogels from uronate polysaccharides and biodegradable films on their basis

2019 ◽  
Vol 21 (91) ◽  
pp. 100-103
Author(s):  
N. V. Kondratiuk ◽  
T. M. Stepanova ◽  
O. O. Chernushenko
Keyword(s):  
Scientific Research ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Innovative Technologies ◽  
Food Engineering ◽  
Hydrogel Matrix ◽  
The Matrix ◽  
The Creation ◽  
Search For Information ◽  
Active Substances

The article is devoted to the analysis of the state and dynamics of scientific developments in the field of creating products for life and health, based on hydrogels from uronate polysaccharides (HUP). The article is reflected the results of the global scientific research monitoring and their changes in the field of technologies for the creation and use of HUP. The results of a retrospective analysis of existing technologies based on poorly studied in the field of food technologies uronic acids, as glucuronic, idouronic, hyaluronic were presented. The study showed, that nowadays the industry of products with their content is acquiring market traits, although it has insufficient scientific substantiation. Development segments with widely used uronate polysaccharides – pectins and alginates – according to the types of hydrogels (swollen hydrogel, cross-linked hydrogel, xerogel) were developed. The article presents examples and identified the required properties of substances intended for immobilization or encapsulation in the hydrogel matrix of uronate polysaccharides. The basic principles of uronate polysaccharides crosslinking chains in the hydrogel phase are determined. Possible methods of biologically active substances (BAS) retention in the matrix of uronate polysaccharides to reduce the risk of premature oxidation, destruction, decomposition, decomposition, evaporation were described. The search for information allowed us to identify key technological areas for the development of scientific research on the creation and use of HUP to improve people's lives and health. The archives of the world's leading publications in the field of food chemistry, biotechnology, food engineering, chemistry of new materials, food polymers and hydrocolloids were analyzed. The authors used in their work the resources of the Science Direct search system, which made it possible to determine the most promising and modern lines of development of HUP technologies and products based on them. The analysis of technologies has shown that existing innovative technologies are formed on “basic” technologies for producing solutions of high-molecular compounds under various conditions. Active modernization is carried out in the direction of creating products with immobilized biologically active substances, as well as in attempts to compose a composition with other polysaccharides and/or peptide components. The article notes that existing technologies allow developing other technologies with the help of which it is possible to expand the field of HUP application.

Conference "Pharmacology and toxicology of organophosphorus compounds and other biologically active substances" dedicated to the 75th anniversary of Prof. I.V. Zaikonnikova

1997 ◽  
Vol 78 (3) ◽  
pp. 236-236
Author(s):  
I. A. Studentsova
Keyword(s):  
Organophosphorus Compounds ◽  
Scientific Research ◽  
Main Direction ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
75Th Anniversary ◽  
The Past ◽  
Pharmacology And Toxicology ◽  
Active Substances

The conference was opened by Prof. R.S. Garaev, Head of the Department of Pharmacology. In the report "The main directions of scientific research of the Department of Pharmacology" he gave an overview of the works carried out over the past 5 years. The main direction is still the study of new organophosphorus compounds synthesized in Kazan.

scholarly journals Prospects for improving immunoprophylaxis of infectious diseases

2021 ◽  
Vol 23 (3) ◽  
pp. 189-194
Author(s):  
Alexander V. Stepanov ◽  
Vadim A. Myasnikov ◽  
Vasiliy Ya. Apcel
Keyword(s):  
Adverse Effects ◽  
Infectious Diseases ◽  
Mechanisms Of Action ◽  
Mass Scale ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Subunit Vaccines ◽  
Protective Antigens ◽  
The Creation ◽  
Active Substances

This study described the perspective and significance of using complex vaccine systems in improving immunoprophylaxis of major infectious diseases of various etiologies and genesis. Immunobiological drugs traditionally used for this purpose, along with the advantages, have disadvantages, such as increased reactogenicity and development of post-vaccine reactions and complications in some cases. Such adverse effects are serious obstacles to immunoprophylaxis on a mass scale. This circumstance was the reason for the improvement of immunoprophylaxis, and the main focus was the creation of chemical, recombinant, and subunit vaccines. However, compared with traditional drugs, these vaccines have inferior effectiveness, even if they are practically reactogenic and do not lead to the development of post-vaccine reactions and complications. The main approaches to the development of effective and safe methods of immunoprophylaxis are considered based on the development of complex vaccine systems, and the components can be protective antigens, biologically active substances of the corresponding microorganisms, adjuvants applied or embedded in the corresponding biologically active, and safe biotechnological platforms. Among the latter, nanoparticles and microparticles of polylactoglycolic acid, liposomes, lipids, and copolymers are recognized as the most suitable for the construction of complex vaccine systems. This paper highlighted new trends in the development of these methods of immunoprophylaxis and their advantages in comparison with traditionally used immunobiological drugs. Moreover, prospects are characterized and examples of developed vaccine preparations are presented. The mechanisms of action of postvaccination immunity and factors that influence its formation are described.

scholarly journals Food Engineering of Meat Bio-Products to Immunity Strengthening

2021 ◽  
Vol 29 ◽  
pp. 01021
Author(s):  
Julia Bazarnova ◽  
Aleksey Korzh ◽  
Natalya Barsukova ◽  
Svetlana Eliseeva ◽  
Ekaterina Fedinishina
Keyword(s):  
Meat Products ◽  
Theory And Practice ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Adequate Nutrition ◽  
Food Engineering ◽  
Healthy Nutrition ◽  
Human Immunity ◽  
Technological Methods ◽  
Active Substances

The mainstream of healthy nutrition during the new coronavirus pandemic is adequate and balanced nutrition based on strengthening human immunity. The authors consider the main aspects of developing theory and practice of adequate nutrition using innovative biotechnologies. Based on the St. Petersburg startup GASTROMAN.LAB there was developed new line of Bio-products enriched with probiotic cultures of microorganisms, biologically active substances of plants and prebiotics that was implemented using modern technological methods of food engineering. The recipes of original meat products of the Petersburg cuisine were used as basis for new developed recipes of bio-culinary products.

scholarly journals PHYTOCHEMICALS AND TECHNOLOGICAL STUDY OF THE BARENTS SEA ALGAE

2020 ◽  
Vol 11 (4) ◽  
pp. 178-197
Author(s):  
E.D. Obluchinskaya ◽  
Keyword(s):  
Barents Sea ◽  
Raw Materials ◽  
Arctic Region ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
The Arctic ◽  
The Barents Sea ◽  
Quantitative Characteristics ◽  
The Creation ◽  
Active Substances

The paper presents the results ofa study of the phytochemical and technological aspects of the creation of biological products from algae of the Barents Sea, conducted at MMBI RAS in the period from 2015 to 2019. The features of studying the qualitative and quantitative characteristics of biologically active substances (BAS) of algae of the Barents Sea, the technology of processing algae raw materials, biopharmaceutical and pharmacological studies are considered. The developed technologies for processing renewable algal raw materials to produce biologically active substances are the basis for the creation of useful products of medicinal, therapeutic, food and agricultural purposes. Data are presented on the phytochemical composition and quantitative characteristics of biologically active substances of algae in the Arctic region associated with the characteristics of growth in high latitudes, as well as studies of the stability of biological substances in algae during harvesting and storage.

Microscopic fungi of lithobiont communities of Argentine Islands Region: Data from the 22nd Ukrainian Antarctic Expedition

2020 ◽  
Vol 62 (1-2) ◽  
pp. 49-68
Author(s):  
T. O. Kondratiuk ◽  
T. V. Beregova ◽  
I. Yu. Parnikoza ◽  
S. Y. Kondratyuk ◽  
A. Thell
Keyword(s):  
Filamentous Fungi ◽  
Mucor Circinelloides ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Microscopic Fungi ◽  
Rhodotorula Rubra ◽  
Yeast Fungi ◽  
Antarctic Expedition ◽  
Geomyces Pannorum ◽  
Active Substances

The identification of the diversity of microscopic fungi of lithobiont communities of the Argentine Islands in specimens collected during the 22nd Ukrainian Antarctic Expedition was the purpose of this work. Samples of rock, soil, mosses and lichens of rock micro-habitats of “Crustose lichen sub-formation and fruticose lichen and moss cushion sub-formation” were used in the work. These samples were used for extracting and cultivation of filamentous fungi on dense nutrient media. Determination of physiological and biochemical characteristics and identification of yeast-like fungi were performed using a microbiological analyser ‘Vitek-2’ (‘Bio Merieux’, France). Cultivation of microorganisms was carried out at temperatures from +2 to +37 °C. In results cultures of microscopic fungi of Zygomycota (Mucor circinelloides), Ascomycota (species of the genera cf. Tlielebolus, Talaromyces), representatives of the Anamorphic fungi group (Geomyces pannorum, species of the genera Alternaria, Acremonium, Aspergillus, Penicillium, and Cladosporium) were isolated from Antarctic samples. Microscopic fungi Penicillium spp. were dominated after the frequency in the studied samples (54.5%). Rhodotorula rubra and Candida sp. among isolated yeast fungi, and dark pigmented fungi represented by Aureobasidium pulhdans and Exophiala spp. were identified. The biological properties of a number of isolated fungi (the potential ability to synthesise important biologically active substances: melanins, carotenoids, lipids) are characterised. Mycobiota of rock communities of Argentine Islands is rich on filamentous and yeast fungi similarly to other regions of Antarctica. A number of fungi investigated are potentially able to synthesise biologically active substances. The dark pigmented species of the genera Cladosporium, Exophiala, Aureobasidium pulhdans, capable of melanin synthesis; ‘red’ yeast Rhodotorula rubra (carotenoid producers and resistant to toxic metals); Mucor circinelloides and Geomyces pannorum, lipid producers, are among these fungi. Yeast-like fungi assimilated a wide range of carbohydrates, which will allow them to be further used for cultivation in laboratory and process conditions. The collection of technologically promising strains of microorganisms, part of the Culture Collection of Fungi at Taras Shevchenko National University of Kyiv (Ukraine), is updated with isolated species (strains) of filamentous fungi and yeast – potential producers of biologically active substances, obtained within this study.

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