scholarly journals Comparative characteristics of different methods of treatment of microsporia

2021 ◽  
Vol 23 (104) ◽  
pp. 47-54
Author(s):  
Y. V. Martyniv ◽  
Ya. V. Kisera
Keyword(s):  
Antifungal Agent ◽  
Basal Layer ◽  
Antifungal Drugs ◽  
Common Disease ◽  
Microsporum Canis ◽  
T Suppressors ◽  
Source Of Infection ◽  
Therapeutic Measures ◽  
T Helpers ◽  
Methods Of Treatment

Microsporia is the most common disease of fungal etiology, most often caused by the pathogen Microsporum canis. Treatment of this disease requires a comprehensive approach, because the disease is dangerous to humans. Therefore, in the treatment of microspores, it is important not only to carry out therapeutic measures, but also to prevent the spread of the pathogen of the fungus in the environment and increase the immune status of the organism in the fight against infection. The main source of infection is cats. In order to determine the effectiveness of treatment of microsporia by various methods, studied of the blood and skin of guinea pigs infected with the pathogen M. canis. Sick animals were divided into three groups. The first group was treated with the systemic antifungal itraconazole and topical treatment with a solution of clotrimazole. Treatment of the second group was performed with a topical antifungal agent (1% solution of clotrimazole) with vaccination with the antifungal vaccine “Vakderm”. For the third group, the developed drugs were used – antifungal agent “Micromar” and immunostimulant “Biogluk”. During treatment, hematological and immunological blood researches and histological skin examinations were performed. During treatment with antifungal drugs (itraconazole and clotrimazole) the number of leukocytes decreases from 11.13 ± 0.72 to 7.13 ± 0.22, rod-shaped neutrophils from 15.76 ± 1.29 to 5.50 ± 0.76, and segmental increases from 12.17 ± 1.47 to 24.17 ± 2.27, decreases ESR from 5.67 ± 0.67 to 2.33 ± 0.42, which occurs when inhibiting the inflammatory response of the organism to infection. Thrombocytopenia (from 231.17 ± 7.60 to 184.33 ± 7.65) and eosinophilia (from 2.70 ± 0.73 to 7.33 ± 1.33) are also noted. There is a slight increase in T-helpers and a decrease in T-suppressors. Histologically, the infiltration of the dermis by histiocytes and  eosinophils under skin  persists. In the treatment of microsporia by treatment with 1 % solution of clotrimazole and vaccination with the vaccine “Vakderm” the results of studies showed that the number of leukocytes decreases from 11.13 ± 0.72 to 5.35 ± 0.31 (P < 0.01), rod-shaped neutrophils from 15.76 ± 1.29 to 7.67 ± 0.56, and segmental increases from 12.17 ± 1.47 to 22.17 ± 0.91 (P < 0.001), decreases). The number of T-helpers is increasing. The histological picture on day 7 is characterized by hyperkeratosis, and on day 14 the hyperemia of the basal layer of the epidermis persists. When using the antifungal drug “Micromar” and immunostimulant “Biogluk” the results of studies showed that the number of leukocytes decreases from 11.13 ± 0.72 to 6.95 ± 0.10, rod-shaped neutrophils from 15.76 ± 1.29 to 6.17 ± 0.65, and segmental increases from 12.17 ± 1.47 to 22.00 ± 0.86, decreases ESR from 5.67 ± 0.67 to 2.17 ± 0.31. Increases the number of T-helpers and the number of natural killers and T-suppressors is gradually decreasing. Histological changes are presented in the form of dilation of blood vessels and visualization of single erythrocytes in the dermis on day 14 of treatment.

Physiotherapy Complex for the Treatment of Children with Somatoform Dysfunction, Often Suffering from Recurrent Infection

2020 ◽  
Vol 98 (4) ◽  
pp. 140-148
Author(s):  
N.G. Kulikova ◽  
I.V. Volkova ◽  
A.S. Tkachenko
Keyword(s):  
B Lymphocytes ◽  
Blood Cells ◽  
White Blood Cells ◽  
Recurrent Infection ◽  
Recurrent Infections ◽  
T Suppressors ◽  
Children With Adhd ◽  
Therapeutic Measures ◽  
T Helpers ◽  
Head Area

The aim. to optimize the treatment of children with ADHD who often suffer from recurrent infections by justifying the effectiveness of a therapeutic and physiotherapy complex that includes a BOS-bioacoustic effect on the head area and NILI on the projection of the cubital area and thymus. Method of research. In children (140 people) with a verified diagnosis of ADHD, often suffering from recurrent infection, humoral-cellular immunity indicators (immunoglobulins: IgA; IgG; IgM); T-and B-lymphocytes; cytokines) were studied in the dynamics of the use of therapeutic measures. Depending on the applied physiotherapy method of treatment, the children were divided into 3 groups: the 1st group-received NILI on the projection of the cubital area and thymus, the 2nd – received BOS-bioacoustic effect on the head area, the 3rd – developed physiotherapy complex, including BOS-bioacoustic effect on the head area and NILI on the projection of the cubital area and thymus. Conclusion. the developed physiotherapy complex, including BOS-bioacoustic effect on the head area and NILI on the projection of the cubital area and thymus, can be considered as a therapeutic and preventive model of respiratory viral attacks in children with SSDVNS, since it reduces the number of recurrent viral attacks by 3.7 times, correcting the activity of circulating cytokines, T-lymphocytes (CD3+), T-helpers (CD4+) and T-suppressors (CD8+) in the population white blood cells.

THE EFFECTS OF ELECTROACUPUNCTURE COMBINED WITH ACUPRESSURE POINTS, MASSAGE TREATMENT AND “DOC HOAT TANG KY SINH” REMEDY ON TREATING SCIATICA DUE TO LUMBAR SPONDYLOSIS

2020 ◽  
pp. 105-111
Author(s):  
Giang Huynh Huong ◽  
Tan Nguyen Thi ◽  
Hung Nguyen Van
Keyword(s):  
Traditional Medicine ◽  
Modern Medicine ◽  
Common Disease ◽  
Working Ability ◽  
Treatment Results ◽  
Lumbar Spondylosis ◽  
Before And After ◽  
Massage Treatment ◽  
Long Time ◽  
Methods Of Treatment

Background: Sciatica due to lumbar spondylosis is a common disease syndrome, include pathological signs from lumbar spine and sciatic nerve. It occurs for a long time and affects to working ability and daily life. Currently there are many methods of treatment with modern medicine and traditional medicine. Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a highly effective method on treating sciatica due to lumbar spondylosis. Objectives: To evaluate the effectives of electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy on treating sciatica due to lumbar spondylosis. Materials and Method: A total of 43 patients was diagnosed sciatica caused by lumbar spondylosis who treated at Thua Thien Hue Traditional Medicine Hospital. The study was designed by method of prospective study, assessed the results before and after the treatment. Results: Very good: 34.9%; good: 34.9%; average 7%. There was not any unexpected effects observed in this trial. Conclusion: Electroacupuncture combined with acupressure point, massage treatment and “Doc hoat tang ky sinh” remedy is a effective method on treating sciatica caused by lumbar spondylosis. Key words: sciatica, lumbar spondylosis, acupuncture, electroacupuncture, acupressure point, massage treatment

Reconstructed interfollicular feline epidermis as a model for Microsporum canis dermatophytosis

2007 ◽  
Vol 56 (7) ◽  
pp. 971-975 ◽  
Author(s):  
Jeremy Tabart ◽  
Aline Baldo ◽  
Sandy Vermout ◽  
Betty Nusgens ◽  
Charles Lapiere ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Pathogenic Fungus ◽  
Basal Layer ◽  
Histopathological Analysis ◽  
Microsporum Canis ◽  
Living Tissue ◽  
Cutaneous Infection ◽  
Interfollicular Epidermis

Microsporum canis is a pathogenic fungus that causes a superficial cutaneous infection called dermatophytosis. The complexity of mechanisms involved in dermatophytic infections makes relevant in vivo studies particularly difficult to perform. The aim of this study was to develop a new in vitro model of M. canis dermatophytosis using feline fetal keratinocytes in reconstructed interfollicular epidermis, and to investigate its relevance in studying the host–pathogen relationship. Histological analysis of reconstructed interfollicular feline epidermis (RFE) revealed a fully differentiated epidermis. A proliferation assay showed replicating cells only in the basal layer, indicating that RFE is a well-stratified living tissue, leading to the formation of a horny layer. Histopathological analysis of RFE infected by M. canis arthroconidia revealed that the fungus invades the stratum corneum and produces SUB3, a keratinase implicated in the infectious process. In view of these results, an M. canis dermatophytosis model on RFE seems to be a useful tool to investigate mechanisms involved in natural M. canis feline infections.

scholarly journals CONCEPT OF DOSHAJA KASA – A REVIEW ARTICLE

2020 ◽  
Vol 8 (7) ◽  
pp. 3919-3924
Author(s):  
Divya Badwal ◽  
Ruby Rani Agarwal ◽  
Shashikant Tiwari ◽  
Shobhit Kumar
Keyword(s):  
Effective Treatment ◽  
Review Article ◽  
Prodromal Symptoms ◽  
Etiological Factors ◽  
Therapeutic Measures ◽  
Methods Of Treatment

In the Ayurvedic classics, Kasa is considered as an independent disease. It may also occur as Lakshana (symptom) or Upadarava (complication) in other diseases. It is an example of Pranavaha Srotas Dushti. According to Acharya Charaka, the Moola of Pranavaha Srotas are Hridya (Brain, Heart) and Mahasro-tas. Acharyas have described definition, etiological factors, prodromal symptoms, symptoms, types of Kasa along with all Pathya (wholesome) & Apathya (unwholesome) and therapeutic measures. Kasa is manifested with the vitiation of Vata & Kapha. Understanding and differentiating Kasa is important for its effective treatment. The study of Kasa is necessary as it can be associated with many complications if left untreated. In this context different Lakshanas (symptoms) of Doshaja Kasa explained by Acharyas can be used for diagnosis as well as prognosis of the disease. Thus, with help of this study alternate safe methods of treatment can be employed. So, its identification as Doshaja Kasa can be a ray of hope for the diagno-sis.

scholarly journals European Hedgehogs (Erinaceus europaeus L.) as a Reservoir of Dermatophytes in Poland

2021 ◽  
Author(s):  
Sebastian Gnat ◽  
Dominik Łagowski ◽  
Mariusz Dyląg ◽  
Aneta Nowakiewicz
Keyword(s):  
Human Life ◽  
Primary Source ◽  
Trichophyton Mentagrophytes ◽  
Antifungal Drugs ◽  
Microsporum Canis ◽  
Missense Mutations ◽  
Erinaceus Europaeus ◽  
Trichophyton Erinacei ◽  
Trichophyton Benhamiae ◽  
European Hedgehog

AbstractThe European hedgehog (Erinaceus europaeus Linnaeus) frequently colonises areas located close to human life in cities, as these are more suitable nest sites offering an abundance of food and allowing avoidance of predators. However, urbanisation has a significant impact on the epidemiology of infectious diseases, including dermatophytoses, the primary source of which are wild animals. In this study, we determined the spectrum of dermatophytes isolated from the European hedgehog and assessed their susceptibility profile to antifungal drugs. Symptomatic and asymptomatic dermatophyte infections were observed in 7.7% and 8% of the 182 examined free-living hedgehogs, respectively. In the pool of the isolated dermatophyte strains, Trichophyton erinacei was dominant (29.9%), followed by Trichophyton mentagrophytes (17.9%), Trichophyton benhamiae (13.4%), Nannizzia gypsea (11.9%), Microsporum canis (10.4%), Nannizzia nana (7.5%), Paraphyton cookei (6.0%), and Nannizzia fulva (3.0%). Susceptibility tests revealed the highest activity of luliconazole and the lowest of activity fluconazole among the azole drugs applied. Although terbinafine generally exhibited high efficacy, two Trichophyton mentagrophytes isolates showed resistance to this drug (MIC = 2 µg/ml) resulting from missense mutations in the SQLE gene corresponding to the amino acid substitution Leu393Phe. Summarising, our study has also revealed that such wildlife animals as hedgehogs can be a reservoir of pathogenic human dermatophytes, including harmful strains resistant to commonly used antifungal drugs. Graphical Abstract

1,2,4-triazoles Clubbed Pyrimidine Compounds with Synthesis, Antimicrobial, Antituberculosis, Antimalarial, and Anti-protozoal Studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Navin B. Patel ◽  
Hetal I. Soni ◽  
Rahul B. Parmar ◽  
Manuel J. Chan-Bacab ◽  
Gildardo Rivera
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
New Products ◽  
Antifungal Drugs ◽  
Bioactive Molecules ◽  
Mass Spectral Analysis ◽  
Mass Spectral

: Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, an-tituberculosis, antimalarial, and anti-protozoal. N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and anti-protozoal activities. These com-pounds satisfied the bioactive response and simple way for the synthesis.

The Combined Laser Therapy in Patients with Psoriasis

2015 ◽  
Vol 22 (4) ◽  
pp. 99-103
Author(s):  
Утц ◽  
S. Utts ◽  
Москвин ◽  
S. Moskvin ◽  
Шнайдер ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Pulse Repetition Frequency ◽  
Local Effect ◽  
Research Centre ◽  
Treatment Technique ◽  
External Impact ◽  
Therapeutic Measures ◽  
Inflammatory Changes ◽  
Methods Of Treatment ◽  
Made In

One of the known methods of treatment of patients with psoriasis is laser therapy, however, the task of improving the efficiency of this method is still relevant. The objective of this study was the evaluation of the effectiveness of treatment technique of patients with psoriasis, including the intravenous laser light of blood and the local effect of pulse infrared laser radiation. 42 patients with widespread forms of psoriasis in the stage of progression (12 women and 30 men) aged 35 to 60 years (the average age 47), having a disease duration of 5 to 20 years, were observed. In the complex of therapeutic measures of the main group the laser therapy was included. It is the original technique by means of laser therapeutic apparatus ʺLasmik‐VLOKʺ (Registration certificate № RZN 2014/1410 from 06.02.2014) with the laser emitting heads KL‐VLOK‐525‐20 for intravenous laser light of blood and ML‐635‐ 40 for external impact. For this technique the disposable sterile lights KIVL ‐01 on TU 9444‐005‐72085060‐ 2008 made in Research centre ʺMatrixʺ (Russia, Moscow) were used.It is shown that the combined laser therapy of patients with moderate form of psoriasis (PASI index 40‐ 50), including local effects on psoriatic lesions by pulsed radiation of the red spectrum (635 nm) of 40 watts with the change of the pulse repetition frequency to 10000 Hz and VLOK‐525, allows effectively to stop the inflammatory changes, to decrease of erythema, infiltration and desquamation. The rapid decrease in the area affected of the skin is observed.

scholarly journals Francisella tularensis in muscle from diseased hares – a risk factor for humans?

2017 ◽  
Vol 145 (16) ◽  
pp. 3449-3454 ◽  
Author(s):  
G. HESTVIK ◽  
H. UHLHORN ◽  
T. JINNEROT ◽  
S. ÅKERSTRÖM ◽  
F. SÖDERSTEN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Francisella Tularensis ◽  
Human Infection ◽  
Common Disease ◽  
Pathological Changes ◽  
Game Species ◽  
Source Of Infection ◽  
Gross Lesions ◽  
Sources Of Infection

SUMMARYTularemia caused by the bacterium Francisella tularensis is a zoonotic disease. Tularemia is a common disease in the hare, and as a game species can be an important source of infection for humans. In this study, hares diagnosed with tularemia were examined with the aim to investigate whether the muscle (meat) had any pathological changes and/or contained F. tularensis. Real-time PCR and/or immunohistochemistry (IHC) detected the bacteria in muscle samples from 40 out of 43 investigated hares. IHC showed that bacteria were few and most commonly located in the peri- and endomysium. Histopathology showed occasional perimysial necroses and mild inflammation in association to the bacteria. Attempts to culture from 14 muscle samples were successful in two cases, both stored in the freezer <1 year. The result of this study shows that since F. tularensis is present in the muscle of infected hares, there is a risk for human infection when consuming undercooked hare meat. The risk is enhanced by the fact that some hares do not have easily detected gross lesions. The study contributes to a better understanding of sources of infection and risk factors for humans to contract tularemia.

Reconstructed interfollicular feline epidermis as a model for the screening of antifungal drugs against Microsporum canis

2008 ◽  
Vol 19 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Jeremy Tabart ◽  
Aline Baldo ◽  
Sandy Vermout ◽  
Bertrand Losson ◽  
Bernard Mignon
Keyword(s):  
Antifungal Drugs ◽  
Microsporum Canis

scholarly journals INTRAABDOMINAL HYPERTENSION SYNDROME: CURRENT STATE OF THE PROBLEM

2020 ◽  
pp. 35-42
Author(s):  
V. A. Samartsev ◽  
V. A. Gavrilov ◽  
B. S. Pushkarev
Keyword(s):  
Abdominal Cavity ◽  
Abdominal Pressure ◽  
Current Trends ◽  
Current State ◽  
Abdominal Hypertension ◽  
Practical Research ◽  
Intraabdominal Hypertension ◽  
Therapeutic Measures ◽  
Methods Of Treatment ◽  
Extensive Surgery

Syndrome of intra-abdominal hypertension (SIAH) is a dangerous complication that can occur in patients with a surgical profile after surgery in the abdominal cavity. Only in the past 25 years has the SIAH been recognized. According to W. Ertel et al., In one third of patients with peritonitis, pancreatic necrosis, injuries of the abdominal cavity and after extensive surgery, there is an increase in intra-abdominal pressure (IAP), while SIAH develops in 5.5% of such patients. Mortality in SIAH is 42–68%. The reason for the development of so many deaths is the presence of diagnostic, preventive and therapeutic measures, as well as differences in the interpretation of terms. Today, much attention is paid to the study of SIAH, official attempts are being made to standardize and define terms and recommended methods of treatment, but this problem needs further study. The review presents data on the current state of the problem, current trends in the diagnosis, prevention and treatment of patients with IAP and SIAH, their use in practical research.

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