scholarly journals Efek Kombinasi Ramuan Jamu Terhadap Tekanan Darah dan Kolesterol Pasien di Rumah Riset Jamu Hortus Medicus

2018 ◽  
Vol 1 (3) ◽  
pp. 152-157
Author(s):  
Peristiwan Ridha Widhi Astana ◽  
Fajar Novianto ◽  
Agus Triyono
Keyword(s):  
Blood Pressure ◽  
Combination Therapy ◽  
Systolic Blood Pressure ◽  
Health Problem ◽  
Retrospective Cohort ◽  
Normal Blood Pressure ◽  
Hypertensive Patients ◽  
Cholesterol Levels ◽  
Before And After ◽  
Paired T Test

Hipertensi dan hiperkolesterolemia masih merupakan masalah di bidang kesehatan. Penanganan pasien hipertensi yang disertai hiperkolesterolemia memerlukan perhatian khusus. Di Rumah Riset Jamu (RRJ) terdapat banyak pasien hipertensi dengan hiperkolesterolemia yang diterapi menggunakan kombinasi ramuan jamu antihipertensi dan antihiperkolesterolemia. Penelitian ini bertujuan untuk mengetahui efek kombinasi ramuan jamu tersebut dalam menurunkan tekanan darah dan kadar kolesterol. Penelitian ini dilakukan menggunakan metode kohort retrospektif. Sampel didapatkan dari data rekam medik pasien hipertensi yang disertai hiperkolesterolemia di RRJ Hortus Medicus tahun 2017. Subjek penelitian ini adalah pasien yang berusia 20-65 tahun dan telah menjalani terapi kombinasi ramuan jamu antihipertensi dan antihiperkolesterol minimal 28 hari. Analisis dilakukan dengan membandingkan tekanan darah dan kadar kolesterol pasien pada hari ke-0 dan hari ke-28 masing-masing menggunakan uji t berpasangan. Sebanyak 223 data pasien didapatkan. Setelah 28 hari, terdapat 74 orang yang berhasil mencapai tekanan darah normal dan 115 orang berhasil mencapai kadar kolesterol normal. Tekanan darah sistolik berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu, p=0,000. Demikian juga tekanan darah diastolik berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu p=0,005. Kadar kolesterol di dalam darah pasien juga berbeda secara signifikan antara sebelum dan setelah pemberian ramuan jamu, p=0,014. Berdasarkan hasil di atas, dapat disimpulkan bahwa pemberian kombinasi ramuan jamu antihipertensi dan antihiperkolesterolemia selama 28 hari dapat menurunkan tekanan darah dan kadar kolesterol pasien secara signifikan.   Hypertension and hypercholesterolemia are still a health problem. Treatment of hypertensive patients comorbid with hypercholesterolemia requires special attention. At the Jamu Research House (RRJ) there are many hypertensive patients with hypercholesterolemia who are treated using a combination of antihypertensive and antihypercholesterolemic herbs. This study aimed to determine the effect of the combination of jamu in lowering blood pressure and cholesterol levels. This study was conducted using a retrospective cohort method. Samples were obtained from medical record of hypertensive patients comorbid with hypercholesterolemia at RRJ Hortus Medicines in 2017. The subjects of this study were patients aged 20-65 years and had undergone a combination therapy of antihypertensive and antihypercholesterolemicjamu at least 28 days. The analysis was carried out by comparing the blood pressure and cholesterol levels of patients on day 0 and day 28 using paired t test. A number of 223 patient data were obtained. After 28 days, there were 74 people who reach normal blood pressure and 115 people achieve normal cholesterol levels. Systolic blood pressure was significantly different between before and after the administration of jamu, p = 0,000. Likewise, diastolic blood pressure was significantly different between before and after the administration of jamu with p = 0.005. Cholesterol levels in the patient's blood also differed significantly between before and after administration of jamu formula, p = 0.014. Based on the above results, it can be concluded that the combination of antihypertensive and antihypercholesterolemic jamu for 28 days significantly reduced blood pressure and patient cholesterol levels

scholarly journals PENGARUH THERAPY BEKAM BASAH TERHADAP TEKANAN DARAH PASIEN HIPERTENSI

2018 ◽  
Vol 6 (2) ◽  
pp. 102-105
Author(s):  
Leli Mulyati
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Cupping Therapy ◽  
Control Group ◽  
Pressure Measurements ◽  
Hypertensive Patients ◽  
Average Systolic Blood Pressure ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental

This study aims to determined the effected of wet cupping therapy on blood pressure in hypertensive patients. The study used a quasi-experimental method with one group pre-test and post-test without a control group. The study subjects total 30 respondents consisting of patients with hypertension. All subjects are given wet cupping treatment twice with an interval of 2 weeks. Blood pressure measurements made ​​before and after wet cupping. The results of analysis used a t-dependent, decrease in average systolic blood pressure was 13 333 ± 12 042 wet cupping mmHg and diastolic 4667 ± 3294 mmHg. At week 2 a decrease in average systolic blood pressure mmHg while the 8667 ± 8308 6667 ± 5525 mmHg diastolic. Decrease in average systolic and diastolic blood pressure there were significant differences (p <0.05) in the first wet cupping and second wet cupping. This shows that wet cupping therapy affects blood pressure in hypertension patients.

scholarly journals Pengaruh Pemberian Jus Averrhoa carambola terhadap Penurunan Tekanan Darah pada Lansia Penderita Hipertensi

2018 ◽  
Vol 9 (1) ◽  
pp. 51
Author(s):  
Putri Aulia Arza ◽  
Andri Irawan
Keyword(s):  
Blood Pressure ◽  
Statistical Analysis ◽  
Systolic Blood Pressure ◽  
Fruit Juice ◽  
Hypertensive Patients ◽  
Averrhoa Carambola ◽  
Star Fruit ◽  
Before And After ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

<p>Hypertension, or high blood pressure, is a very common and serious condition that can lead to or complicate many health problems.Solving this problem by nonpharmacologic, it is needed to bedeveloped, for example with consuming star fruit juice. Star fruit <em>(AverrhoaCarambola) </em>is rich in Vitamin C, and contains high levels of potassium and low in sodium which has the effect of lowering blood pressure. This study aimed to determine the effect of star fruit juice to the reduction of blood pressure in elderly hypertensive patients.  The study used a pre-experimental study with one group pretest-posttest design with 10 respondents selected by purposive sampling. The results showed that systolic blood pressure in statistical analysis showed that p=0.000 (p˂ 0.05) means that Hypotheses received or systolic blood pressure between before and after consumption star fruit juice significantly their influence. That the diastolic blood pressure in statistical analysis showed that p=0.001 (p˂0.05), which means that Hypotheses received or systolic blood pressure between before and after consumption star fruit juice significantly their influence.The result is expected to give any benefit for the society and become one of the solutions to treat the hypertension suffers.</p>

scholarly journals TERAPI TERTAWA DAN PERUBAHAN TEKANAN DARAH PADA MAHASISWA DI UNIVERSITAS ADVENT INDONESIA

2016 ◽  
Vol 2 (2) ◽  
pp. 187
Author(s):  
Tawarina Surbakti ◽  
Gilny Aileen Joan ◽  
Denny Ricky
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Normal Blood ◽  
Test Design ◽  
Normal Blood Pressure ◽  
Purposive Sampling ◽  
Average Value ◽  
Before And After ◽  
Post Test

ABSTRAK Penelitian ini dilatarbelakangi hasil penelitian Ramdhani (2013) yang menunjukan adanya perubahan penurunan tekanan darah yaitu setelah dilakukan terapi tertawa selama dua minggu sebanyak enam kali pemberian. Maka peneliti merasa perlu dilakukan uji ulang pemberian terapi tertawa pada tekanan darah normal dengan satu kali pemberian. Tujuan penelitian untuk menganalisis perbedaan tekanan darah sebelum dan sesudah pemberian terapi tertawa pada mahasiswa di Universitas Advent Indonesia. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimen yang menggunakan One Group Pre-Test and Post-Test Design dengan melibatkan satu kelompok subjek. Intervensi dalam penelitian yang dilakukan ini adalah pemberian terapi tertawa selama 20 menit. Subjek penelitian ini berjumlah 30 orang mahasiswi di Universitas Advent Indonesia. Pengambilan sampel dilakukan dengan teknik purposive sampling. Hasil penelitian ini menunjukan bahwa nilai rata-rata tekanan darah pada mahasiswi di Universitas Advent Indonesia sebelum pemberian terapi tertawa yaitu dengan nilai tekanan darah sistolik adalah  115.6 mmHg dan nilai tekanan darah diastolik 75.0 mmHg. Nilai rata-rata tekanan darah sistolik sesudah pemberian terapi tertawa adalah  110.8 mmHg dan tekanan darah diastolik 73.8  mmHg. Nilai tekanan darah sebelum dan sesudah pemberian terapi tertawa mempunyai nilai yang signifikan pada nilai uji-t pada tekanan sistolik. Tekanan diastolik tidak terjadi perubahan yang signifikan.   Kata kunci: Tekanan darah normal, Terapi tertawa   ABSTRACT This research is based on the writing of Ramdhani (2013) showing that there is a change in blood pressure after given six times laughter therapy for two weeks. Researchers find it necessary to repeat the laugh therapy on person with normal blood pressure with one provision. The purpose of this research is to identify changes in blood pressure before and after given laugh therapy. The research design used in this study is One Group Pre-Test and Post-Test Design experimental research that uses. Intervention conducted in this research is laughing therapy for 20 minutes. Subjects of this research were 30 students of Adventist University of Indonesia. That were by purposive sampling technique. The results of this research showed that the average value of blood pressure in students of Universitas Advent Indonesia before given laugh therapy with a systolic blood pressure value of 115.6 mm Hg and diastolic blood pressure value of 75.0 mmHg. The average value of systolic blood pressure after the administration of laughter therapy was 110.8 mmHg and a diastolic blood pressure value of 73.8 mmHg. Systolic blood pressure values before and after administration of laughter therapy has a significant change but not with the diastolic. Keywords: Normal blood pressure value, Laugh therapy

scholarly journals Korelasi Perubahan Tekanan Darah dengan Perubahan Kadar Kolesterol Total Pasien Prolanis yang Mendapatkan Jus Lidah Buaya (Aloe vera)

2020 ◽  
Vol 3 (1) ◽  
pp. 51-59
Author(s):  
Vina Yuliawati ◽  
Ade Teti Vani ◽  
Fredia Heppy
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Health Center ◽  
Diastolic Blood Pressure ◽  
Aloe Vera ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Before And After

Introduction: One factor of hypertension is hypercholesterolemia. Efforts to lower cholesterol levels in the blood beside taking the medicine, can also with a healthy lifestyle change and diet. Diet is an effective way to lower cholesterol levels in the blood. One of the ingredients that has the benefits of anti-hypercholesterolemia is Aloe vera. Aims: Knowing the correlation between changed blood pressure and changed the Total cholesterol for Prolanis patients with cholesterol disorder that get Aloe vera juice in the Padang Air Dingin Health Center in 2018. Method: This study was conducted on the Prolanis patient in the Padang Air Dngin Helth Center conducted from July – August 2018. The type of research used was a colerative analytic analytic with cross sectional study design. The affordable population are all prolanis patient in the Padang Air Dingin Health Center with 15 samples using simple random sampling technique. Univariate data analysis presented in the form of the average, standard deviation, minimum, maximum, and bivariates analyses using the Spearman rho test, using the SPSS program. Result: Systolic blood pressure before and after consuming Aloe vera juice obtained on average 137.26 mmHg and 119.86 mmHg. Diastolic blood pressure before and after consuming Aloe vera juice was obtained on average 86.13 mmHg and 77.80 mmHg. The amount of cholesterol before and after consuming Aloe vera juice was obtained on average 264.93 and 240.36. Systolic blood pressure obtained r = 0.875 values (very strong categories), the value P = 0,000 (P < 0.05) and at the diastolic blood pressure obtained r = 0.631 values (strong categories), Value P = 0,012 (P < 0.05). Conclusion: there is a correlation betweeen changed blood pressure and changed the total cholesterol for patients with cholesterol disorder (hypercholesterolemia) that get aloe vera juice in the Padang Air Dingin Health Center in 2018.

scholarly journals Pengaruh senam Prolanis terhadap penyandang hipertensi

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Deiby O. Lumempouw ◽  
Herlina I.S Wungouw ◽  
Hedison . Polii
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Degenerative Diseases ◽  
Hypertensive Patients ◽  
Purposive Sampling ◽  
Group Design ◽  
Before And After ◽  
Post Test ◽  
Blood Pressures

Abstract: Hypertension is one of the degenerative diseases commonly found in Indoensia. It is characterized by an increase of blood pressure above its normal level and is caused by various factors. This study aimed to obtain the influence of Prolanis exercise on hypertensive patients. This was an experimental field study with a pre-post test one group design conducted for 4 weeks. There were 25 respondents in this study obtained by using purposive sampling. Data were analyzed with the paired t-test.The results showed that there were significant differences between before and after two-times-per-week Prolanis exercise in systolic blood pressure ( p = 0,003 < α =0,001) and in diastolic blood pressure ( p = 0,002 < α =0,001). There were significant differences before and after three- times-per-week Prolanis exercise in systolic blood pressure (p = 0,000 < α = 0,01) and in diastolic blood pressure (p = 0,000 < α = 0,01). There were changes in mean blood pressure before and after Prolanis exercise two times per week and there times perweek. Conclusion: In the two groups, there were significant decreases of systolic and diastolic blood pressures after Prolanis exercise for 4 weeks consecutively. Keywords: senam Prolanis, hypertension Abstrak: Hipertensi merupakan salah satu penyakit degenerative yang banyak ditemukan di Indonesia, ditandai oleh kenaikan tekanan darah diatas nilai normal yang dapat diakibatkan oleh berbagai macam faktor. Penelitian ini bertujuan untuk mengetahui pengaruh senam Prolanis terhadap penderita hipertensi. Jenis penelitian ini ialah ekperimental lapangan dengan pre-post test one group design. Sampel penelitian berjumlah 25 orang lansia yang diperoleh melalui purposive sampling. Senam Prolanis dilakukan selama 4 minggu. Analisis data menggunakan uji t berpasangan. Hasil penelitian memperlihatkan terdapat perbedaan bermakna antara tekanan darah sistolik awal dan akhir pada latihan 2 kali/minggu (p = 0,003 <α =0,001); antara tekanan darah diastolik awal dan akhir pada latihan 2 kali/minggu (p = 0,002 <α =0,001); antara tekanan darah sistolik awal dan akhir pada latihan 3 kali/minggu (p = 0,000 <α = 0,01); dan antara tekanan darah diastolik awal dan akhir pada latihan 3 kali/minggu (p = 0,000 <α = 0,01). Terdapat perubahan rerata tekanan darah sebelum dan sesudah latihan senam baik pada latihan 2 kali/minggu maupun 3 kali/minggu. Simpulan: Pada kedua kelompok latihan terdapat penurunan bermakna tekanan darah sistolik dan diastolik setelah senam Prolanis selama 4 minggu berturut-turut.Kata kunci: senam prolanis, hipertensi

scholarly journals Pengaruh Senam Jantung Sehat terhadap Tekanan Darah Penderita Hipertensi di Wilayah Kerja Puskesmas Lepo-Lepo

MEDULA ◽  
2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Amiruddin Eso ◽  
Dwi Pascawitasari ◽  
I Putu Sudayasa
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Intervention Group ◽  
Health Centers ◽  
Wilcoxon Test ◽  
Control Group ◽  
Parasympathetic Nerve ◽  
Hypertensive Patients ◽  
Before And After

ABSTRACTHypertension is the increase in systolic and diastolic blood pressure that occurs persistently. Healthy heart gymnastic is one of the non pharmacologic therapies for hypertensive patients. Healthy heart gymnastic can increase activity of  parasympathetic nerve and decrease activity of sympathetic nerve, so that could lead decrease of blood pressure. The aim of this research was to find out the effect of healthy heart gymnastic towards blood pressure before and after exercise in hypertensive patients. Research design was quasi experimental with pre test and post test control group design. The Samples were 20 hypertensive patients aged 18 to 65 years, determined by using purposive sampling techniques. Samples were divided into two groups, i.e control group (n=10) consisted of 3 males and 7 females and intervention group (n=10) consisted of 10 females.  Healthy heart gymnastic Intervention implemented during four weeks with modrate intensity (60% MHR) and fifth times in a week. The research was held in Health Centers Lepo-Lepo, Kendari, Southeast Sulawesi. Measurement of blood pressure by indirect method and measurements of pulse pressureby pulse meter. Data were analyzing by paired t test for systolic blood pressure in intervention group and Wilcoxon test for diastolic blood pressure in intervention group.  Data have considered if p value < 0,05. The results have shown  there were significant differences in systolic blood pressure (p = 0,000) and diastolic blood pressure (p = 0,004) before and after healthy heart gymnastic in intervention group. Conclusion of this research is healthy heart gymnastic can decrease blood pressure in hypertensive patients, so that usable as one of alternative treatment in hypertensive patients.Key Words: healthy heart gymnastic, hypertension, decrease of blood pressure, health centers lepo-lepo

EFEKTIVITAS PEMBERIAN HYDROTHERAPI RENDAM KAKI PADA PENDERITA HIPERTENSI DI BANJAR SRI MANDALA, KELURAHAN DAUHWARU KABUPATEN JEMBRANA

2019 ◽  
Vol 10 (01) ◽  
pp. 33-44
Author(s):  
N.L.G. Sudaryati ◽  
I P. Sudiartawan ◽  
Dwi Mertha Adnyana
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Pressure Measurement ◽  
Blood Pressure Measurement ◽  
Reduce Blood Pressure ◽  
Second Grade ◽  
Control Group ◽  
Hypertensive Patients ◽  
First Category

The aim of the study was to determine the effectiveness of giving hydrotherapi foot soak in hypertensive patients. The study was conducted with one group pretestposttest design without a control group by measuring blood pressure (pretest) before being given an intervention in the form of foot soak hydrotherm against 15 people with hypertension in Banjar Sri Mandala, Dauhwaru Village, Jembrana Subregency. Then do the blood pressure measurement again (posttest) after finishing the intervention. After the study was completed, the results showed that before the hydrotherapi foot bath intervention, there were 0% of patients classified as normal, 13.32% in prehypertension category, 60.08% in hypertension category I and 26.60% in hypertension category II. After the intervention was given, there were 13.32% of the patients classified as normal, 66.68% in the prehypertension category, 20.00% in the first category of hypertension and no patients belonging to the second grade hypertension category. There is a decrease of 20-30 mmHg for systolic blood pressure and 0-10 mmHg for diastolic blood pressure after intervention. Based on the results of the study it can be concluded that the hydrotherapi foot bath is effectively used to reduce blood pressure in hypertensive patients in the Banjar Sri Mandala, Dauhwaru Village, Jembrana District.

Landscape of Combination Therapy – Which Way Forward? Proceedings of the Satellite Symposium Held at the ESH European Meeting on Hypertension and Cardiovascular Protection, 27 April 2012, London

2012 ◽  
Vol 8 (3) ◽  
pp. 192
Author(s):  
Patricia Fonseca ◽  
Anna F Dominiczak ◽  
Stephen Harrap ◽  
◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Risk ◽  
Combination Therapy ◽  
Enzyme Inhibitor ◽  
Synergistic Effects ◽  
Term Treatment ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Patients ◽  
Long Term Treatment

Early combination therapy is more effective for hypertension control in high-risk patients than monotherapy, and current guidelines recommend the use of either an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) for first-line therapy in patients younger than 55 years. Recent evidence shows that ACEIs reduce mortality, whereas ARBs show no apparent benefit despite their blood pressure lowering action. However, it is important to consider which blood pressure parameters should be targeted given that different drugs have distinct effects on key parameters. Remarkably, a high percentage of hypertensive patients whose treatment has brought these parameters within target ranges still remain at high risk of cardiovascular disease due to additional risk factors. Combination therapy with synergistic effects on blood pressure and metabolic control should thus be considered for the long-term treatment of hypertensive patients with co-morbid conditions.

ASSESSING THE OUTCOMES OF TREATMENT AND MANAGEMENT, 400 HYPERTENSIVE PATIENTS IN BONG SON GENERAL HOSPITAL, BINH DINH PROVINCE

2016 ◽  
pp. 31-40
Author(s):  
Long Nhon Phan ◽  
Van Minh Huynh ◽  
Thi Kim Nhung Hoang ◽  
Van Nham Truong
Keyword(s):  
Blood Pressure ◽  
Risk Stratification ◽  
Hypertensive Patient ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Blood Pressure Target ◽  
Average Risk ◽  
Hypertensive Patients ◽  
Average Systolic Blood Pressure ◽  
Complications Of Stroke

Objective: To evaluate the results of treatment achieved blood pressure goal (BP goal) and results of hypertensive patient management. Subjects and methods: A study of 400 hypertensive patient intervention, treatment and management after 2 year. To assess the results of BP target, monitor the use of medicines, the situation of hospitalization and complications of stroke. Results: Treatment: -100% of patients using diuretics and angiotensin-converting enzyme inhibitors (ACEIs), 33% of patients using angiotensin receptor blockers (ARBs), 46.25% of patients using calcium channel blockers (CCBs) and 19.5% of patients using beta-blocker. After 24 months of treatment: 50.5% of patients using 1 antihypertensive drug, 22% of patients using 2 drugs, 20.5% of patients using 3 drugs and 7% of patients taking more than 3 drugs. After 24 months of treatment: 91.75% achieved BP target and 8.25% fail. -Average risk stratification: 97.32% achieved BP target, hight risk stratification: 95.91% and very hight risk stratification: 73.03%. After 24 months of treatment. -Stage 1: 88.48% achieved BP target, stage 2: 92.85% achieved BP target and stage 3: 71.08% achieved BP target. After 24 months of treatment. -Hypertesive results before treatment were: 159.80 ± 20,22mmHg average systolic blood pressure and 82.97 ± 5,82mmHg average diastolic blood pressure. After treatment: average systolic blood pressure 125.38 ± 6,88mmHg and average diastolic blood pressure 79.83 ± 1,79mmHg. No adverse change in the index of tests about lipidemia, liver, kidney, glucomia and no recorded cases of drug side effects. Management of patients: -There were 89% non-medical examinational patients 1 month, 5.25% non-medical examinational patients 2 months, 4.25% non-medical examinational patients 3 months and 1.5% non-medical examinational patients 4 months. There were 93.5% drop pill 1 month, 3.25% drop pill 2 months, 4.25% drop pill 3 months and no patient drop pill over 3 months. In 24 months follow-up, 47% hospitalized inpatients <5 times, 44.5% hospitalized inpatients 5-10 times, 3% hospitalized inpatients 11-15 times, 4.75% hospitalized inpatients from 16-20 times and 0.75% hospitalized inpatients > 20 times. -There were 32.75% hospitalized inpatients for reasons of hypertension and 63.75% hospitalized inpatients for other common diseases. -There were a total of 11592 contacts directly by phone for medical advice, medical reminders and examinational reminders during 24 months of management. -There were 0.5% of patients stroked during 24 months of treatment and management. Conclusion: Treatment by protocol and management by phone directly for medical taking and re-examinational reminders is the best resulted method of achieving blood pressure target and reducing complications of stroke for hypertensive patients. Key word: : blood pressure target; risk stratification; treatment; management; stage; phone.

Bioinformatics Study on Serum Triglyceride Levels for Analysis of a Potential Risk Factor Affecting Blood Pressure Variability

2019 ◽  
Vol 14 (5) ◽  
pp. 376-385 ◽  
Author(s):  
Lin Xu ◽  
Jiangming Huang ◽  
Zhe Zhang ◽  
Jian Qiu ◽  
Yan Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Partial Correlation ◽  
Pearson Correlation ◽  
Target Organ Damage ◽  
Serum Triglyceride ◽  
Hypertensive Patients ◽  
Group A ◽  
Group B

Objective: The purpose of this study was to establish whether Triglycerides (TGs) are related to Blood Pressure (BP) variability and whether controlling TG levels leads to better BP variability management and prevents Cardiovascular Disease (CVD). Methods: In this study, we enrolled 106 hypertensive patients and 80 non-hypertensive patients. Pearson correlation and partial correlation analyses were used to define the relationships between TG levels and BP variability in all subjects. Patients with hypertension were divided into two subgroups according to TG level: Group A (TG<1.7 mmol/L) and Group B (TG>=1.7 mmol/L). The heterogeneity between the two subgroups was compared using t tests and covariance analysis. Results: TG levels and BP variability were significantly different between the hypertensive and non-hypertensive patients. Two-tailed Pearson correlation tests showed that TG levels are positively associated with many BP variability measures in all subjects. After reducing other confounding factors, the partial correlation analysis revealed that TG levels are still related to the Standard Deviation (SD), Coefficient of Variation (CV) of nighttime systolic blood pressure and CV of nighttime diastolic blood pressure, respectively (each p<0.05). In the subgroups, group A had a lower SD of nighttime Systolic Blood Pressure (SBP_night_SD; 11.39±3.80 and 13.39±4.16, p=0.011), CV of nighttime systolic blood pressure (SBP_night_CV; 0.09±0.03 and 0.11±0.03, p=0.014) and average real variability of nighttime systolic blood pressure (SBP_night_ARV; 10.99±3.98 and 12.6±3.95, p=0.024) compared with group B, even after adjusting for age and other lipid indicators. Conclusion: TG levels are significantly associated with BP variability and hypertriglyceridemia, which affects blood pressure variability before causing target organ damage.

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