Estimated doses of melatonin for treating deadly virus infections: focus on COVID-19

2020 ◽  
Vol 3 (3) ◽  
pp. 276-296 ◽  
Author(s):  
Dun-Xian Tan ◽  
Rüdiger Hardeland
Keyword(s):  
Adverse Effect ◽  
Animal Studies ◽  
Viral Infections ◽  
Biological Significance ◽  
The Other ◽  
Virus Infections ◽  
Limited Disease ◽  
Daily Dose ◽  
Long Term Experience

Increased evidence implies that melatonin may be a promising molecule for combating COVID-19 due to its potent antioxidative, anti-inflammatory and immunoregulatory capacities. A frequently asked question concerns the suitable dosage of melatonin for deadly virus infections including COVID-19 patients. The golden standards for a suitable dosage of medicine are safety and effectiveness. By reviewing the pharmacokinetics as well as animal studies and clinical trials of melatonin in the deadly viral infections and sepsis, we estimate that a dose of 8 mg/kg/day of melatonin is suitable for COVID-19 patients, especially for the severe cases. To maintain an elevated melatonin serum level lasting longer and smoother, this daily dose can be divided into 5 sub-doses with the initial dose of doubling over the other sub-doses. The recommended dose is in the ranges used to treat septic patients clinically and is devoid of any adverse effect; thus, it is safe. This dose is calculated from an effective dose which significantly reduces the mortality of virus-infected mice and is, therefore, assumed to be effective for COVID-19 severe patients. In our opinion, a dose or a medicine which can only improve the symptoms of mild or moderately severe patients of COVID-19 lack biological significance since virus infection is a self-limited disease and most of the patients with mild or moderate symptoms will recover by themselves whether treated or not. A meaningful treatment is to target the severe patients and significantly reduce the resulting mortality. The suggested melatonin dose is, thus, mainly recommended for the severe COVID-19 patients. The possibility of using suppositories for the delivery of highly dosed melatonin is also addressed, since long-term experience with this treatment is available for another disease. 

scholarly journals Patients with Severe Asthma: Analysis of Future Risks

2021 ◽  
Vol 15 (5) ◽  
pp. 893-897
Author(s):  
Sajida Parveen ◽  
Ghufran Zafar ◽  
Rukhshanda Nosheen
Keyword(s):  
Adverse Effect ◽  
Severe Asthma ◽  
Acute Asthma ◽  
The Other ◽  
Lung Damage ◽  
Routine Practice ◽  
Asthma Risk ◽  
Oral Corticosteroids ◽  
Keywords Asthma

The upcoming severe health problems can be due to the asthmatic burdens. Severe asthma can lead to dangerous exacerbation and damage of pulmonary function. It can also affect medication-related problems for example steroids. In routine practice, the risk of asthma is not easily detectable. The present tools for the measurement and diagnosis of asthma and asthma-related morbidity cannot surely predict the upcoming risks of morbidity due to medication. The article reviews the existing evidence of upcoming danger in people with asthma. This review is pivoted on the danger in people with “controlled” acute asthma. It is obvious from some studies that long-term use of corticosteroids cannot stop the progression of asthma and lung damage. The other results show that the adverse effect of the drugs increases even with the lesser dose of oral corticosteroids. So, there is a need for new therapies for the reduction of upcoming risks due to asthma. Keywords: Asthma, Risk, Severity.

scholarly journals Can Aaripiprazole Normalize Yatrogenic Hyperprolactinemia?

2020 ◽  
Author(s):  
Roberto Lozano ◽  
Reyes Marin ◽  
Asuncion Pascual ◽  
María-Jesús Santacruz
Keyword(s):  
Adverse Effect ◽  
Metabolic Syndrome ◽  
Combined Treatment ◽  
The Other ◽  
Gonadal Function ◽  
Short Term ◽  
Thromboembolic Risk ◽  
Partial Dopamine Agonist ◽  
The Ideal

Aripiprazole is a second generation atypical antipsychotic (AAP), with properties of partial dopamine agonist, used in schizophrenia, bipolar disorder and depression, among others. On the other hand, the side effects associated with AAP treatment are drug-specific, with hyperprolactinemia and metabolic syndrome being some of the most important. Hyperprolactinemia is an adverse effect with consequences both in the short term, alterations in gonadal function and parkinsonism, and in the long term, osteopenia-osteoporosis, metabolic syndrome and / or increased thromboembolic risk. Therefore, normalization or reduction of prolactinemia is sufficient to avoid them. According to our results, aripiprazole would be the ideal component for the combined treatment with those other antipsychotics that cause hyperprolactinemia, such as risperidone, reducing it and alleviating or eliminating the adverse effects derived from chronic hyperprolactinemia.

Speech Playing Heading of Modern Printed Mass-Media as a Form of Communication

2016 ◽  
Vol 5 (3) ◽  
pp. 52-55
Author(s):  
Тортунова ◽  
I. Tortunova
Keyword(s):  
Mass Media ◽  
The Other ◽  
Modern Media ◽  
Other Hand ◽  
The Press ◽  
Media Texts ◽  
Long Term Experience

Research is sanctified to the analysis of the modern heading of materials of printed mass-media as form of communication. Description of basic forms of speech game is in-process given, correlation of heading is analysed with maintenance of material and format of newspaper and magazine. An author examines heading, from one side, as independent texts due to that modern mediacommunication comes true. On the other hand, indissoluble connection of maintenance of the article and his title is illuminated. Long-term experience of author is in-process systematized in research of heading of the news materials and reasons, presented in the press of entertaining character. An author offers the classification of forms of speech game, based on the philological analysis of modern media-texts.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

Long Term Experience with Seawalls on an Exposed Coast

1989 ◽  
Author(s):  
Orville T. Magoon ◽  
Joan L. Pope ◽  
Robert L. Sloan ◽  
Donald D. Treadwell
Keyword(s):  
Long Term Experience

Hidden “holes” in the capital of banks and the supply of credit to the real sector of economy

2018 ◽  
pp. 49-68 ◽  
Author(s):  
M. E. Mamonov
Keyword(s):  
Credit Risk ◽  
The Other ◽  
Real Sector ◽  
Capital Management ◽  
Loan Loss ◽  
Short Term ◽  
The Real ◽  
Ex Post ◽  
The One

Our analysis documents that the existence of hidden “holes” in the capital of not yet failed banks - while creating intertemporal pressure on the actual level of capital - leads to changing of maturity of loans supplied rather than to contracting of their volume. Long-term loans decrease, whereas short-term loans rise - and, what is most remarkably, by approximately the same amounts. Standardly, the higher the maturity of loans the higher the credit risk and, thus, the more loan loss reserves (LLP) banks are forced to create, increasing the pressure on capital. Banks that already hide “holes” in the capital, but have not yet faced with license withdrawal, must possess strong incentives to shorten the maturity of supplied loans. On the one hand, it raises the turnovers of LLP and facilitates the flexibility of capital management; on the other hand, it allows increasing the speed of shifting of attracted deposits to loans to related parties in domestic or foreign jurisdictions. This enlarges the potential size of ex post revealed “hole” in the capital and, therefore, allows us to assume that not every loan might be viewed as a good for the economy: excessive short-term and insufficient long-term loans can produce the source for future losses.

Interrelationships between municipal spatial policy strategy and airport operation and development. Lodz Airport case study

2018 ◽  
Vol 59 (1) ◽  
pp. 65-79
Author(s):  
Katarzyna Nikorowicz-Zatorska
Keyword(s):  
Land Use ◽  
Urban Planning ◽  
Cultural Development ◽  
The Other ◽  
Local Authorities ◽  
Spatial Management ◽  
The One ◽  
Surrounding Areas

Abstract The present paper focuses on spatial management regulations in order to carry out investment in the field of airport facilities. The construction, upgrades, and maintenance of airports falls within the area of responsibility of local authorities. This task poses a great challenge in terms of organisation and finances. On the one hand, an active airport is a municipal landmark and drives local economic, social and cultural development, and on the other, the scale of investment often exceeds the capabilities of local authorities. The immediate environment of the airport determines its final use and prosperity. The objective of the paper is to review legislation that affects airports and the surrounding communities. The process of urban planning in Lodz and surrounding areas will be presented as a background to the problem of land use management in the vicinity of the airport. This paper seeks to address the following questions: if and how airports have affected urban planning in Lodz, does the land use around the airport prevent the development of Lodz Airport, and how has the situation changed over the time? It can be assumed that as a result of lack of experience, land resources and size of investments on one hand and legislative dissonance and peculiar practices on the other, aviation infrastructure in Lodz is designed to meet temporary needs and is characterised by achieving short-term goals. Cyclical problems are solved in an intermittent manner and involve all the municipal resources, so there’s little left to secure long-term investments.

Assessment of micro and macro nutrients in poultry feeds available in Dhaka city, Bangladesh.

2017 ◽  
Vol 1 ◽  
pp. 264
Author(s):  
Md Didarul Islam ◽  
Ashiqur Rahaman ◽  
Fahmida Jannat
Keyword(s):  
Heavy Metals ◽  
Adverse Effect ◽  
The Other ◽  
Nutrient Level ◽  
Dhaka City ◽  
Toxic Heavy Metals ◽  
High Concentration ◽  
Low Concentration ◽  
Feed Formulation ◽  
Macro Nutrients

This study was based on to determine the concentration of macro and micro nutrients as well as toxic and nontoxic heavy metals present in the chicken feed available in Dhaka city of Bangladesh. All macro nutrients, if present in the feed at high concentration have some adverse effect, at the same time if this nutrient present in the feed at low concentration this have some adverse effect too. So that this nutrient level should be maintained at a marginal level. On the other side toxic heavy metals if present in the feed at very low concentration those can contaminate the total environment of the ecosystem. In this study six brand samples (starter, grower, finisher and layer) which was collected from different renowned chicken feed formulation industry in Bangladesh. Those samples were prepared for analysis by wet ashing and then metals were determined by Atomic Absorption Spectroscopy. It was found that 27.7 to 68.4, 57.3 to 121.9, 0.21 to 4.1, 0.32 to 2.1, 0.11 to 1.58, 0.28 to 2.11 and 0.28 to 1.78 for zinc, iron, copper, mercury, cadmium, nickel and cobalt respectively. It was found that essential macro and micro nutrients were present in the feed in low concentration on the other side mercury was present in high concentration in the feed samples.

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