Hubungan Derajat Aktivitas Penyakit Lupus Eritematosus Sistemik Berdasarkan Skor Mex-Sledai Dengan  Kejadian Anemia  Pada Penderita Lupus Eritematosus Sistemik Di  Komunitas Odapus Lampung

ABSTRACT : RELATIONSHIP OF SYSTEMIC LUPUS ERYTHEMATOSUS ACTIVITIES BASED ON MEX-SLEDAI SCORE WITH INCIDENCE OF ANEMIA IN SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS IN THE ODAPUS LAMPUNG COMMUNITY, 2020Background : Systemic Lupus Erytematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against the cell nucleus and involving many organ systems in the body. Anemia in LES patients varies between chronic disease anemia, hemolytic anemia, blood loss, renal insufficiency, infection, myelodysplasia, and aplastic anemia. What often occurs in LES anemia is due to erythropoesis suppression due to chronic inflammation. Anemia in LES patients is an immune or non-immune disease. Anemia is a non-immune disease is anemia in chronic disease, iron deficiency anemia, sideroblastic anemia, anemia in kidney disease, anemia indicated by drugs, and anemia secondary to other diseases (eg sickle cell anemia).Research purposes : This study was to determine the degree of activity of systemic lupus erythematosus based on max-sledai and hemoglobin levels in systemic lupus erythematous patients in the ODAPUS Lampung community in 2020.Methode :The analytical observational method was used using a cross sectional approach. The research subjects were 30 respondents who used the total sampling technique from members of the ODAPUS Lampung community by conducting MEX-SLEDAI interviews and blood sampling conducted from November 2019 to February 2020. Statistical test used Fisher exact test.Results: From 30 study subjects, disease activity based on MEX-SLEDAI was above the average of 21 patients (70%). And the results of blood tests were 18 patients (60%) who were not anemia and 12 patients (40%) had anemia.Conclusion : There was a significant relationship between the degree of activity of Systemic Lupus Erythematosus based on the MEX-SLEDAI score and the incidence of anemia with p value = 0.024 meaning the p value ≤ 0.05. Keywords : LES; Incidence of Anemia; MEX-SLEDAI INTISARI : HUBUNGAN DERAJAT AKTIVITAS PENYAKIT LUPUS ERITEMATOSUS SISTEMIK BERDASARKAN SKOR MEXSLEDAI DENGAN KEJADIAN ANEMIA PADA PENDERITA LUPUS ERITEMATOUS SISTEMIK DI KOMUNITAS ODAPUS LAMPUNG Latar belakang : Systemic Lupus Erytematosus (SLE) merupakan penyakit autoimun yang kompleks ditandai oleh adanya autoantibodi terhadap inti sel dan melibatkan banyak sistem organ dalam tubuh. Anemia pada pasien LES bervariasi antara anemia penyakit kronis, anemia hemolitik, kehilangan darah, insufisiensi ginjal, infeksi, mielodisplasia, dan anemia aplastik. Yang sering terjadi anemia pada LES disebabkan supresi eritropoesis karena inflamasi yang kronis. Anemia pada pasien LES merupakan penyakit imun atau non-imun. Anemia merupakan penyakit non-imun adalah anemia pada penyakit kronik ,anemia defisiensi besi, anemia sideroblastik, anemia pada penyakit ginjal, anemia indikasi obat, dan anemia sekunder terhadap penyakit lain ( misalnya anemia sel sabit ).Tujuan Penelitian : Penelitian ini untuk mengetahui hubungan drajat aktivitas penyakit lupus eritematosus sistemik berdasarkan max-sledai dengan kadar hemoglobin pada penderita lupus eritematous sistemik di komunitas ODAPUS lampung tahun 2020.Metode : Digunakan metode observasional analitik menggunakan pendekatan cross sectional. Subjek penelitian sebanyak 30 responden yang menggunakan teknik total sampling dari anggota komunitas ODAPUS Lampung dengan melakukan wawancara MEX-SLEDAI dan pengambilan sampel darah yang dilakukan pada bulan November 2019 s/d Februari 2020. Uji statistic menggunakan Fisher exact test.Hasil : Dari 30 subjek penelitian didapatkan aktifitas penyakit berdasarkan MEX-SLEDAI di atas rata – rata sebanyak 21 pasien (70%). Dan hasil peneriksaan darah yaitu 18 pasien (60%) yang Tidak anemia dan yang mengalami Anemia ada 12 pasien (40%).Kesimpulan : Terdapat hubungan bermakna antara derajat aktivitas penyakit Lupus Eritematosus Sistemik berdasarkan skor MEX-SLEDAI dengan Kejadian Anemia dengan p value =0.024 berarti nilai p value ≤ 0.05. Kata Kunci : LES; Kejadian Anemia; MEX-SLEDAI

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Hubungan Derajat Aktivitas Penyakit Lupus Eritematosus Sistemik Berdasarkan Skor Mex-Sledai Dengan Kejadian Anemia Pada Penderita Lupus Eritematosus Sistemik Di Komunitas Odapus Lampung

Malahayati Nursing Journal ◽

10.33024/manuju.v3i2.3596 ◽

2021 ◽

Vol 3 (2) ◽

pp. 192-202

Author(s):

Rina Kirwiastiny ◽

Ringgo Alfarisi ◽

Hidayat Hidayat ◽

Ageel Al-Aziz Marjaen

Keyword(s):

Systemic Lupus Erythematosus ◽

Chronic Disease ◽

Lupus Erythematosus ◽

Deficiency Anemia ◽

P Value ◽

Systemic Lupus Erythematous ◽

Systemic Lupus ◽

Immune Disease ◽

Cross Sectional ◽

Sledai Score

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Hubungan Aktifitas Penyakit SLE (Systemic Lupus Erythematosus) Berdasarkan Mex-Sledai Scoring Terhadap Depresi Di Komunitas Odapus Kota Bandar Lampung

MAHESA : Malahayati Health Student Journal ◽

10.33024/mahesa.v1i4.3949 ◽

2021 ◽

Vol 1 (4) ◽

pp. 370-382

Author(s):

Rina Kriswiastiny ◽

Festy Ladyani Mustofa ◽

Syuhada Syuhada ◽

Reychan Gustiawan Putra

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Health Sector ◽

Point Of View ◽

P Value ◽

Systemic Lupus Erythematosus Disease ◽

Systemic Lupus ◽

Cross Sectional ◽

Cross Sectional Design

ABSTRACT: RELATIONSHIP OF SLE (SYSTEMIC LUPUS ERYTHEMATOSUS) ACTIVITIES BASED ON MEX-SLEDAI SCORING ON DEPRESSION IN ODAPUS COMMUNITIES BANDAR LAMPUNG Background: Depression is a clinical manifestation that can occur in patients with SLE and it is suspected that the level of SLE disease activity can affect these events (Nery, et al. 2007). Ironically, this section is a part that is often overlooked by many people, including the health sector. In fact, by understanding this point of view, cross-scientific collaborative treatment such as the Internal and Psychiatry Fields can be done to improve the treatment and quality of life of patients.Objective: To determine the relationship between SLE (Systemic lupus Erythematosus) disease activity based on MEX-SLEDAI Scoring against depression in the Odapus Community, Bandar Lampung City 2020.Methodology: The type of research used in this study is correlative analytic with cross-sectional design. The sample used in this study were patients with SLE (Systemic lupus Erythematosus) based on MEX-SLEDAI Scoring for depression in the Odapus Community, Bandar Lampung City 2020. Data analysis used the Spearman test.Results: In the activity variable SLE and depression, the P value = 0.001 (P <0.05) with a correlation value of r = 0.490 was obtained.Conclusion: There is a relationship between SLE (Systemic lupus Erythematosus) disease activity based on MEX-SLEDAI Scoring against depression in Odapus Community, Bandar Lampung City 2020 with moderate correlation strength. Keywords: Lupus, Depression, MEX-Sledai INTISARI: HUBUNGAN AKTIFITAS PENYAKIT SLE (SYSTEMIC LUPUS ERYTHEMATOSUS) BERDASARKAN MEX-SLEDAI SCORING TERHADAP DEPRESI DI KOMUNITAS ODAPUS KOTA BANDAR LAMPUNGLatar Belakang: Depresi merupakan manifestasi klinis yang dapat muncul pada penderita SLE dan diduga tingkat aktivitas penyakit SLE dapat mempengaruhi kejadian-kejadian tersebut (Nery, dkk. 2007). Ironisnya, bagian ini merupakan bagian yang sering luput diperhatikan oleh banyak orang, termasuk bidang kesehatan. Padahal, dengan memahami sudut pandang ini, pengobatan kolaboratif lintas keilmuan seperti Bidang Interna dengan Bidang Psikiatri dapat dilakukan untuk meningkatkan pengobatan dan kualitas hidup pasien.Tujuan: Untuk mengetahui hubungan aktifitas penyakit SLE (Systemic lupus Erythematosus) berdasarkan MEX-SLEDAI Scoring terhadap depresi di Komunitas Odapus Kota Bandar Lampung 2020.Metodologi: Jenis penelitian yang digunakan dalam penelitian ini adalah analitik korelatif dengan desain cross sectional. Sampel yang digunakan pada penelitian ini adalah penderita penyakit SLE (Systemic lupus Erythematosus) berdasarkan MEX-SLEDAI Scoring terhadap depresi di Komunitas Odapus Kota Bandar Lampung 2020. Analisa data menggunakan Uji Spearman.Hasil: Pada variabel aktifitas penyakit SLE dan depresi diperoleh nilai P value = 0,001 (P<0,05) dengan nilai korelasi r = 0,490.Kesimpulan: Terdapat hubungan aktifitas penyakit SLE (Systemic lupus Erythematosus) berdasarkan MEX-SLEDAI Scoring terhadap depresi di Komunitas Odapus Kota Bandar Lampung 2020 dengan kekuatan korelasi sedang.Kata Kunci : Lupus, Depresi, MEX-Sledai

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Resilience and Treatment Adhesion in Patients with Systemic Lupus Erythematosus

The Open Rheumatology Journal ◽

10.2174/1874312920140127001 ◽

2014 ◽

Vol 8 (1) ◽

pp. 1-8 ◽

Cited By ~ 15

Author(s):

Daniella Antunes Pousa Faria ◽

Luciana Silva Revoredo ◽

Maria José Vilar ◽

Maia Eulália Maria Chaves

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Demographic Data ◽

Working Hours ◽

Cross Sectional Study ◽

P Value ◽

Systemic Lupus ◽

Chi Square ◽

Access To Treatment ◽

Cross Sectional

Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune, rheumatic inflammatory disease that can cause significant morbidity with evident psychological impacts and obvious harm to quality-of-life that require the patient to adapt treatment. Objective: Assessment of resilience and the self-reported treatment adhesion behaviors of patients with SLE, investigating which of these factors are associated to resilience. Method: Cross-sectional study of 40 women with SLE. A questionnaire with social demographic data, health history and the Wagnild Young Resilience Scale were used. Results: 62.5% followed the medical treatment properly but 55% found it difficult. 27.5% of the patients presented low resilience, 57.5% medium and 15% high resilience. Resilience was associated in the chi-square test (p-value < 0.05) with the variables work, understanding SLE, trying to find out about SLE, following the treatment correctly, difficulty in following the treatment and stopping some activity because of the disease. In the correlation analysis, resilience was associated with age (-0.3960), number of working hours (0.5533), specialized treatment duration (-0.8103) and disease duration from diagnosis (-0.8014). Conclusion: Patients with high resilience tended to follow treatment correctly, tried to understand the disease and adhered more to the treatment to avoid risks and promote protection factors. Therefore knowledge of resilience in patients with SLE is necessary. It is important that the state takes necessary actions to facilitate access to treatment, to educational programs and to medical support. Awareness and counselling sessions must be initiated to develop and promote individual capacities to learn how to tackle with the disease for which psychological support of family and doctors can play a significant role.

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Serum Osteoprotegerin Level as a Risk Factor for Atherosclerosis in Systemic Lupus Erythematosus Patients: A Cross Sectional Study

Biomedical & Pharmacology Journal ◽

10.13005/bpj/2246 ◽

2021 ◽

Vol 14 (3) ◽

pp. 1435-1447

Author(s):

Shrookmousa S ◽

Ahmed Laymouna ◽

NagwaAbd El Ghaffar Mohamed ◽

Mary Wadie ◽

Mariana V Philip

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Subclinical Atherosclerosis ◽

Intima Media Thickness ◽

Cross Sectional Study ◽

P Value ◽

Qtc Interval ◽

Sectional Study ◽

Systemic Lupus ◽

Cross Sectional

Background: Prediction ofthe risk of atherosclerosis in Egyptian patients with systemic lupus erythematosus (SLE) by measuring serum osteoprotegerin (OPG) level and correlation between OPG levels and SLE disease activity (assessed by Systemic Lupus Erythematosus Disease Activity Index [SLEDAI] score), is the aim of this study. Methods:A cross sectional study in which all patients were subjected to full medical history, full clinical examination (with special emphasis to SLE symptoms and signs e.g. photosensitivity, arthralgia, arthritis, malar rash, blood pressure and lower limb edema), laboratory investigations (CBC, random blood sugar [RBS], ESR, albumin/creatinine ratio, serum urea and creatinine, serum albumin, C3, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium and phosphorus). Electrocardiography (ECG) was done to calculate QTc interval using Bazett’s formula: QTC = QT / √ RR. Serum osteoprotegerin level was measured using ELISA technique. All participants were subjected to imaging in the form of: Carotid duplex: to assess intima-media thickness just two cm before carotid bifurcation, and to assess any plaques, if present. Also brachial artery flow mediated dilatation method: for detection of subclinical atherosclerosis. Results: There was a statistically significant negative correlation between serum levels of osteoprotegerin and brachial flow mediated dilation percentage (FMD %) values (P value > 0.001) which means a significant correlation between high serum OPG levels and subclinical atherosclerosis in SLE patients. There were statistically significant differences between SLE cases and controls in right and left carotid intima-media thickness (P value: 0.034 & 0.036 respectively), serum osteoprotegerin levels (P value: > 0.001) and QTc values (P value: 0.011) which were all statistically significantly higher in SLE patients, while brachial FMD % was statistically significantly lower in SLE patients than in controls (P value: > 0.001). Also, there was a statistically significant positive correlation between serum OPG levels and QTc interval (P value: 0.006). Conclusion: We have concluded that serum OPG level has a significant correlation with subclinical atherosclerosis and endothelial dysfunction, which was measured by CIMT and brachial mediated flow dilation method.

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Association of anti dsDNA antibodies titer with non-renal manifestations of Systemic Lupus Erythematosus and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)

Journal of Fatima Jinnah Medical University ◽

10.37018/gpgq6331 ◽

2021 ◽

Vol 15 (1) ◽

pp. 35-39

Author(s):

Sadaf Andleeb ◽

Tafazzul-E-Haque Mahmud ◽

Aflak Rasheed ◽

Muhammad Shahid Mehmood ◽

Iram Gull ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Activity Index ◽

P Value ◽

Systemic Lupus ◽

Cutaneous Manifestations ◽

Sledai Score ◽

The Mean ◽

Dsdna Antibodies

Background: Early diagnosis and effective treatment in systemic lupus erythematosus (SLE) has very crucial role. Anti dsDNA is very important diagnostic tool and activity marker in SLE. This study aimed to determine the association of anti dsDNA antibodies titer with non-renal manifestations of systemic lupus erythematosus and systemic lupus erythematosus disease activity index (SLEDAI). Patients and methods: It was a cross-sectional study and was carried out at Department of Rheumatology and Immunology, Tertiary Care Hospital, Lahore from Feb 2021 to May 2021. The study involved 69 male and female patients satisfying the systemic lupus international collaborating clinics (SLICC) classification criteria. Questions regarding different symptoms were asked and disease activity parameters were noted excluding renal parameters. Anti-dsDNA titers were measured from standard laboratory using immunofluorescence technique and were correlated with SLEDAI score. A written informed consent was obtained from every patient. Results: The mean age of the patients was 30.7±10.2 years while the mean duration of disease 1.94±2.65 years. We observed a female predominance among these patients with male to female ratio of 1:7.6. There were fifty-four (78.3%) patients with active disease. The mean anti-dsDNA levels were significantly higher in patients with active disease (315.73±481.68 vs. 78.46±113.64 IU/mL; p-value=0.003). There was a significantly strong positive correlation between anti-dsDNA levels and SLEDAI score (r=0.358; p-value=0.006). When compared, significant difference was observed in mean anti-dsDNA titers in patients with chronic cutaneous manifestations (p-value=0.040), lymphopenia (p-value= 0.012), pleurisy/pericarditis (p-value= 0.024) and leukopenia <3000/mm3 (p-value= 0.001). Conclusion: Anti-dsDNA antibodies titers are remarkably increased in patients with non-renal manifestations of systemic lupus erythematosus particularly with chronic cutaneous manifestations and leukopenia and positively correlate with disease activity status and SLEDAI score.

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B-Cell-Attracting Chemokine CXCL13 As a Marker of Disease Activity in Systemic Lupus Erythematosus (SLE)

Aktuelle Rheumatologie ◽

10.1055/s-0043-121875 ◽

2017 ◽

Vol 44 (02) ◽

pp. 115-120

Author(s):

Eman Omran ◽

Eman El-Hakeim ◽

Marwa Galal ◽

Nada Nasr ◽

Eman Mosaad

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Significant Positive Correlation ◽

Full Blood Count ◽

P Value ◽

Systemic Lupus ◽

Urine Protein ◽

Sledai Score ◽

Positive Correlation

Abstract Background A correlation was detected between the chemokine CXC ligand 13 (CXCL13) and lupus nephritis, but there is no data recorded in the literature about a relationship with other disease manifestations in systemic lupus erythematosus (SLE). Therefore, we sought to investigate the relationship between CXCL13 and overall disease activity and other disease manifestations in SLE. Patients and Methods Fifty-seven SLE patients (51 female, 6 male) aged 18–60 years, fulfilling≥4 SLICC classification criteria for the classification of SLE, were enrolled in a cross-sectional study. Disease activity was scored using the SLE Disease Activity Index (SLEDAI) scoring system. The serological workup included routine lab investigations (full blood count, liver and kidney function tests, and urinalysis) as well as ESR, CRP, anti-ds DNA, C3, C4, 24-h urine protein, and creatinine clearance. Plasma CXCL13 levels were detected by ELISA. Results CXCL13 levels were elevated in active SLE patients. A significant positive correlation was found between the total score of SLEDAI and CXCL13 levels (r=0.547, p-value <0.0001). A statistically significant difference was found regarding the mean CXCL13 levels between the patient groups (classified according to SLEDAI score) (inactive <3, mild/moderate ≥3–12, severe ˃12) (p-value<0.001). The anti-ds DNA antibody titre showed a significant positive correlation with CXCL13 levels (r=0.335, p-value<0.05). The complement levels (C3, C4) showed a significant negative correlation with CXCL13 levels (p-value<0.001). Also there was a significant positive correlation between 24-h urine protein and urinary casts and CXCL13 levels (p-value<0.05). Conclusion Our study revealed elevated levels of serum CXCL13 in active SLE patients. We demonstrated a highly significant positive correlation between serum CXCL13 levels in active SLE patients and SLE disease activity, which supports the role of CXCL13 in the pathogenesis of SLE disease and its activity. Among the variants used in calculating the SLEDAI score, we detected significant relations between level of serum CXCL13 and each of total and extra-renal SLEDAI score.

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Hubungan Derajat Penyakit Terhadap Kualitas Tidur Pasien Systemic Lupus Erythematosus Di Komunitas Odapus Lampung

MAHESA : Malahayati Health Student Journal ◽

10.33024/mahesa.v1i4.3992 ◽

2021 ◽

Vol 1 (4) ◽

pp. 461-470

Author(s):

Festy Ladyani Mustofa ◽

Fitra Editama

Keyword(s):

Systemic Lupus Erythematosus ◽

Sleep Quality ◽

Lupus Erythematosus ◽

Bivariate Analysis ◽

P Value ◽

Poor Sleep ◽

Systemic Lupus ◽

Chi Square ◽

Cross Sectional ◽

The Relationship

ABSTRACT: RELATIONSHIP OF SLEEP DISEASE TO SLEEP QUALITY OF SYSTEMIC LUPUS ERYTHEMATOUS PATIENTS IN ODAPUS COMMUNITY LAMPUNGBackground: Systemic Lupus Erythematosus (SLE) is a disease that attacks the immune system that has no known cause and which can damage various organs of the human body. The clinical symptoms of SLE patients depend largely on the area of the organs involved. Symptoms of SLE are classified into three degrees, namely mild, moderate, and severe. Based on the evaluation of SLE disease activity, patients with SLE may experience sleep disturbances. So the authors conducted a study examining the relationship between degrees of disease and sleep quality. Objective: To determine the relationship between the degree of disease and the sleep quality ofpatients systemic lupus erythematosus in the ODAPUS community in Lampung 2020. Research Methods: this type of research is an observational analytic study with primary data using a questionnaire with aapproach cross-sectional. The sample of this study was all 40 patients who joined the ODAPUS community in Lampung. Data analysis used univariate and bivariate analysis using tables in data presentation. Results: From the results of the bivariate analysis, it is known that there is a significant relationship between the degree of disease and the sleep quality ofpatients systemic lupus erythematosus in the ODAPUS Lampung 2020 community. This is evidenced by thetest Chi Square with a P value of 0.008 with (α) = 5% then P <0.05. Also obtained an OR 11,625 (95% CI 1,467-92,139), which means that respondents with a severe disease degree were 11.625 times more likely to have poor sleep quality than those with mild disease degrees. Conclusion: There is a relationship between the degree of disease and the sleep quality ofpatients systemic lupus erythematosus in the ODAPUS community in Lampung 2020. Keywords: Disease Degree, Sleep Quality, SLE INTISARI: HUBUNGAN DERAJAT PENYAKIT TERHADAP KUALITAS TIDUR PASIEN SYSTEMIC LUPUS ERYTHEMATOSUS DI KOMUNITAS ODAPUS LAMPUNG Latar Belakang: Systemic Lupus Erythematosus (SLE) merupakan penyakit yang menyerang sistem kekebalan tubuh yang tidak dapat diketahui penyebabnya dan yang dapat merusak berbagai organ tubuh manusia. Gejala klinis dari pasien SLE sangat bergantung pada daerah organ yang terlibat. Gejala SLE dikelompokan menjadi tiga derajat yaitu ringan, sedang, dan berat. Berdasarkan evaluasi pada aktivitas penyakit SLE, pasien penderita SLE dapat mengalami gangguan tidur. Sehingga penulis melakukan penelitian yang mengkaji tentang hubungan derajat penyakit terhadap kualitas tidur.Tujuan: Untuk mengetahui hubungan antara derajat penyakit terhadap kualitas tidur pasien systemic lupus erythematosus di komunitas ODAPUS Lampung 2020.Metode Penelitian: Jenis penelitian ini adalah analitik observasional dengan data primer menggunakan kuesioner dengan pendekatan Cross- sectional. Sampel penelitian ini adalah seluruh pasien yang bergabung di komunitas ODAPUS Lampung sebanyak 40 orang. Analisis data menggunakan analisis univariat dan bivariat dengan menggunakan tabel dalam penyajian data.Hasil: Dari hasil analisis bivariat diketahui bahwa adanya hubungan yang bermakna antara derajat penyakit terhadap kualitas tidur pasien systemic lupus erythematosus di komunitas ODAPUS Lampung 2020. Hal ini dibuktikan berdasarkan uji Chi Square dengan nilai P value sebesar 0,008 dengan (α) = 5% maka P < 0,05. Diperoleh pula OR 11,625 (95% CI 1,467-92,139) yang berarti bahwa responden dengan derajat penyakit berat berpeluang 11,625 kali lebih besar memiliki kualitas tidur yang buruk dibandingkan dengan derajat penyakit yang ringan.Kesimpulan: Adanya hubungan antara derajat penyakit terhadap kualitas tidur pasien systemic lupus erythematosus di komunitas ODAPUS Lampung 2020. Kata Kunci : Derajat Penyakit, Kualitas Tidur, SLE

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Interleukin-34 and Disease Activity in Systemic Lupus Erythematosus Patients

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v27i2.1636 ◽

2021 ◽

Vol 27 (2) ◽

pp. 196

Author(s):

Rizki Luly Ya Fatwa Pulungan ◽

Ratna Akbari Ganie ◽

Zuhrial Zubir

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Activity Index ◽

Enzyme Linked Immunosorbent Assay ◽

Close Monitoring ◽

Systemic Lupus Erythematosus Disease ◽

Systemic Lupus ◽

Cross Sectional ◽

Sledai Score

Systemic Lupus Erythematosus (SLE) is characterized by exacerbation and remission, which needs close monitoring ofthe disease activity. Systemic lupus erythematosus disease activity can be determined by the SLE Disease Activity Index(SLEDAI) score. Evaluation of the disease activity is essential to be a guidance for treatment. Interleukin-34 (IL-34) is relatedto the pathogenesis of SLE. Serum IL-34 can be a candidate marker to evaluate SLE disease activity, and it is correlated withthe SLEDAI score. This study aimed to determine the correlation between IL-34 level and disease activity in SLE patientsbased on the SLEDAI (Mex-SLEDAI) score. An observational analytical study with a cross-sectional design was carried out insix months (June-November 2019) in 27 SLE patients in the Department of Internal Medicine, Faculty of Medicine, SumateraUtara University/Adam Malik General Hospital, Medan. Systemic lupus erythematosus disease activity was measured basedon the Mex-SLEDAI score. Serum and urine were collected to obtain the Mex-SLEDAI score and IL-34 level. IL-34 level wasmeasured in all subjects by using Enzyme-Linked Immunosorbent Assay (ELISA). Spearman correlation test was used todetermine the correlation between IL-34 level and disease activity in SLE patients based on the SLEDAI (Mex-SLEDAI) score.There was a significant correlation between IL-34 level and disease activity in SLE patients based on SLEDAI (Mex-SLEDAI)score (r=0.965, p < 0.001). Further studies were needed with a sample of SLE patients in a balanced proportion based ontheir disease activity to obtain representative IL-34 levels in SLE patients based on their disease activity.

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HUBUNGAN ANTARA TINGKAT KEPARAHAN PENYAKIT, AKTIVITAS FISIK DAN KUALITAS TIDUR TERHADAP KELELAHAN PADA PASIEN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Unnes Journal of Public Health ◽

10.15294/ujph.v5i3.5854 ◽

2016 ◽

Vol 5 (3) ◽

pp. 221

Author(s):

Rizky Ayu Fandika ◽

Dyah Mahendrasari Sukendra

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Sampling Technique ◽

Dominant Factor ◽

Bivariate Analysis ◽

P Value ◽

Systemic Lupus ◽

Cross Sectional ◽

Factors Associated ◽

R Value

ABSTRAK Systemic Lupus Erythematosus (SLE) merupakan penyakit autoimun yang prevalensinya tiap tahun meningkat di dunia maupun di Indonesia. Kelelahan yang parah dapat menyebabkan kekambuhan pada pasien SLE. Kelelahan merupakan gejala yang paling melemahkan dan mengganggu fungsi fisik, sosial dan emosional. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kelelahan pada pasien SLE di Yayasan Lupus Indonesia Panggon Kupu Semarang. Jenis penelitian ini adalah penelitian deskriptif analitik dengan rancangan penelitian cross sectional. Sampel penelitian adalah 30 pasien SLE yang diperoleh dengan menggunakan teknik Total Sampling. Analisis data dilakukan secara univariat dan bivariat. Hasil analisis bivariat menunjukan faktor yang berhubungan dengan kelelahan yaitu: tingkat keparahan penyakit (r value = 0,853, sig = 0,00) dan kualitas tidur (r value = 0,796, sig = 0,00), dan faktor yang tidak berhubungan yaitu aktivitas fisik (r value = -0,79). Hasil analisis multivariat menunjukan faktor yang paling dominan yang berhubungan dengan kelelahan yaitu kualitas tidur (p value = 0,043, exp (OR) = 16,500) memiliki probabilitas terhadap terjadinya kelelahan sebesar 61,89%. Kata Kunci: Kelelahan, SLE. Systemic Lupus Erythematosus ( SLE ) was an autoimmune disease whose prevalence was increasing every year in the world as well as in Indonesia. Severe fatigue can lead to relapse in patients with SLE. Fatigue was a symptom of the most debilitating and interfere with the functioning of physical, social and emotional. The objective of the study to know factors associated with fatigue in patients SLE at Indonesian Lupus Panggon Kupu Foundation in Semarang City. This research was descriptive analytic research with Cross Sectional design. The samples were 30 patients with SLE were obtained using total sampling technique. Data analysis was performed using univariate and bivariate. Bivariate analysis results showed that factors associated with fatigue were: the severity of disease (r value = 0,853, sig = 0,00) and sleep quality (r value = 0,796, sig = 0,00), while the factors that was not associated were: physical activity (r value = -0,79). Multivariate analysis showed that the most dominant factor associated to the fatigue was the quality of sleep (p value = 0,043, exp (OR) = 16,500) have the probability of the occurrence of fatigue by 61.89 %.

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THE CLINICAL, LABORATORY MANIFESTATIONS AND HISTOPATHOLOGY IN NEPHROTIC PATIENTS WITH LUPUS NEPHRITIS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2018.2.9 ◽

2018 ◽

pp. 52-58

Author(s):

Le Thuan Nguyen ◽

Bui Bao Hoang

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Nephritis ◽

Lupus Erythematosus ◽

Clinical Laboratory ◽

Activity Index ◽

Clinical Manifestations ◽

Systemic Lupus ◽

Cross Sectional ◽

Organ Systems ◽

Tubulointerstitial Lesions

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems. The kidney appears to be the most commonly affected organ, especially nephrotic is a serious kidney injury. The clinical, laboratory manifestations and histopathology are very useful for diagnosis, provide the means of predicting prognosis and guiding therapy in nephrotic patients with lupus nephritis. Methods: Descriptive cross-sectional study of nephrotic patients with lupus treated in the Department of Nephrology Trung Vuong Hospital and Cho Ray Hospital between May/2014 and May/2017. Renal histopathological lesions were classified according to International Society of Nephrology/Renal Pathology Society - ISN/RPS ’s 2003. The clinical, laboratory manifestations and histopathological features were described. Results: Of 32 LN with nephritic range proteinuria cases studied, 93.7% were women. The 3 most common clinical manifestations were edema (93.8%), hypertension (96.8%) and pallor (68.9%), musculoskeletal manifestions (46.9%), malar rash (40.6%). There was significant rise in laboratory and immunological manifestions with hematuria (78.1%), Hb < 12g/dL (93.5%), increased Cholesterol (100%), and Triglycerid (87.5%), Creatinine > 1.4 mg/dL (87.5%), increased BUN 71.9%, ANA (+) 93.8%, Anti Ds DNA(+) 96.9%, low C3: 96.9%, low C4: 84.4%. The most various and severe features were noted in class IV with active tubulointerstitial lesions and high activity index. Conclusion: Lupus nephritis with nephrotic range proteinuria has the more severity of histopathological feature and the more severity of the more systemic organ involvements and laboratory disorders were noted. Key words: Systemic lupus, erythematosus (SLE) lupus nepphritis, clinical

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