EFEK KONSUMSI BERBAGAI JENIS MINYAK GORENG TERHADAP KETEBALAN TUNIKA INTIMA  PADA TIKUS JANTAN STRAIN WISTAR

CVD has close relationship with nutrition and food. But the results of another study did not support the close relationship between saturated fat intake with blood lipid levels and risk of CVD. The aim is to determine the effect of various types of fried oil consumption to the thickness of tunica intima in male rats of wistar strain. This study was an experimental research. The sample were 25 rats based on inclusion and exclusion criteria. Treatment groups were separated and each given long chain saturated fatty acid (LCSFA) cow fat, medium chain saturated fatty acid (MCSFA) VCO, polyunsaturated fatty acid (PUFA) corn oil and monounsaturated fatty acid (MUFA) olive oil orally 2.5 ml/day for 2 months. Data were obtained include the sample characteristics and thickness of tunica intima. The highest mean of tunica intima thickness was corn oil 16385,61±1715,79 nm and the lowest olive oil 12075,97±2464,34 nm (p=0,033). This study shows that the harmful effects of SFA and the protective effects of UFA to the thickness of tunica intima need to be corrected because not all SFA is bad and UFA is good for health. It is therefore recommended to inform about foods are beneficial for health.

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Decomposition of a long chain saturated fatty acid with some additives in hot compressed water

Energy Conversion and Management ◽

10.1016/j.enconman.2006.01.009 ◽

2006 ◽

Vol 47 (18-19) ◽

pp. 3344-3350 ◽

Cited By ~ 106

Author(s):

Masaru Watanabe ◽

Toru Iida ◽

Hiroshi Inomata

Keyword(s):

Fatty Acid ◽

Saturated Fatty Acid ◽

Hot Compressed Water ◽

Long Chain ◽

Chain Saturated Fatty Acid

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Protective effects of dietary omega-3 fatty acid supplementation on organophosphate poisoning

Toxicology and Industrial Health ◽

10.1177/0748233717737646 ◽

2017 ◽

Vol 34 (2) ◽

pp. 69-82 ◽

Cited By ~ 6

Author(s):

Bahattin Avci ◽

S. Sirri Bilge ◽

Gokhan Arslan ◽

Omer Alici ◽

Ozge Darakci ◽

...

Keyword(s):

Fatty Acid ◽

Olive Oil ◽

The Body ◽

Control Group ◽

Organophosphate Poisoning ◽

Protective Effects ◽

Omega 3 ◽

Sprague Dawley ◽

Omega 3 Fatty Acid ◽

Locomotor Activities

In this study, we aimed to study the possible preventive effect of docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, on toxicity caused by chlorpyrifos (CPF). Six groups of Sprague Dawley rats (200–250 g) consisting of equal numbers of males and females (n = 8) were assigned to study. The rats were orally given for 5 days. The control group was administered pure olive oil, which was the vehicle for CPF. The CPF challenge groups were administered oral physiological saline, pure olive oil, or DHA (50, 100 and 400 mg/kg dosages) for 5 days. The animals were weighed on the sixth day and then administered CPF (279 mg/kg, subcutaneously). The rats were weighed again 24 h following CPF administration. The body temperatures and locomotor activities of the rats were also measured. Blood samples, brain and liver tissues were collected for biochemical, histopathological and immunohistochemical examinations. A comparison with the control group demonstrated that CPF administration increased malondialdehyde (MDA) levels in blood, brain and liver, while it reduced catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) concentrations ( p < 0.05–0.001). Advanced oxidation protein products (AOPPs) increased only in the brain ( p < 0.001). DHA reduced these changes in MDA and AOPP values ( p < 0.05–0.001), while it increased CAT, SOD and GPx concentrations ( p < 0.05–0.001). Similarly, DHA prevented the decreases in body weight, body temperature and locomotor activities caused by CPF at 100 mg/kg and 400 mg/kg dosages ( p < 0.05–0.001). Similar to the physiological and biochemical changes, the histopathological damage scores, which increased with CPF ( p < 0.05–0.01), decreased at all three dosages of DHA ( p < 0.05–0.01). Our findings suggest that DHA, by supporting the antioxidant mechanism, reduces toxicity caused by CPF.

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