Development of Ethosomal Gel from Withania Somnifera

Novel drug delivery systems are used to increase administration of drugs through transdermal system. Ethosomes has the ability to permeate through the stratum corneum. Ethosomes are the delivery carriers that enable the drugs to reach the deep skin layers as well as the systemic circulation. These vesicles are well known for their importance in cellular communication and in particle transportation for many years. This article reviews various aspects of ethosomes which includes their preparation, characterization, advantages and their applications in drug delivery. Ethosomes has number of important benefits such as, it improves the drug’s efficacy, enhances the patient compliance, comfort and reduces the total cost of treatment.

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Vehicles for Drug Delivery and Cosmetic Moisturizers: Review and Comparison

Pharmaceutics ◽

10.3390/pharmaceutics13122012 ◽

2021 ◽

Vol 13 (12) ◽

pp. 2012

Author(s):

Tanya M. Barnes ◽

Dalibor Mijaljica ◽

Joshua P. Townley ◽

Fabrizio Spada ◽

Ian P. Harrison

Keyword(s):

Drug Delivery ◽

Stratum Corneum ◽

Patient Compliance ◽

Active Drug ◽

Systemic Circulation ◽

Dry Skin ◽

Topical Product ◽

Advantages And Disadvantages ◽

The World ◽

Regulatory Bodies

Many dermatological conditions, such as eczema and psoriasis, are treated with topical therapeutic products. Instead of applying the active drug directly onto the skin, it is combined with a vehicle to aid in its delivery across the stratum corneum (SC) and into deeper regions of the skin, namely the epidermis and dermis. Absorption into the systemic circulation is minimized. Topical vehicles are also used as cosmetic moisturizers (often termed emollient therapy) to ameliorate dry skin, which is a cornerstone of the management of various dermatological conditions, including xerosis, eczema, psoriasis, and aging. The most common topical vehicles include ointments, creams, gels, and lotions, among others. It is crucial that topical vehicles are chosen based upon the size and properties (wet/dry, mucous/non-mucous, healthy/diseased) of the skin to be treated in order to optimize application and contact of the product with the skin, as this can have profound impacts on potency, efficacy, and patient compliance. This review examines common topical vehicles used for drug delivery and cosmetic moisturizers, including their formulation, advantages and disadvantages, and effects on the skin. The unique rules imposed by governing regulatory bodies in Australia and around the world, in terms of topical product claims, are also briefly examined.

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Echogenic bubbles: An new avenue for cancer therapy

International Journal of Technology ◽

10.52711/2231-3915.2021.00002 ◽

2021 ◽

pp. 6-18

Author(s):

Rajeswari Saripilli1 ◽

Pikkala Shirisha

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Cost Effective ◽

Disease Diagnosis ◽

Systemic Circulation ◽

Therapeutic Agents ◽

Site Specific ◽

Non Invasive ◽

Ultrasound Molecular Imaging ◽

Novel Drug

The development of micro and nanobubbles as theranostics is been an emerging trend in the 21st century. Ultrasound molecular imaging is a real-time non-invasive, cost-effective, promising non-viral tool, which is been widely used in the recent times. These micro and nanobubbles are marked as ultrasound agents for both diagnosis and targeting therapeutic agents. These are designed in order to obtain efficient drug delivery. Micro and nanobubbles are very much used for targeting drug and achieving site specific release. These are stable and have longer residence time in systemic circulation, finally shows efficient and promising drug delivery [1]. These echogenic bubbles are helpful for disease diagnosis and therapy more prominently when compared with other novel drug delivery systems. This review describes about functioning of micro and nanobubbles along with mechanism, preparation and studies which describes the works on micro and nanobubbles.

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Role of Novel Drug Delivery Systems in Bioavailability Enhancement: At A Glance

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v6i1.8884 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Mehta Abhinav ◽

Jain Neha ◽

Grobler Anne ◽

Vandana Bharti

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Systemic Circulation ◽

Delivery Systems ◽

New Drugs ◽

Target Tissue ◽

Drug Bioavailability ◽

Bioavailability Enhancement ◽

Advantages And Disadvantages ◽

Novel Drug

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Most of the new drugs used today have poor bioavailability and are required to be administered at higher doses because only a small fraction of the administered dose is absorbed in the systemic circulation and able to reach the target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

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Nanoparticulate Drug Delivery System

Advances in Medical Diagnosis, Treatment, and Care - Enhancing the Therapeutic Efficacy of Herbal Formulations ◽

10.4018/978-1-7998-4453-2.ch007 ◽

2021 ◽

pp. 173-185

Author(s):

Akshada Bakliwal ◽

Swati Gokul Talele ◽

Shweta Shaileshkumar Gedam ◽

Vijay Sharadkumar Chudiwal ◽

Swapnil Sharadkumar Jain

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Drug Delivery Systems ◽

Herbal Medicines ◽

Delivery Systems ◽

Drug Bioavailability ◽

Therapeutic Value ◽

Ancient Times ◽

Novel Drug ◽

Improve Patient

The herbal medicines have been extensively used worldwide since ancient times and have been accepted by physicians and patients for their improved therapeutic value as they have less adverse effects in contrast with modern medicines. Phytotherapeutics requires a scientific approach to carry the components in a sustained manner to increase patient compliance and to reduce the frequency of administration. This can be accomplished by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the frequency of drug administration to improve patient compliance but also help to enhance the therapeutic value by dropping toxicity and enhancing the drug bioavailability. A nanotechnology is a new approach in which nano-sized drug delivery systems of herbal drugs have a prospective future for enhancing the therapeutic activity and conquer problems associated with plant medicines. Hence, the addition of the nanotechnology as an NDDS in traditional medication is essential for the treatment of more chronic diseases like cancer, diabetes, asthma, and others.

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A Review on Fast Dissolving Tablet

International Journal of Current Pharmaceutical Review and Research ◽

10.25258/ijcprr.v8i03.9218 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Sagar T. Malsane ◽

Smita S. Aher ◽

R. B. Saudagar

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Research Area ◽

Oral Route ◽

Dosage Forms ◽

The Novel ◽

The Past ◽

Orally Disintegrating Tablets ◽

Novel Drug ◽

Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

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Amoxicilin and Clavulanic Acid Intercaled Nanostructures for Dentistry Uses

Materiale Plastice ◽

10.37358/mp.19.2.5193 ◽

2019 ◽

Vol 56 (2) ◽

pp. 396-398

Author(s):

Georgeta Zegan ◽

Daniela Anistoroaei ◽

Elena Mihaela Carausu ◽

Eduard Radu Cernei ◽

loredana Golovcencu

Keyword(s):

Drug Delivery ◽

Clavulanic Acid ◽

Bacterial Infections ◽

Drug Delivery Systems ◽

Intracellular Transport ◽

Oral Treatment ◽

Chitosan Nanoparticles ◽

Well Being ◽

Cell Penetrating ◽

Novel Drug

Amoxicillin and clavulanic acid are two of the most commonly prescribed antibacterial worldwide for treating oral infectious diseases. Oral health is of big importance for well-being and general health. A few novel drug delivery systems were designed for oral treatment and prophylaxis of different diseases in the oral cavity. This work focused on the latest drug delivery development of the most common oral pathologies, namely, periodontitis, oral mucosal infections, dental caries and oral cancer. Herein we reveal the synthesis, characterization and application of chitosan nanoparticles for intracellular transport of the weakly cell-penetrating amoxicillin and clavulanic acid in order to improve their efficacy on bacterial infections.

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Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

Current Pharmaceutical Design ◽

10.2174/1381612826666201021130146 ◽

2020 ◽

Vol 26 ◽

Author(s):

Ritu Mishra ◽

Swati Gupta

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Autoimmune Disease ◽

Drug Delivery Systems ◽

Clinical Manifestations ◽

Adaptive Immune Response ◽

Delivery Systems ◽

Current Therapy ◽

Genetic And Environmental Factors ◽

Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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