scholarly journals Role of Novel Drug Delivery Systems in Bioavailability Enhancement: At A Glance

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mehta Abhinav ◽  
Jain Neha ◽  
Grobler Anne ◽  
Vandana Bharti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
New Drugs ◽  
Target Tissue ◽  
Drug Bioavailability ◽  
Bioavailability Enhancement ◽  
Advantages And Disadvantages ◽  
Novel Drug

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Most of the new drugs used today have poor bioavailability and are required to be administered at higher doses because only a small fraction of the administered dose is absorbed in the systemic circulation and able to reach the target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

An overview of Osmotic Drug Delivery System: An update review

2017 ◽  
Vol 6 (7) ◽  
pp. 5426 ◽  
Author(s):  
Hiren J. Patel ◽  
Vaishnavi P. Parikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Life Cycle Management ◽  
Delivery Systems ◽  
Osmotic Pump ◽  
Factors Affecting ◽  
Advantages And Disadvantages ◽  
New Chemical Entities ◽  
History Of ◽  
Novel Drug

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

A Review of Niosomes as Novel Drug Delivery Systems

2021 ◽  
Vol 14 (6) ◽  
pp. 5654-5664
Author(s):  
Anil Kumar Chilka ◽  
Vadithe Vasu Naik
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Ionic Surfactant ◽  
Target Tissue ◽  
New Approach ◽  
Surfactant Vesicles ◽  
Novel Drug ◽  
Subcellular Level

The aim of this review is to present the structure of niosome, benefits and drawbacks, fundamentals of niosome preparation and characterization as well as a description of their applications in drug delivery. This review will provide an overview on the increasing interest on niosomes in the field of drug delivery. Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area of action within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosomes. Niosomes are the type of non-ionic surfactant vesicles, which are biodegradable, non-toxic, more stable and inexpensive, a new approach to liposomes. Their structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes. The niosomes have the tendency to load different type of drugs.

scholarly journals A Comprehensive Map of FDA-Approved Pharmaceutical Products

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 263 ◽  
Author(s):  
Hao Zhong ◽  
Ging Chan ◽  
Yuanjia Hu ◽  
Hao Hu ◽  
Defang Ouyang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Generic Drugs ◽  
Pharmaceutical Products ◽  
Delivery Systems ◽  
Market Potential ◽  
New Drugs ◽  
Drug Candidates ◽  
Four Quadrant ◽  
Novel Drug

With the increasing research and development (R&D) difficulty of new molecular entities (NMEs), novel drug delivery systems (DDSs) are attracting widespread attention. This review investigated the current distribution of Food and Drug Administration (FDA)-approved pharmaceutical products and evaluated the technical barrier for the entry of generic drugs and highlighted the success and failure of advanced drug delivery systems. According to the ratio of generic to new drugs and the four-quadrant classification scheme for evaluating the commercialization potential of DDSs, the results showed that the traditional dosage forms (e.g., conventional tablets, capsules and injections) with a lower technology barrier were easier to reproduce, while advanced drug delivery systems (e.g., inhalations and nanomedicines) with highly technical barriers had less competition and greater market potential. Our study provides a comprehensive insight into FDA-approved products and deep analysis of the technical barriers for advanced drug delivery systems. In the future, the R&D of new molecular entities may combine advanced delivery technologies to make drug candidates into more therapeutically effective formulations.

scholarly journals A REVIEW ON NANOSPONGES A REVIEW ON NANOSPONGES: A BOON TO TARGETED DRUG DELIVERY FOR ANTICANCER DRUG

2019 ◽  
pp. 1-7
Author(s):  
NIKITA SEHGAL ◽  
VISHAL GUPTA N ◽  
SANDEEP KANNA
Keyword(s):  
Drug Delivery ◽  
Health Care ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Delivery Systems ◽  
New Drugs ◽  
Stimuli Responsive ◽  
Drug Bioavailability ◽  
Conventional Drug

In recent decades, the rise in the investigation of new drugs had made health-care system expensive compared to conventional drug delivery systems and techniques. The present drug delivery systems have become highly productive and are growing fast. Majority of the anticancer agent has low water solubility resulting in multistep synthetic routes that require higher selectivity and specificity that can cause difficulty in the development of the formulation. Nanosponges (NSs) are branched cyclodextrin (CD) polymeric systems which have proven to be a boon in the pharmaceutical and biomedical fields. Different kinds of NSs based on different types of CDs and crosslinkers are used for developing of new drug formulations from the past few years for various applications in health care. Nanotechnology has overcome the issues regarding the drug solubility, stability, and other parameters and has attained success in achieving of sustained release, increased activity, improved permeability, delivery of nucleoprotein, the stimuli-responsive release of the drug, and improved drug bioavailability. There is a huge eruption of research on NSs for cancer treatment. Multiple anticancer moieties have been developed, taking into account the pharmacological and physicochemical perspective of the drug to develop a NS formulation. Our target in this review is to catch an efficient and far-reaching NSs for malignancy cancer treatment announced until now. This survey will give a perfect stage for providing details for researchers taking a shot at using new polymers for improving the treatment of the disease using nanotechnology. The present article provides details regarding antineoplastic molecules and provides ideas on CD-based NSs specifically using curcumin, tamoxifen, resveratrol, quercetin, oxygen-NSs, temozolomide, doxorubicin, and 5-fluorouracil (5-FU), and erlotinib (ETB) glutathione.

Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

2020 ◽  
Vol 26 ◽  
Author(s):  
Joel Hardwick ◽  
Jack Taylor ◽  
Meenu Mehta ◽  
Saurabh Satija ◽  
Keshav R. Paudel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Limiting Factors ◽  
Drug Bioavailability ◽  
Pharmacokinetic Properties ◽  
Anti Oxidant ◽  
Novel Drug

: Curcumin is a major curcuminoid present in turmeric. The compound is attributed with various therapeutic properties, which include, anti-oxidant, anti-inflammatory, anti-bacterial, anti-malarial, and neuroprotection. Due to its therapeutic potential, curcumin has been employed for centuries in treating different ailments. Curcumin has been investigated lately as a novel therapeutic agent in the treatment of cancer. However, the mechanisms by which curcumin exerts its cytotoxic effects on malignant cells are still not fully understood. One of the main limiting factors in the clinical use of curcumin is its poor bioavailability and rapid elimination. Advancements in drug delivery systems such as, nanoparticle based vesicular drug delivery platforms have improved several parameters, namely, drug bioavailability, solubility, stability, and controlled release properties. The use of curcumin-encapsulated niosomes to improve the physical and pharmacokinetic properties of curcumin is one such approach. This review provides an up-to-date summary on nanoparticle based vesicular drug carriers and their therapeutic applications. Specifically, we focus on niosomes as novel drug delivery formulations and their potential in improving the delivery of challenging small molecules, including curcumin. Overall, the applications of such carriers will provide a new direction for novel pharmaceutical drug delivery, as well as, biotechnology, nutraceutical, and functional food industries.

scholarly journals Clinical implications of polymers and lipids in designing drug delivery systems in geriatric use

2020 ◽  
Vol 2 (3) ◽  
pp. 66-70
Author(s):  
Sai Raj Kappari
Keyword(s):  
Older Adults ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
The United States ◽  
Delivery Systems ◽  
Clinical Implications ◽  
Drug Bioavailability ◽  
Advantages And Disadvantages ◽  
Polymer Hybrids

This paper will emphasize some of the clinical implications of polymers and lipids in designing drug delivery systems in the geriatric population. This article will give us an overview of the advantages and disadvantages of polymers and lipids in formulating DDS in individuals over 65 in the United States. Lipid polymer hybrids can be advantageous in systemic drug bioavailability to patients who have decreased drug carrier capacity. Older adults may benefit from lipid polymer hybrids as it enhances drug delivery and drug targeting process. Most of the older adults use a minimum of 4 to 6 medications for a variety of medical ailments and conditions. Polypharmacy may be an advent situation in some of the cases, which can be reduced by innovative drug delivery options.

scholarly journals A COMPREHENSIVE REVIEW ON SUPERSATURABLE SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM

2021 ◽  
pp. 40-44
Author(s):  
MUTHADI RADHIKA REDDY ◽  
KUMAR SHIVA GUBBIYAPPA
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Water Soluble ◽  
In Vitro Tests ◽  
Drug Bioavailability ◽  
Advantages And Disadvantages ◽  
Anti Cancer

Lipid-based drug delivery systems are extensively reported in the literature for enhancing drug solubility, permeability, and bioavailability. Self-nanoemulsifying drug delivery systems (SNEDDS) are a superior strategy for enhancing solubility and bioavailability of poorly water-soluble compounds and the most prevailing and commercially viable oil-based approach for drugs that exhibit low dissolution rate and inadequate absorption. However, these formulations have few limitations that include in vivo drug precipitation, inferior in vitro in vivo correlation owing to unavailability of in vitro tests, handling issues of liquid formulation, and physicochemical instability of drugs. These limitations are overcome by potential systems such as supersaturable SNEDDS (S-SNEDDS) which are prepared by addition of precipitation inhibitors into formulated SNEDDS to maintain drug supersaturation post dispersion in gastrointestinal tract. These systems improve drug bioavailability and reduce the inconsistency of exposure. In addition, these formulations also help to overcome the drawbacks of liquid and capsule dosage forms. The S-SNEDDS provides an effective approach for improving the dissolution and bioavailability of anti-cancer agents. In this article, an attempt was made to present an overview of SNEDDS, S-SNEDDS, their mechanism, formulation excipients, recent advancements, advantages, and disadvantages of SNEDDS formulations. The article also focuses on reviewing the application of S-SNEDDS in enhancing the solubility and bioavailability of anti-cancer drugs in cancer therapy.

Nanoparticulate Drug Delivery System

2021 ◽  
pp. 173-185
Author(s):  
Akshada Bakliwal ◽  
Swati Gokul Talele ◽  
Shweta Shaileshkumar Gedam ◽  
Vijay Sharadkumar Chudiwal ◽  
Swapnil Sharadkumar Jain
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Drug Delivery Systems ◽  
Herbal Medicines ◽  
Delivery Systems ◽  
Drug Bioavailability ◽  
Therapeutic Value ◽  
Ancient Times ◽  
Novel Drug ◽  
Improve Patient

The herbal medicines have been extensively used worldwide since ancient times and have been accepted by physicians and patients for their improved therapeutic value as they have less adverse effects in contrast with modern medicines. Phytotherapeutics requires a scientific approach to carry the components in a sustained manner to increase patient compliance and to reduce the frequency of administration. This can be accomplished by designing novel drug delivery systems (NDDS) for herbal constituents. NDDSs not only reduce the frequency of drug administration to improve patient compliance but also help to enhance the therapeutic value by dropping toxicity and enhancing the drug bioavailability. A nanotechnology is a new approach in which nano-sized drug delivery systems of herbal drugs have a prospective future for enhancing the therapeutic activity and conquer problems associated with plant medicines. Hence, the addition of the nanotechnology as an NDDS in traditional medication is essential for the treatment of more chronic diseases like cancer, diabetes, asthma, and others.

scholarly journals Noisomes: as novel vesicular drug delivery system

2018 ◽  
Vol 8 (6) ◽  
pp. 335-341 ◽  
Author(s):  
Sudhir Kumar Ray ◽  
Nargish Bano ◽  
Tripti Shukla ◽  
Neeraj Upmanyu ◽  
Sharad P. Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Ionic Surfactant ◽  
Target Tissue ◽  
Advantages And Disadvantages ◽  
Repulsive Forces

Target-specific drug-delivery systems for the administration of pharmaceutical compounds enable the localization of drugs to target sites within the body.  The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Niosome are microscopic non-ionic surfactant bilayer vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or their lipids. The amphiphilic nature of niosomes promotes their efficiency in encapsulating lipophilic or hydrophilic drugs.  Noisome are promising vehicle for drug delivery and being non-ionic, more stable, inexpensive, biodegradable, biocompatible, non immunogenic and exhibit flexibility in their structural characterization. Various additives in niosomes include nonionic surfactant as film forming agent, cholesterol as stabilizing and rigidizing agent for the bilayer and various charge inducers which develop a charge on the surface of niosomes and stabilize the prepared formulation by the resulting repulsive forces. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections, microbial diseases, psoriasis, leishmaniasis, migraine, parkinson and other diseases. Niosomes can prolong the circulation of the entrapped drug in body. Encapsulation of drug in vesicular system can be predicted to prolong the existence of drug in the systemic circulation and enhance penetration into target tissue, perhaps reduce toxicity if selective uptake can be achieved. In addition to conventional, oral and parenteral routes, they are amenable to be delivered by ocular, transdermal, vaginal and inhalation routes. Delivery of biotechnological products including vaccine delivery with niosomes is also an interesting and promising research area. More concerted research efforts, however, are still required to realize the full potential of these novel systems. This review article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, separation of unentrapped drug, factors influencing the niosomal formulation and characterization, marketed formulations of niosomes and also gives up to date information regarding recent applications of niosomes in drug delivery. Keyword:  Drug-delivery system, Niosomes, 

Sign in / Sign up

Export Citation Format

Share Document