scholarly journals Influence of Maternal Glycemic Status (HbA1c) at Delivery and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 2 (2) ◽  
pp. 84-88
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Maherun Nessa ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Good Control ◽  
Significant Negative Correlation ◽  
Glycemic Status ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Control Study ◽  
Diabetic Mothers

Objective: To examine the influence of maternal HbA1c level at delivery and risk of hypoglycemia in infants of diabetic mothers. Method: This case-control study was done with sixty neonates born to diabetic mothers in BIRDEM hospital. Out of sixty neonates, 30 neonates who developed hypoglycemia during the first 24 hours of age were considered as cases and another 30 neonates who did not develop hypoglycemia during the first 24 hours were considered as controls. Maternal glycemic status was examined by measurement of Glycosylated hemoglobin (HbA1c) and level of <6 % considered good control. Babies were screened for hypoglycemia at birth, then 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of newborns and their mothers of cases and controls did not show any significant difference. In majority of cases (73.3%) hypoglycemia was detected by 6 hours of age. Most of babies were asymptomatic (93.3%). Majority of mothers (76.7%) in controls and 46.7% of were in good glycemic controls (HbA1c <6%). The mean HbA1c level of mothers of cases was significantly higher than that of control mothers (6.02 ± 0.98 vs 5.44 ± 0.78; P = 0.014) and significant negative correlation between maternal HbA1c and blood glucose level of neonates ( r=0.422 p= 0.001). Conclusion: There is an association between maternal HbA1c level and neonatal hypoglycemia in infants of diabetic mothers.DOI: http://dx.doi.org/10.3329/birdem.v2i2.12308 (Birdem Med J 2012; 2(2): 84-88)

Blood Glucose and Plasma Amino Acid Concentrations in Infants of Diabetic Mothers

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 77-82
Author(s):  
Gyula Soltész ◽  
Károly Schultz ◽  
Julius Mestyán ◽  
Imre Horváth
Keyword(s):  
Amino Acids ◽  
Blood Glucose ◽  
Amino Acid ◽  
Blood Glucose Concentration ◽  
Birth Asphyxia ◽  
Plasma Amino Acid ◽  
Total Plasma ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Diabetic Mothers

Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

scholarly journals Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 36 (2) ◽  
pp. 71-75
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Child Health ◽  
Umbilical Cord ◽  
Clinical Characteristics ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Peptide Level ◽  
The Relationship ◽  
Diabetic Mothers

Objective: To examine the relationship between umbilical cord C-peptide and risk of hypoglycemia in infants of diabetic mothers. Method: Sixty neonates born to diabetic mothers were studied in BIRDEM hospital. Thirty infants who developed hypoglycemia at any time during the first 24 hours of age were considered as cases. Another 30 infants who did not develop hypoglycemia during the first 24 hours were considered as controls. Umbilical cord C-peptide levels were measured in both groups. All babies were screened for hypoglycemia at 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of cases and controls and their mothers did not show any significant difference. In 73.3% of cases hypoglycemia was detected by 6 hours of age. Most babies were asymptomatic (93.3%). It was found that IDMs who developed hypoglycemia had significantly higher cord C-peptide level at birth compared to those who remained normoglycemic (4.57±2.50 vs. 2.81± 2.11 ng/ml, P= 0.005). That means, there is significant association between raised level of cord C-peptide and hypoglycemia in IDMs. Conclusion: Hypoglycemia in infants of diabetic mothers associated with raised cord blood C-peptide levels. DOI: http://dx.doi.org/10.3329/bjch.v36i2.13082 Bangladesh J Child Health 2012; Vol 36 (2): 71-75

scholarly journals Association of Risk Factors and Glycemic Status in Hospital Patients of Different Types of Myocardial Infarction in a Tertiary Care Hospital

2017 ◽  
Vol 5 (1) ◽  
pp. 3-6
Author(s):  
Aparna Rahman ◽  
Md Babul Miah ◽  
Shabnam Jahan Hoque ◽  
Md Zahid Alam ◽  
SM Rezaul Irfan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Blood Glucose ◽  
Hba1c Level ◽  
Fasting Blood Glucose ◽  
Care Hospital ◽  
Glycemic Status ◽  
Significant Difference ◽  
Different Types ◽  
St Elevation

Background: Glycometabolic state at hospital admission is an important risk marker for long-term mortality in patients with acute myocardial infarction. Our aim was to ascertain the associated risk factors and glycemic status in patients with different types of myocardial infarction, and to assess whether such abnormalities can be identified in the early course of myocardial infarction.Methodology: This cross sectional observational study was carried out enrolling 100 subjects with ST elevation (42 subjects) and non ST elevation (58 subjects) myocardial infarction, in the Department of Cardiology, BIRDEM General Hospital, Shahbagh, Dhaka, over a period of six months from January 2012 to June 2012. We did fasting blood glucose and glycatedhaemoglobinA1C (HbA1C) level next day following admission with or without history ofdiabetes mellitus and observed the difference between two types of myocardial infarction (ST elevation and non ST elevation ).Results: Mean age and gender difference was significant between ST elevation and non ST elevationmyocardial infarction. Significant differences in pre-existing risk factors such as Diabetes (95.2%,vs 86.2% ), Dyslipidemia (72.91%, vs 44.82%), Hypertension (79.16%, vs 36.2%) and family history of Ischemic Heart Disease(75%, vs 29.31%) were observed between ST elevation and non ST elevation groups. It was revealed that mean fasting blood glucose (FBG) in ST elevation and non ST elevation was 10.23 mmol/l and 8.42 mmol/l respectively. Mean HbA1C level was 9.2% and 8.9% in ST elevation and non ST elevation. Significant difference in fasting blood glucose and HbA1C was observed between ST elevation and non ST elevation group.Conclusion: Glycemic status is relatively more uncontrolled in ST elevated MI and must be managed with all possible therapeutic modules to minimize further complications.Bangladesh Crit Care J March 2017; 5(1): 3-6

scholarly journals Cardiovascular malformations in infants of diabetic mothers: a retrospective study

2019 ◽  
Vol 6 (5) ◽  
pp. 1998
Author(s):  
Poornima Shankar ◽  
Jayalalitha S. Marol ◽  
Shilpa Deborah Lysander ◽  
Abhishek Manohar
Keyword(s):  
Maternal Diabetes ◽  
Cardiac Anomaly ◽  
Cardiac Complications ◽  
Retrospective Case ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Cardiovascular Anomalies ◽  
Control Study ◽  
Diabetic Mothers

Background: Despite improvements in medical care provided during pregnancy to diabetic mothers, the cardiac complications in their infants are still more frequent than in infants of general population.Methods: A retrospective case-control study was performed between the years 2017-2018 on two groups of newborns, recording details of outcome of live born babies born to diabetic and non-diabetic mothers.Results: Data were extracted from medical records, and the descriptive and analytical statistics of this information was duly applied. in a total of 50 studied infants, 40 cases (80%) of cardiovascular anomalies have been diagnosed. Most of the cardiac anomaly was hypertrophic cardiomyopathy. The incidence of cardiovascular anomalies in infants of diabetic mothers is significantly higher than the infants of non-diabetic mothers (P=0.002). The type of maternal diabetes (diabetes mellitus, overt or gestational diabetes) did not bring about any significant difference in the incidence of cardiac malformations in infants (P=0.406).Conclusions: The incidence of cardiovascular anomalies in infants of diabetic mothers is significantly higher than the infants of non-diabetic mothers. Many of the infants were asymptomatic and therefore clinical examination and follow up in infants of diabetic mothers is important.

Epicardial fat thickness in infants of diabetic mothers

2021 ◽  
pp. 1-6
Author(s):  
M.M. Vela-Huerta ◽  
N. Amador-Licona ◽  
R. Domínguez-Damiá ◽  
A. Heredia-Ruiz ◽  
H.V. Orozco-Villagomez ◽  
...  
Keyword(s):  
Interventricular Septum ◽  
Left Ventricular ◽  
Epicardial Fat ◽  
Left Ventricular Ejection ◽  
Epicardial Fat Thickness ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Fat Thickness ◽  
Diabetic Mothers

BACKGROUND: Epicardial fat thickness (EFT) in adults and children has been related to the metabolic syndrome and other cardiovascular risk factors; however, scarce studies have evaluated it in infants of diabetic mothers (IDM) in whom, alterations in the thickness of the interventricular septum have been reported. This study compares the EFT in IDM versus infants of non-diabetic mothers (INDM) and its association with others echocardiographic parameters. METHODS: We performed a cross sectional study in 93 infants (64 IDM and 29 INDM). To evaluate EFT dimensions, an echocardiogram was performed within the first 24h of extrauterine life in both groups. In diabetic mothers, HbA1c was also determined. RESULTS: There was no significant difference in birth weight between the groups although gestational age was lower in IDM. The EFT (3.6 vs. 2.5 mm, p <  0.0001), the interventricular septum thickness (IVST) (6.2 vs. 5.2 mm, p <  0.0001) and the IVST / left ventricle posterior wall (1.3 vs. 1.1, p = 0.001) were higher in the IDM; while the left ventricular expulsion fraction [LVFE] (71.1 vs. 77.8; p <  0.0001) was lower than in the INDM, respectively. We found a positive correlation between EFT with IVST (r = 0.577; p = 0.0001), LVPW (r = 0.262; p = 0.011), IVST/LVPW index (r = 0.353; p = 0.001), and mitral integral early velocity (r = 0.313; p = 0.002), while a negative correlation with LVFE was observed (r = –0.376; p = 0.0001). CONCLUSIONS: The EFT is higher in IDM than in INDM. It was positively related with echocardiographic parameters of left ventricular thickness and negatively with left ventricular ejection function.

scholarly journals A Randomized Study to Compare the Effects of Once-Weekly Dulaglutide Injection and Once-Daily Glimepiride on Glucose Fluctuation of Type 2 Diabetes Mellitus Patients: A 26-Week Follow-Up

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Huiqin Li ◽  
Xiaohua Xu ◽  
Jie Wang ◽  
Xiaocen Kong ◽  
Maoyuan Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycosylated Hemoglobin ◽  
Oxidation Stress ◽  
Once Daily ◽  
Glucose Fluctuation ◽  
Significant Difference

Objective. To evaluate the effects of once-weekly dulaglutide injection and once-daily glimepiride on glucose fluctuation in patients with type 2 diabetes mellitus (T2DM) using the Continuous Glucose Monitoring System (CGMS). Methods. A total of 23 patients with T2DM were randomly assigned into two groups for 26 weeks: the dulaglutide group (n=13) and the glimepiride group (n=10). 72-hour CGMS was applied to all patients: before and after the treatment. General clinical data were collected and measured, such as fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), tumor necrosis factor-α (TNF-α), 8-iso-prostaglandin F2α (8-iso-PGF2α), and interleukin-6 (IL-6). Results. HbA1c of the dulaglutide group was reduced from 8.38±0.93% to 6.68±0.73% after the treatment (P<0.05); similarly, it was reduced from 7.91±0.98% to 6.67±0.74% (P<0.05) in the glimepiride group. The levels of serum 8-iso-PGF2α, TNF-α, and IL-6 all decreased significantly in both groups after treatment, and there was no significant difference found between the two groups (P>0.05). The Mean Blood Glucose (MBG) of the two groups declined significantly after therapy (P<0.05). However, the Standard Deviation of Blood Glucose (SDBG) decreased significantly only in the dulaglutide group (from 2.57±0.74 mmol/L to 1.98±0.74 mmol/L, P<0.05). There were no significant changes of Mean Amplitude of Glycemic Excursion (MAGE) and Absolute Means of Daily Difference (MODD) after treatment in both groups. Furthermore, no statistically significant difference was found between the two groups in MBG, SDBG, MAGE, and MODD (P>0.05). The percentage time (PT) (>10 mmol/L and 3.9-10 mmol/L) of the two groups was significantly changed after the treatment (P<0.05). However, this was not seen in the PT<3.9 mmol/L after the treatment (P>0.05). Conclusion. Once-weekly dulaglutide injection has the same effectiveness as daily glimepiride on lowering blood glucose and decreasing oxidation stress and inflammation and is more effective in controlling glucose fluctuation as compared with glimepiride. This trial is registered with ClinicalTrials.gov NCT01644500.

scholarly journals Impact of Admission Glycosylated Hemoglobin A1c on Angiographic Characteristics and Short Term Clinical Outcomes of Nondiabetic Patients with Acute ST-Segment Elevation Myocardial Infarction

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Islam El-sherbiny ◽  
Baher Nabil ◽  
Tamer Saber ◽  
Fathy Elsayed Abdelgawad
Keyword(s):  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
University Hospital ◽  
Complete Revascularization ◽  
Cardiac Events ◽  
Short Term ◽  
Acute Stemi ◽  
Adverse Cardiac Events ◽  
Significant Difference ◽  
Hba1c Levels

We aimed to assess the predictive value of admission HbA1c level in nondiabetic patients presented by acute STEMI, on outcome of PCI and short term outcome of adverse cardiac events.Methods. 60 nondiabetic patients were admitted to Cardiology Department, Zagazig University Hospital, with acute STMI: 27 patients with HbA1c levels of 4.5% to 6.4% (group 1), 17 patients with HbA1c levels of 6.5% to 8.5% (group 2), and 16 patients with HbA1c levels higher than 8.5% (group 3). Either invasive intervention was done at admission by (pPCI) or coronary angiography was done within month (3–28 days) from taking thrombolytic. Participants were followed up for 6 months.Results. There was significant difference among different groups of HbA1c as regards the number of diseased vessels, severity of CAD lesions (pvalue < 0.01), and TIMI flow grades (pvalue < 0.05). There was significant difference among different groups as regards the adverse cardiac events on short term follow-up period (pvalue < 0.05).Conclusion. The present study showed that admission higher HbA1c level in patients presented by acute STEMI is associated with more severe CAD, lower rate of complete revascularization, and higher incidence of adverse cardiac events.

scholarly journals Comparative Study of Creatinine and Urea in the Case of Well and Poorly Controlled Diabetes

2015 ◽  
Vol 23 (1) ◽  
pp. 25-36
Author(s):  
Gonțea Mihaela ◽  
Olteanu Grigoruț Elena ◽  
Cozma G. Dănuț
Keyword(s):  
Comparative Study ◽  
Medical Practice ◽  
Protein Metabolism ◽  
Biochemical Parameters ◽  
Glycosylated Hemoglobin ◽  
Good Control ◽  
Glycemic Status ◽  
Control Of Diabetes

Abstract The glycosylated hemoglobin is useful in monitoring diabetes regardless of its type allowing a retroactive evaluation over a period of 45 days according to the last studies, being a suggestive mirror for the glycemic status. The protein metabolism is evaluated through biochemical determinations of creatinine and urea. The medical practice is interested in how ensuring a good control or a less good control, of diabetes, will generate changes in the case of these biochemical parameters.

Umbilical Cord Glycosylated Hemoglobin in Infants of Diabetic Mothers: Relationships to Neonatal Hypoglycemia, Macrosomia, and Cord Serum C-Peptide

Diabetes Care ◽  
1982 ◽  
Vol 5 (6) ◽  
pp. 566-570 ◽  
Author(s):  
J. M. Sosenko ◽  
J. L. Kitzmiller ◽  
R. Fluckiger ◽  
S. W. H. Loo ◽  
D. M. Younger ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Glycosylated Hemoglobin ◽  
Neonatal Hypoglycemia ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Cord Serum ◽  
Diabetic Mothers
Sign in / Sign up

Export Citation Format

Share Document