scholarly journals Acute Diarrhea in Exclusively Breast Fed Infants in relation to Zinc Level

2021 ◽  
Vol 15 (5) ◽  
pp. 1431-1435
Keyword(s):  
Zinc Deficiency ◽  
Acute Diarrhea ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Control Group ◽  
Control Group ◽  
Serum Zinc Level ◽  
Healthy Control ◽  
The Mean ◽  
Breast Fed

Background: Zinc deficiency is associated with alteration in gastrointestinal tract structure, function, and impaired immune function. Aim: To analyze the effects of zinc deficiency on the occurrence of acute diarrhea in exclusively breast-fed infants. Methods: In a case-control study, including a total of 72 exclusively breast-fed infants aged ≤ 6 months, 34 of them with acute diarrhea were in the study group and 38 infants as the healthy control group. Demographic characteristics of all infants and their parents were studied. Serum Zinc level was measured for all participants. Results: Zinc level had significant (p-value =0.000) differences between infants with acute diarrhea and the healthy control group. The mean serum zinc value ± SEM in children with acute diarrhea was 63.11 ± 1.7 which was significantly (p = 0.000) different from the mean serum zinc value ± SEM (78.6 ± 1.6) in healthy infants. A cut-off value 60.6μg/dl of total serum zinc level was significantly (p = 0.000) associated with a sensitivity of 100 % with the occurrence of acute diarrhea among exclusively breast-fed infants. Conclusions: Low serum zinc level is associated with the occurrence of acute diarrhea in exclusively breast-fed infants. A cutoff serum zinc value of 60.6 μg/dl has 100% sensitivity with the occurrence of acute diarrhea among breast-fed infants. Keywords: Zinc deficiency, diarrhea, infants, breastfeeding.

scholarly journals Nutritional Assessment and Serum Zinc Level in Children with Acute Lymphoblastic Leukaemia

2017 ◽  
Vol 40 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Akma Morshed ◽  
Ikram Soma ◽  
TR Choudhury ◽  
Shahnoor Islam ◽  
Md Salim ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Z Score ◽  
Serum Zinc Level ◽  
The Mean ◽  
Height For Age

Background: Acute lymphoblastic leukaemia (ALL) is a common malignancy in children which may cause significant nutritional problem as well as micronutrient deficiency like zinc. These deficiencies ultimately affect the outcome of the patient.Objective: The present study was done to identify the relationship of height, weight and serum zinc with acute lymphocytic leukemia in pediatric patients.Methods: This observational study was carried out in the Department of Pediatric Haematology and Oncology, Dhaka Medical College Hospital, Dhaka over a period of one year from July 2013 to June 2014. All children ranging from 1-10 years with newly diagnosed acute lymphocytic leukaemia were enrolled as case. An equal number of healthy children of similar age and sex were also included as control. The outcome measures were weight for height (wasting) and height for age (stunting) in children 5 or below 5 years of age and BMI in children > 5 years of age. The serum zinc level was also studied as a measure of micronutrient status.Result: Majority (80%) of the cases and 60% of the controls were 5 or < 5 years old. The mean ages of the children of cases and controls were almost similar (4.2 ± 2.3 vs. 4.8 ± 1.8 years, p >0.05). The groups were significantly different in terms of sex with male children being more prone to develop leukaemia than the females (p <0.05). Anaemia was invariably present. Majority (83.3%) of the children in the case group was wasted (weight for height Z-score lie below -2SD) as opposed 22.2% in the control group (p < 0.001). About 37% the children in the case group were stunted (height for age Z-score lies -2SD) as opposed to 16.7% in the control group (p< 0.05). The mean BMI was significantly lower in the case group than that in the control group (8.8 ± 2.7 vs. 17.1 ± 1.8, p < 0.001). Serum zinc level was also significantly lower in the former group than that in the latter group (0.7 ± 0.1 vs. 1.5 ± 0.5 mg/dl, p< 0.05).Conclusion: A good number leukaemia patients present with wasting and stunting and low BMI. Serum zinc level is significantly reduced which, in turn, may hamper various enzymatic functions in the body thereby reducing growth.Bangladesh J Child Health 2016; VOL 40 (1) :12-16

scholarly journals Evaluation of serum zinc level and IL-18 mRNA expression in children with pneumonia

2021 ◽  
Vol 67 (3) ◽  
pp. 168-171
Author(s):  
Shixiong Yang ◽  
Jin Shi
Keyword(s):  
Mrna Expression ◽  
Zinc Deficiency ◽  
Internal Control ◽  
Serum Zinc ◽  
Rna Isolation ◽  
Zinc Level ◽  
Control Group ◽  
Healthy Children ◽  
Serum Zinc Level ◽  
Zinc Levels

Pneumonia is currently one of the leading causes of death in children. Increased susceptibility to pneumonia may be due to their decreased immunity. One of the reasons for the decrease in immunity is zinc deficiency. In children with pneumonia, on the other hand, some cytokines are secreted, resulting in inflammation that spreads, persists, and makes treatment difficult for specialists. In this study, we investigated the serum zinc level in children with pneumonia and healthy children. Also, we tried to find its relationship with IL-18 mRNA expression as an inflammatory cytokine. For this purpose, serum zinc levels and IL-18 mRNA expression were evaluated in 120 children aged 3-60 months with pneumonia and 120 healthy children. After taking 2ml of blood from children and measuring serum zinc level, the level of the IL-18 mRNA was measured by real-time PCR. Total RNA was extracted by bioZOL™-G RNA Isolation Reagent kit. The primary cDNA was amplified by the extracted RNA, and in the next step, 2µl of cDNA were amplified by specific primers to measure IL-18 mRNA. The Beta-actin gene was also used as internal control and housekeeping gene. Results showed that the level of zinc in the patient group was 412.625±28.87?M and in the control group was 514.40±49.67?M. This difference was statistically significant (P=0.0053). Also, the expression of the IL-18 gene was increased in children with pneumonia, significantly (P=0.0015). Therefore, from the results, it can be deduced that children with zinc deficiency were at higher risk for a lung infection. Inflammatory cytokines such as IL-18 also were increased in these children. Hence, it can be concluded that zinc levels can reduce the expression of IL-18 mRNA and play an important role in the prevention and treatment of children with pneumonia.

scholarly journals Serum zinc levels in children with simple febrile seizures

2019 ◽  
Vol 6 (4) ◽  
pp. 1480
Author(s):  
Malavika P. Santappanawar ◽  
Habeeb U. Khan ◽  
Jaidev M. Devdas ◽  
Sujonitha John ◽  
Pavan Hegde
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Nutritional Deficiencies ◽  
Control Group ◽  
Serum Zinc Level ◽  
Chi Square ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common seizures in childhood and are often associated with nutritional deficiencies. The present study was done to find any correlation of serum zinc levels in children with simple febrile seizures.Methods: This study was a hospital based prospective case control study, involving 60 children (30 cases and 30 controls) aged between 6 months to 60 months. Serum zinc level was measured in all subjects by atomic absorption spectrophotometer. Data was analysed by using frequency, percentage and Pearson’s chi square test..Results: Most cases (80%) had serum zinc levels <90 mcg/dl, in comparison with children in the control group where only 30% had serum zinc levels <90 mcg/dl. The mean serum zinc level was 78.9±14.26 mcg/dl in cases with simple febrile seizures and 96.7±12.12 mcg/dl in the control group.Conclusions: The mean serum zinc level was significantly lower in children with simple febrile seizures in comparison with controls.

Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

2016 ◽  
Vol 86 (1-2) ◽  
pp. 9-17 ◽  
Author(s):  
Bekir Ucan ◽  
Mustafa Sahin ◽  
Muyesser Sayki Arslan ◽  
Nujen Colak Bozkurt ◽  
Muhammed Kizilgul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hashimoto’S Thyroiditis ◽  
Healthy Control Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Endocrine Society ◽  
Thyroid Autoantibody ◽  
Healthy Control ◽  
The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Zinc deficiency may play a crucial role in dialysis-associated bacterial infections

2020 ◽  
Vol 11 (1) ◽  
pp. e9-e9
Author(s):  
Zahra Lotfi ◽  
Abbas Ali Zeraati ◽  
Elaheh Dashti ◽  
Tina Zeraati ◽  
Maryam Arghiany ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Bacterial Infections ◽  
Critical Role ◽  
Serum Zinc ◽  
Zinc Level ◽  
Healthy Individuals ◽  
Mortality And Morbidity ◽  
Increased Risk ◽  
The Mean

Introduction: Systemic bacterial infections are a common cause of mortality and morbidity in hemodialysis patients. Zinc has a critical role in several immune system functions. Patients who have enough amounts of zinc are able to better face infections caused by various pathogens in comparison to those with zinc insufficiency Objective We sought to assess the role of zinc deficiency in dialysis-associated bacterial infections. Patients and Methods: Eighty-Three adult patients with end-stage renal disease (ESRD) on hemodialysis including 43 patients with bacterial infectious complications and 40 non-infected patients as well as 41 healthy individuals were enrolled. Clinical data, laboratory values including serum zinc level and imaging findings were collected. SPSS was utilized to analyze the data with a significance cutoff set at P < 0.05. Results: Out of 124 participants, 80 (64.51%) were males and 44 (35.49%) were females. The mean age of infected hemodialysis group, non-infected hemodialysis group, and healthy controls were 50.8 ± 16.25, 49.1 ± 18.1, and 56.3 ± 18.2 years, respectively. Catheter site infection (37.3%) and urinary tract infection (30.2%) were the most common infections. The mean serum zinc concentration was significantly lower in the infected patients, compared to non-infected patients and healthy individuals (P < 0.001). Conclusion: The ESRD patients on hemodialysis have lower serum zinc levels which are associated with increased risk of bacterial infection. The role of screening for zinc deficiency and use of supplemental zinc in these patients need to be studied.

scholarly journals Association of serum zinc and vitamin E levels with Acne vulgarisin Bangladeshi acne patients

2021 ◽  
Vol 45 (1) ◽  
pp. 49-58
Author(s):  
Tania Sultana ◽  
Aklima Akter ◽  
Fatima Tuz Zohra ◽  
Md Quddusur Rahman ◽  
Yearul Kabir
Keyword(s):  
Vitamin E ◽  
Serum Vitamin ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Healthy Control ◽  
Male Patients ◽  
Acne Treatment

The serum level of zinc and vitamin E were measured to understand the association of various nutrients on acne pathogenesis. Both zinc and vitamin E are antioxidants used as a supplement in acne treatment. However, their effect and status in acne patients are not fully understood. This study included 48 acne patients and 48 sex- and age-matched healthy controls. The zinc and vitamin E concentration was measured in the serum by flame atomic absorption spectroscopy (AAS) and HPLC methods. Compared to the healthy control, a significant deficiency of serum vitamin E level in acne patients (p<0.001) was found, although the patients were not deficient in serum zinc level (p=0.22). In addition, female acne patients had a slightly lower zinc level than male patients (p=0.06). The low serum vitamin E level suggests that supplementation of vitamin E might be helpful in acne treatment. However, further studies are required to understand the dose and mechanism of vitamin E supplements in acne treatment. J. Bangladesh Acad. Sci. 45(1); 49-58: June 2021

scholarly journals Effects of Iron and Amloki (EmblicaOfficinalis) on Serum Zinc Level in Anaemia with Pregnancy

2021 ◽  
Vol 49 (1) ◽  
pp. 33-37
Author(s):  
Tahmina Akter ◽  
Qazi Shamima Akther ◽  
Saima Haque Lisa ◽  
Mst Ariza Sultana ◽  
Farhana Sultana ◽  
...  
Keyword(s):  
Side Effects ◽  
Iron Deficiency Anaemia ◽  
Iron Supplementation ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Serum Zinc Level ◽  
Deficiency Anaemia ◽  
Medical College ◽  
And Control

Pregnancy is associated with several trace elements deficiency in developing countries. Supplementation of iron in iron deficiency anaemia (IDA) has several side effects including alterations of serum zinc level. Traditionally, amloki is used as a well known supplement in pregnancy, which is rich in trace elements.To determine the effects of iron and amloki on serum zinc level in IDA with pregnancy. The study was a non blind, non random sampling interventional type of clinical trial. This study was performed in the Department of Physiology, Dhaka Medical College, Dhaka on 43 pregnant women between 13th to 20th weeks of gestation with IDA from July 2016 to June 2017.  They were recruited from Outpatient Department of Obstetrics and Gynaecology of Dhaka Medical College Hospital. Anaemic pregnant women supplemented with oral iron and amloki were considered as study group (A) and control group (B) were with only iron supplementation for 45 days. Serum zinc level was estimated in the laboratory of the Department of Soil, Water and Environment, University of Dhaka, Bangladesh.  For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s‘t’ test were considered using SPSS 22.0 version. Significant decrease (p<0.001) of serum zinc level was observed after intervention of iron in both groups. In this study, there was no significant difference in serum zinc level in between study and control group. It can be concluded that oral iron supplementation causes decrease in serum zinc level in IDA with pregnancy. Amloki shows no significant role in preventing decrease of serum zinc level in this study.  Emblicaofficinalis (amloki) is traditionally used to treat iron deficiency anaemia. It can increase haemoglobin concentration and decrease side effects of iron supplementation. Bangladesh Med J. 2020 Jan; 49 (1): 33-37

scholarly journals C5n 5 55Detection of Some Immunological Parameters in Psoriatic Iraqi Female Patients

2020 ◽  
pp. 2515-2524
Author(s):  
Rehab Morad Khazem ◽  
Shaima R. Ibraheem
Keyword(s):  
Serum Levels ◽  
Interleukin 10 ◽  
Living Condition ◽  
Healthy Control Group ◽  
Control Group ◽  
Immunological Parameters ◽  
Female Patients ◽  
Healthy Control ◽  
The Mean ◽  
Severity Of The Disease

Psoriasis is a common, chronic, immune-mediated skin disease with systemic pro-inflammatory activation.  This study was designed to estimate the level of two cytokines, Interleukin-36 (IL-36) and Interleukin-10 (IL-10), in psoriasis female patients. The study was accomplished on 50 Iraqi patients with psoriasis who were referred to the consulting clinic at Al-Yarmouk Teaching Hospital during the period from November 2018 to March 2019. These patients were diagnosed under the supervision of dermatologists. For the purpose of comparison, the study included 30 healthy women as a healthy control group. The serum levels of cytokines  were measured using the enzyme-linked immunosorbent technique (ELISA).The results of this study showed that the mean age of the female patients was 35.9 ± 1.85 years, whereas the age of the patients with a severity of higher than 30% ranged 15-25 years. Most of the patients were married, in an average living condition, and non-smokers, and their menstrual cycle was continuous. It was also found that 28% of the psoriatic patients had other chronic diseases. The study showed statistically significant differences (p <0.05) in the mean level of IL-36 between the patients and healthy control group, whereas there was no statistical difference in the mean level of IL-10. In conclusion,   the   decrease in the level of IL-36 in the patients might be related to the increase in the severity of the disease.

scholarly journals Correlation between Serum Zinc Level and Erythrocyte Superoxide Dismutase (SOD) Activity in Non-frail and Frail Geriatric Patients

2017 ◽  
Vol 1 (1) ◽  
pp. 34
Author(s):  
Rosnah Pinontoan ◽  
Savitri Sayogo ◽  
Arya Govinda Roosheroe
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Venous Blood ◽  
Serum Zinc ◽  
Zinc Level ◽  
Zn Deficiency ◽  
Serum Zinc Level ◽  
Physical Measurements ◽  
Significant Difference ◽  
The Mean

Introduction: Frailty syndrome (FS), as a health problem in elderly, can interfere with the quality of life. Many factors play roles in its occurrence, one of which is oxidative stress. Superoxide dismutase (SOD), in which one of its components is zinc (Zn), is one of the endogenous antioxidants that plays a role in preventing oxidative stress. This study was aimed to know the correlation between serum zinc level (sZn) and erythrocyte SOD (eSOD) activity in non-frail and frail geriatric patients.Methods: This was cross-sectional study with consecutive sampling method conducted in the Geriatric Clinic Cipto Mangunkusumo hospital, from August through September 2014, on 60 patients (30 patients for each group of non-frail and frail). Data were collected from interviews, physical measurements, and venous blood sampling.Results: Among 90% of the subjects had low Zn intake, at the same time, the mean of sZn was 8.41 ± 1.36mol/l and 93.3% of the subjects had experienced Zn deficiency. The mean of eSOD activity was 1526 ± 508U/gHb, and there was no significant difference between the groups. There were no significant correlation between sZn and eSOD activity both in the overall subject (r = -0.04; p = 0.076), as well as the non-frail group (r = -0.099; p=0.604) and frail  group (r = 0.01; p = 0.957).Conclusion: Serum zinc level did not have any significant correlation with the eSOD activity, neither on overall or both non-frail and frail groups.

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