scholarly journals An Extramedullary Plasmacytoma of the Nasopharynx : A rare entity

2016 ◽  
Vol 15 (3) ◽  
pp. 477-479
Author(s):  
Abdul Mokhti Abdullah ◽  
Zambri Ibrahim ◽  
Zulkifli Yusuf ◽  
Ramiza Ramza Ramli
Keyword(s):  
Multiple Myeloma ◽  
Smooth Surface ◽  
Medical Science ◽  
Extramedullary Plasmacytoma ◽  
Endoscopic Biopsy ◽  
Medical Illness ◽  
Rare Entity ◽  
Nasal Blockage ◽  
Surface Mass ◽  
History Of

A 64 year old female with no underlying medical illness presented with 3 months history of unilateral nasal blockage and rhinorrhoea. Nasopharyngeal examination revealed a smooth surface mass in the posterior nasal space. Endoscopic biopsy confirmed the mass to be Extramedullary Plasmacytoma. Investigation pertaining to multiple myeloma revealed no evidence of the disease. The mass was excised endoscopically and the patient completed 25 cycles (50Gy) radiotherapy. Patient had no evidence of recurrence after 6 months follow up.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.477-479

scholarly journals Pulsatile Midline Solitary Plasmacytoma in the Frontal Head Region-A Case Report”

2016 ◽  
Vol 32 (1) ◽  
pp. 39-42
Author(s):  
Md Atikur Rahman ◽  
Aklaque Hossain Khan ◽  
Kanak Kanti Barua
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Case Report ◽  
Histological Examination ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Solitary Plasmacytoma ◽  
Rare Entity ◽  
Head Region ◽  
Malignant Plasma Cell

Primary craniocerebral plasmacytomas are uncommon and represent only 0.7 % of all plasmacytomas. In this case solitary plasmacytoma in the midline frontal head region of the skull and discuss the clinical features and prognosis of this tumor. Plasmacytoma can present as multiple myeloma, solitary plasmacytoma of the bone or extramedullary plasmacytoma. Solitary plasmacytoma is a rare entity that composes of malignant plasma cells and involves the bone to form only one or two lesions without evidence of disease dissemination. It accounts for only 4% of malignant plasma cell tumors. 50 years old male was suffering from plasmacytoma in the frontal head region in our case which is pulsatile. On images showed multiple differential diagnosis but after operation histological examination revealed plasmacytoma. Bangladesh Journal of Neuroscience 2016; Vol. 32 (1): 39-42

scholarly journals PC3 - 216 Presentation of Intradural Extramedullary Plasmacytoma with Intratumoral Hemorrhage: Case Report and Review of Literature

2016 ◽  
Vol 43 (S4) ◽  
pp. S22-S22
Author(s):  
A. Ghare ◽  
F. Haji ◽  
K. MacDougall
Keyword(s):  
Multiple Myeloma ◽  
Differential Diagnosis ◽  
Plasma Cells ◽  
Extramedullary Plasmacytoma ◽  
Left Frontal Lobe ◽  
Axial Mass ◽  
Dural Tail ◽  
History Of ◽  
Intradural Extramedullary ◽  
Contrast Ct

Plasmacytomas are solitary tumours characterized by neoplastic proliferation of plasma cells and can be found isolated or in associated with multiple myeloma. Plasmacytomas uncommonly occur intracranially, and dural plasmacytomas without involvement of the calvarium are exceedingly rare. Reported cases indicate durally-based plasmacytomas mimick the appearance of meningioma, lymphoma or sarcoma of the dura. The authors report a case of a 77-year-old male with known multiple myeloma who presented with a 3-week history of confusion, speech impediment, and right sided weakness. A non-contrast CT scan revealed a dense extra-axial mass in the left frontal lobe with initial concerns of an extra-axial hemorrhage. A subsequent MRI demonstrated a contrast enhancing mass with a broad-based dural tail and no underlying calvarial lesion. Differential diagnosis included meningioma or intracranial plasmacytoma. The patient underwent surgical resection and was found to have intratumoural hemorrhage, with pathology confirming plasmacytoma. In the published literature, there are only 20 prior reports of dural plasmacytomas (with and without primary calvarial infiltration), of which only five previous cases reported associated intratumoural hemorrhage. Our case, along with this literature, suggests that new onset of focal neurologic deficits in patients with a history of multiple myeloma merits careful investigation, and that intracranial plasmacytoma should be considered on the differential diagnosis even when imaging reveals masses consistent with hemorrhage or meningioma.

scholarly journals Pleomorphic Adenoma Presenting as an Atypical Nasal Mass in a 26-Year-Old Female

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Racheal Hapunda ◽  
Chibamba Mumba ◽  
Owen Ngalamika
Keyword(s):  
Nasal Cavity ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Rare Entity ◽  
Gland Tumor ◽  
Diagnostic Dilemma ◽  
Nasal Blockage ◽  
History Of ◽  
The Right ◽  
Radiological Image

Pleomorphic adenoma (PA) is a salivary gland tumor that may rarely occur in the nasal cavity. It can be a clinical diagnostic dilemma in many instances due to many possible differential diagnoses. We report the case of a 26-year-old female who presented with a 3-year history of a right nasal growth associated with ipsilateral nasal blockage, nasal pain, and rhinorrhea. Radiological image showed a mild enhancing lesion in the right nasal cavity. The patient underwent a lateral rhinotomy with wide excision of the mass. Histopathological exam was consistent with PA. Nasal PA is a rare entity and should be suspected as a diagnosis for intranasal tumors.

Schwannoma of Tonsillolingual Sulcus: First Case Report and Review of Literature

2013 ◽  
Vol 5 (2) ◽  
pp. 8-9
Author(s):  
Hitesh Verma ◽  
RPS Punia
Keyword(s):  
Smooth Surface ◽  
Parapharyngeal Space ◽  
Needle Aspiration ◽  
Rare Entity ◽  
Review Of Literature ◽  
Common Site ◽  
Aspiration Cytology ◽  
First Case ◽  
History Of ◽  
Needle Aspiration Cytology

ABSTRACT Schwannoma is a benign, encapsulated tumor that is derived from schwann's cells. The most common site is parapharyngeal space of the neck; oropharyngeal occurrence is extremely rare. Fourteen year male boy presented with a history of difficulty in swallowing, more for solids for the last 8 months. The patient also had a change of voice for the last 5 months and was muffled in character. Examination showed single lobulated mass having smooth surface, of the size of approximately 5 × 4 cm and was arising from the tonsillolingual sulcus. The fine needle aspiration cytology from the lesion, reported to be schwannoma. The mass was excised completely under general anesthesia with the help of bipolar cautery. We report first case of schwannoma of tonsillolingual sulcus and also review the literature of the rare entity.

scholarly journals Depression, Anxiety and Stress among Obese Patients with Chronic Illnesses: Prevalence and Associated Factors in North East Malaysia

2019 ◽  
Vol 18 (2) ◽  
pp. 252-259
Author(s):  
Raihan Hassan ◽  
Maryam Mohd Zulkifli ◽  
Imran Ahmad ◽  
Siti Suhaila MohdYusoff
Keyword(s):  
Family History ◽  
Outpatient Clinic ◽  
Psychiatric Illness ◽  
Medical Science ◽  
High Body Mass Index ◽  
Medical Illness ◽  
Obese Patients ◽  
Factors Associated ◽  
Younger Age ◽  
History Of

Introduction: Concomitant obesity and chronic medical illness is a significant health problem in Malaysia and worldwide. The comorbid psychological impact in obese patients is associated with a social stigma and low self-esteem. The aim of this study was to determine the prevalence and the factors associated with depression, anxiety and stress in obese patients with chronic medical illnesses attending an outpatient clinic. Methods: This was a cross-sectional study among obese patients with chronic medical illnesses presenting at the Universiti Sains Malaysia Hospital outpatient clinic. A total of 274 patients were involved. The 21-item Depression, Anxiety and Stress Scale questionnaire was used, and the results were evaluated using single and multiple logistic regression analyses. Results: The prevalences of depression, anxiety and stress among the obese patients with chronic medical illnesses were 13.9%, 23.4% and 10.9%, respectively. Younger age [p=0.003, adjusted odds ratio (AOR),1.0; 95%confidence interval (CI),0.91–0.98], unemployed employment(p=0.013, AOR,3.7;95% CI,1.32–10.09) and smoking (p=0.022, AOR,3.2; 95% CI,1.18–8.55) were associated with depression. No formal education (p=0.011, AOR,5.7; 95%CI,1.49–21.89), high body mass index (p=0.029, AOR,1.1;95% CI,1.01–1.13) and family history of psychiatric illness (p=0.018, AOR,5.1; 95% CI,1.33–19.56) were associated with anxiety. Stress was strongly associated with females (p=0.004, AOR,5.0; 95% CI,1.70–15.13) and smoking(p=0.002, AOR,6.5; 95% CI,2.03–20.7). Conclusion: Interestingly, younger age group was associated with depression. Current smokers, no education, family history of psychiatric illness and female sex were significantly associated with anxiety and stress. This notifies new emerging knowledge on factors associated with obese patients that would empower the development of effective preventive strategies for it. Bangladesh Journal of Medical Science Vol.18(2) 2019 p.252-259

Unilateral Multiple Extramedullary Plasmacytoma of the Choroid and Conjunctiva: A Case Report

2019 ◽  
Vol 4 (2) ◽  
pp. 152-156
Author(s):  
Shymaa Mohamed ◽  
Truman Silvasi ◽  
Anthony Kubat ◽  
Thomas Aaberg
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Radiation Dose ◽  
Poor Prognosis ◽  
Clinical Manifestations ◽  
Excisional Biopsy ◽  
Extramedullary Plasmacytoma ◽  
Eye Pain ◽  
History Of ◽  
Conjunctival Nodule

Purpose: We report a case of multiple extramedullary plasmacytoma (EMP) of the choroid and conjunctiva as a sign of multiple myeloma (MM) relapse. Methods: An observational case report with clinicopathologic correlation is presented. Results: A 45-year-old man with a 2.5-year history of MM presented with left eye pain. Examination revealed a conjunctival nodule and choroidal infiltrate in the left eye. Excisional biopsy demonstrated plasmacytoma of the conjunctiva and choroid. Despite radiotherapy and chemotherapy, multiple EMP recurred and the patient died 8 months after initial presentation. Conclusions: Multiple EMP of the choroid and conjunctiva has a poor prognosis and can present as a sign of MM relapse. Our imaging demonstrates the clinical manifestations of this tumor and can aid future diagnoses. Our radiation dose (20 Gy) was inadequate, which is an important reportable factor for future patients.

scholarly journals Extramedullary Plasmacytoma Mimicking Pancreatic Cancer: An Unusual Presentation

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Daniela Sciancalepore ◽  
Sergio Musci ◽  
Maria Rosaria Fracella ◽  
Grazia D’Alesio ◽  
Azzurra Sportelli ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cell ◽  
Extramedullary Plasmacytoma ◽  
Endocrine Glands ◽  
Autologous Transplant ◽  
History Of ◽  
Remission Phase ◽  
Timing Of Onset ◽  
Gallbladder Fossa

Multiple myeloma is a plasma cell tumor that homes to and expands in the bone marrow and that, despite the new available drugs, remains incurable. Extramedullary plasmacytoma is a not frequent manifestation during the natural history of multiple myeloma and is frequently associated with plasma cell bone marrow infiltration. The most common locations for an EMP include the gastrointestinal tract, pleura, testis, skin, peritoneum, liver, endocrine glands, and lymph nodes. Primary involvement of the gallbladder fossa is exceedingly rare. In this report, we describe a patient with multiple myeloma who achieved a clinical and serological remission after autologous transplant but progressed rapidly at extramedullary site mimicking a second cancer (i.e., pancreatic or biliary cancer). In this case, the extramedullary localization was refractory to standard therapy, differently from bone marrow localization, but responded to lymphoma-like therapy. In this patient (i) the particular site of developing plasmacytoma is the gallbladder fossa, (ii) the timing of onset of this neoplasm is immediately after autologous transplant, and (iii) its disjunction from primary myeloma is that it appears in clinical and serological remission phase which may be confounding during the diagnostic approach simulating a different tumor (solid tumor).

scholarly journals Backache could be an indication of multiple myeloma: An unusual case report

2018 ◽  
Vol 17 (2) ◽  
pp. 311-315
Author(s):  
Muhammad Rizwan Ullah ◽  
Muhammad Kashif ◽  
Ahmed Nadeem ◽  
Romeeza Tahir ◽  
Zain Rizwan ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Malignant Disease ◽  
Unusual Case ◽  
Medical Science ◽  
Diagnostic Dilemma ◽  
The Past ◽  
History Of ◽  
Unusual Case Report ◽  
Rule Out

Unusual presentation of multiple myeloma (MM) poses a diagnostic dilemma. The objective of this case report is to document the unique presentation of MM and to highlight the importance of backache which could be the only indicator for the diagnosis of MM. Although a history of trauma in the past is present in this case, but there is no molecular basis/evidence to declare trauma as a risk factor for MM. It can be concluded that the patients with backache should be thoroughly investigated to rule out any possibility of malignant disease process.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.311-315

scholarly journals A Rare Case of Sinonasal Extramedullary Plasmacytoma with Orbital Involvement

2015 ◽  
Vol 6 (3) ◽  
pp. 121-124 ◽  
Author(s):  
Ramanathan Chandrasekharan ◽  
Gaurav Ashish ◽  
Harshad Parmar
Keyword(s):  
Multiple Myeloma ◽  
Rare Case ◽  
Neck Region ◽  
Bone Marrow Examination ◽  
Extramedullary Plasmacytoma ◽  
Excision Biopsy ◽  
Rare Entity ◽  
Orbital Involvement ◽  
Sinonasal Mass ◽  
Rare Differential Diagnosis

ABSTRACT Extramedullary plasmacytoma (EMP) is a rare entity in the head and neck region. It is phenotypically and immunologically different from multiple myeloma. Chronic transformation to multiple myeloma or its disseminated form is well known. It may even be the first manifestation of multiple myeloma also popularly known as secondary EMP. We present a 43-year-old male patient with history of persistent progressive nasal obstruction with occasional epistaxis. Endoscopy revealed a right sinonasal mass which on excision biopsy was consistent with features of EMP. Extramedullary plasmacytoma is a rare differential diagnosis for sinonasal mass. However, multiple myeloma should be ruled out via bone marrow examination, bone scan and serum and urine electrophoretic evaluation before arising at a diagnosis of EMP. In spite of EMP of nasal cavity being a rare entity, it should be considered as one of the rare differential diagnoses. How to cite this article Ashish G, Chandrasekharan R, Parmar H. A Rare Case of Sinonasal Extramedullary Plasmacytoma with Orbital Involvement. Int J Head Neck Surg 2015; 6(3):121-124.

scholarly journals Carcinosarcoma of the nasopharynx: a case report

2021 ◽  
Vol 7 (9) ◽  
pp. 1531
Author(s):  
Monica Kotu ◽  
Ian Paul Olwoch ◽  
Thabo Kgomo
Keyword(s):  
Complete Loss ◽  
High Recurrence Rate ◽  
High Morbidity ◽  
Rare Entity ◽  
Nasal Blockage ◽  
Recurrent Epistaxis ◽  
Histological Appearance ◽  
History Of ◽  
Clear Guideline ◽  
Aggressive Tumor

<p>Carcinosarcoma is a malignant tumor with a dual histological appearance, a squamous epithelial (sarcomatous), and a mesenchymal component. Carcinosarcomas are characterized by a high recurrence rate, metastatic spread, and high morbidity and mortality. Carcinosarcoma can arise from any squamous epithelial lining but rare in the sino-nasal tract. We are presenting a case of a 19-year-old male with a 3-month history of recurrent epistaxis associated with nasal blockage, anosmia, and bilateral complete loss of vision over a few weeks. Carcinosarcoma of the sino-nasal tract is a rare entity and can mimic any sino-nasal malignancy. The optimal treatment of this disease is controversial and lacks a clear guideline, therefore challenging to the treating oncologists.<strong> </strong>Carcinosarcoma of the head and neck is a rare and aggressive tumor. It poses diagnostic and treatment challenges.</p>

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