scholarly journals Association of 25-hydroxyvitamin D and Anemia parameters in elderly with anemia of inflammation and non-inflammation

2018 ◽  
Vol 17 (2) ◽  
pp. 302-306
Author(s):  
Vitasari Indriani ◽  
Nyoman Suci W ◽  
Herniah Asti W
Keyword(s):  
Vitamin D ◽  
Medical Science ◽  
The Elderly ◽  
World Health ◽  
Hydroxyvitamin D ◽  
Cell Counts ◽  
Inflammatory Mechanism ◽  
Inflammatory Processes ◽  
25 Hydroxyvitamin D ◽  
Anemia Of Inflammation

Background: Vitamin D deficiency and anemia are conditions commonly in eldery. Both result in significant morbidity in eldery. Relationship between 25-hydroxyvitamin D and anemia need to be concern, particularly in the elderly. including those characterized by inflammatory processes. The aim of this study is to analyze association and differentiations between of 25-hydroxyvitamin D levels and anemia parameters in elderly with anemia inflammation and non-inflammation.Methods: An observational study, at Posyandu Lansia Puskesmas Sokaraja, was conducted among 40 subjects aged ≥60 years consecutively, between September - November 2015. 25-Hydroxyvitamin D, hemoglobin levels, hematocrit and red blood cell counts were measured. 25-Hydroxyvitamin D deficiency defined in level <30 ng/mL and anemia defined by the World Health Organization.Results: After adjustment for CRP levels and leucocyte count, 25-Hydroxyvitamin D was inversely associated with anemia inflammation (p=0,018; p=0,010; p=0,000)and non-inflammation (p= 0,002; p=0,002; p=0,000). There was significantly differences 25-hydroxyvitamin D levels (p = 0.003) in elderly with anemia of inflammation and non-inflammation.Conclusion: 25-Hydroxyvitamin D levels was associated with anemia inflammation and non-inflammation in eldery. Vitamin D may suppress inflammatory mechanism, and studies to determine whether chronic disease involves anemia inflamation are warranted.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.302-306

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Blood ◽  
2011 ◽  
Vol 117 (10) ◽  
pp. 2800-2806 ◽  
Author(s):  
Todd S. Perlstein ◽  
Reena Pande ◽  
Nancy Berliner ◽  
Gary J. Vanasse
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
World Health ◽  
Elderly Persons ◽  
Increased Risk ◽  
Health Organization ◽  
Anemia Of Inflammation

AbstractAnemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D deficiency with anemia subtypes in persons aged ≥ 60 years. Vitamin D deficiency was defined as serum levels < 20 ng/mL, and anemia was defined according to World Health Organization criteria. Vitamin D deficiency was associated with anemia prevalence independent of age, sex, or race/ethnicity (odds ratio, 1.47; 95% confidence interval, 1.06-2.05; P = .02) and varied significantly by anemia subtype (P overall = .003). The prevalence of vitamin D deficiency was 33.3% in the nonanemic population, 56% in anemia of inflammation (AI; P = .008), and 33.0% in unexplained anemia (P = .55). Non-Hispanic blacks had a 7-fold increased risk of AI compared with whites, and this was partially attenuated after adjusting for vitamin D deficiency. These data show that vitamin D deficiency is associated with specific subtypes of anemia in the elderly, especially in those with AI. Vitamin D may suppress inflammatory pathways, and studies to determine whether vitamin D supplementation ameliorates AI are warranted.

scholarly journals Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D

2003 ◽  
Vol 88 (1) ◽  
pp. 185-191 ◽  
Author(s):  
Reinhold Vieth ◽  
Yasmin Ladak ◽  
Paul G. Walfish
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Age Groups ◽  
The Elderly ◽  
Age Group ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Vitamin D requirements are thought to vary with age, but there is little comparative evidence for this. One goal in establishing a vitamin D requirement is to avoid secondary hyperparathyroidism. We studied 1741 euthyroid, thyroid clinic outpatients without evidence of calcium abnormalities, ranging in age from 19 to 97 yr, whose serum and urine had been analyzed for calcium, vitamin D, and parathyroid status. We found no effect of age on the 25-hydroxyvitamin D [25(OH)D] concentration associated with specific vitamin D intakes, and there was no relationship between 25(OH)D and 1,25hydroxyvitamin D [1,25(OH)2D]. In every age group, serum 1,25(OH)2D declined with increasing creatinine (P &lt; 0.001). What changed with age included creatinine, which correlated with 25(OH)D (r = 0.146, P &lt; 0.001) only in the youngest age group (19–50 yr) but not in the older age groups (P &gt; 0.1). Creatinine did not correlate with PTH in the youngest age group, but the relationship became significant as age increased (e.g. for the elderly, r = 0.365, P &lt; 0.001). Linear regression of log PTH vs. log 25(OH)D agreed with the natural shape of the relationship observed with scatterplot smoothing, and this showed no plateau in PTH as 25(OH)D increased. We compared PTH concentrations among age groups, based on 20 nmol/liter increments in 25(OH)D. Mean PTH in adults older than 70 yr was consistently higher than in adults younger than 50 yr (P &lt; 0.05 by ANOVA and Dunnett’s t test). PTH levels of the elderly who had 25(OH)D concentrations greater than 100 nmol/liter matched PTH of younger adults having 25(OH)D concentrations near 70 nmol/liter. This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function.

scholarly journals Effects of Vitamin D and K on Interleukin-6 in COVID-19

2022 ◽  
Vol 8 ◽  
Author(s):  
Margot P. J. Visser ◽  
Anton S. M. Dofferhoff ◽  
Jody M. W. van den Ouweland ◽  
Henny van Daal ◽  
Cornelis Kramers ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inflammatory Response ◽  
Vitamin K ◽  
Elastic Fiber ◽  
Matrix Gla Protein ◽  
Central Component ◽  
Hydroxyvitamin D ◽  
Fiber Degradation ◽  
Inflammatory Processes ◽  
25 Hydroxyvitamin D

BackgroundPathology during COVID-19 infection arises partly from an excessive inflammatory response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed as potential modulators of this process.MethodsWe assessed vitamin D and K status by measuring circulating 25-hydroxyvitamin D (25(OH)D) and desphospho-uncarboxylated Matrix Gla-Protein (dp-ucMGP), respectively in 135 hospitalized COVID-19 patients in relation to inflammatory response, elastic fiber degradation and clinical outcomes.ResultsComparing good and poor disease outcomes of COVID-19 patients, vitamin 25(OH)D levels were not significantly different. IL-6 levels, however, were significantly higher in patients with poor outcome, compared to patients with good outcome (30.3 vs. 153.0 pg/mL; p &lt; 0.0001). Dp-ucMGP levels as biomarker of extrahepatic vitamin K status was associated with IL-6 levels (r = 0.35; p &lt; 0.0001). In contrast, 25(OH)D levels were only borderline statistically significant correlated with IL-6 (r = −0.14; p &lt;0.050). A significant association was also found between IL-6 and elastic fiber degradation. Contrary to vitamin K status, 25(OH)D did not correlate with elastic fiber degradation.ConclusionsDp-ucMGP associates with IL-6 as a central component of the destructive inflammatory processes in COVID-19. An intervention trial may provide insight whether vitamin K administration, either or not in combination with vitamin D, improves clinical outcome of COVID-19.

scholarly journals Influence of physical mobility and season on 25-hydroxyvitamin D-parathyroid hormone interaction and bone remodelling in the elderly

2000 ◽  
pp. 673-679 ◽  
Author(s):  
R Theiler ◽  
HB Stahelin ◽  
M Kranzlin ◽  
G Somorjai ◽  
L Singer-Lindpaintner ◽  
...  
Keyword(s):  
Vitamin D ◽  
The Elderly ◽  
Serum Concentrations ◽  
Institutionalized Elderly ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Physical Mobility ◽  
25 Hydroxyvitamin D ◽  
Mobility Status

OBJECTIVE: To investigate influences of physical mobility and season on 25-hydroxyvitamin D-intact parathyroid hormone (iPTH) interaction in the elderly. DESIGN: We examined 188 frail institutionalized elderly at the expected nadir of their serum vitamin D concentrations (winter). This group was compared with 309 healthy ambulatory elderly at the expected time of maximum vitamin D repletion (summer), to accentuate the influences of season and physical activity. METHODS: Serum concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, iPTH and urinary deoxypyridinoline (DPD) were measured. RESULTS: Vitamin D metabolites were significantly lower in the institutionalized elderly (P<0.0001), with an 82.5% prevalence of vitamin D deficiency (25-hydroxyvitamin D <12ng/ml) in institutionalized elderly in wintertime and 15.5% in ambulatory elderly in summertime. Overall, median iPTH did not differ between groups. However, median iPTH secretion in the presence of low vitamin D serum concentrations (5-30ng/ml) was greater in ambulatory elderly. This could be explained by lower mobility status being correlated with greater serum calcium concentrations (r=0.24, P=0.02 in women; r=0.35, P=0. 001 in men) and greater urinary excretion of DPD (r=0.41, P=0.0001 in women; r=0.42, P=0.0002 in men), independent of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and iPTH. CONCLUSIONS: These data support the hypothesis that immobility, even in the presence of vitamin D deficiency, acts as an overriding influence on bone metabolism by promoting bone resorption (measured as urinary DPD) and increasing serum calcium independent of iPTH. Therefore mobility status may substantially affect 25-hydroxyvitamin D threshold values and the degree to which patients benefit from vitamin supplementation.

Prevalence of 25-Hydroxyvitamin D Deficiency in Korean Patients with Anemia

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 5164-5164
Author(s):  
Eun-Hyung Yoo ◽  
Hyun-Jung Cho
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Iron Deficiency Anemia ◽  
Cellular Proliferation ◽  
World Health ◽  
Deficiency Anemia ◽  
Korean Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Abstract Abstract 5164 Background: Vitamin D deficiency is a very common health problem in Korea. Vitamin D has been suggested to have an important role on nonskeletal functions including cellular proliferation and differentiation, muscle function, immunity and erythropoiesis. Recent studies have been reported that vitamin D deficiency had associated with iron deficiency anemia, anemia of chronic kidney disease, and anemia of inflammation. In this study, we investigated the prevalence of vitamin D deficiency in Korean patients with anemia and also analyzed the association between vitamin D status and specific subtypes of anemia. Methods: A total of 147 anemic patients (median age 66 years, range 19∼91 years) and 300 nonanemic controls (median age 60 years, range 29∼87 years) were included. Anemia was defined according to World Health Organization (WHO) criteria. Serum 25- hydroxyvitamin D [25(OH)D] was measured using electrochemiluminescence immunoassay. The deficiency of 25(OH)D was defined as <20 ng/mL and severe deficiency was defined as <10 ng/mL. We compared serum 25(OH)D levels based on the presence and subtypes of anemia. Results: The prevalence of 25(OH)D deficiency was 74% (109/147) and 70% (210/300) in anemic (median Hb 9. 6 g/dL) and nonanemic group (median Hb 14. 3 g/dL), respectively. The prevalence of severe 25(OH)D deficiency was significantly higher in anemic group than in nonanemic group [44. 8% (66/147) vs 11. 7% (35/300), P<0. 0001] Odds ratio for severe 25(OH)D deficiency in anemic patients was 6. 17 (95% CI 3. 820–9. 965, P<0. 0001). The prevalence of 25(OH)D deficiency was not different between iron deficiency anemia (IDA) group and anemia of chronic disease (ACD) group. However, the serum 25(OH)D levels of ACD patients were lower than those of IDA patients in male (median 25(OH)D 14. 34 ng/mL vs 23. 04 ng/mL, P=0. 04). Conclusion: This study demonstrates that severe vitamin D deficiency is associated with anemia in Korea. Although vitamin D deficiency is also very common in nonanemic Korean population, anemia is related to much worse vitamin D deficient status. Multiple factors including poor nutritional status and potential roles of vitamin D on inflammation and erythropoiesis might be considered. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Serum 25-hydroxyvitamin D and muscle atrophy in the elderly

2011 ◽  
Vol 71 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Bess Dawson-Hughes
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Meta Analysis ◽  
The Elderly ◽  
Muscle Performance ◽  
Vitamin D Receptors ◽  
Hydroxyvitamin D ◽  
Human Skeletal Muscle Cells ◽  
Supplemental Vitamin ◽  
25 Hydroxyvitamin D

The objective of this review is to consider the mechanisms by which vitamin D affects muscle and the evidence that vitamin D status is important for muscle performance and fall prevention in older adults. Vitamin D receptors have been identified in human skeletal-muscle cells. Activation of these receptors by 1,25-dihydroxyvitamin D is involved in the action of vitamin D on the myocyte. Several studies have examined the effect of supplemental vitamin D on muscle strength, balance and falls. Among those examining muscle strength, results have been either positive for vitamin D or null. A recent meta-analysis of seventeen such trials revealed no significant effect of vitamin D overall, but a significant improvement in strength was observed in the trials in which the mean starting level of 25-hydroxyvitamin D was 25 nmol/l or below. Evidence for an effect of vitamin D on balance, measured as sway, is less abundant but more consistently positive. Many trials have evaluated the effect of supplemental vitamin D on falls. Overall, there is about a 20% lower risk of falling with supplementation. One meta-analysis considered the vitamin D dose administered and concluded that doses up through 15 μg (600 IU) were ineffective and doses of 17·5–25 μg/d (700–1000 IU/d) significantly lowered fall risk. The minimal 25-hydroxyvitamin D level needed for benefit was 60 nmol/l.

scholarly journals Predictors of 25-hydroxyvitamin D status among adults in two British national surveys

2008 ◽  
Vol 101 (5) ◽  
pp. 760-764 ◽  
Author(s):  
Vasant Hirani ◽  
Annhild Mosdøl ◽  
Gita Mishra
Keyword(s):  
Vitamin D ◽  
Low Income ◽  
Adult Population ◽  
The Elderly ◽  
Nutrition Survey ◽  
Hydroxyvitamin D ◽  
Three Samples ◽  
National Prevention ◽  
25 Hydroxyvitamin D ◽  
The Uk

Several recent reports have found a high prevalence of vitamin D deficiency in the adult British population. The present paper investigates the associations of low income/material deprivation and other predictors of serum 25-hydroxyvitamin D (25(OH)D) status in two surveys: The National Diet and Nutrition Survey (NDNS) of the population aged 19–64 years in mainland Britain and the Low Income Diet and Nutrition Survey (LIDNS) of adults aged ≥ 19 years in all regions of the UK who were screened to identify low-income/materially deprived households. A valid serum 25(OH)D sample was obtained in 1297 and 792 participants from the NDNS and LDNS respectively. The NDNS participants who were not receiving benefits (n 1054) had a mean 25(OH)D of 50·1 nmol/l, which was higher than among NDNS participants receiving benefits (n 243) with a mean 25(OH)D of 43·0 nmol/l (P < 0·001) and the LIDNS sample (46·5 nmol/l; P < 0·05). For all three samples, the season of drawing blood, skin colour, dietary intake of vitamin D, and intake of dietary supplements were significant predictors (P < 0·05) of serum 25(OH)D status in mutually adjusted regression models. National prevention and treatments strategies of poor vitamin D status need to be targeted to include the adult population, particularly deprived populations, in addition to the elderly and ethnic minorities.

Sign in / Sign up

Export Citation Format

Share Document