scholarly journals Dyslipidemia, C-reactive protein and leptin levels in non diabetic obese subjects

1970 ◽  
Vol 1 (1) ◽  
pp. 41-50
Author(s):  
Sowbhagya Lakshmi ◽  
DM Ravichand
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Protective Factor ◽  
Normal Subjects ◽  
Normal Weight ◽  
Serum Samples ◽  
Obese Subjects ◽  
Cardio Vascular ◽  
Relationship Of

Introduction: The objective of the study is to find the relationship of obesity with dyslipidemia and Leptin levels. Material and Methods: The study was carried out in the Department of clinical Biochemistry, Bangalore Medical College. Cases and controls were chosen from the subjects attending the out patient department of Victoria hospital for their routine check up.The protocol of the study was to study and compare the linear relationship of obesity, dyslipidemia, CRP and Leptin levels is Non Diabetic obese persons to Non Diabetic persons with normal weight. The protocol was based on inclusion and exclusion criteria and is approved by local ethical committee Serum samples were stored at -200C for estimation of Leptin and CRP levels. The samples were thawed on one stretch for the estimation. Leptin was analyzed by DRG Leptin sand witch ELISA method by using kit from DRG Company. Results: About 8.0% of patients had elevated Total cholesterol in normal subjects when compared to 84.0% in Obese subjects, indicates that patients with obesity are 60.37 times more likely to have elevated Total cholesterol (>200 mg/dl) when compared to Normal. Patients with obesity (98.0%) are 46.23 times more likely to have elevated Triglycerides when compared to normal subjects (52.0%). Subjects in Obese groups, 76.0% had decreased HDL when compared to only 12.0% on Normal group, which 8.14 times more likely in obsess group. Subjects with obesity (80.0%) are 29.33 times more likely to have elevated LDL (>150 mg/dl) when compared to Normal subjects (12.0%). The elevated VLDL is 21.0 times more likely in obese subjects (84.0%) when compared to normal subjects (20.0%). Subjects in obese are 46.58 times more likely to have elevated LP (a) when compared to normal subjects. Conclusions: Present study has shown a strong link between obesity, dislipidemia and cardiovascular disease in accordance with other studies. The role of Leptin associated with cardiovascular disease is not well established, so prospective study should be carried out to elucidate the role of Leptin in cardio vascular disease and Diabetes to establish its role as, whether it is causative, additive risk factor or a protective factor. Leptin may play a role to prevent metabolic syndrome by its interaction with neuroendocrine systems to maintain metabolic homeostasis, similar to the role played by Insulin in homeostasis of blood sugar level.   doi: 10.3329/blj.v1i1.2625 Bangladesh Liver Journal Vol.1(1) 2009 p.41-50 

scholarly journals Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2244
Author(s):  
Melania Melis ◽  
Mariano Mastinu ◽  
Stefano Pintus ◽  
Tiziana Cabras ◽  
Roberto Crnjar ◽  
...  
Keyword(s):  
Food Preferences ◽  
Specific Weight ◽  
Normal Weight ◽  
Nutrition Status ◽  
Salivary Proteins ◽  
Specific Proteins ◽  
Obese Subjects ◽  
And Gender ◽  
Cystatin Sn

Taste plays an important role in processes such as food choices, nutrition status and health. Salivary proteins contribute to taste sensitivity. Taste reduction has been associated with obesity. Gender influences the obesity predisposition and the genetic ability to perceive the bitterness of 6-n-propylthiouracil (PROP), oral marker for food preferences and consumption. We investigated variations in the profile of salivary proteome, analyzed by HPLC-ESI-MS, between sixty-one normal weight subjects (NW) and fifty-seven subjects with obesity (OB), based on gender and PROP sensitivity. Results showed variations of taste-related salivary proteins between NW and OB, which were differently associated with gender and PROP sensitivity. High levels of Ps-1, II-2 and IB-1 proteins belonging to basic proline rich proteins (bPRPs) and PRP-1 protein belonging to acid proline rich proteins (aPRPs) were found in OB males, who showed a lower body mass index (BMI) than OB females. High levels of Ps-1 protein and Cystatin SN (Cyst SN) were found in OB non-tasters, who had lower BMI than OB super-tasters. These new insights on the role of salivary proteins as a factor driving the specific weight gain of OB females and super-tasters, suggest the use of specific proteins as a strategic tool modifying taste responses related to eating behavior.

scholarly journals The Impact of Strenuous Group Physical Activity on Mood States, Personal Views, Body Composition, and Markers of Myocardial Damage in Overweight/Obese Adults: The “Step-by-Step Italy’s Coast to Coast” Trek

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Claudia Mazzeschi ◽  
Natalia Piana ◽  
Daniela Capezzali ◽  
Antonella Mommi ◽  
Cristina Aiello ◽  
...  
Keyword(s):  
Body Composition ◽  
Psychological Impact ◽  
Myocardial Damage ◽  
Normal Weight ◽  
Obese Adults ◽  
Long Distance ◽  
Obese People ◽  
Obese Subjects ◽  
Relationship Of ◽  
The Impact

It is clinically relevant to understand whether it is safe to recommend to trained overweight/obese people long-distance treks and whether these experiences could have a negative psychological impact or become even dangerous exposing the trekkers to the risk of clinically silent myocardial damage. To answer these questions we have performed a quantitative/qualitative study comparing the changes in mood profiles, personal views, body composition, and plasma troponin levels of 40 overweight/obese subjects with those of 36 healthy normal weight subjects after the participation in a trek of 388 km from the Adriatic to the Tyrrhenian seas trek: the “Step by step…Italy’s coast to coast”. The results of this study demonstrate that long-distance treks are a safe activity for trained overweight/obese people which should be recommended because they improve mood, health status, and the relationship of participants with themselves and with the regular practice of exercise with effects similar to those obtained by healthy normal weight subjects.

scholarly journals Metabolic Syndrome: The Complex Relationship of Diet to Conditions of Disturbed Metabolism

2011 ◽  
Vol 1 (2) ◽  
pp. 1 ◽  
Author(s):  
Jeffrey S. Bland
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Clinical Studies ◽  
Inflammatory Responses ◽  
Lifestyle Modification ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Public Health Challenge ◽  
Relationship Of

The widespread prevalence and deleterious effects of metabolic syndrome have become a major public health challenge as it is associated with the development of type 2 diabetes and cardiovascular disease. Lifestyle modification focusing on diet has shown promise for managing cardiovascular disease risk, and clinical studies provide evidence that a Mediterranean diet supplemented with phytochemicals is a successful interventional approach. The role of phytochemicals in regulating gene expression and modulating intracellular kinase activity has only recently begun to be appreciated. Clinical studies investigating the effects of specific phytochemicals in metabolic syndrome patients have produced encouraging results, including normalization of metabolic function, reduction of cardiovascular risk, and resolution of metabolic syndrome. As research advances our understanding of the evolutionary relationships between plants and humans, details are emerging about the mechanisms by which phytochemicals regulate insulin signaling and inflammatory responses. This expanding field of research is likely to lead to novel, effective clinical approaches for combating chronic diseases such as metabolic syndrome.

scholarly journals Role of cardiotrophin‐1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24‐h circulating CT‐1 profiles in normal‐weight and overweight/obese subjects

2017 ◽  
Vol 31 (4) ◽  
pp. 1639-1649 ◽  
Author(s):  
Miguel Lópeź‐Yoldi ◽  
Kimber L. Stanhope ◽  
Marta Garaulet ◽  
X. Guoxia Chen ◽  
Beatriz Marcos‐Gómeź ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Clock Genes ◽  
Normal Weight ◽  
Obese Subjects

scholarly journals Physical Activity and Body-Mass-Index: Do Family, Friends and Teachers Restrain the Risk for Physical Inactivity in Adolescents?

2021 ◽  
Vol 13 (13) ◽  
pp. 6992
Author(s):  
Denise Renninger ◽  
David Joseph Sturm ◽  
Adilson Marques ◽  
Miguel Peralta ◽  
Stevo Popovic ◽  
...  
Keyword(s):  
Social Support ◽  
Family Support ◽  
Peer Support ◽  
Teacher Support ◽  
Normal Weight ◽  
Moderating Effect ◽  
Obese Adolescents ◽  
School Aged Children ◽  
Relationship Of

Background: The present study investigates the role of different sources of social support in the relationship of BMI and PA in an international sample of children and adolescents. Methods: Data included 170,211 adolescents (51.5% female), aged 10–16 (M = 13.6, SD = 1.64) from 37 European countries/regions and were retrieved from the 2013/14 Health Behaviour in School-aged Children (HBSC) international database. Results: PA levels in adolescents are lower for girls, decrease with age, and are lower for overweight and obese adolescents compared to underweight and normal-weight adolescents. Peer support and teacher support significantly predict PA (ORpeer = 1.11; ORteacher = 0.97) and vigorous PA frequency (ORpeer = 1.13; ORteacher = 0.94). Family support only affected vigorous PA frequency (OR = 1.03). Family support had a moderating effect on PA in overweight (ORfamily*BMI(overweight) = 0.94) and obese (ORfamily*BMI(obese) = 0.90) adolescents. Peer support had a moderating effect on vigorous PA frequency in obese (ORpeer*BMI(obese) = 1.08) adolescents. Teacher support had a moderating effect on PA (ORteacher*BMI(normal) = 1.05; ORteacher*BMI(overweight) = 1.09) and vigorous PA frequency (ORteacher*BMI(normal) = 1.07; ORteacher*BMI(overweight) = 1.08) in normal-weight and overweight adolescents. Conclusion: Social support helps adolescents to be active. Especially for obese adolescents, support by and relations with peers are important to reach a significant amount of PA.

scholarly journals Relationship of microRNA locus with type 2 diabetes mellitus: a case-control study

2021 ◽  
Author(s):  
Qiuyu Huang ◽  
Hanshen Chen ◽  
Fan Xu ◽  
Chao Liu ◽  
Yafeng Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protective Factor ◽  
Aberrant Expression ◽  
Single Nucleotide ◽  
Hereditary Factors ◽  
Relationship Of

Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms may affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR-variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a rs2910164 C>G, -196a2 rs11614913 T>C and -499 rs3746444 A>G loci and carried out an investigation to identify whether these miR- loci could influence T2DM occurrence. In this investigation, a Bonferroni correction was harnessed. After adjustment, we found that rs2910164 single nucleotide polymorphism (SNP) was a protective factor for T2DM (GG vs. CC/CG: adjusted P=0.010), especially in never drinking (GG vs. CC/CG: adjusted P=0.001) and ≥24 kg/m2 (GG vs. CC/CG: adjusted P=0.002) subgroups. We also identified that rs11614913 SNP was a protective factor for T2DM in smoking subjects (CC/TC vs. TT: adjusted P=0.002). When we analyzed an interaction of SNP-SNP with the susceptibility of T2DM. Rs11614913/rs3746444, Rs2910164/rs3746444, and rs11614913/rs2910164 combinations were not associated with the risk of T2DM. In summary, the present study highlights that rs2910164 SNP decreases a susceptibility of T2DM, especially in BMI ≥24 kg/m2 and never drinking subgroups. In addition, we also identify that rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking subgroup.

scholarly journals The Expanding Armamentarium of Innovative Bioengineered Strategies to Augment Cardiovascular Repair and Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Stefan Elde ◽  
Hanjay Wang ◽  
Y. Joseph Woo
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cell Therapy ◽  
Crucial Role ◽  
Cellular Tissue ◽  
Myocardial Regeneration ◽  
Regenerative Processes ◽  
Relationship Of ◽  
Insight Into

Cardiovascular disease remains the leading cause of death worldwide. While clinical trials of cell therapy have demonstrated largely neutral results, recent investigations into the mechanisms of natural myocardial regeneration have demonstrated promising new intersections between molecular, cellular, tissue, biomaterial, and biomechanical engineering solutions. New insight into the crucial role of inflammation in natural regenerative processes may explain why previous efforts have yielded only modest degrees of regeneration. Furthermore, the new understanding of the interdependent relationship of inflammation and myocardial regeneration have catalyzed the emergence of promising new areas of investigation at the intersection of many fields.

A reduced number of insulin receptors in patients with Prader-Willi syndrome

1983 ◽  
Vol 104 (3) ◽  
pp. 345-351 ◽  
Author(s):  
Arne M. Kousholt ◽  
Henning Beck-Nielsen ◽  
Hans T. Lund
Keyword(s):  
Insulin Resistance ◽  
Insulin Receptor ◽  
Insulin Response ◽  
Insulin Receptors ◽  
Normal Subjects ◽  
Normal Weight ◽  
Target Cells ◽  
Prader Willi Syndrome ◽  
Plasma Insulin Concentration ◽  
Obese Subjects

Abstract. The Prader-Willi syndrome is among other features characterized by obesity and a high prevalence of glucose intolerance. The fasting plasma insulin concentration and the insulin response to glucose are often increased, indicating some insulin resistance in this disease. To investigate whether this could be due to an insulin receptor defect 7 patients with Prader-Willi syndrome, 10 normal weight subjects and 8 obese subjects were tested for the binding of [125I]insulin to monocytes. Monocytes from patients with Prader-Willi syndrome bound significantly less insulin than cells from normal subjects (P < 0.01). However, no difference was found between Prader-Willi patients and the obese controls (P > 0.1). It is concluded that the insulin resistance found in Prader-Willi patients, similar to that found in obese subjects, in part, may be explained by an insulin receptor defect on target cells for insulin action.

scholarly journals BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yanqiu Wang ◽  
Qinglei Yin ◽  
Min Xu ◽  
Qicheng Ni ◽  
Weiqing Wang ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Statistical Significance ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Weight Group ◽  
Cholesterol Levels ◽  
Lipid Parameters

The impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention. It is currently unknown whether BMI influences such interaction. In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid healthy adults. Our results show that thyroid parameters are differentially associated with lipid profile. FT3 is positively correlated with total cholesterol (β=0.176±0.046, P<0.001) and LDL cholesterol levels (β=0.161±0.040, P<0.001). FT4 is negatively correlated with TG (β=−0.087±0.029, P<0.01) while positively correlated with HDL cholesterol levels (β=0.013±0.005, P<0.01). TSH is positively associated with TG (β=0.145±0.056, P<0.05) and total cholesterol levels (β=0.094±0.030, P<0.01). Importantly, BMI modulates the effect of TH on lipid profile: the interaction of FT4 and BMI and the interaction of FT3 and BMI reach statistical significance in predicting TG and HDL cholesterol levels, respectively. Stratified according to BMI levels, most associations between TH and lipid profile are significant only in normal-weight group. In conclusion, in euthyroid adults, high normal FT3, TSH levels, and low normal FT4 levels are associated with unfavorable lipid profile. BMI mediates the effect of thyroid function on lipid profile in euthyroid adults.

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