scholarly journals Evaluation of Diclofenac by UV-Vis Spectrophotometer in Some Locally Produced Tablets

2017 ◽  
Vol 65 (2) ◽  
pp. 163-165
Author(s):  
MK Hasan ◽  
MA Hossain ◽  
A Sultana ◽  
M Shoeb ◽  
N Nahar
Keyword(s):  
Correlation Coefficient ◽  
Active Ingredient ◽  
Calibration Curve ◽  
Diclofenac Sodium ◽  
Pharmaceutical Product ◽  
Concentration Levels

Diclofenac is a common and randomly used pharmaceutical product, was evaluated for its active ingredient by UV-Vis spectrophotometer at 282 nm. Diclofenac sodium of 50 mg dose of seven different companies of Bangladesh was extracted from the tablets, cleaned up and the active ingredient was evaluated. Evaluation was carried out with respect to calibration curve of standard diclofenac sodium. Amount of diclofenac in 50 mg tablets of seven different companies were found to be in the range of 47.91 ± 0.90 to 58.52 ± 0.41 mg. Recovery experiments were done by spiking excipient of the medicine at two different concentration levels with 5-7 replicate studies. Correlation coefficient (r2) was found to be 0.9974 and the recovery was103.39 ± 3.93 to 107.96 ± 3.56 % for the drug. Dhaka Univ. J. Sci. 65(2): 163-165, 2017 (July)

Use of Molecular Microspectroscopy to Characterize Pigment-Loaded Polypropylene Single Fibers

1994 ◽  
Vol 48 (11) ◽  
pp. 1387-1393 ◽  
Author(s):  
S. P. Bouffard ◽  
A. J. Sommer ◽  
J. E. Katon ◽  
S. Godber
Keyword(s):  
Correlation Coefficient ◽  
Polypropylene Fibers ◽  
Effective Technique ◽  
Pigment Identification ◽  
Infrared Microspectroscopy ◽  
Positive Identification ◽  
Fiber Analysis ◽  
Heating Effects ◽  
Relative Standard ◽  
Concentration Levels

Molecular microspectroscopy was used to characterize different pigments loaded into polypropylene fibers. Single-fiber analysis by infrared, visible, and Raman microspectroscopies proved to be quite complementary for identification and quantitation of these materials. Infrared microspectroscopy was effective not only for identification of pigments loaded into the fibers, but also for quantitation of concentration levels at 1% (w/w) and greater. Visible microspectroscopy was effective for quantitation of pigment levels between the range of 0.1 and 1% (w/w). However, it may not be successful for positive identification of most pigments. Raman microspectroscopy was an effective technique for pigment identification and quantitation over all examined concentration levels provided that the sample showed no signs of fluorescence or heating effects. Quantitation for all techniques gave correlation coefficient values of 0.99+ and relative standard deviations typically ranging from 5 to 20%.

Determination and Confirmation of cis-9-Tricosene in Technical Materials by Capillary Gas Chromatography and Gas Chromatography/Mass Spectrometry

1992 ◽  
Vol 75 (5) ◽  
pp. 878-882
Author(s):  
Jinren Ko ◽  
Jack Nguyen ◽  
Jim Burleson
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Correlation Coefficient ◽  
Calibration Curve ◽  
Capillary Gas Chromatography ◽  
Methylene Chloride ◽  
Internal Standard ◽  
Gas Chromatography Mass Spectrometry ◽  
Technical Material ◽  
Standard Calibration

Abstract A capillary gas chromatographic (GC) method was developed for the quantitation of cis-9-tricosene in technical material. This method is capable of resolving cis-9-tricosene from the trans-9-tricosene isomer and other impurities in technical 9-tricosene. Samples are dissolved in methylene chloride and analyzed by splitless GC using docosane as an internal standard. The integrity and purity of the peak of interest were confirmed by GC/mass spectrometry. The overall recovery of this method was 101.3 ± 0.82%. The correlation coefficient of the standard calibration curve was 0.9999. The system and method precision for cis-9-tricosene were 0.18 and 0.20%, respectively. The reproducibility of the method by different analysts was within 0.5%.

Determination of Sucralose by Controlled UV Photodegradation Followed by UV Spectrophotometry

2013 ◽  
Vol 96 (3) ◽  
pp. 603-606
Author(s):  
Mohd Idris ◽  
V Jayathirtha Rao ◽  
Deepak Middha ◽  
Sudhir Kumar Shukla ◽  
Tulsidas Ramachandra Rao Baggi
Keyword(s):  
Correlation Coefficient ◽  
Alkaline Medium ◽  
Spectrophotometric Method ◽  
Calibration Curve ◽  
Artificial Sweeteners ◽  
Uv Spectrophotometry ◽  
Medium Ph ◽  
Accuracy And Precision ◽  
Uv Photodegradation

Abstract A simple and time-efficient UV spectrophotometric method was developed for the determination of sucralose in artificial sweeteners. The procedure is based on the UV spectrophotometric determination of the photodegraded product at 270 nm in alkaline medium (pH 12). LOD for this method was 0.02 g/L, and the calibration curve was found to obey Beer's law in the concentration range of 0.1 to 1.2 g/L, with a correlation coefficient (R2) value of 0.9977. The proposed method was studied for accuracy and precision.

scholarly journals Comparative Study of Compartmental Modeling of Sustained Release Oral Dosage Forms and Intramuscular Injection

2019 ◽  
Vol 22 (3) ◽  
pp. 222-226
Author(s):  
Khawla H. Rasheed
Keyword(s):  
Sustained Release ◽  
Kinetic Parameters ◽  
Correlation Coefficient ◽  
Intramuscular Injection ◽  
High Performance ◽  
Diclofenac Sodium ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Compartmental Modeling ◽  
Oral Dosage Forms

This study has been performed to compare the compartmental modeling of two types of extravascular routes, sustained-release (SR) oral dosage forms and intramuscular (IM) injection. Twenty healthy volunteers received a single dose of 100 mg Diclofenac Sodium (DS) sustained-release tablet, then 75 mg DS Intramuscular injection after two weeks washout period. The concentrations of DS in plasma were measured using reverse-phase high-performance liquid chromatography (HPLC). The data analyzed using compartmental modeling, with single time-variant input and output. Primary kinetic parameters for both formulations, ( , , ) and other kinetic parameters were evaluated. The result shows that the IM injection needs a shorter time to reach the maximum concentration with convergent bioavailability to SR oral dosage forms, in another hand the data of IM injection fitted to single-compartment model with a correlation coefficient of 0.93 and the data of SR tablet fitted to two-compartment models with a correlation coefficient of 0.97.

Turbidimetric latex immunoassay of placental lactogen on microtiter plates.

1989 ◽  
Vol 35 (1) ◽  
pp. 141-143 ◽  
Author(s):  
D Collet-Cassart ◽  
J N Limet ◽  
L Van Krieken ◽  
R De Hertogh
Keyword(s):  
Correlation Coefficient ◽  
Calibration Curve ◽  
Reaction Vessel ◽  
Placental Lactogen ◽  
Human Placental Lactogen ◽  
Serum Dilution ◽  
Microtiter Plates

Abstract In this latex immunoassay for human placental lactogen, microtiter plates are used as the reaction vessel and the absorbance at 405 nm is measured to quantify the reactions. This 30-min assay necessitates only one serum dilution and two pipetting steps. The calibration curve extends from 0.5 to 15 mg/L. CVs range from 4.2% to 7.0% for within-run determination and from 7.0% to 11.2% for between-run determinations. A correlation coefficient of 0.949 was obtained for 84 sera when the method was compared with a commercial radioimmunoassay.

scholarly journals A Water-Soluble Microencapsulated Milk Thistle Extract as Active Ingredient for Dermal Formulations

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1547 ◽  
Author(s):  
Tiziana Esposito ◽  
Francesca Sansone ◽  
Paola Russo ◽  
Patrizia Picerno ◽  
Rita Patrizia Aquino ◽  
...  
Keyword(s):  
Delivery System ◽  
Active Ingredient ◽  
Pharmaceutical Product ◽  
Water Soluble ◽  
Raw Material ◽  
In Vitro Dissolution ◽  
Milk Thistle ◽  
Health Products ◽  
Productive Process

The choice of formulation is often of crucial importance in order to obtain a pharmaceutical product for the administration of poorly soluble drugs. Recently, a new water-soluble microparticulate powder form (MTE-mp) for the oral administration of a high functionality/low solubility silymarin rich milk thistle extract (MTE) has been developed. Findings showed that extract-loaded microparticles by spray-drying were produced with high and reproducible yields and encapsulation efficiency. The in vitro dissolution and permeation rates of silymarin were dramatically improved with respect to the raw material, and also enhanced the silymarin anti-inflammatory abilities. Given these successful results, the new MTE-mp delivery system has been proposed as an active ingredient for dermal applications. The aim of this research was the design and development of two topical formulations, hydrogel and emulgel (O/W emulsion), containing the MTE-mp delivery system or MTE raw extract. All the formulations were compared to each other in terms of handling and incorporation amount of the active ingredient during the productive process. Moreover, the addition to the emulgel of lecithin (L) as enhancer of permeation was tested. The MTE-mp ingredient that resulted was stable and more-easily incorporated both in hydrogel and emulgel than raw MTE extract, obtaining the best permeation profile for MTE-mp from emulgel with the addition of L. The obtained results confirm that the MTE-mp system could be used as a stable, water-soluble, and easy-handling functional ingredient, giving the opportunity to develop new strategies for MTE delivery in health products.

scholarly journals ANALISIS KANDUNGAN KAFEIN PADA KOPI DI DESA SESAOT NARMADA MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS

Jurnal Kimia ◽  
2016 ◽  
Author(s):  
Aryanu Fahmi Arwangga ◽  
Ida Ayu Raka Astiti Asih ◽  
I Wayan Sudiarta
Keyword(s):  
Water Content ◽  
Correlation Coefficient ◽  
Calibration Curve ◽  
Coffee Bean ◽  
Caffeine Content ◽  
Coffee Powder ◽  
Food And Drink ◽  
Curve Equation ◽  
Maximum Limit ◽  
Standard Solutions

Coffee is one of the agriculture commodities that are cultivated by farmers. One of the compounds in the coffee is caffeine. Caffeine is one of alkaloids which contains in coffee bean. The purpose of this study was to determine the contents of caffeine in unripe coffee, pure coffee powder, and mix coffee powder by using UV-Vis spectrophotometer. Standard solutions of caffeine used were 1 ppm; 3 ppm; 6 ppm; 9 ppm; 12 ppm; and 15 ppm. Caffeine calibration curve equation was y = 0.0494x ??+ 0.01862 with a correlation coefficient (r) of 0.99714. Caffeine content in unripe coffee was 1,28±0,82 % with water content 3%, pure coffee powder 1,63±0,13 % with water content 1%, and mix coffee powder 0,87±0,01 % with water content 1%. According to SNI 01-7152-2006 maximum limit of caffeine in food and drink was 150 mg/day and 50 mg/dish.

Stress degradation studies of hydrochlorothiazide and development of validated method by UV spectroscopy

2018 ◽  
Vol 5 (2) ◽  
pp. 9-11
Author(s):  
Devi Velmurugan
Keyword(s):  
Correlation Coefficient ◽  
Calibration Curve ◽  
Uv Spectroscopy ◽  
Regression Equation ◽  
International Conference ◽  
Stability Indicating ◽  
Percentage Recovery ◽  
Ich Guidelines ◽  
Stress Degradation ◽  
Degradation Studies

To develop a simple, precise, accurate, and stability indicating a UV-method for estimation of Hydrochlorothiazide(HCT)in bulk and formulated dosage form.The drug was alsosubjected to stress degradation at different conditions recommended by the International Conference on Harmonization (ICH). The samples are generated and used for the degradation studies.The λmax of the HCTwas found to be 273nm.The linearity of calibration curve (Absorbance Vs Concentration) in pure solution was checked over the concentration ranges of about 5-30μg/mLwith the correlation coefficient higher than 0.99. The regression equation of the curve was Y = 0.598x + 0.0042.% RSD was found to be within the limit as per ICH guidelines. The obtained percentage recovery of HCTwas found to be within the limit100% ± SD.  Stress degradation studies revealed thatitwas within the limit(5-20%).

Drying in Pharmaceutical and Biotechnological Industries

2003 ◽  
Vol 9 (3) ◽  
pp. 237-243 ◽  
Author(s):  
M. Guerrero ◽  
C. Albet ◽  
A. Palomer ◽  
A. Guglietta
Keyword(s):  
Active Ingredient ◽  
Structural Changes ◽  
Degradation Products ◽  
Drug Product ◽  
Polymorphic Form ◽  
Pharmaceutical Product ◽  
Residual Solvents ◽  
Drug Substances ◽  
Chemical Purity ◽  
Drying Conditions

The process used for drying pharmaceuticals has a high impact on the final product characteristics, both on the active ingredient (high chemical purity product) and the end drug product (complexgalenic formulation). For example, it is well-known that there is a direct relation between the absorption of the active ingredient and its characteristic crystalline or polymorphic form. In some cases, the latter is related to the procedure and conditions of drying. The consequences of the process used to dry a pharmaceutical product may be different depending on the development phase: pre-clinical studies or manufacture (production). The drying process may greatly influence the quality of the drug substances in several aspects: the polymorphic form of the active ingredient, the structural changes that may have an effect on the activity of the substance, the degradation products formed due to the drying conditions and the presence of residual solvents undesirable or above the permitted limits after drying. Consequently, it is important to know the influence of all the factors and to establish the product specifications, as well as the nature and limits of residual solvents, in agreement with current regulations.

scholarly journals Uji Toksisitas Bahan Aktif Niklosamida Terhadap Crustacea Sebagai Water Treatment dalam Budidaya Udang Vannamei (Litopenaus vannamei)

2017 ◽  
Vol 15 (3) ◽  
Author(s):  
Aan Fahrizki ◽  
Herman Yulianto Yulianto ◽  
Asep Saefulloh
Keyword(s):  
Water Treatment ◽  
Active Ingredient ◽  
Toxicity Test ◽  
Residual Effect ◽  
Probit Analysis ◽  
Residual Effects ◽  
Toxicity Tests ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Concentration Levels

This study aims to determine the level of toxicity of the active ingredient based niclosamide on the value LC50- 24h against crustaceans and the duration of the residual effect of niclosamide in water. Methods This study used a completely randomized design with 4 different concentration levels and 0 ppm as a control. Toxicity tests using a concentration of 1.7783; 3.1623; 5.6235 and 10.0002 ppm. To determine the duration of the test using the residual effects of detoxification. In the detoxification test stick with a concentration in the toxicity test. Probit analysis results in test animals showed values (LC50) - 24 hours amounted to 3.6282 ppm, while the length of the residual effects of niclosamide in water for 96 hours. Kata kunci : Crustacea, niclosamide, and toxicity

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