scholarly journals Effects of Methanol Extract of Piper chaba Stem Bark on Chronic Inflamation in Rats

1970 ◽  
Vol 2 (2) ◽  
pp. 37-39 ◽  
Author(s):  
Fouzia Begum ◽  
Kamal Uddin ◽  
Syeeda Sultana ◽  
Abul Hasnat Ferdous ◽  
Zinnat Ara Begum
Keyword(s):  
Chronic Inflammation ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Granuloma Formation ◽  
Medicinal Value ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Implantation Method ◽  
Inflammatory Effect

Piper chaba Hunter (Piperaceae), a climbing glabrous shrub grows in plenty in southern Bangladesh. Popularly known as ‘Choi' it is used as spices and believed to have medicinal value in a wide variety of disease conditions including arthritis, asthma, bronchitis and piles. Earlier studies on methanol extract of Piper chaba stem bark have reported anti-inflammatory activities against acute inflammation. In the present study, effect of methanol extract of Piper chaba stem bark on chronic inflammation has been reported. The anti-inflammatory effect was studied in rats using cotton pellet implantation method, where granuloma formation was used as an index of chronic inflammation. Methanol extracts of Piper chaba stem bark given orally for 14 days daily at doses of 125 and 250 mg/kg body weight produced statistically significant (p < 0.05 and p < 0.01) anti-inflammatory effect compared to control. The percent inhibition of granuloma formation was 25% and 28% respectively, which however was less compared to aspirin (41%) and hydrocortisone (58%). The results suggest that in case of chronic inflammation, Piper chaba stem bark possess mild to moderate anti-inflammatory effect compared to that of aspirin and hydrocortisone. Ibrahim Med. Coll. J. 2008; 2(2): 37-39 Key Words: Rats, chronic inflammation, Piper chaba, aspirin, hydrocortisone, choi   doi: 10.3329/imcj.v2i2.2934

scholarly journals Effects of Methanol Extract of Piper chaba Stem Bark on Acute Inflammation in rats

2012 ◽  
Vol 7 (1) ◽  
pp. 26-28
Author(s):  
F Begum ◽  
ZA Begum ◽  
MR Uddin ◽  
AHMZ Haider ◽  
RC Barman
Keyword(s):  
Body Weight ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Oedema Formation ◽  
Medicinal Value ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The plant Piper chaba Hunter (Piperaceae), a climbing glabrous shrub grows in plenty in southern Bangladesh. Popularly known as 'Choi' it is used as spices and believed to have medicinal value in a wide variety of disease conditions including arthritis, asthma, bronchitis and piles. In the present study, effect of methanol extract of Piper chaba stem bark on acute inflammation has been reported. The anti-inflammatory effect was studied in rats by injecting 0.1ml of 1% carrageenan suspension into the planter surface, where oedema of the rat's hind paw was used as an index of acute inflammation. Methanol extract of Piper chaba stem bark given orally 1 hour before injection at doses of 125 and 250 mg/kg body weight, produced significant (p< 0.05) anti inflammatory effect compared to control and the percentage of inhibition of oedema formation was 33% and 35% respectively, which however was less compared to aspirin (46%) and hydrocortisone (56%). The result suggest that in case of acute inflammation, Piper chaba stem bark possess mild to moderate anti inflammatory effect compared to that of aspirin and hydrocortisone.DOI: http://dx.doi.org/10.3329/fmcj.v7i1.10294Faridpur Med. Coll. J. 2012;7(1): 26-28

Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice

2020 ◽  
Vol 20 ◽  
Author(s):  
Karam Hossein Hasanvand ◽  
Mojtaba Khaksarian ◽  
Maryam Alipour ◽  
Hormoz Mahmoudvand ◽  
Massumeh Naizi ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Chronic Inflammation ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Significant Activity ◽  
Paw Edema ◽  
Ear Edema ◽  
Edema Volume ◽  
Cotton Pellet ◽  
Acute And Chronic Inflammation

Introduction: The present study deals with the effect of Nectaroscordum koelzi fruit extract on acute and chronic inflammation. Methods: Totally, 84 NMRI mice were used in this study. The extract effect on acute inflammation was analyzed by increasing vascular permeability via acetic acid and xylene induced ear edema among mice. The extract was evaluated in terms of effects on chronic inflammation by means of the cotton pellet test among mice. For the assessment of inflammation degree, the mice paw edema volume was measured by the plethysmometric test. Results: The findings showed that the extract was effective on acute inflammation induced by acetic acid in mice. In the xylene ear edema, N. koelzi extract indicated the significant activity in mice. In the cotton pellet method, the methanol extract produced a significant reduction in comparison with the control and dexamethasone. Mice paw edema volume decreased with the extract. Conclusion: In general, the data from the experiments indicated that the methanol extract of N. koelzi has an anti-inflammatory effect on acute and chronic inflammation. However, the exact contributing mechanisms have not been investigated for the pharmacological effects.

scholarly journals Anti-Inflammatory Effect of Ethanolic Extract of Carica Papaya Leaves and Indomethacin in Cotton Pellet Induced Granuloma in Animal Model

2019 ◽  
Vol 6 (1) ◽  
pp. 2-5 ◽  
Author(s):  
Afroza Sultana ◽  
Rumana Afroz ◽  
Onayza Yasmeen ◽  
Muqbula Tasrin Aktar ◽  
Md Abdullah Yusuf
Keyword(s):  
Animal Model ◽  
Carica Papaya ◽  
Ethanolic Extract ◽  
Granuloma Formation ◽  
Rat Paw Edema ◽  
Group I ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Group Ii ◽  
Inflammatory Effect

Background: Anti-inflammatory effect can be exerted by Carica papaya. Objective: The purpose of the present study was to see the anti-inflammatory effect of ethanolic extract of Carica papaya leaves and indomethacin in carrageenan induced rat paw edema animal model. Methodology: This was an animal study carried out in the Department of Pharmacology at Dhaka Medical College, Dhaka, Bangladesh during the period from July 2014 to June 2015 for a period of one (01) year. The leaves of Carica Papaya collected from Botanical garden, Mirpur, Dhaka, Bangladesh. The animals were divided into four groups. The animals were divided into four groups. In all the animals granuloma were induced by implantation of autoclaved cotton pellet on the 1st day and they treated as follows: Group I were served as control that was received normal saline. Group II were received ethanolic extract of Carica Papaya leaves. Group III were received ethanolic extract of Carica Papaya leaves. Group IV were received indomethacin. On the 15th day animals were anesthetized, implanted pellets were dissected out, dried at hit air oven and the final weights were measured. Result: The experiment was carried out on 48 Long Evan Norwegian rats. Rats were divided in 4 groups of six animals each. The mean increase of weight of cotton pellet was 48.06±1.02, 24.48±0.36, 22.42±0.56 and 18.02±0.43 in group I, II, III and IV respectively. The inhibition of granuloma formation was 49.06%, 53.35% and 62.51% in group II, III and IV respectively. Conclusion: In conclusion the ethanolic extract of Carica Papaya leaves has effects on cotton pellet induced granuloma formation in experimental rat. Journal of Current and Advance Medical Research 2019;6(1):2-5

scholarly journals Pharmacognostic Screening and Anti-inflammatory Investigation of the Methanol extract of stem bark of Blighia unijugata Baker (Sapindaceae)

2020 ◽  
Vol 10 (4) ◽  
pp. 146-152
Author(s):  
Felix N. Osuala ◽  
Uchenna E. Odoh ◽  
VictoriaC. Onuigbo ◽  
Sylvester C. Ohadoma
Keyword(s):  
Methanol Extract ◽  
Lethal Dose ◽  
Numerical Data ◽  
Stem Bark ◽  
Water Soluble ◽  
Herbal Remedies ◽  
Albino Rats ◽  
Standard Drug ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction: Blighia unijugata is a potent medicinal plant extensively employed in traditional herbal remedies for the treatment of various diseases such as fever, fertility, inflammation, hypertension, migraine and treatment of infections due to microorganisms. Aim: This work, investigates the pharmacognostic screening and anti-inflammatory activities of the methanol extract of B. unijugata stem bark. Method: Collection, drying, pulverization, and methanol extraction of the stem bark were done accordingly. The screening of phytochemical constituents and Pharmacognostic numerical data were carried out. The chromatographic analysis was carried out using TLC. The acute toxicity was determined using Lorke’s method. Methanol extract was investigated for anti-inflammatory effect in albino rats using egg-induced hind paw oedema at doses of 200, 400 and 600mg/kg body weight respectively. Result: The macroscopical investigation showed the stem bark outer layer is greyish and, the inner layer is pale reddish brown, disagreeable odour, bitter, Microscopical screening revealed the presence of starch grains, trichomes and sclerenchyma cells. Chemomicroscopic result revealed the presence of lignin, starch, calcium oxalate, cellulose, stone cells. Qualitative phytochemical screening of the powdered bark showed the presence of saponins, steroids, tannins, and resins. Numerical data: moisture content/ weight loss on drying gave value of 7.7%, percentage yield of 6.7%, alcoholic soluble extractive 5.6%, water soluble extractive 6.3%, total ash of 7.1%,  acid insoluble ash 0.57% and water soluble ash 4.56%. The chromatographic screening results were close compared with the standard drug. Toxicity test established the lethal dose of greater than 5000mg/kg. There was a significant inhibition of the edema p>0.05, the presence of various bioactive constituents may have contributed to the anti-inflammatory properties of the plant extract. Conclusion: The result of this study confirms that the barks of B. unijugata have anti-inflammatory effect and justifies the use as traditional treatment of inflammation and pain. Keywords: Blighia unijugata, Inflammation, Inflammatory agents, Anti inflammatory

scholarly journals Anti-inflammatory effect of the methanol extract from Anthocephalus cadamba stem bark in animal models

2010 ◽  
Vol 1 (1) ◽  
pp. 6 ◽  
Author(s):  
Kodangala Subraya Chandrashekar ◽  
Kodangala Subraya Prasanna ◽  
Borthakur Abinash
Keyword(s):  
Methanol Extract ◽  
Stem Bark ◽  
Cellular Migration ◽  
Inflammatory Activity ◽  
Traditional Use ◽  
Aerial Parts ◽  
Anti Inflammatory ◽  
Design And Methods ◽  
Anthocephalus Cadamba ◽  
Inflammatory Effect

Background:<em> Anthocephalus cadamba </em>(Rebox)Miq. (Rubiaceae) is widely distributed throughout the greater part of India, especially at low levels in wet place. Traditionally the bark is used as tonic, febrifuge and to reduce the pain and inflammation. The anti-inflammatory effect of methanol extract obtained from <span style="font-style: italic;"> Anthocephalus cadamba </span> aerial parts, MEAC, were investigated in this study. Design and methods: The effects of MEAC on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin) induced paw edema and cotton pallet-induced granuloma, respectively. The anti-edema effect of MEAC was compared with 10 mg/kg of indomethacin orally. Results: The results suggested that MEAC possess potent anti-inflammatory activity. The acute inflammatory model showed that all the doses of MEAC effectively suppressed the edema produced by histamine, so it may be suggested that its anti-inflammatory activity is possibly backed by its antihistaminic activity. In chronic inflammatory model the effect may be due to the cellular migration to injured sites and accumulation of collagen and mucopolysaccharide. Conclusions: On the basis of these findings, it may be inferred that <span style="font-style: italic;"> Anthocephalus cadamba </span> is an anti-inflammatory agent and the results are in agreement with its traditional use.

scholarly journals Effects of aqueous and ethanolic extracts of Aegle marmelos (BAEL) leaves on chronic inflammation in rats

2016 ◽  
Vol 9 (2) ◽  
pp. 52-54
Author(s):  
Sharmin Rahman ◽  
Eliza Omar Eva ◽  
Rezaul Quader ◽  
Muqbula Tasrin ◽  
Md Ismail Khan
Keyword(s):  
Chronic Inflammation ◽  
Granuloma Formation ◽  
Aegle Marmelos ◽  
Inflammatory Conditions ◽  
Flower Stem ◽  
Ethanolic Extracts ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Acute And Chronic Inflammation ◽  
Inflammatory Effect

Aegle Marmelos Linn (Rutaceae) is used as ethno medicine against various human ailments. Several curde extracts from various parts (Leaves, flower, stem, root etc) of the plant A. marmelos Linn have shown variable anti-inflammatory effects in acute and chronic inflammation in animal models. The anti-inflammatory effects of A marmelos linn may be of special advantage compared to conventional anti-inflammatory drugs. The present study has therefore been undertaken with the objective to evaluate the anti inflammatory effect of aqueous and ethanolic extracts of A. marmelos leaves, compared to a standard anti-inflammatory drug (indomethacin) in chronic inflammatory conditions. The anti-inflammatory effect was studied in rats using cotton pellet implantation, where granuloma formation was used as an index of chronic inflammation. Aqueous and ethanolic extracts of A. marmelos leaves were given orally for 7 days daily at doses of 100 mg/kg body weight. The percent inhibition of granuloma formation following treatment with aqueous and ethanolic extracts of A. marmelos leaves, and indomethacin compared to control were 16.5%, 25.72%, and 39.37% respectively. The differences were statistically significant (p<0.05 in case of aqueous and ethanolic extracts and p<0.001 in case of indomethacin). The results suggest that in case of chronic inflammation, both aqueous and ethanolic extracts of A. marmelos have significant anti- inflammatory effect. The ethanolic extracts compared to aqueous extract produced greater anti- inflammatory effects.Ibrahim Med. Coll. J. 2015; 9(2): 52-54

scholarly journals Anti-Inflammatory Effect of Supercritical-Carbon Dioxide Fluid Extract from Flowers and Buds ofChrysanthemum indicumLinnén

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Xiao-Li Wu ◽  
Chu-Wen Li ◽  
Hai-Ming Chen ◽  
Zu-Qing Su ◽  
Xiao-Ning Zhao ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Acetic Acid ◽  
Chemical Composition ◽  
Supercritical Carbon Dioxide ◽  
Granuloma Formation ◽  
Ear Edema ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Inflammatory Effect ◽  
Supercritical Carbon

The aim of this study was to analyze the chemical composition and investigate the anti-inflammatory property of the supercritical-carbon dioxide extract from flowers and buds ofC. indicum(CISCFE). The anti-inflammatory effect was evaluated in four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse hind paw edema, and cotton pellet-induced rat granuloma formation. The results indicated that CISCFEsignificantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, reduced carrageenan-induced paw, and inhibited the cotton pellet-induced granuloma formation in a dose-dependent manner. Histopathologically, CISCFEabated inflammatory response of the edema paw. Preliminary mechanistic studies demonstrated that CISCFEdecreased the MDA level via increasing the activities of anti-oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of NF-κB, TNF-α, IL-1β, IL-6, PGE2and NO, and suppressed the activities of iNOS and COX-2. In phytochemical study, 35 compounds were identified by GC-MS, and 5 compounds (chlorogenic acid, luteolin-7-glucoside, linarin, luteolin and acacetin) were reconfirmed and quantitatively determined by HPLC-PAD. This paper firstly analyzed the chemical composition by combining GC-MS with HPLC-PAD and explored possible mechanisms for the anti-inflammatory effect of CISCFE.

The Effect of Sho-saiko-to on the Concentration of Acid Soluble Glycoprotein in Serum and on Granuloma Formation in Carrageenin Cotton Pellet-induced Granuloma Rats

1993 ◽  
Vol 21 (02) ◽  
pp. 171-177 ◽  
Author(s):  
Kazuo Yoshida ◽  
Hiromi Mizukawa ◽  
Akie Honmura ◽  
Yasuhiko Uchiyama ◽  
Hidehiko Kaku ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Significant Negative Correlation ◽  
Granuloma Formation ◽  
Control Group ◽  
Inhibition Rate ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The effect of Sho-saiko-to on the concentration of acid soluble glycoprotein in serum and on the granuloma formation in carrageenin cotton pellet-induced rats was investigated. As a result, a significant negative correlation between the concentration of acid soluble glycoprotein and granuloma weight was observed. Furthermore, both the concentration of acid soluble glycoprotein and the inhibition rate of the granuloma formation were significantly higher in the Sho-saiko-to group than in the control group. These results suggest that acid soluble glycoprotein plays an important role in promoting the anti-inflammatory effect of Sho-saiko-to.

scholarly journals The Effect of Niella sativa Linn. Ground Seed Extract on Cotton Pellet Induced Inflammation in Rats

2010 ◽  
Vol 15 (Number 2) ◽  
pp. 19-23
Author(s):  
S Parveen ◽  
Z A Begum
Keyword(s):  
Body Weight ◽  
Ethanolic Extract ◽  
Seed Extract ◽  
Granuloma Formation ◽  
Reference Standard ◽  
Ground Seed ◽  
Cotton Pellet ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The study was done to find out the anti-inflammatory effects of the ethanolic extract of ground seeds of Nigella swim in inflammed rats. The effect was compared with reference standard drugs aspirin and hydrocortisone. Chronic it was induced by implantation of a sterile cotton pellet in rut's groin region. Treatment with Nigella saliva extract at a dose of 250 mg/kg body weight and at a dose of 500 mg/kg body weight orally daily for 14 days produced anti-inflammatory effect. The percentage of inhibition of granuloma formation were 19.30% and 41.42% respectively. Administration of aspirin and hydrocortisone for 14 days showed also anti-inflanunatoq effect and the percentage of inhibition of granuloma formation were 27.67% and 38.58% respectively.

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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