scholarly journals Cyclophosphamide induced anemia in Wistar rats: can it be prevented by Sajna (Moringaoleifera)?

2020 ◽  
Vol 15 (1) ◽  
pp. 11-16
Author(s):  
Farhana Fatema ◽  
Sharmin Nahar ◽  
Qazi Shamima Akhter
Keyword(s):  
Wistar Rats ◽  
Dose Schedule ◽  
Free Access ◽  
Medical College ◽  
Before And After ◽  
The Mean ◽  
Level Of Significance ◽  
Group B ◽  
Access To Food ◽  
Post Hoc

Background: Chemotherapy-induced anemia is a multifactorial challenge to the treatment of malignancy. Herbal medicine may help totreat such anemia due to its natural compatibility. Moringaoleifera (Sajna), is well known for preventing and curing anemia. Objective: To evaluate the preventive effect of aqueous extract of Moringaoleiferaleaf (AEMOL) on cyclophosphamide (CP) induced anemia in Wistar rats. Method: The experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka from July 2015 to June 2016. Thirty Wistar ratsof both sexes weighing 175±25 gm were grouped as A[normal saline (1ml/kg); oral],and B [CP (3mg/kg);i. p.], C[AEMOL (300mg/kg);oral], D [AEMOL(300mg/kg); oral and CP(3 mg / kg) i. p. simultaneously for 14 consecutive days] and E [AEMOL(300mg/kg); oralfor 14 consecutive days and CP(30mg/ kg); i. p. on 12th, 13th,14th day] with 6 rats in each group.All the rats had free access to food and distilled water during the period of acclimatization (seven days) and experiment(fourteen days).Total count(TC)) of RBC, hemoglobin (Hb) level and packed cell volume (PCV)were estimated to assess anemia in all rats before and after experiment. The statistical analyses were done by one way ANOVA followed by Bonferroni post hoc test where p<0.05 was accepted as level of significance. Result: The mean TCof RBC, Hb% and PCV were significantly (p<0.001) lower in CP treated rats (group B), in comparison to all other rats of different groups (A, C, D and E). In addition, all these three variables were significantly higher in AEMOLtreated group(C) compared to saline treated rats (A)but almost similar in rats with two groups of different dose schedule of AEMOL and CP (D, E). Conclusion:From the study, it can be concluded that CP induced anemia can be prevented by AEMOL used either simultaneously or in an anticipating manner. J Bangladesh Soc Physiol. 2020, June; 15(1): 11-16

scholarly journals SUPERSTITIOUS BEHAVIOR AMONG JUDO, TAEKWONDO AND BOXING PLAYERS

2016 ◽  
Vol 20 (2) ◽  
pp. 50-59
Author(s):  
Dureja Gaurav ◽  
Singh Gagandeep
Keyword(s):  
Sampling Technique ◽  
College Level ◽  
Mean Values ◽  
Superstitious Behavior ◽  
Group A ◽  
The Mean ◽  
Level Of Significance ◽  
Group B ◽  
Post Hoc ◽  
Affiliated Colleges

Purpose: The present study was designed to measure superstitious behavior among Judo, Taekwondo and Boxing players. Material: Thirty (N=30) male inter-college level players with the age group of 19-25 years were selected through purposive sampling technique to act as subjects from affiliated colleges of Panjab University, Chandigarh. They were further divided into three groups: Group-A [Judo (n=10)], Group-B [Taekwondo (n=10)] and Group-C [Boxing (n=10)]. One Way Analysis of Variance (ANOVA) was applied to find out the differences among judo, taekwondo and boxing players. Where F values found significant, Least Significant Differences (LSD) Post-hoc test was applied to find out the direction and degree of difference. Results: The level of significance was set at 0.05. The result revealed significant differences among judo, taekwondo and boxing players on the sub parameters: clothing and appearance, preparation, team ritual and coach. However, no significant differences have been observed on the sub-parameters fetish, game/competition, prayer and parameter superstitious (Total). Conclusions: The obtained results showed significant differences on the sub-parameter Coach among Judo, Taekwondo and Boxing players. While calculating the mean values of entire groups, it has been observed that Boxing players demonstrate significantly better on the sub-parameter Coach. Therefore, it can be ascertained that Boxing players are more confident that coach bring a lucky charm to our game.

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

Evaluation of Changes in Depression Levels of Bruxism Patients Treated With Botulinum Toxin-A

2021 ◽  
pp. 232020682110065
Author(s):  
Deniz Erdil ◽  
Nilsun Bagis ◽  
Hakan Eren ◽  
Melike Camgoz ◽  
Kaan Orhan
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Age Groups ◽  
Treatment Method ◽  
Definitive Treatment ◽  
Toxin A ◽  
Physiological Factors ◽  
Before And After ◽  
The Mean ◽  
Post Hoc

Aim: Bruxism is defined as the involuntary recurrent masticatory muscle activity characterized by gnashing, grinding, clenching of teeth, and/or pushing the mandible. Factors creating its etiology are peripheral (morphological) or central (physiopathological and physiological), and exogenous. Recently, among physiological factors, depression and bruxism were considered to be related. A definitive treatment method does not exist for bruxism; however, botulinum toxin-A (BT-A) application is an up-to-date and effective way of treatment. The present study is aimed to evaluate the levels of depression in bruxism patients treated with BT-A application. Materials and Methods: A total of 25 individuals (23 females and 2 males) who were diagnosed as bruxism patients were included in the study. 25 U of BT-A for each masseter muscle was injected into the patients. Patients were prospectively observed for a possible change in depression levels by using Beck’s Depression Inventory. The inventory was implemented before and six months after the BT-A application. Depression levels before and six months after the injection were compared. A paired t-test was used to compare “before” and “after” treatment values. One-way analysis of variance and post-hoc Tukey tests were used to evaluate the change in Beck’s Depression Inventory scores according to age groups. Results: The mean total score was 7.80 ± 8.10 before the treatment and 7.16 ± 6.52 six months after the treatment. The decrease in the mean score was not statistically significant ( P > .05). Conclusion: In conclusion, despite the decrease in the mean Beck’s Depression Inventory scores, a statistically significant decrease in the depression levels of patients was not observed.

scholarly journals Fetal and maternal outcome following expectant management of severe pre-eclampsia remote from term

2017 ◽  
Vol 6 (12) ◽  
pp. 5420
Author(s):  
Deepak A. V. ◽  
Reena R. P. ◽  
Deepa Anirudhan
Keyword(s):  
Expectant Management ◽  
Severe Preeclampsia ◽  
Close Monitoring ◽  
Antenatal Corticosteroids ◽  
Maternal Complications ◽  
Medical College ◽  
Difficult Decision ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Expectant management of severe preeclampsia, remote from term is often a difficult decision. Maternal and foetal complications may occur while trying to achieve a more favourable perinatal outcome. We wanted to find out the foetal and maternal outcomes of expectant management in these women.Methods: A prospective cohort study was conducted at Government Medical College, Thrissur, India between May 2013 and April 2015. Women with severe preeclampsia remote from term, who were admitted, managed expectantly and delivered in our hospital during the study period, were recruited. The study subjects were grouped into: Group A (between 28 weeks and 31 weeks 6 days) and Group B (between 32 weeks and 33 weeks 6 days). A structured proforma was used to collect demographic and clinical details. The maternal and foetal outcomes were noted.Results: There were 4786 deliveries during the study period. Among them 76 (1.58% of total deliveries) women with severe preeclampsia between 28 weeks and 33-week 6 days gestation on expectant management were included in the study. The mean duration of expectant management was 7.92 days in group A (27 women) and 6.67 days in group B (49 women). Most women required termination of pregnancy for foetal distress (36.8%). HELLP syndrome and imminent eclampsia were the maternal complications that occurred. Perinatal loss was significantly more in Group A when compared to Group B.Conclusions: Expectant management of women with severe preeclampsia remote from term, especially between 32weeks and 33weeks 6 days, with antenatal corticosteroids and close monitoring, seems a reasonable option in developing countries.

scholarly journals The penetration of methanol into bovine cardiac and hepatic tissues is faster than ethanol and formalin

2018 ◽  
Author(s):  
Michelle Steicke ◽  
Guang Yang ◽  
Tam Nguyen Dinh ◽  
Matthew Dunster-Jones ◽  
Owen Sargisson ◽  
...  
Keyword(s):  
Liver Tissue ◽  
Penetration Rate ◽  
Biological Tissues ◽  
Heart Tissue ◽  
Penetration Distance ◽  
Before And After ◽  
Tissue Shrinkage ◽  
The Mean ◽  
Post Hoc ◽  
Liver Tissues

Methanol, ethanol and formalin are commonly used as fixatives to preserve biological tissues from decay in the preparation of histological sections. Fixation of the inner layers of the tissue depends on the ability of the fixative to diffuse into the tissue. It is unknown whether methanol penetrates tissues at similar rates to other fixatives. This study aimed to compare the penetration rates of methanol, ethanol and formalin into bovine heart and liver tissues. The penetration distance and tissue shrinkage or expansion were measured by analysing the digital images of tissue before and after immersion in different fixatives for 1, 2, 6 or 10 h. Data were analysed using two-way ANOVA, followed by Bonferroni’s post-hoc test. The penetration distance of methanol was significantly greater in both heart and liver tissues compared with that of ethanol (N=4, P<0.001). Methanol or ethanol immersion led to similar shrinkage of both tissues (P>0.05). The penetration rate of formalin was similar to that of ethanol in both tissues however it was significantly slower than methanol (N=4, P<0.005 in the heart; P<0.001 in the liver). The mean penetration coefficients of methanol, formalin and ethanol in the heart tissue were 2.609, 1.994 and 1.801, respectively, and 3.012, 2.153 and 2.113, respectively, in the liver tissue. The penetration coefficient of methanol was significantly greater than that of ethanol or formalin in both tissues (P<0.001 for each comparison). In conclusion, methanol penetrates tissue significantly faster than ethanol and formalin.

scholarly journals A novel prediction of simulated fluid responsiveness by echocardiography assessment of tricuspid annulus tissue velocity with passive leg raising

2019 ◽  
Vol 27 (5) ◽  
pp. 270-276
Author(s):  
Erden Erol Ünlüer ◽  
Arif Karagöz ◽  
Serdar Bayata ◽  
Sibel Çatalkaya ◽  
Hüseyin Bozdemir
Keyword(s):  
Cardiac Output ◽  
Fluid Responsiveness ◽  
Vital Signs ◽  
Peak Systolic Velocity ◽  
Passive Leg Raising ◽  
Tricuspid Annulus ◽  
Mean Values ◽  
Before And After ◽  
The Mean ◽  
Level Of Significance

Background: Fluid responsiveness can be predicted by the effect of passive leg raising on cardiac output. Objectives: This research aimed to compare the changes in cardiac output and the peak systolic velocity values of Tricuspid annulus velocity at the free wall (S’) before and after passive leg raising in healthy volunteers. Methods: The study was approved by ethical commission. The desired sample size was 28, and 57 volunteers were included after they signed informed consent. The first measurements, including vital signs, S’, and cardiac output, were taken with the participants lying supine and were performed in the morning after 12 h fast. The participants were then asked to lie in a semirecumbent position for 3 min. After 3 min, the head of the bed was lowered to the supine position and the participants’ legs were elevated at 45°. Secondary measurements were repeated in this position. The differences between vital signs, cardiac output, and S’ measurements before and after passive leg raising were statistically compared. The level of significance was set as p < 0.05. Results: The mean values of cardiac output and S’ before passive leg raising was 9.59 L/min and 11.57 cm/s, respectively; however, those increased to 11.44 L/min and 13.72 cm/s after passive leg raising. The average increases were 16.17% for cardiac output and 15.67% for S’. The changes of cardiac output and S’ were statistically significant. The changes of vital signs before and after passive leg raising were statistically insignificant. Conclusion: This study has demonstrated the concordance of rise in cardiac output with S’ change by passive leg raising in healthy subjects. Further studies are needed to validate the use of S’ values in critically ill subjects.

scholarly journals Vitamin E in the treatment of primary dysmenorrhoea

2018 ◽  
Vol 7 (6) ◽  
pp. 2257
Author(s):  
Vilvapriya S. ◽  
Vinodhini S.
Keyword(s):  
Vitamin E ◽  
Cost Effective ◽  
Pain Severity ◽  
Medical College ◽  
Primary Dysmenorrhoea ◽  
Relieve Pain ◽  
Significant Difference ◽  
Before And After ◽  
Pain Duration ◽  
The Mean

Background: The objective of this study is to determine the efficacy of Vitamin E in the treatment of primary dysmenorrhoea compared to the placebo.Methods: Sixty women, aged 17-25 years old who suffered from primary dysmenorrhoea, among 1000 Women attending the gynec OPD in Kilpauk Medical College. 30 women were given 200 units of vitamin E (each tablet twice daily) and 30 were given a placebo tablets (each tablet twice daily). The treatment began two days before the beginning of menstruation and continued through the first three days of bleeding. The severity of pain and duration of pain before and after the treatment was studied. Treatment in both groups was carried out in three consecutive menstrual periods.Results: As to the findings, the mean age of the participants was 22.6 years. There was a significant difference between the pre- and post-treatment periods in terms of pain severity (P=0.72 and P=0.002, respectively) and pain duration (P=0.514 and P=0.027, respectively) in Vitamin E group. There was a significant difference observed between the Vitamin E group and placebo group regarding the mean of pain severity and duration (P=0.002 and p=0.027 respectively).Conclusions: Vitamin E helps to relieve pain in primary dysmenorrhoea. As this is a relatively easier method for control of pain with lesser amount of side effects and as it is cost effective, it can be considered as a universal drug in the treatment of primary dysmenorrhoea.

scholarly journals Study of the Efficacy of Ksharaplota in Dushtavrana w.s.r to Infected Wound

2020 ◽  
Vol 11 (2) ◽  
pp. 314-321
Author(s):  
Anantkumar V Shekokar ◽  
Vijay P Ukhalkar
Keyword(s):  
Clinical Presentation ◽  
Healing Time ◽  
Control Group ◽  
Infected Wound ◽  
Group Assessment ◽  
Before And After ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
Vast Range

Vrana ( wound and ulcer) & process of healing is the soul of Shalyatantra Chikitsa (Surgical treatment ). Dushta Vrana means getting vitiated by Dosha & hence Dushta Vrana or infected wound is characterized by bad smell, abnormal color with profuse discharge, severe pain and longer healing time. The severity of infected wounds and their vast range of etiologies, The treatment is cleaning & dressing the wound or it can be more extensive. It may require surgical intervention to close the wound and stabilize the patient. Acharya Sushruta defines Kshara as the substance possessing Ksharana and Kshanan properties. Ksharaplota formulation was selected and applied over the affected infected wound with the help of gauze piece. During the preparation of Ksharaplota, it is coated with Snuhi kshira, Apamarga kshara & Haridra. All these drugs are Shodhana & Ropana. It was observed that Ksharaplota has the properties as sustained release of drug, absorbs discharges, less painful & easily acceptable by the patient with excellent Sodhana & Ropana Karma. The clinical study has been done on 438 patients, selected randomly and divided in two groups. Group A 220 patients i.e. trial group, were treated with local application of Ksharaplota. The Group B 218 patients i.e. control group, were treated with Gold standard. The clinical assessment was done on the basis of clinical presentation of Dushta Vrana, (Infected wound) before and after the treatment. As grading used for assessment of parameters which were ordinal in nature, “Wilcoxon Signed Ranks test” was used for within the group assessment (i.e. before and after treatment of a group). For between the group assessment of parameters, Mann Whitney – U test was applied. We had tested hypothesis for each parameter and result was interpreted accordingly. The level of significance was kept at 5% (P=0.05). And the result of the present study found significant.

scholarly journals The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)

Sains Medika ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 27
Author(s):  
Ayyasi Izaz Almaz ◽  
Ratna Dama Purnawati ◽  
Hermawan Istiadi ◽  
Neni Susilaningsih
Keyword(s):  
Hydrogen Peroxide ◽  
Alternative Treatment ◽  
Wistar Rats ◽  
Vegf Expression ◽  
Group Design ◽  
Degree Burn ◽  
Group B ◽  
Post Hoc ◽  
Observation Results ◽  
Second Degree

Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase.Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton�, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney.Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05.Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton�

scholarly journals Conventional treatment versus vacuum therapy for diabetic foot ulcers treatment

2017 ◽  
Vol 5 (1) ◽  
pp. 49 ◽  
Author(s):  
Vigna Sai Potula
Keyword(s):  
Therapy Group ◽  
Vacuum Therapy ◽  
College Hospital ◽  
Medical College ◽  
Randomized Controlled ◽  
Number Of Patients ◽  
Group A ◽  
Randomized Controlled Trail ◽  
The Mean ◽  
Group B

Background: This study compares the efficacy of vacuum therapy against conventional iodine povidone dressing with respect to area and time of ulcer.Methods: This study is a randomized controlled trail which was conducted in Meenakshi Medical College hospital and research institute Enathur Kanchipuram. The number of patients selected were 50, which were divided into 2 groups, Group A which consisted of 25 and received vacuum therapy, Group B which consisted of 25 and received povidone-iodine solution.Results: This study was a 16 days study, mean area of ulcer on day 0 was 11.25 cm2 in group B, 10.89 cm2 in group A. On day 6, mean area of ulcer was 10.44 cm2 in group B, 8.98 cm2 in group A. Mean area of ulcer was 10.39 cm2 in group B, 7.66 cm2 in group A on the end of the day 16. The results show that both the groups showed decrease in the area of ulcers, but patients in group A who underwent vacuum therapy have shown greater decrease in the mean area of ulcer. The decrease in surface area of ulcer was statistically significant i.e. p=0.025. There was a greater decrease in infection in group A on 16th day compared to group A on 16th day. On day 0, 48% and 60% growth of microorganisms was observed in patients of group B and group A respectively (p=0.428). On day 16, 28% and 8% growth of microorganisms was observed in patients of group B and group A respectively (p=0.034).Conclusions: Vacuum therapy was more effective compared to conventional method of povidone-iodone solution dressing in rate of healing and time of healing.

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