scholarly journals Two cases of chronic myeloid leukemia in pediatric and young adolescent age group

2017 ◽  
Vol 25 (1) ◽  
pp. 74-76
Author(s):  
Mohammad Zaid Hossain ◽  
Pratyay Hasan ◽  
Benozir Ahmed ◽  
Kazi Tuba E Mozazfia ◽  
Zannatul Ferdush ◽  
...  
Keyword(s):  
Young Adults ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
The Elderly ◽  
Young Adolescent ◽  
Specific Rate ◽  
Age Group ◽  
Geographical Differences ◽  
Medical College ◽  
Pediatric Age Group

The incidence of chronic myeloid leukemia (CML) is 1-2 cases/100 000/year, without major geographical differences and the median age of presentation is 60–65 years1 or approximately 67 years. Commonly known as a disease of the elderly, CML rarely affects the pediatric group (0-14 years), or adolescent and young adults (15-29 years). Age specific rate of CML per 100,000 of population, have been reported in pediatric age group as 0.04 and in young adults and adolescent group as 0.22. There is also much scarcity of available literature on the characteristic, presentation, outcome and response to standard protocol treatment in this age group, although it has been noted recently by many researchers that, they differ significantly from the much commonly affected elderly population. We here report two cases of pediatric and young adolescent CML.J Dhaka Medical College, Vol. 25, No.1, April, 2016, Page 74-76

scholarly journals Myeloproliferative neoplasms

JBMTCT ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 129
Author(s):  
Neysimelia Costa Villela ◽  
Gustavo Zamperlini ◽  
Patrícia Shimoda Ikeuti ◽  
Roseane Vasconcelos Gouveia ◽  
Simone De Castro Resende Franco ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Myeloid Leukemia ◽  
Myeloproliferative Neoplasms ◽  
Primary Myelofibrosis ◽  
Age Group ◽  
Pediatric Age ◽  
Pediatric Age Group ◽  
Low Incidence

  In addition to the chronic myeloid leukemia (CML) BCR-ABL1+, classic myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis. These have a very low incidence in the pediatric age group and there is no consensus on treatment in children.

scholarly journals Differences among young adults, adults and elderly chronic myeloid leukemia patients

2015 ◽  
Vol 26 (1) ◽  
pp. 185-192 ◽  
Author(s):  
F. Castagnetti ◽  
G. Gugliotta ◽  
M. Baccarani ◽  
M. Breccia ◽  
G. Specchia ◽  
...  
Keyword(s):  
Young Adults ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia

A Clinicopathological Study of Various Conjunctival Lesions in Children

2016 ◽  
Vol 1 (4) ◽  
pp. 143-147
Author(s):  
Juhi Goel ◽  
Swapnila Prasad ◽  
Ashutosh Dokania
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Uttar Pradesh ◽  
Capillary Hemangioma ◽  
Treatment Modalities ◽  
Age Group ◽  
Pediatric Age ◽  
Medical College ◽  
Pediatric Age Group ◽  
Clinicopathological Study

ABSTRACT Conjunctival cysts are of a common occurrence in clinical parlance. These tend to be mostly asymptomatic. However, the underlying cause may be vision threatening. Thus, we conducted a clinicohistopathological study of conjunctival cysts in pediatric age group who presented to our outpatient department in Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India. The aim was to analyze the risk factors, clinical presentation, treatment modalities, and a certain type of cysts in order of their frequency. Significant history, detailed ocular examination, and relevant investigations that were carried out in 10 cases of conjunctival lesions were noted. The management was done and the histopathological examination (HPE) reports were charted. Despite a similar clinical presentation, HPE revealed varied diagnosis. These comprised choristomatous cysts (4), subconjunctival cysticercosis (2), inclusion cysts (2), inflammatory cyst (1), and capillary hemangioma (1). Conjunctival cysts are not just a cosmetic blemish. A detailed ocular examination, early diagnosis, and treatment can help prevent various vision-threatening complications. How to cite this article Goel J, Prasad S, Dokania A. A Clinicopathological Study of Various Conjunctival Lesions in Children. Int J Adv Integ Med Sci 2016;1(4):143-147.

scholarly journals Chronic Myeloid Leukemia in Adolescents and Young Adults Treated with Generic Form of Imatinib in Resource Limited Setting: A Single Center Experience from Myanmar

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5451-5451
Author(s):  
Yin Nwe Han ◽  
Aye Aye Gyi ◽  
Khin Thida Htut
Keyword(s):  
Young Adults ◽  
Chronic Myeloid Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Chronic Phase ◽  
Female Ratio ◽  
Resource Limited ◽  
One Year ◽  
Male To Female ◽  
Limited Setting

Abstract Chronic myeloid leukemia (CML) is an acquired myelo-proliferative disorder characterized by the presence of BCR-ABL1 fusion transcript with deregulated tyrosine kinase activity. Leukemias are one of the leading causes of cancer related deaths in adolescents and young adults (AYA) particularly in resource limited countries. Recent democratic government in Myanmar holds supportive policies for treatment of cancers in younger population and subsidizes some therapies including imatinib mesylate, a selective BCR-ABL 1 tyrosine kinase inhibitor, although there is still limitation for cytogenetic and molecular monitoring of therapy. This study on response to imatinib in newly diagnosed chronic phase CML was carried out during January 2016 to February 2018 at the North Okkalapa General and Teaching Hospital of Yangon, Myanmar where molecularly confirmed new CML in chronic phase were treated with generic form of imatinib bought by hospital tender system, Unitinib (United Biotech (P) ltd. India) followed by cytogenetic analysis of bone marrow and molecular detection of BCR-ABL1 transcript from peripheral blood by in house real time PCR machine at one year. They are divided into AYA (aged 15-39 years) and adult age groups (40 years and older) and clinical parameters and response to treatment with imatinib 400mg per day were compared. Among 56 cases (median age of 39.5 years, male to female ratio of 1.5:1), half were AYA (28 of 56) with median age of 28.5 years compared to 50 years in adult group with higher male to female ratio of 3.6:1 in AYA group. Patients in AYA had larger spleen size (11 vs 5.5 cm) and higher median white cell count compared to adults (366 x 109/l vs 224 x 109/l) although initial platelet count, peripheral blood eosinophil, basophil and blast percent and Sokal score were comparable. Additional chromosomal abnormalities were detected in 2 AYA and 3 adults with CML. There was no difference in complete haematologic response at 3 and 12 months between AYA and adults (96.4% vs 96.4% and 92.9% vs 89.3% respectively). At 12 months, complete cytogenetic response of AYA at 67.9% was less than 75.0% of adults, it was statistically not significant. Using in house molecular method although not standardized, 14.3% of AYA and 32.1% of adults were molecularly undetectable at one year. The response of AYA to imatinib in this study was comparable to adults despite having adverse prognostic features and receiving only generic forms of treatment in resource limited setting and it would further help support from authorities for leukemia in younger population. Disclosures No relevant conflicts of interest to declare.

scholarly journals Outcome of young adults with chronic myeloid leukemia treated with upfront imatinib: A single institutional experience

2015 ◽  
Vol 6 (4) ◽  
pp. 157 ◽  
Author(s):  
Sandip Ganguly ◽  
GovindK Babu ◽  
Aditi Thanky ◽  
LinuAbraham Jacob ◽  
MC Suresh Babu ◽  
...  
Keyword(s):  
Young Adults ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Institutional Experience

scholarly journals A Study of Hematological Malignancies in Tripura Medical College & Dr. BRAM Teaching Hospital

2021 ◽  
Vol 10 (31) ◽  
pp. 2456-2459
Author(s):  
Nabaneet Majumder ◽  
Sayandeep Nath
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Acute Leukemia ◽  
Teaching Hospital ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Hematological Malignancies ◽  
Hematological Malignancy ◽  
Care Hospital ◽  
Hematopoietic Stem ◽  
Medical College

BACKGROUND Hematological malignancies are a major health problem in our society due to their high mortality and morbidity. It includes diverse and biologically distinct subgroups and can be defined as clonal neoplasm of hematopoietic stem cells characterized by uncontrolled proliferation of immature cells in bone marrow and spilling into peripheral blood. The patterns of subtypes of hematological malignancies vary in different populations and geographic areas because of genetic, environmental, dietary and social factors. Research of epidemiological features of leukemia are poorly reported in Tripura. The objective of the study was to get an idea about the pattern of hematological malignancies in our institute which will help to get an idea of the disease in our state and find out the incidence of hematological malignancies in Tripura Medical College, a tertiary care hospital in Tripura. METHODS This is a one-year prospective study, conducted in the Department of Pathology, Tripura Medical College & DR BRAM teaching hospital from July 2017 to June 2018. Medical records of all patients admitted to our hospital and diagnosed as a case of hematological malignancy were reviewed for demographic and clinical characteristics at diagnosis. Data analysis was performed by using statistical package for social sciences (SPSS) version 16. RESULTS Our study included 19 diagnosed cases of hematological malignancies, of which 15 were of acute leukemia and 3 cases were of chronic leukemia. Amongst the cases of acute leukemia, 9 were diagnosed as acute myeloid leukemia (AML) whereas 6 were diagnosed as acute lymphoblastic leukemia (ALL). Out of chronic leukemic cases, all were diagnosed as CML. We reported a solitary case of multiple myeloma in a elderly male patient. Present study showed male predominance, invariably affecting the adults. Commonest form of leukemia in adults were AML followed by chronic myeloid leukemia (CML) whereas all cases of ALL were found in children.The most common peripheral blood finding in hematological malignancy was pancytopenia followed by bicytopenia. CONCLUSIONS In our study, acute leukemia was the most common subtype of leukemia in all age groups. Of all leukemia cases, majority were of AML. Demographic characteristics were almost the same as other regional reports. Our observation is mostly comparable with other studies from India and the neighborhood countries. The differences observed in few demographic parameters may be due to geographic variation and genetic difference of study population. KEY WORDS Hematological Malignancies, Acute Leukemia, Chronic Myeloid Leukemia

scholarly journals An Analytical Study on Anemia in Rural Population

2020 ◽  
Vol 3 (2) ◽  
pp. 28-33
Author(s):  
Shirish Ardhapuskar ◽  
Raghu Rammulu
Keyword(s):  
Age Groups ◽  
The Elderly ◽  
Medical Problem ◽  
Morbidity And Mortality ◽  
Common Symptom ◽  
Age Group ◽  
Expert Group ◽  
Adult Males ◽  
Medical College ◽  
The Common

Background: Anemia is one of the common Hematological disorders in India and worldwide. It affects all the age groups both in Males and Females. Moderate to Severe Anemia causes increased morbidity and mortality in elderly patients (AWHO expert group) - According to Worlds Health Organization, Anemia is a define when adults males are having Hemoglobin less than 13.5gr% when adults females non-pregnant less than 12 gr% and when pregnant females are having less than 11 ger%. The incidence of Anemia is very high in old age people who are more than 75 years of age. It ranges from 9% to 41%. In India Anemia is commonly due to nutrition, pregnancy, Hookworm infestation, DUB in the case of females, and Malignancy. The prevalence of anemia in the elderly has been found to range from 9% to 42% with the highest prevalence in 80 years and above. The common causes of anemia in India are Nutritional, Pregnancy, Hookworm infestation, and DUB in the case of Females and Malignancy. The common symptom is General weakness, Fatigue, Lack of concentration, Shortness of Breath, and Palpitations. A WHO expert group proposed that anemia should be considered when hemoglobin level below 13.5gr& in adult males; 12gr% in adults females non-pregnant; 11 gr% in adult female pregnant; 12gr% in children over 14yrs(1). The aim is to evaluate the etiology and clinical features of anemia in adults in rural medical colleges. Subjects & Methods: This study is conducted at GEMS Medical College, Srikakulam, A.P for the period of 1 year from April 2018 to March 2019. This study includes 120 patients with Anemia. The age group is between 20 years and 70 years. Males were 56 and females were 64. Results: We have conducted this study at GEMS Medical College, Srikakulam for 1 year, from April 2019 to March 2019 total no. of patients included in this study are 120 males 56 and females 64. The age group is between 20 years and 70 years. The maximum patients are in between 30 years and 70 years in both sexes. Conclusion: Anemia is a common medical problem in developing countries. In a rural part of India, the disorders will complicate the pregnancy also. So periodical examination and education of the people can decrease morbidity and mortality. In our area still, the common cause is nutritional.

scholarly journals Monitoring the safety of nilotinib in patients with chronic myeloid leukemia

2019 ◽  
Vol 65 (2) ◽  
pp. 67-72
Author(s):  
Marija Pendovska ◽  
Zorica Naumovska ◽  
Irina Panovska ◽  
Marica Pavkovic ◽  
Goce Kalcev ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Adverse Reactions ◽  
Kinase Inhibitors ◽  
Chronic Phase ◽  
Age Group ◽  
Duration Of Treatment ◽  
Men And Women ◽  
The Mean ◽  
Future Evaluation

The aim of the study was to evaluate the safety profile of nilotinib administered to chronic myeloid leukemia (CML) at patients. The study was conducted from March 2018 to May 2019 and it included 20 patients with CML in chronic phase. Of these 20 patients, 17 had previously been treated with imatinib and 3 with hydroxyurea. The mean duration of treatment with Nilotinib was 6.75 months. In nine patients treated with nilotinib (400 mg), 55% complained of fatigue, 33% of headache and 22.2% of pruritus. In five patients treated with Nilotinib (600 mg), 20% complained of headache, 40% of fatigue and 20% of pruritus. In addition, in six patients treated with nilotinib (800 mg), 50% complained of headache and fatigue, 17% with pruritus and visual disorder was observed in 20% of cases. In the study, the adverse reactions were observed between the age of 20 and 40 and it was 7.1%, in contrast to the group of patients between the age of 40 and 60 where the incidence of adverse reactions was 21.42%. The incidence of adverse reactions in patients in the age group over 60 years it was 57.1%. In terms of gender, the incidence of adverse reactions was equal to 50% for both men and women. In conclusion, this study showed that treatment with nilotinib was well tolerated, with adverse reactions of an easy degree. Future evaluation is necessary in order to understanding the adverse reaction of nilotinib in comparison with other tyrosine kinase inhibitors. Keywords: nilotinib, pharmacovigilance, safety, chronic myeloid leukemia

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