scholarly journals Platelet Count In Preeclampsia

2013 ◽  
Vol 18 (2) ◽  
pp. 24-26 ◽  
Razia Sultana ◽  
SM Fazlul Karim ◽  
Farhana Atia ◽  
Shahnila Ferdousi ◽  
Selina Ahmed

Preeclampsia is one of the most leading causes of maternal mortality in developing countries like Bangladesh. Several studies have demonstrated the relationship between platelets count and preeclampsia. The aim of the study was to assess the association of platelets count with preeclampsia. A case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in third trimester of pregnancy attending in Obstetrics & Gynaecology Department of Dhaka Medical Hospital were selected as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Platelet count was measured in all study subjects. The mean platelet count in cases and controls were 1,44,260±96,472 and 1,98,100±51,219 respectively. The present study showed significant difference of mean platelet count between cases and controls. The study revealed that low platelets count is associated with preeclampsias. DOI: J. Dhaka National Med. Coll. Hos. 2012; 18 (02): 24-26

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259543
Solomon Gebre Bawore ◽  
Wondimagegn Adissu ◽  
Berhanu Niguse ◽  
Yilma Markos Larebo ◽  
Nigussie Abebe Ermolo ◽  

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

2018 ◽  
Vol 35 (11) ◽  
pp. 1093-1099 ◽  
Leslie Skeith ◽  
Karim Abou-Nassar ◽  
Mark Walker ◽  
Tim Ramsay ◽  
Ronald Booth ◽  

Background While anti-β2 glycoprotein 1 (anti-β2GP1) antibody positivity is included in the diagnostic criteria for antiphospholipid syndrome (APS), the association between anti-β2GP1 and the obstetrical complications of APS has been inconsistently reported and remains unclear. Objective We completed a case–control study nested within the Canadian Ottawa and Kingston (OaK) Birth Cohort to evaluate the association between anti-β2GP1 antibody positivity and placenta-mediated pregnancy complications. Study Design Five hundred cases were randomly selected among pregnant women who experienced any of the following independently adjudicated placenta-mediated pregnancy complications: preeclampsia, placental abruption, late pregnancy loss (≥ 12 weeks' gestation), and birth of a small-for-gestational age (SGA) infant < 10th percentile. Five hundred pregnant women without any placenta-mediated pregnancy complications were selected as controls. Stored blood samples were analyzed for the presence of anti-β2GP1 antibodies by enzyme-linked immunosorbent assay. Results Anti-β2GP1 immunoglobulin G (IgG) and/or immunoglobulin M (IgM) antibodies in titers ≥ 20 G/M units (> 99th percentile) were present in 24 of 497 (4.8%) of controls and 33 of 503 (6.6%) of cases. There was no significant difference between cases and controls for the composite outcome of any placenta-mediated pregnancy complications (odds ratio, 1.38, 95% confidence interval [CI], 0.8–2.37, p = 0.25). Conclusion Our results call into question the association between anti-β2GP1 antibodies and placenta-mediated pregnancy complications, with further research needed.

2020 ◽  
pp. 112067212097533
Merve Beyza Yildiz ◽  
Elvin Yildiz ◽  
Sevcan Balci ◽  
Buse Rahime Hasirci Bayir ◽  
Yılmaz Çetinkaya

Purpose: To evaluate the pupil size, accommodation, and ocular higher-order aberrations (HOAs) in patients with migraine during migraine attacks and compare them with interictal period and healthy controls. Methods: This prospective, case–control study included 48 eyes of 24 patients with migraine and 48 eyes of 24 age and sex-matched healthy controls. Measurements were performed using a Hartmann Shack aberrometer. Accommodative responses to accommodative stimulus ranging from 0 to 5 diopters (D) in increments of 0.5 D were recorded. Spherical, coma, trefoil aberration, and root mean square (RMS) of total HOAs were assessed. Patients with migraine were measured twice during the interictal phase and during migraine attack. Results: The mean pupil size significantly decreased during migraine attack (5.85 ± 0.19 mm) compared with the interictal phase (6.05 ± 0.19 mm) in the patients with migraine ( p = 0.012). There was a significant increase in the accommodative response to accommodative stimulus of 1.5 to 5 D during migraine attack. No significant change was observed in HOAs during migraine attack. In addition, no ictal or interictal period measurements were statistically significantly different from the controls. Comparing symptomatic and non-symptomatic sides in 17 migraine patients with unilateral headache, no significant difference was found in any of the measurements in both ictal and interictal periods. Conclusion: Our results suggest the presence of a subtle oculosympathetic hypofunction in patients with migraine during the ictal period compared to the interictal period. The accommodation status of the eye seems to be affected by this autonomic dysfunction.

2021 ◽  
Vol 16 (1) ◽  
Javad Nazari ◽  
Kimia Jafari ◽  
Maryam Chegini ◽  
Akram Maleki ◽  
Pari MirShafiei ◽  

Abstract Introduction The clinical complications of congenital hypothyroidism such as brain disorders are very subtle and are not recognizable in infancy period. They are recognizable when it is too late for treatment or prevention. General screening of newborns is effective in diagnosing congenital hypothyroidism and initiating initial treatment. The aim of this study is to compare the physical and mental growth pattern of children with congenital hypothyroidism with healthy ones. Methods This case–control study was performed on 34 patients and 68 healthy children who were matched in terms of inclusion and exclusion criteria. Children development screening test (ASQ), children development assessment test (Bayley), preschool Wechsler intelligence scale (WPPSI) and age and steps questionnaire of emotional social development (ASQ-SE) were completed by trained questioners. Data were analyzed using STATA software. Results The results indicated that there was no significant difference between the mean of verbal (P = 0.77), non-verbal (P = 0.81) and general (P = 0.66) IQ in permanent and transient patients and healthy individuals. Also, there was no significant difference between the mean of different ranges of ASQ test (including communication, delicate and large movements, problem solving and social) at 12 months and 42 months (P < 0.05). According to Bayley test, there was no significant difference between the cases (permanent and transient) and controls in the cognitive (P = 0.42) and expressive (P = 0.38) categories. The difference was significant in the perceptual (P = 0.011), large (P = 0.03) and delicate (P = 0.04) movements categories. Conclusion This study emphasized on the high effectiveness of neonate hypothyroidism screening program, so that the difference between 3.5 years old children with and without this disease has decreased significantly. Early diagnosis of the patients, while creating beneficial effects for patients and increasing quality of life, cause reduction in the long-term costs of the health system.

2021 ◽  
Vol In Press (In Press) ◽  
Mansour Karajibani ◽  
Farzaneh Montazerifar ◽  
Razieh Hosseini ◽  
Fatemeh Suni ◽  
Ali Reza Dashipour ◽  

Background: Malnutrition causes nutritional, metabolism, and biochemical disorders and finally leads to mortality. Several studies have highlighted that serum liver enzymes are increased in patients with malnutrition. Objectives: This study aimed to evaluate the relationship between malnutrition and liver enzymes in hospitalized children in Zahedan. Methods: This case-control study was conducted among 145 hospitalized children under six years old, including 74 cases and 71 controls. The case group was diagnosed with malnutrition according to weight for age indices (Z-Score < -2SD), and controls were determined based on the following indices (Z-Score > -2SD) of classification of WHO 2006 growth standards. Serum was isolated after taking blood from the samples. Then liver enzymes, including AST, ALP, and ALT, were measured by spectrophotometric method. Results: A total of 145 subjects were enrolled that consisted of 74 cases and 71 controls. No significant difference was observed in serum liver markers, including AST, ALT, and ALP between the two groups, However, the level of AST, ALT, and ALP was higher than the standard level. There was a significant correlation between AST with ALT (r = 0.74, P < 0.001), and ALP (r = 0.27, P = 0.03). Conclusions: The findings indicated that there was no significant alteration in enzyme markers in the two groups. However, AST and ALT levels increased, and ALP levels decreased compared with the control. Different degrees of malnutrition, including mild, moderate, and severe, can probably change the levels of hepatic enzymes in under-nourished children. Alteration of these liver enzymes could be due to the metabolic modification, which can be the result of protein deficiency.

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Wei Cong ◽  
Xiao-Yan Dong ◽  
Qing-Feng Meng ◽  
Na Zhou ◽  
Xiang-Yang Wang ◽  

Very limited information is available concerning the epidemiology ofT. gondiiinfection in pregnant women in eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this population group and to identify risk factors and possible routes of contamination. Serum samples were collected from 965 pregnant women and 965 age-matched nonpregnant control subjects in Qingdao and Weihai between October 2011 and July 2013. These were screened with enzyme linked immunoassays for the presence of anti-ToxoplasmaIgG and anti-ToxoplasmaIgM antibodies. 147 (15.2%) pregnant women and 167 (17.3%) control subjects were positive for anti-T. gondiiIgG antibodies, while 28 (2.9%) pregnant women and 37 (3.8%) controls were positive for anti-T. gondiiIgM antibodies (P=0.256). There was no significant difference between pregnant women and nonpregnant controls with regard to the seroprevalence of either anti-T. gondiiIgG or IgM antibodies. Multivariate analysis showed thatT. gondiiinfection was associated with location, cats in home, contact with cats and dogs, and exposure to soil. The results indicated that the seroprevalence ofT. gondiiinfection in pregnant women is high compared to most other regions of China and other East Asian countries with similar climatic conditions.

Nidhi Ahuja ◽  
Anjali Dabral ◽  
Sheeba Marwah ◽  
Rekha Bharti ◽  
Deepti Pachauri ◽  

Introduction: Intrahepatic Cholestasis of Pregnancy (IHCP) is a disorder of the second and third trimester causing pruritis without a rash in the women. To avoid the adversities, early delivery is indicated before serum bile acids levels of >40 μmol/L is reached. In the settingswhere bile acid testing is not available, serum transaminases can be used for diagnosis and management of IHCP. Aim: To find out value of Alanine Transaminase (ALT) for the prediction of adverse outcomes. Materials and Methods: This case-control study was carried out from October 2018 to March 2020, enrolled 75 singleton women with IHCP and 75 controls in their third trimester. The diagnosis was based on the presence of pruritis without an identifiable dermatological cause along with raised serum transaminases. Serum ALT levels and the foetomaternal outcomes were noted. Statistical analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. Mann-Whitney test, Chi-square test and Fisher’s exact test were used to compare all variables. The p-value of <0.05 was considered statistically significant. Results: The mean age of women in the IHCP and control groups was 24.81±4.2 and 25.95±5.13 years, respectively and the mean gestational age of women was 34±2.89 weeks. Women with IHCP had increased incidence of induction of labour (p=0.0003) and meconium staining of liquor (p=0.002) as compared to controls. Serum ALT levels showed a significant positive association with meconium staining of liquor (p=0.041), Intrauterine Death (p=0.01), and Neonatal Intensive Care Unit (NICU) admission (p=0.006) in women with IHCP. An ALT value of 133 U/L was found to be predictive of adverse foetal outcomes with sensitivity, specificity and likelihood ratio of 65.7%, 82.5% and 3.76, respectively. Conclusion: IHCP leads to adverse foetal outcomes. But pruritis is the only maternal distress. ALT >133 U/L is predictive of adverse foetal outcome, therefore, termination of pregnancy can be advocated above this level.

2014 ◽  
Vol 25 (2) ◽  
pp. 63-66
Mafruha Khanam ◽  
Mohammad Ilias

The physiological changes in the thyroid gland during pregnancy were well understood. Serum TSH levels were significantly increased without changes in free T3 and T4 in preeclamptic patient compared to normal pregnancy. This study tried to find out a possible relationship between preeclampsia and thyroid profile. The present study determines thyroid hormonal levels in cases of preeclampsia in the third trimester of pregnancy. TSH level were significantly higher in preeclamptic group as compared to control. A prospective case control study was conducted in the Department of Obstetrics and Gynecology, Chittagong Medical College Hospital, Chittagong. Thyroid hormone, namely Triiodothyronine (Free T3), Thyroxine (Free T4) and Thyroid Stimulating Hormone (TSH) were evaluated by radioimmunoassay. In this case control study pregnant women with preeclampsia were recruited after the diagnosis were made and compared with equal number of healthy normotensive pregnant women in third trimester. The data were analyzed using unpaired ‘t’ test and chi-square test. When P value were <0.05, the result were accepted as significant. Increase TSH level were associated with a risk for occurrence of preeclampsia DOI: Medicine Today 2013 Vol.25(2): 63-66

2021 ◽  
Hüseyin Küçükali ◽  
Osman Hayran ◽  
Şeyda İleri ◽  
Berkay Kurt ◽  
Fatmanur Kuru ◽  

Abstract BackgroundMost of the studies regarding the relationship between socioeconomic status and occurrence of COVID-19 are usually ecological studies and have limitations due to ecological fallacy. The aim of this study is to investigate the relationship between socioeconomic status and individual-level risk of developing COVID-19.MethodsWe conducted a community-based, age and gender matched, case-control study in a district of Istanbul. The case group was defined as all confirmed COVID-19 cases (n=232) that were reported to the district health directorate in a week of August 2020. Control group was defined as people who were matched with cases in terms of age and gender and selected randomly from the directory of the same primary care provider in the district in 1:1 ratio. Participants were communicated via telephone. The socioeconomic status score was measured by Turkish Socioeconomic Status Index which considers three dimensions of it: education, occupation, and income.Results168 cases (72.4% response) and 168 controls are included in the study. 48.8% of participants are female and the mean age is 37.66±15.32 for each group. The mean socioeconomic status score is 70.28±7.09 for cases and 69.25±7.46 for controls (p=0.201). 15.2% (n=25) of cases and 22.4% (n=37) of controls is in lower socioeconomic status group (p=0.091). Neither bivariate nor logistic regression analysis revealed a statistically significant difference between study groups.ConclusionsOur findings indicate that socioeconomic status is not a significant predictor of COVID-19 occurrence at individual-level. The disease seems to be a common threat to all individuals of the global community.

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