scholarly journals Effect of Clinical and Subclinical Hypothyroidism on Fetal Outcomes among Pregnant Women: A Sub-Specialty Department Experience

2021 ◽  
Vol 7 (1) ◽  
pp. 29-32
Author(s):  
Farzana Sharmin ◽  
Mahfuja Asma ◽  
Khandaker Shehneela Tasnim ◽  
Afzal Momin ◽  
Shimul Akhter ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Apgar Score ◽  
Fetal Distress ◽  
Fetal Outcome ◽  
Fetal Outcomes ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Medical University

Background: Hypothyroidism can effect on the fetal outcomes during pregnancy. Objective: The purpose of the present study was to compare the effects of clical and subclinical hypothyroidism on fetal outcomes among pregnant women. Methodology: This cohort study was conducted in the Feto-Maternal Department of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from a period of 6 months dated from September 2019 to February 2020. All cases of the clinical and sub-clinical hypothyroid pregnant women admitted in this department. Fetal outcomes of clinical and sub-clinical hypothyroid pregnant women during delivery were recorded. Findings of the cases recorded carefully. Result: A total number of 75 patients were recruited for this study who were divided in to two group designated as group I or sub clinical hypothyroidism and group II or clinical hypothyroidism. Fetal distress was 22(51.1%) cases in group I and 9(33.3%) cases in group II. The fetal outcome of the study patients had observed that 8(27.6%) and 12(80.0%) of the baby had low (<2.5 kg) birth weight in group I and group II' respectively. In group I most (62.1%) of the baby APGAR score was >7 and 11(73.3%) cases had < 6 APGAR score at 1st minute. Majority of the study patients had >7 APGAR score at 5 min in both groups which was 25(86.2%) and 12(80.0%) in group I and group II respectively. Conclusion: In conclusion there is a significant difference found in overt and sub-clinical hypothyroidism considering fetal stress, IUD and prematurity. Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 29-32

Comparison of Maternal Outcomes between Clinical and Subclinical Hypothyroid Pregnant Women admitted in a Subspecialty Department of a Tertiary Hospital

2021 ◽  
Vol 8 (1) ◽  
pp. 7-11
Author(s):  
Farzana Sharmin ◽  
Mahfuja Asma ◽  
Sanzida Mahmud ◽  
Afzal Momin ◽  
Tripti Rani Das ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Tertiary Hospital ◽  
Maternal Outcomes ◽  
Complication Rates ◽  
Age Group ◽  
Group I ◽  
Abruptio Placenta ◽  
Group Ii ◽  
Medical University

Background: Women with Hypothyroidism have higher pregnancy complication rates. Objective: The purpose of the present study was to compare the effects of clinical and subclinical hypothyroidism on maternal outcomes. Methodology: This cohort study was conducted in the Feto-Maternal Department of  Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from a period of 6 months dated from September 2019 to February 2020 for a period of 6 months. All cases of the clinical and sub-clinical hypothyroid pregnant women admitted in this department. Maternal outcomes of both groups during pregnancy were recorded. Findings of the cases recorded carefully. Result: This study was conducted among 75 patients, which was 14.79% of the total admitted cases during study period. Maximum (62.79%) number was found in the age group of 25 to 44 years in group I and 65.62% cases in group II.  (p<0.05). Severe Pre Eclampsia was observed 2(4.65%) cases and 6(18.75%) Group II. Abruptio placenta was observed 5(15.62%) cases in group II and none in group I. However Preterm delivery are three times more 39.5% in group I cases. Uterine rupture, abortion are   observed only in group II patients (p<0.05). Conclusion: In conclusion maternal outcomes are significantly varied in clinical and subclinical hypothyroidism women during pregnancy. Journal of Current and Advance Medical Research, January 2021;8(1):7-11

Comparison between two different regimens of anticoagulants for pregnant women with prosthetic heart valves

2017 ◽  
Vol 6 (6) ◽  
pp. 2158
Author(s):  
Mustafa Bahloul ◽  
Armia Michael ◽  
Mansour Y. Kandeel ◽  
Ahmed M. Abbas
Keyword(s):  
Pregnant Women ◽  
Heart Valves ◽  
Oral Anticoagulants ◽  
Prosthetic Heart Valves ◽  
Fetal Outcomes ◽  
Warfarin Group ◽  
Group I ◽  
Significant Difference ◽  
Sequential Regimen ◽  
Group Ii

Background: The current study aims to assess the maternal and fetal outcomes of pregnant females with prosthetic heart valves receiving oral anticoagulants only versus the sequential regimen of heparin and OA throughout pregnancy.Methods: An observational was carried out at Assiut Women's Health Hospital, Egypt between February and December 2016. All pregnant women with prosthetic heart valves attending the emergency department during the study period were enrolled in the study. All included patients were classified into two groups; women who receive low molecular weight heparin (LMWH) during the first trimester then shift to warfarin till 36 weeks of gestation then continue on LMWH till delivery (Group I) and those who continue the all period of pregnancy on warfarin (Group II). The primary outcome of the study was the difference in the rate of maternal cardiac complications during labor between both groups.Results: The study included 72 patients have prosthetic valve replacement and on anticoagulants. Twenty-one were on oral anticoagulant; warfarin (Group II) and 51 pregnant women were on sequential regimen. Both groups were comparable in their basic and clinical data on admission. No difference between both groups in the mode of delivery (p=0.52), postpartum hemorrhage (0.09), sub rectal hematomas (p=0.08), the need for postpartum admission to ICU (p=0.93) and the duration of hospital stay (p=0.47). Additionally, no statistical significant difference between both groups as regard the mean birth weight (p=0.97), Apgar score (p=0.62), fetal sex (p=0.92) and congenital anomalies (p=0.08).Conclusions: The use of sequential LMWH and oral anticoagulants appears to be a safe option for those women although there is no difference in maternal and fetal outcomes with the use of continuous oral anticoagulants throughout the pregnancy.

NORMALAND ABNORMAL LIQUOR VOLUME AND ITS CORRELATION WITH PERINATAL OUTCOME

2021 ◽  
pp. 4-6
Author(s):  
Kumari Nisha ◽  
Renu Jha ◽  
Kumudini Jha ◽  
Debarshi Jana
Keyword(s):  
Apgar Score ◽  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Fetal Distress ◽  
Special Unit ◽  
Group I ◽  
Group Ii ◽  
The Difference ◽  
One Year ◽  
Four Quadrant

Aim:To assess and compare the perinatal outcome among mothers with normal and abnormal amniotic uid volume. Method: A prospective comparative study was conducted for a period of one year from January 2020 to December 2020. Group I consist of 50 patients with normal amniotic uid and group II consists of 50 patients with either oligohydramnios or polyhydramnios. Amniotic uid index (AFI) was calculated using Phalen's four quadrant technique using ultrasound. The perinatal outcome was judged by assessing the fetal distress predicted by abnormal fetal heart rate (FHR) or meconium stained liquor, one minute and 5 minute Apgar score, frequency of admission to neonatal intensive care unit (NICU), baby weight of less than 10th percentile for gestation age and perinatal mortality. Results: Induction of labour, caesarean section and meconium stained liquor was found to be most common among the patients in group II (abnormal AFI) in comparison with normal AFI subjects and similarly the perinatal outcome measures like low birth weight, increased frequency of admission to NICU due to respiratory distress and a low APGAR score was more commonly found in abnormal AFI group and the difference was found to be statistically signicant. Conclusion: AFI measurement in antepartum or intrapartum period can help to identify women who need increased antepartum surveillance for pregnancy complications and such women should be managed in a special unit to combat the complications effectively.

scholarly journals Sildenafil Citrate Versus Nifedipine and Dydrogesreone in Prevention of Preterm Labor with Short Cervix

2018 ◽  
Vol 2 (1) ◽  
pp. 01-05
Author(s):  
Abd El-Naser Abd El-Gaber Ali ◽  
Khaled M Abdallah ◽  
Ahmed Abdelhamid
Keyword(s):  
Pregnant Women ◽  
Preterm Labor ◽  
Cervical Length ◽  
Sildenafil Citrate ◽  
Health Concern ◽  
P Value ◽  
Short Cervix ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background: Prevention of the premature birth occurrence remains is considered one of the most tough challenges for obstetricians worldwide, mainly to avoid neonatal prematurity complications leading to short and long term morbidities additionally prematurity prevention will reduce premature neonatal mortality rates which is considered a major health concern of obstetricians, neonatologists and families. Objective: To compare and contrast the efficacy of Sildenafil citrate, Nifedipine and Dydrogesrone in prevention of premature labor in gestations with short cervix. Setting: Obstetrics & Gynecology Departments, Faculties of medicine, south Valley and Al-Azhar (Asyut) Universities, Egypt. Duration: from September 2014 to March 2018. Patients And Methds: the study was conducted on 300 pregnant women who randomly divided into three groups: Group I included 100 cases received Sildenafil citrate (Respatio tablet 20mg twice daily orally), Group II included 100 cases received Nifedipine (Epilat retard tablets 20mg twice daily orally) and Group III included 100 pregnant women received dydrogesreone 10 mg (Duphaston) twice daily orally. Results: incidence of preterm labor was (9.37, 8.51 and 14.28) in (Group I, Group II and Group II) respectively. Mean ± SD of cervical length at 32 weeks of gestation was mildly statistically significant among groups (p value <0.05) but no significance in neonatal outcome (p value >0.05) except birth weight which had a highly statistically significant difference (p value < 0.001). There was a highly statistically significant difference among studied groups as regard to drug side effects in (p value <0.001). Conclusion: Sildenafil citrate was as effective as Nifedipine and better than oral Dydrogesterone on myometrial relaxation and prevention of preterm birth in pregnant women who had short cervix.

Prevalence of Lower Back Pain in Pregnant Women with Pre-Eclampsia

2021 ◽  
Vol 15 (9) ◽  
pp. 2773-2776
Author(s):  
Parveen Shafi ◽  
Rahim Khan ◽  
Tariq Ahmad ◽  
Syed Alam Zeb ◽  
Ahsan Sajjad
Keyword(s):  
Back Pain ◽  
Pregnant Women ◽  
Lower Back Pain ◽  
Gestational Age ◽  
Domestic Work ◽  
Cross Sectional ◽  
Lower Back ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Objective: The aim of this study is to determine the prevalence of lower back pain in pregnant women with pre-eclampsia. Study Design: Cross sectional study Place and Duration: Mardan Medical Complex/BKMC, Tahseel Headquarter Hospital, Takht Bhai Mardan, Swabi Medical Complex /GKMC, from October 2019 to October 2021. Methods: Total 160 pregnant women were presented in this study. Patients were aged between 18-45 years. Detailed demographics of enrolled cases age, body mass index, gestational age, and residency and education status were calculated after taking informed written consent. Patients were divided into two groups. Group I had 80 patients with pre-eclampsia and group II had 80 patients with normotensive. Gravidity among both groups was assessed. Symptoms and prevalence of lower back pain among both groups were assessed and compared. Complete data was analyzed by SPSS 22.0 version. Results: Mean age of the patients in group I was 27.09±5.66 years with mean gestational age 33.14±7.41 weeks while in group II mean age was 26.55±8.26 years with mean gestational age 32.47±8.33 weeks. Thirty seven patients (46.3%) in group I was primigravida and 40 (50%) in group II was primigravida. Thirty nine patients (48.8%) had urban residency in group I and in group II thirty seven (46.3%) cases were from urban area. Frequency of literacy among both groups were 42 (52.5%) and 44 (55%). Prevalence of lower back pain in group I was 55 (68.8%) higher as compared to group II 53 (66.3%) with no any significant difference. Domestic work was the most common cause among both groups followed by social work (Job), lifting of heavy object and medication pain. Conclusion: We concluded in this study the prevalence of lower back pain among pregnant women was significantly high among both pre-eclampsia and normotensive cases. Most common causes of lower back among women was domestic work. Health professionals must be proactive in diagnosing LBP and providing proper management due to the enormous impact of it on the quality of life. Keywords: Pregnant Women, Low Back Pain, Prevalence, Symptoms, causes.

scholarly journals Risk Profiles Associated with Endometriosis among Infertile Women

2020 ◽  
Vol 33 (2) ◽  
pp. 131-139
Author(s):  
Jaglul Haider Khan ◽  
Saifur Rahman ◽  
Chowdhury Taslima Nasreen ◽  
Jahangir Alam ◽  
Pervin Fatema
Keyword(s):  
Risk Factors ◽  
Educational Status ◽  
Infertile Women ◽  
Group I ◽  
Significant Difference ◽  
Study Population ◽  
Group Ii ◽  
The Difference ◽  
Vegetables And Fruits ◽  
Medical University

Background: Endometriosis is a common gynaecological disorder which is found in about5% of women and in 30% of infertile women. Identification of risk factors and timely interventionis useful. Methods: A case control study was conducted in the Dept. of obs & gynae of BangabandhuSheikh Mujib Medical University, Shahbag, Dhaka, from October 2015 to March 2016 on50 infertile patients attending the Infertility unit of the institute with the objective to determinethe risk factors of endometriosis. Twenty five women with endometriosis was taken ascases (group-I) and twenty five women without endometriosis was taken as controls(group-II). Result: The mean age was 32.8±5.4 years in group I and 35.1±5.7 years in group II which issimilar. Urban residents were 3.21 times (with 95% CI 0.87-12.71%) more likely to developendometriosis than rural resident which was statistically significant (p<0.05).Among the study population BMI of 72% patients in group I and 68% in group II were within19-24 kg/m2. The difference was not statistically significant (p>0.05) . There was notstatistically significant difference (p>0.05) between two groups in OCP use (84%vs80%).Women with endometriosis had less physical activity than the women without endometriosis;the differences was statistically significant (p<0.05). Consumption of caffeine, red meat,vegetables and fruits has no effect on endometriosis. Women with pain during menstruationwere 29.33 times (with 95% CI 5.17-100%) and women with heavy amount of blood flow were5.09 times (with 95% CI 1.24-22.06%) more likely to be endometriosis, which was statisticallysignificant (p<0.05) . Other risk factors like- age, occupation, educational status, age atmenarche and cycle length were not significantly (p>0.05) associated with endometriosis. Conclusion: Urban residence and all types of physical activities d”1 hour per day weresignificantly higher in infertile women with endometriosis. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(2) : 131-139

scholarly journals Impact of Timing of Admission in Labour on Subsequent Outcome

2013 ◽  
Vol 2 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Junnu Rayen Janna ◽  
Saleha Begum Chowdhury
Keyword(s):  
Caesarean Section ◽  
Hospital Stay ◽  
Apgar Score ◽  
Caesarean Delivery ◽  
Active Phase ◽  
Cervical Dilatation ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Latent Phase

To examine the effect of timing at which women admitted either in active or latent phase of spontaneous labour on subsequent outcome. This cross-sectional study was conducted at labour ward, department of Obstetrics and Gynaecology, BSMMU hospital, Dhaka, Bangladesh, from August 2007 to November 2007, where data were collected prospectively. A total of 60 women with term, singletone pregnancy, cephalic presentation with spontaneous onset of labour admitted in labour either in active or latent phase were selected for evaluation. Patients with any medical or obstetric complications, rupture of membrane, antenatally diagnosed foetal anomalies or death and with prior caesarean section were excluded from the study. Patients with cervical dilatation at less than 4cm were categorized as latent phase and were in group I. On the other hand, patients with cervical dilatation of 4 cm or more were marked as in active phase and were allocated in group II. Baseline characteristics were compared. Outcome differences were compared using chi-square(X2) test, t test, fisher’s exact test, A ‘p’ value <0.05 considered significant.  Duration of labour, mode of delivery, indication for caesarean section, need for oxytocin, labour analgesia, Apgar score <7, birth weight of baby, maternal PPH and postpartum hospital stay. A total of 60 patients were enrolled during the study period. Of them 35 patients (58.3%)were in group I and 25 patients (41.7%) in group II. Duration of labour was more in early admitted group compared to late admitted group (mean± SD 17.0 ± 2.8 vs 14.3 ± 2.4). Latent phase women needed more caesarean delivery than active phase women (62.9% vs 28.0%). Dystocia was the main indication for caesarean delivery in the present study which was 68.2% and 28.6% in early and late admitted group respectively. Second commonest indication for caesarean section was foetal distress (6 in group I and 5 in group II). Oxytocin for augmentation was used in 62.9% in group I and 56.0% in group II and nulliparae women were the one who needed more augmentation (40.0% in group I, 36.0% in group II). Mean foetal weight between two groups did not reach any significant difference (p>0.05). Apgar score <7 shows insignificant difference between two groups. PPH was found in 5.7% cases and all were from group I. Total postpartum hospital stay was significantly longer in group I than group II (p<0.05). t is shown that early admission to the hospital in low-risk women may negatively affect the outcome of labour and are at increased risk of prolonged labour, more need for analgesia, increased rate of caesarean section, increased PPH and postpartum hospital stay. DOI: http://dx.doi.org/10.3329/cbmj.v2i1.14177 Community Based Medical Journal Vol.2(1) 2013 21-28

scholarly journals Overt and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome

2015 ◽  
Vol 40 (2) ◽  
pp. 52-57 ◽  
Author(s):  
M Sharmeen ◽  
PA Shamsunnahar ◽  
TR Laita ◽  
SB Chowdhury
Keyword(s):  
Adverse Effects ◽  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Perinatal Outcomes ◽  
Fetal Outcome ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Adequate Treatment ◽  
In Pregnancy

Objectives: Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are few data from Bangladesh about the prevalence of thyroid dysfunction in pregnancy. With this background, this study aims to find out thyroid dysfunction (both overt and subclinical hypothyroidism) in pregnancy and its impact on obstetrical outcome.Methods: We studied the evaluation of 50 admitted pregnancies corresponding to 29 women with subclinical hypothyroidism and rest 21 was overt hypothyroidism. Detailed history and examination were performed. Apart from routine obstetrical investigations, Thyroid Stimulating Hormone (TSH) estimation was done. Their obstetrical and perinatal outcomes were noted.Results: Overt hypothyroidism was significantly (p<0.05) higher in 25 to 44 years age group. However two and three abortions were significantly (p<0.05) higher in overt hypothyroidism patients. In sub clinical hypothyroidism 86.2% conceived firstly within 2 years and 66.7% in overt hypothyroidism patients conceived firstly in between 3 to 5 years after marriage. Overt hypothyroids were prone to have pregnancy-induced hypertension 42.9%, intrauterine growth restriction (P=0.001) and gestational diabetes (38.1%) as compared to subclinical cases. Neonatal complications were significantly more in overt hypothyroidism group. Mean TSH level was significantly (p<0.05) higher in overt hypothyroidism patients but mean FT4 level was almost similar in both groups. Majority of the patient underwent caesarean section in both groups due to associated medical and obstetrical complications. None of the babies showed hypothyroidism by cord blood tests. In this analysis our results showed that overt hypothyroidism among Bangladeshi pregnant women are associated with more maternal complication & adverse parental outcome than subclinical hypothyroidism. The adequate treatment of hypothyroidism during gestation minimizes risks and generally, makes it possible for pregnancies to be carried to term without complications. Significant adverse effects on maternal and fetal outcome were seen emphasizing the importance of routine antenatal thyroid screening.Bangladesh Med Res Counc Bull 2014; 40 (2): 52-57

scholarly journals Impact of hemodialysis on the wellbeing of chronic kidney diseases patients: a pre-post analysis

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Um-e-Kalsoom ◽  
Sabiha Khan ◽  
Israr Ahmad
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Perceived Social Support ◽  
Kidney Diseases ◽  
Chronic Kidney Diseases ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
The Impact

Abstract Background Hemodialysis may have serious psychological impact upon patients suffering from chronic kidney diseases. The aim of the present study is to investigate the impact of hemodialysis on the wellbeing of individuals with chronic kidney diseases (CKD). Result A sample consists of (N = 100) CKD patients referred from neurology ward of Leady Reading Hospital Peshawar. Data was collected from both male (50%) and female (50%) in 2017. Participants were divided into two groups on the basis of pre-set criteria. In group I, individuals with 4–5 stage of CKD referred first time for dialysis treatment were recruited. Group II comprised of CKD patients with 1–3 stage. Demographic data sheet, Pakistan Anxiety and Depression, WHO Quality of Life scale, and Perceived Social support scale (PSS) were used to test the hypotheses. Paired sample t test was use to see the difference between pre- and post-analysis of depression, anxiety, QOL, and PSS in group I (experimental group). Results suggests significant difference on depression (p > .001), anxiety (p > .001), and QOL (p > .001), while no significant difference was reported on perceived social support (p <.673). Findings also indicate no significant difference between group I and group II on QOL depression, anxiety, and PSS. Conclusion The findings concluded that patients under hemodialysis treatment suffered from depression, anxiety, and poor quality of life.

Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

2021 ◽  
Author(s):  
Mahir Tıraş ◽  
Emrah Can ◽  
Şahin Hamilçıkan
Keyword(s):  
Cord Blood ◽  
Total Serum ◽  
Healthy Controls ◽  
Term Neonates ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Positive Direct ◽  
Severe Hyperbilirubinemia

Objective This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. Study Design This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO–DCT), and group III featured 70 healthy controls. COHb was determined by an OSM3 hemoximeter. Results Group I differed from groups II and III for cord blood bilirubin, cord blood hemoglobin, and cord blood hematocrit. Groups I and II had higher mean total serum bilirubin (TSB) levels than group III, while there was no difference in the mean TSB levels between groups I and II. There was no significant difference between the COHb group means for groups I, II, and III (p = 0.98). The area under the receiver operating characteristic curve calculated for group I/group III and group II/group III were found to be 0.62 and 0.54, respectively. Conclusion COHb levels did not prove to be superior to the DCT for predicting the risk of developing severe hyperbilirubinemia in term neonates. Key Points

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