scholarly journals Studies of Antimicrobial Activity of 2',4',5'- and 2',3',4'-Trimethoxy Flavanones

2016 ◽  
Vol 8 (2) ◽  
pp. 209-216
Author(s):  
A. Rahim ◽  
R. Ali ◽  
A. Islam
Keyword(s):  
Pathogenic Bacteria ◽  
Sclerotium Rolfsii ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Filter Paper Disc ◽  
Antibacterial And Antifungal ◽  
Paper Disc

 2',4',5'- and 2',3',4'-trimethoxy flavanones have been synthesized starting with 2-hydroxyacetophone and substituted aldehyde. Antibacterial activities of the flavanones have been tested along with their corresponding chalcones against two human pathogenic bacteria (Streptococcus-b-haemolyticus and  Klebsiella sp. (G-)). Antifungal activities of the flavanones have also been investigated against  two plants pathogenic mold fungi (Rhizactonia solani Sclerotium rolfsii). The structures of the synthesized compounds have been characterized with the help of  UV, IR and 1H NMR and 13C-NMR spectra. The antibacterial and antifungal screening were performed in vitro by the filter paper disc diffusion method and poisoned food technique. The flavanones showed antibacterial activity while no activity was observed to their corresponding chalcones against the tested bacteria. On the other hand, chalcones and their corresponding flavanones both showed fungicidal activities.

scholarly journals IN-VITROSTUDIES ON ANTIFUNGALACTIVITY OF SOMEMISTLETOE SPECIES

2021 ◽  
Vol 9 (06) ◽  
pp. 420-427
Author(s):  
R. Neelima ◽  
◽  
B. Sujatha ◽  
N.V. Ramana ◽  
B.V. Rao ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Ethyl Acetate ◽  
Phytophthora Infestans ◽  
Inhibitory Activity ◽  
Sclerotium Rolfsii ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Leaf Extracts

In vitro evaluation of antifungal activity by disc diffusion method was carried out on leaf extracts of D.falcata, D. falcata var pubescens, V. monoicum and V. orientale and stem extracts of D. falcata, D. falcata var pubescens, V. articulatum and V.orientale using three different solvents viz., methanol, n-hexane and ethyl acetate. The antifungal activity was tested on three fungal strains include Fusarium oxysporum, Phytophthora infestans, Sclerotium rolfsii. Overall leaf extracts exerted better inhibitory activity than stem counterparts. Among all, only V. orientale was effective against the three fungal species.Compared to stem extracts, leaf extracts of D. falcata var pubescens have shown higher antifungal activity.

scholarly journals Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine

2012 ◽  
Vol 64 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Irena Novakovic ◽  
Jelena Penjisevic ◽  
V. Sukalovic ◽  
Deana Andric ◽  
G. Roglic ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Salmonella Enteritidis ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Clostridium Sporogenes ◽  
In Vitro Antibacterial Activity ◽  
Derivatives Of

The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.

scholarly journals Antibacterial and Antifungal Evaluation of Chloroflavones

2018 ◽  
Vol 10 (1) ◽  
pp. 67-76
Author(s):  
M. A. Rahim ◽  
M. M. H. Bhuiyan ◽  
M. M. Matin ◽  
M. R. Alam
Keyword(s):  
Pathogenic Bacteria ◽  
Salmonella Typhi ◽  
Aspergillus Ochraceus ◽  
Diffusion Method ◽  
Dilution Method ◽  
Significant Activity ◽  
Filter Paper Disc ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Two chloroflavones, 6 and 7 along with their corresponding chalcones, 4 and 5 have been tested for antibacterial and antifungal activities against six human pathogenic bacteria viz. Bacillus cereus (G+), Staphylococcus aureus (G+), Escherichia coli (G-), Vibrio choloriae (G-), Pseudomonas aeruginosa (G-), and Salmonella typhi (G-), and four plant as well as mold fungi viz. Aspergillus flavus, Aspergillus ochraceus, Aspergillus niger and Rhizopus spp.. The antibacterial and antifungal screens of the synthesized compounds were performed in vitro by the filter paper disc diffusion method and the poisoned food technique, respectively. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of these synthesized compounds in comparison to ampicillin were also determined by broth micro-dilution method. Some of them were found to possess significant activity, when compared to standard drugs.

Note: Inhibition of Pathogenic Bacteria by Essential Oils at Different Concentrations

2003 ◽  
Vol 9 (2) ◽  
pp. 85-88 ◽  
Author(s):  
G. Özkan ◽  
O. Sağdiç ◽  
M. Özcan
Keyword(s):  
Essential Oils ◽  
Pathogenic Bacteria ◽  
Antibacterial Agents ◽  
Antimicrobial Effect ◽  
Inhibitory Effect ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
E Coli ◽  
Paper Disc

The antimicrobial effect of 11 selected Turkish spice essential oils was investigated against seventeen pathogenic bacteria. The antimicrobial activity of the essential oils of six spices (cumin, fennel, laurel, mint, marjoram, oregano, pickling herb, sage, savory, thyme (black) and thyme) was tested at four concentrations (0.2, 0.4, 1 and 2%) on various microorganisms ( E. aerogenes, E. coli, E. coli O157:H7, K. pneumoniae, P. vulgaris, S. enteritidis, S. gallinarum, S. typhimurium, S. aureus, Y. enterocolitica, A. hydrophila, C. xerosis, M. luteus, M. smegmatis, E. feacalis, P. aeruginosa and P. fluorescens). All preparations showed antibacterial activity against at least one or more bacteria. The inhibitory effect of the essential oils was evaluated through paper disc diffusion method. In general, the essential oils at 1 and 2% levels were effective. The most active essential oils were marjoram, thyme and oregano. According to the results, the studied essential oils potentially might be used as antibacterial agents to prevent the spoilage of food products, although further research is needed.

scholarly journals The chemical composition of the essential oil and the antibacterial activities of the essential oil and methanol extract of Teucrium montanum

2008 ◽  
Vol 73 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Nenad Vukovic ◽  
Tanja Milosevic ◽  
Slobodan Sukdolak ◽  
Slavica Solujic
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Methanol Extract ◽  
Bacterial Species ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Inhibitory Effects ◽  
Disc Diffusion Method

This study was designed to examine the chemical composition of the essential oil and the in vitro antibacterial activities of the essential oil and methanol extract of Teucrium montanum. The inhibitory effects of the essential oil and the methanol extracts of Teucrium montanum were tested against thirteen bacterial species using the disc-diffusion method. GC/MS analyses revealed that the essential oil contained mainly sesquiterpenes, such as ?-cadinene (17.19 %), ?-selinene (8.16 %) and ?-calacorene (4.97 %). The highest activities were obtained with the essential oil of Teucrium montanum against K. pneumoniae, B. subtilis, B. mycoides, E. cloaceae and A. chlorococcum. In addition, comparison of the antibacterial activities of the essential oil and the methanol extract showed that the essential oil exhibited the stronger antibacterial activities.

scholarly journals Antibacterial Activities of Some Schiff Bases Involving Thiosemicarbazide and Ketones

2014 ◽  
Vol 26 ◽  
pp. 53-61 ◽  
Author(s):  
S.M.S. Shariar ◽  
M. Jesmin ◽  
M.M. Ali
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Schiff Bases ◽  
Cytotoxic Effect ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method

Three Schiff bases derived from thiosemicarbazide and ketones (Vanillin, Benzophenone and Acetophenone) were used to study their antibacterial activities against some pathogenic bacteria by disc diffusion method. Of these, benzophenone thiosemicarbazone showed significant antibacterial activity as compared with that of Kanamycin. All these three compounds were found to possess cytotoxic effect. Minimum inhibitory concentration of these compounds was also determined.

Biological evaluation of 10-(diphenylmethylene)- 4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives

2009 ◽  
Vol 4 (3) ◽  
pp. 362-368 ◽  
Author(s):  
Joanna Stefańska ◽  
Anna Bielenica ◽  
Marta Struga ◽  
Stafan Tyski ◽  
Jerzy Kossakowski ◽  
...  
Keyword(s):  
Agar Medium ◽  
Inhibition Zone ◽  
Biological Evaluation ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Antibacterial And Antifungal Activity ◽  
Disc Diffusion Method ◽  
Growth Inhibition Zone ◽  
Antibacterial And Antifungal

AbstractAntibacterial and antifungal activity of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives were examined by the disc-diffusion method (growth inhibition zone diameter in agar medium). The MIC’s for the most active agents were determined. Title compounds were also evaluated in vitro against representatives of different virus classes. Most of the tested compounds exhibit activity against CVB-2 virus.

scholarly journals Bactericidal And Antioxidant Effects of Domestic Essential Oils On Certain Pathogenic Bacteria.

2021 ◽  
Author(s):  
Faisal MB. Al-Sarraj ◽  
Ahmad M. Qumri
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Pathogenic Bacteria ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Bacterial Strains ◽  
Disc Diffusion Method ◽  
Rapd Pcr

Abstract Background: Essential oils (EOs) are volatile, liquid substances that come from natural sources such as plants. As secondary metabolites of most plant species, that are typically found in leaf chloroplasts or from the hydrolysis of certain glycosides, their primary function is to combat attacks from predators as well as attract pollinators. Due to their biological activity, EOs have gained popularity in industries such as food processing, cosmetics, and personal care products as well as the pharmaceutical industry. In this study, the antimicrobial nature and antioxidant activity of Saudi Arabian EOs were compared with the antimicrobial activity of known antibiotics.Methods: The In vitro evaluation of antibacterial activity and antioxidant capacity of EOs collected from Jeddah domestic market for gram-negative and gram-positive pathogenic bacteria was carried out using the disc diffusion method. Disc diffusion method was used for the assessment of bactericidal activity of local EOs. The antioxidant activity was determined using phosphomolybdenum method. Furthermore, RAPD-PCR was used to compare the effects of these EOs on DNA in both untreated and treated pathogenic bacterial strains.Results and Conclusion: Bacterial strains with varying antibiotic resistance potential have been successfully isolated. The inhibition zone measurement revealed that the EOs used had some antibacterial effects on the bacterial strains as well as some selectivity on the bacterial strains that they acted on.

scholarly journals Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tanveer MahamadAlli Shaikh ◽  
Habtamu Debebe
Keyword(s):  
Antimicrobial Activities ◽  
New Drugs ◽  
Diffusion Method ◽  
Indole Derivatives ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Standard Drug ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.

scholarly journals Chemical Composition and Antimicrobial Activity of the Essential Oil of Saccocalyx satureioides Coss. et Dur

2006 ◽  
Vol 1 (8) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Hocine Laouer ◽  
Salah Akkal ◽  
Claire Debarnot ◽  
Bruno Canard ◽  
Uwe J. Meierhenrich ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Hepatitis C ◽  
Chemical Composition ◽  
Essential Oil ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

The chemical composition of the essential oil of Saccocalyx satureioides Coss. et Dur. (Lamiaceae) was analyzed by chiral and achiral GC/MS and 42 components were identified. The main constituents were (+)-α-terpineol (35.9%), thymol (15.6%) and borneol (12.4%). The in vitro antibacterial and antifungal activities of the essential oil were assessed by the disc diffusion method, and were significant on the six microorganisms tested. A moderate inhibitory activity against hepatitis C virus polymerase was also evidenced.

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