scholarly journals Antibacterial Activities of Some Schiff Bases Involving Thiosemicarbazide and Ketones

2014 ◽  
Vol 26 ◽  
pp. 53-61 ◽  
Author(s):  
S.M.S. Shariar ◽  
M. Jesmin ◽  
M.M. Ali
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Schiff Bases ◽  
Cytotoxic Effect ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method

Three Schiff bases derived from thiosemicarbazide and ketones (Vanillin, Benzophenone and Acetophenone) were used to study their antibacterial activities against some pathogenic bacteria by disc diffusion method. Of these, benzophenone thiosemicarbazone showed significant antibacterial activity as compared with that of Kanamycin. All these three compounds were found to possess cytotoxic effect. Minimum inhibitory concentration of these compounds was also determined.

scholarly journals Studies of Antimicrobial Activity of 2',4',5'- and 2',3',4'-Trimethoxy Flavanones

2016 ◽  
Vol 8 (2) ◽  
pp. 209-216
Author(s):  
A. Rahim ◽  
R. Ali ◽  
A. Islam
Keyword(s):  
Pathogenic Bacteria ◽  
Sclerotium Rolfsii ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Filter Paper Disc ◽  
Antibacterial And Antifungal ◽  
Paper Disc

 2',4',5'- and 2',3',4'-trimethoxy flavanones have been synthesized starting with 2-hydroxyacetophone and substituted aldehyde. Antibacterial activities of the flavanones have been tested along with their corresponding chalcones against two human pathogenic bacteria (Streptococcus-b-haemolyticus and  Klebsiella sp. (G-)). Antifungal activities of the flavanones have also been investigated against  two plants pathogenic mold fungi (Rhizactonia solani Sclerotium rolfsii). The structures of the synthesized compounds have been characterized with the help of  UV, IR and 1H NMR and 13C-NMR spectra. The antibacterial and antifungal screening were performed in vitro by the filter paper disc diffusion method and poisoned food technique. The flavanones showed antibacterial activity while no activity was observed to their corresponding chalcones against the tested bacteria. On the other hand, chalcones and their corresponding flavanones both showed fungicidal activities.

scholarly journals Determination of antibiotic resistance and minimum inhibitory concentration of meropenem and imipenem growth in Klebsiella strains isolated from urinary tract infection in Shahrekord educational hospitals

2019 ◽  
Vol 21 (2) ◽  
pp. 80-85
Author(s):  
Farshad Kakian ◽  
Behnam Zamzad ◽  
Abolfazl Gholipour ◽  
Kiarash Zamanzad
Keyword(s):  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Minimum Inhibitory Concentration ◽  
Bacterial Infections ◽  
Inhibitory Concentration ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Accurate Identification ◽  
Tract Infections

Background and aims: Klebsiella is an opportunistic organism that is the cause of severe diseases such as pneumonia, septicemia, and urinary tract infections (UTIs). In addition, high antibiotic resistance has challenged the treatment of this bacterium. However, carbapenem antibiotics are considered as the therapeutic agents for selecting the treatment of penicillin- and cephalosporin-resistant gram-negative bacterial infections. The present study aimed to determine the resistance and minimum inhibitory concentration (MIC) of meropenem and imipenem. Methods: A total of 80 Klebsiella spp isolated from UTIs were collected in various educational wards (i.e., urology, obstetrics, and gynecology, as well as the units of infectious diseases, internal medicine, and intensive care) in different hospitals of Shahrekord. The isolates were then identified by using biochemical tests. Further, disc diffusion method was employed to determine the antibiotic resistance. Furthermore, MIC was estimated by the Epsilon-test strip. Moreover, P=Q=0.50, an error of 0.05, and an accuracy of 0.11 were considered for determining the sample size (n=80). Results: Based on the results of disc diffusion method, 24 strains were resistant to meropenem and imipenem. Additionally, the MIC was 24 (30%) by the E-test. In addition, 24 isolates had a MIC of ≥4 μg/mL for meropenem and imipenem and thus were resistant while 18 isolates were found to have a MIC of 1≤ MIC<4 μg/mL and therefore, were considered semi-sensitive (P<0.001). Conclusion: In general, Klebsiella strains were found to be resistant to meropenem and imipenem. Therefore, rapid and accurate identification of these strains and the selection of appropriate antibiotics can help quickly eradicate the infections caused by these bacteria. Accordingly, a waste of time, the consumption of medication, or even an increased resistance are prevented.

scholarly journals Antibacterial Activity of Cissus quadrangularis Stem Extract on the Pathogenic and Industrial Waste Watered Bacteria

2020 ◽  
pp. 28-38
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Industrial Waste ◽  
Xanthomonas Campestris ◽  
Pathogenic Bacteria ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Cissus Quadrangularis

Cissus quadrangularis (Vitaceae) is a popular climber conspicuous by its flesh quadrangular stem widespread throughout Bangladesh. The in vitro antimicrobial activity of C. quadrangularis extracts was studied against selected pathogenic bacteria, industrial wasted bacteria, and broth dilution assay. The most commonly used method of microbiological assay is the disc diffusion method. C. quadrangularis stem extracted with four solvents (Petroleum spirit, methanol, ethyl acetate, and dichloromethane) were tested for antimicrobial activities against some pathogenic microorganisms Sarcina lutea (002-1), Xanthomonas campestris (004-1), Escherichia coli (005-1), Klebsiella pneumonia (006-1) and some industrial (Tannery, Tobacco, and Sugar mill) waste watered bacteria by disc diffusion method. Among the four extracts, ethyl acetate showed moderate antibacterial activity against X. campestris (004-1) and industrial watered bacteria. But, the commercial disc Oxicycline doesn’t show any antibacterial activity against the industrial waste watered bacteria. Petroleum spirit, methanol, and dichloromethane extract were ineffective against all of the tested bacteria.

scholarly journals Antimicrobial Activity of some Honey Samples against Pathogenic Bacteria

2015 ◽  
Vol 34 ◽  
pp. 15-20 ◽  
Author(s):  
S. Mahendran ◽  
D. Kumarasamy
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Streptococcus Pyogenes ◽  
Western Ghats ◽  
Pathogenic Bacteria ◽  
Research Work ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method

The aim of the present research work to investigate antimicrobial activity of some honey samples six winter honeys six summer honeys collected from different regions of Western Ghats. The microbes used in this study are Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis. Antibacterial activity of the honeys was assayed using the Disc diffusion method. Noticeable variations in the antibacterial activity of the different honey samples were observed. Among the microbes Staphylococcus aureus is the most sensitive against all honey samples shows the maximum inhibitor zone compare to summer honeys.

scholarly journals Investigation of antibacterial activity of cinnamyl derivatives of arylpiperazine

2012 ◽  
Vol 64 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Irena Novakovic ◽  
Jelena Penjisevic ◽  
V. Sukalovic ◽  
Deana Andric ◽  
G. Roglic ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Salmonella Enteritidis ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Clostridium Sporogenes ◽  
In Vitro Antibacterial Activity ◽  
Derivatives Of

The derivatives of cinnamic acid and N-arylpiperazine show antibacterial activity. In this work the potential synergistic effect of cinnamyl derivatives of arylpiperazine in selected bacteria was investigated. The antibacterial activities of the derivatives were evaluated against Gram-positive bacteria: Staphylococcus aureus, Streptosporangium longisporum, Sarcina lutea, Micrococcus flavus, Clostridium sporogenes and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris by the disc diffusion method. The minimum inhibitory concentration (MIC) against the selected bacteria was determined for all compounds that showed activity in the disc diffusion method. The majority of the investigated compounds displayed in vitro antibacterial activity. The effect of the type and structure of the substituent on the aromatic ring on the antibacterial activity is discussed. It was found that two derivatives expressed activity toward S. longisporum and P. aeruginosa that was almost as strong as that of amikacin.

scholarly journals Chemical Composition and Antibacterial Activity of Origanum saccatum P.H. Davis Essential Oil Obtained by Solvent-Free Microwave Extraction: Comparison with Hydrodistillation

2011 ◽  
Vol 94 (1) ◽  
pp. 243-250 ◽  
Author(s):  
Fazli Sozmen ◽  
Burcu Uysal ◽  
Birsen S Oksal ◽  
Elif Odabas Kose ◽  
I Gokhan Deniz
Keyword(s):  
Antibacterial Activity ◽  
Chemical Composition ◽  
Antibacterial Activities ◽  
Solvent Free ◽  
Diffusion Method ◽  
Microwave Extraction ◽  
Disc Diffusion ◽  
Bacterial Strains ◽  
Disc Diffusion Method ◽  
Oxygenated Compounds

Abstract The components of the essential oils (EOs) obtained by solvent-free microwave extraction (SFME) and hydrodistillation (HD) from endemic Origanum saccatum P.H. Davis were identified by using GC/MS. The main constituents of both EOs obtained by SFME and HD, respectively, from O. saccatum were p-cymene (72.5 and 70.6%), thymol (9.32 and 8.11%), and carvacrol (7.18 and 6.36%). The EO obtained by SFME contained substantially higher amounts of oxygenated compounds and lower amounts of monoterpenes than did the EO obtained by HD. The antibacterial activities of the EOs obtained by SFME and HD were evaluated with the disc diffusion method by comparison with 10 different bacterial strains. The antibacterial activity of the EO extracted by SFME was found to be more effective than that of the EO extracted by HD against seven of the tested bacteria.

scholarly journals Antibacterial and Cytotoxic Activity of Longiverbenone Isolated from the Rhizome of Cyperus scariosu

1970 ◽  
Vol 25 (1) ◽  
pp. 82-84 ◽  
Author(s):  
M Shafiqur Rahman ◽  
M Nural Anwar
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Cytotoxic Activity ◽  
Brine Shrimp ◽  
Pathogenic Bacteria ◽  
Inhibitory Concentration ◽  
Ethanolic Extract ◽  
Artemia Salina ◽  
Diffusion Method ◽  
Chromatographic Technique

Longiverbenone is a naturally occurring sesquiterpene isolated from ethanolic extract of Cyperus scariosus rhizome by solvent-solvent portioning and chromatographic technique. The antibacterial activity of longiverbenone was evaluated against eleven potential human pathogenic bacteria using disc diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by broth macrodilution method. Cytotoxic activity (lethal concentration 50%, LC50) of longiverbenone was determined on new borne brine shrimp (Artemia salina). Longiverbenone showed moderate to good antibacterial activity against the test organisms tested herein. It exhibited the lowest MIC (20 μg/ml) and MBC (80 μg/ml) against Vibrio cholerae. The LC50 of the isolated sesquiterpene was found to be 14.38 μg/ml against new borne brine shrimp. Keywords: Antibacterial activity; Cytotoxic activity (LC50); Cyperus scariosu; Longiverbenone; Minimum inhibitory concentration (MIC)DOI: http://dx.doi.org/10.3329/bjm.v25i1.4866 Bangladesh J Microbiol, Volume 25, Number 1, June 2008, pp 82-84

scholarly journals ANTIBACTERIAL ACTIVITY OF A COPPER(II) COMPLEX OF 1-(1H-BENZIMIDAZOL-2-YL)-N- (TETRAHYDROFURAN-2-YLMETHYL) METHANAMINE

2015 ◽  
Vol 2 (1) ◽  
pp. 11-14
Author(s):  
Elayaperumal R ◽  
Kiruthika M ◽  
Dharmalingam P
Keyword(s):  
Antimicrobial Activity ◽  
Cyclic Voltammetry ◽  
Antibacterial Activity ◽  
Free Ligand ◽  
Antibacterial Activities ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Infra Red ◽  
Uv Visible

A mononuclear copper(II) complex of 1-(1H-benzimidazol-2-yl)-N-(tetrahydrofuran-2- ylmethyl)methanamine) was synthesized and characterized by various physicochemical techniques like cyclic voltammetry and elemental analysis, ESI-MS, UV–Visible, Infra red and EPR spectroscopy. The antibacterial activities of the ligand and its complex were screened by disc diffusion method and found that the metal complexes have higher antimicrobial activity than the free ligand.

scholarly journals The mechanism of antibacterial activity of corylifolinin against three clinical bacteria from Psoralen corylifolia L

2018 ◽  
Vol 16 (1) ◽  
pp. 882-889 ◽  
Author(s):  
Nan He ◽  
Juan Zhou ◽  
Miyun Hu ◽  
Changyang Ma ◽  
Wenyi Kang
Keyword(s):  
Electron Microscopy ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Inhibitory Concentration ◽  
Extracellular Protein ◽  
Diffusion Method ◽  
Antibacterial Mechanism ◽  
Disc Diffusion ◽  
Disc Diffusion Method ◽  
Scanning Electron

AbstractEffective antibacterial activity against Grampositive bacteria isolated in clinical strains was exhibited when corylifolinin was tested using the Disc diffusion method (K-B method). Minimum inhibitory concentration (MIC) of corylifolinin against Staphylococcus aureus (SA), Methcillin-resistant Staphylococcus aureus (MRSA) and extended spectrum β-lactamases Staphylococcus aureus (ESBLs-SA) were 0.078, 0.156 and 0.078 mg/mL, respectively. The minimum bactericide concentrations (MBCs) were 0.156, 0.156 and 0.078 mg/mL respectively. Scanning electron microscopy (SEM), alkaline phosphatase (AKP) and bacterial extracellular protein leakage were used to investigate the antibacterial mechanism of corylifolinin. After adding corylifolinin at the MBC level, there were obvious changes to the Staphylococcus aureus of bacteria cells. Both MIC level and MBC levels of corylifolinin led to the leakage of AKP and bacterial extracellular protein.

scholarly journals Evaluation of anticonvulsant, antimicrobial and hemolytic activity of Aitchisonia rosea

2015 ◽  
Vol 10 (4) ◽  
pp. 980
Author(s):  
Shahid Rasool ◽  
Farrukh Zia Khan ◽  
Mobasher Ahmad
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Diffusion Method ◽  
Anticonvulsant Effect ◽  
Disc Diffusion ◽  
Zone Of Inhibition ◽  
Disc Diffusion Method ◽  
Drug Induced ◽  
Hemolytic Effect ◽  
Antimicrobial Assay

<p class="Abstract">The purpose of this study was to evaluate the anticonvulsant, antimicrobial and hemolytic effect of <em>Aitchisonia rosea</em>. The anticonvulsant effect was studied at doses 400 and 800 mg/kg against pentylenetetrazole, strychnine and picrotoxin-induced seizures in albino mice. The antimicrobial assay was conducted by disc diffusion method and minimum inhibitory concentration. Hemolytic effect was analyzed by reported method. Phenolic compounds present in the n-butanol fraction of the plant were estimated by HPLC. The plant showed maximum response against drug-induced convulsions and provided protection to animals at both doses. It also showed maximum zone of inhibition and highly significant MIC against all bacterial and fungal strains. The plant protected the RBCs from hemolysis. The highest amount of phenolics found was caffeic acid (7.5 ± 0.04).</p><p> </p>

Sign in / Sign up

Export Citation Format

Share Document