scholarly journals Routine Histopathological Examination After Cholecystectomy

KYAMC Journal ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 184-187
Author(s):  
Md Abu Bakar Siddiue ◽  
Firoz Mahmud ◽  
M Fardil Hossain Faisal ◽  
Md Fazlur Rahman ◽  
Bidhan C Das ◽  
...  
Keyword(s):  
Observational Study ◽  
Gall Bladder ◽  
General Surgery ◽  
Histopathological Examination ◽  
Chronic Cholecystitis ◽  
Common Finding ◽  
Neoplastic Lesion ◽  
Medical University ◽  
Malignant Condition ◽  
Macroscopic Examination

Background: Cholecystectomy is one of the commonest surgeries in medical practice. Sometimes malignant condition cannot be assessed pre-operatively. Histopathology require for tissue diagnosis. Objective: To assess whether the histopathogical examination is really needed for all bladder specimens resected for cholelithiasis and cholecystitis. Materials and Methods: This observational study was carried out in the General Surgery Unit, Department of Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from May, 2016 to April, 2017. A total number of 95 patients were included in this study. Results: Total of 95 gallbladder specimens were submitted for histopathological examination where 33.7% were males and 66.3 % were females with mean age of 46+12.86 years. Chronic cholecystitis was the most common finding in 91.6% of cases whereas Xanthogranulomatous 2.1%. Six of the gall bladders showed adenocarcinoma (6.3%), of which four had changes on ultrasound and macroscopic gall bladder analysis (MGAS) disturbances were found in 5 cases and 1 case was found incidentally on histopathological examination. On ultrasound, only four (66.66%) and peroperative macroscopic examination by surgeon only 5(83.3%) had a clue of carcinoma. Conclusion: It could be concluded that , routine histopathological examination of gallbladder after cholecystectomy is necessary as USG sometimes can not differentiate neoplastic lesion from inflammatory one. KYAMC Journal Vol. 10, No.-4, January 2020, Page 184-187

Histopathological Evaluation of Gall Bladder In Cholecystectomy Specimens in a Tertiary Health Care Centre of Nepal

2020 ◽  
Vol 22 (4) ◽  
pp. 233-237
Author(s):  
Rakesh Pathak ◽  
M Gupta ◽  
P Poudel ◽  
K Khadka
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
College Teaching ◽  
Cross Sectional Study ◽  
Chronic Cholecystitis ◽  
Dietary Habit ◽  
Health Care Centre ◽  
Cross Sectional ◽  
Medical College ◽  
Neoplastic Lesion

Gall bladder is one of the important digestive organ which encountered with different histopathological changes. Different changes in dietary habit, obesity, oral contraceptives, alcohal have shows increased pattern of cholecystitis and cholelithiasis and other pathological findings. Detail examination of gall bladder in cholecystectomy specimen helps to evaluate different histopathological pattern of gall bladder lesion and also help to differentiate non-neoplastic from neoplastic lesion and also helps in further management. This was a cross sectional study done in the Department of Pathology, Nepal Medical College Teaching Hospital, Kathmandu, Nepal, during the study of period of six months (Feburary 2020 to July 2020). A total of 127 patients between 16 years to 63 years with mean age of 40.54±10.88 years. There were 127 cholecystectomy specimens were received during study period and out of which 94 were female and 33 were male. On histopathologial evaluation, chronic cholecystitis was most common findings followed by chronic cholecystitis with cholesterolosis. Other findings were chronic cholecystitis with adenomyosis, chronic cholecystitis with pyloric metplasia, chronic cholecystitis with intestinal metpalsia, chronic cholecystitis with polyp, acute on chronic cholecystitis, Xanthogranulomatous cholecytsitis and adenocarcarcinoma . Median age was 40.54 years. It was concluded that Chronic cholecystitis was the most common histopathologcial findings and the common groups was 41-50 years. Routine examination of cholecystectomy specimens grossly and microscopically is important for patient management Though a very few cases of carcinoma of Gall bladder is seen, it is very important to make sure that all cholecystectomy specimens undergone histopathological examination, with this, we can achieve timely diagnosis and early managements.

Follicular cholecystitis with cholelithiasis – A diagnostic pitfall

2021 ◽  
Vol 6 (4) ◽  
pp. 316-318
Author(s):  
Jaydeep N Pol ◽  
Neha M Bhosale ◽  
Mahendra Atmaram Patil ◽  
Vaishali J Pol
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
Bladder Wall ◽  
Chronic Cholecystitis ◽  
Bladder Tissue ◽  
Lymphoid Follicles ◽  
Diagnostic Pitfall ◽  
Germinal Centres ◽  
Gall Bladder Wall ◽  
Difficult Cases

Follicular Cholecystitis (FC) is an extremely rare subtype of Chronic Cholecystitis (CC). It is characterized by hyperplastic lymphoid follicles along with prominent germinal centers. It constitutes about 2% of routine cholecystectomies. In this article, we report a case of FC in a 69 years lady. She had abdominal pain, clinically diagnosed as Calculus cholecystitis and managed by laparoscopic cholecystectomy. Grossly, thickening of the gall bladder wall was noted. Histopathological examination revealed gall bladder wall infiltrated by dense lymphoid infiltrate forming lymphoid follicles with prominent germinal centres. Hence, we rendered a diagnosis of FC. The purpose of presenting this case is to make pathologists aware about this entity. One should not mistake this lesion for lymphoma. A careful histopathological examination is diagnostic and Immunohistochemistry may be helpful in difficult cases.Follicular Cholecystitis is extremely rare variant of Chronic cholecystitis. It is characterized by at least 3 Lymphoid Follicles per cm of Gall Bladder tissue with inflammatory infiltrate composed almost exclusively of scattered well-formed Lymphoid Follicles. Pathologist must be familiar with this entity to avoid misdiagnosis of lymphoma.

scholarly journals Histopathological spectrum of gall bladder lesions

2020 ◽  
Vol 8 (3) ◽  
pp. 1056
Author(s):  
Aparna M. Kulkarni ◽  
Esha Devendra Jadhav ◽  
Ravindra V. Ramteke
Keyword(s):  
Gall Bladder ◽  
Adenosquamous Carcinoma ◽  
Histopathological Examination ◽  
Rare Condition ◽  
Chronic Cholecystitis ◽  
Carcinoma Gallbladder ◽  
Common Diagnosis ◽  
The World ◽  
Bladder Diseases ◽  
Perforation Peritonitis

Background: Gall bladder diseases are a very common health problem that affects millions of people throughout the world. Cholelithiasis is commonly associated with carcinoma gallbladder. Cholecystectomy is the most commonly performed surgical procedure done for gall bladder disease.Methods: A total of 161 cases of gall bladder lesions were evaluated from January 2017 to December 2018 which were sent to department of pathology. Specimens were fixed in 10% formalin. Appropriate areas were selected from the specimen and grossed, processed, sectioned, stained using haematoxylin and eosin and were observed under microscope.Results: Out of 161 cases, 105 were female (65.22%) and 56 cases were male (34.78%).Histopathologically, the most common diagnosis was Chronic calculus cholecystitis (57.76%) followed by chronic acalculus cholecystitis (22.36%). Remaining cases were of Acute on chronic cholecystitis (6.21%), Acute on chronic cholecystitis with cholelithiasis (4.96%), Acute on chronic cholecystitis with perforation peritonitis (1.24%), Acute suppurative cholecystitis with perforation peritonitis (0.62%), Biliary Atresia (1.24%), Chronic cholecystitis with choledochal cyst (1.24%), Follicular cholecystitis (1.24%), Adenocarcinoma (0.62%), Adenosquamous carcinoma (0.62%) and one case was inconclusive (0.62%).Conclusions: The incidence of chronic calculus cholecystitis was found to be 57.76% with female preponderance and mostly in third decade. Malignancy of gall bladder is a rare condition. Routine histopathological examination of all cholecystectomy specimens is strongly recommended for the detection of various variants of chronic cholecystitis and also of incidental carcinoma of gall bladder which helps in their treatment and prognosis.

scholarly journals Role of digital photography in evaluation of gallbladder specimens following laparoscopic cholecystectomy for gallstone disease: a prospective observational study

2019 ◽  
Vol 6 (4) ◽  
pp. 1376
Author(s):  
Vidyasagar . ◽  
Manjunath Maruti Pol ◽  
Sunil Chumber ◽  
Yashwant Singh Rathor
Keyword(s):  
Observational Study ◽  
Gall Bladder ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Prospective Observational Study ◽  
Histopathological Examination ◽  
Digital Photography ◽  
Resected Specimen ◽  
Abnormal Finding ◽  
Carcinoma Gall Bladder

Background: Digital photography helps in accurate documentation of macroscopic features of specimens and preventing inaccuracies in description of macroscopic features. Some studies recommend a digital color print be sent with each specimen to histopathology laboratory. The aim of the study was to assess the necessity of histopathological examination of resected specimen of gallbladder with no features suspicious of carcinoma gall bladder on clinicoradiological study.Methods: It is a prospective observational study conducted in the Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, between 2014 and 2016. Patients between 18 to 60 years of age with gall stone disease with no features suspicious of carcinoma gall bladder on clinicoradiological study were recruited in the study. Post-cholecystectomy gallbladder specimens were considered as subjects of study. Specimen were photographed and sent for histopathological examination. Macroscopic features on digital photography were compared with histopathological findings.Results: About, 39/100 (39%) gallbladder specimens showed abnormal findings on digital photography; 30/39 (77%) had ulcerations, 5/39 (13%) had polypoidal lesions and 4/39 (10%) had diffuse wall thickening. 1/39 (2.6%) specimens with abnormal finding on digital photography was found to be malignant on histopathological examination. The sensitivity, specificity, negative predictive value and positive predictive value of digital photography was 100%, 67.7%, 100% and 3.03% respectively.Conclusions: Digital photography can prove to be a good tool in documenting macroscopic features of gallbladder specimens. Digital photography is associated with high sensitivity and negative predictive value; however, larger sample size is required to establish its significant correlation.

scholarly journals Cutaneous Horn-Related Kaposi's Sarcoma: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Nilufer Onak Kandemir ◽  
Banu Dogan Gun ◽  
Figen Barut ◽  
Nilgun Solak Tekin ◽  
Sukru Oguz Ozdamar
Keyword(s):  
Case Report ◽  
Kaposi's Sarcoma ◽  
Histopathological Examination ◽  
English Literature ◽  
Kaposi’S Sarcoma ◽  
Immunohistochemical Analysis ◽  
Cutaneous Lesions ◽  
Cutaneous Horn ◽  
Neoplastic Lesion ◽  
Macroscopic Examination

Cutaneous horn is characterized by the accumulation of abnormal keratinized material and may occur in association with a variety of benign, premalignant, and malignant cutaneous lesions. Cutaneous horn occurs very rarely in association with soft-tissue neoplasias. A cutaneous horn located on the toe was completely removed by excision in a 78-year-old male patient. Macroscopic examination revealed a hemorrhagic nodular lesion, 0.5 cm in diameter, located on the dermis underlying the cutaneous horn with a height of 1 cm. Histopathological examination revealed a neoplastic lesion consisting of fusiform cells and extravasated erythrocytes underlying the compact keratin mass. The immunohistochemical analysis showed immunoexpression of endothelial markers and HHV8 in fusiform cells. The case was evaluated as “cutaneous horn developed in a nodular stage Kaposi's sarcoma.” Our case is the second case of cutaneous horn related to Kaposi's sarcoma reported in the English literature and is presented in this case report with its clinical and histopathological features.

scholarly journals Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India

2017 ◽  
Vol 10 (2) ◽  
pp. 93-98
Author(s):  
Trilok C Guleria ◽  
Shobha Mohindroo ◽  
Narender K Mohindroo ◽  
Ramesh K Azad
Keyword(s):  
Nasal Cavity ◽  
Nasal Polyp ◽  
Paranasal Sinuses ◽  
Histopathological Examination ◽  
Himachal Pradesh ◽  
Common Finding ◽  
Nasopharyngeal Angiofibroma ◽  
Neoplastic Lesion ◽  
Sinonasal Mass ◽  
Nasopharyngeal Masses

ABSTRACT Introduction: Nasal masses are common finding in the ear, nose, and throat outpatient department. Most patients present with complaints of nasal obstruction. A sinonasal mass can have various differential diagnoses. They may be congenital, inflammatory, neoplastic (benign or malignant), or traumatic in nature. A careful histopathological examination is necessary to decide the nature of any particular lesion. Materials and methods: The retrospective study was carried out between January 2011 and December 2013. A total of 185 cases diagnosed with masses of the nasal cavity, paranasal sinuses, and nasopharynx were included. Data from histopathological records were retrieved to confirm the diagnosis. Observations: Among 185 cases, 75% were non-neoplastic and 25% were neoplastic. Among neoplastic masses, 57% were benign and 43% were malignant. The age of presentation ranged from first to eighth decade of life (mean age 37.74 years). The lesions had a stronger predilection for males (1.68:1). Among non-neoplastic lesions, nasal polyp was the commonest lesion followed by ethmoidal mucocele (1.44%) and lupus vulgaris (0.72%). Among benign lesions, inverted papilloma (30.77%) and nasopharyngeal angiofibroma (30.77%) were the commonest followed by capillary hemangioma (15.38%), osteoma (7.68%), nasopharyngeal lymphoepithelioma (3.85%), chondroma (3.85%), pleomorphic adenoma (3.85%), and schwannoma (3.85%). Squamous cell carcinoma (40%) was the commonest malignant neoplastic lesion observed followed by adenoid cystic carcinoma (20%), malignant melanoma (15%), nasopharyngeal carcinoma (10%), esthesioneuroblastoma (10%), and non-Hodgkin lymphoma (5%). Conclusion: Among the noninflammatory lesion, nasal polyp is the commonest lesion. Nasal polyps are more common in hilly area may be due to exposure to pine pollens. There is no difference in the histopathological profile of benign and malignant lesions. How to cite this article: Guleria TC, Mohindroo S, Mohindroo NK, Azad RK, Kumar A. Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India. Clin Rhinol An Int J 2017;10(2):93-98.

scholarly journals Spectrum of Benign Histopathological Lesions in Cholecystectomy Specimens

2020 ◽  
Vol 9 (2) ◽  
pp. 8-13
Author(s):  
Prachi Singh ◽  
Faiyaz Ahmad ◽  
Shyamoli Dutta ◽  
Seema Awasthi ◽  
V. K Singh
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
Chronic Cholecystitis ◽  
Traumatic Rupture ◽  
Common Disease ◽  
Histopathological Analysis ◽  
Bladder Epithelium ◽  
Gall Stones ◽  
Number Of Patients ◽  
Common Diagnosis

Background: The most commonly received specimen in any histopathology laboratory is cholecystectomy specimen. The majority of the cholecystectomies are done for Cholelithiasis. Inflammation may be acute, chronic or acute on chronic. It almost always occurs in association with gallstones, which is responsible for carcinoma and if the diagnosed early prognosis of the carcinoma gall bladder is good. Histopathological examination is therefore a must for diagnosis of early carcinomas. Subjects and Methods: 100 cholecystectomy specimens from patients       of all ages were included. All specimens were subjected to gross and microscopic assessment. Different histological findings were noted in various layers of the gall bladder. The study includes all radiologically confirmed inflammatory pathologies of including metaplastic changes of the gall bladder epithelium, irrespective of age and sex. The study excludes patients with evident gallbladder malignancy, cases with known secondaries from gall bladder, traumatic rupture of gallbladder. Results: The age of patients varied from 16 to 70 years, with a maximum number of patients (25%) belong to 31 to 40 years. Gall stones were associated with 59% cases of cholecystitis. Pigment stones were most common (74%). Histopathologically the most common diagnosis was chronic cholecystitis (69%). Conclusion: Almost all of the gallbladder lesions are inflammatory in origin, of which the most common disease being chronic cholecystitis. Chronic cholecystitis was found to be most probable diagnosis in a female of 30-40 years. Pigmented gall stones were found to be the most common etiology of chronic cholecystitis. Prompt detailed histopathological analysis will help to confirm the benign nature of the disease or to detect any precursors of malignancy.

TO FIND OUT ELECTRO-CARDIOGRAPHIC CHANGES & ECHO CHANGES IN ALUMINIUM PHOSPHIDE AND ETHYLENE DIBROMIDE POISONING

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Hemant Nargawe ◽  
Sumeet Sisodiya
Keyword(s):  
Biochemical Analysis ◽  
Histopathological Examination ◽  
Common Finding ◽  
Histopathological Changes ◽  
Ethylene Dibromide ◽  
Medical College ◽  
Aluminium Phosphide ◽  
Urine Examination ◽  
Cardiovascular Involvement ◽  
Careful Clinical Examination

Background & Method: The study was conducted in the Department of Medicine Shyam Shah Medical College and Associated Sanjay Gandhi Memorial Hospital, Rewa (M.P). History was followed by a careful clinical examination i.e. cardiovascular, respiratory and gastrointestinal and nervous system. Investigations had done included routine haematological examination, Biochemical analysis, urine examination, ECG, 2 D. Echo & Histopathological examination was done. Result: ST-T changes were most common finding in Aluminium phosphide poisoning in relation to mortality. However hyperkalemia was the most ominous finding associated with 100% mortality, ECG finding in EDB was normal ECG. The most ominous finding was arrhythmia which was associated with 100% mortality. Survivors of ethylene dibromide poisoning echocardiography was normal in 11 (84.61%) followed by pericardial effusion in 2 (15.38%) patients. Conclusion: Noteworthy finding was absence of correlation between cardiovascular involvement, histopathological changes and ECG findings. It was seen that even if ECG showed normal pattern there were significant histopathological changes in heart. Keywords: electro-cardiographic, Aluminium phosphide, ethylene dibromide & poisoning.

scholarly journals The giant resectable carcinoma of gall bladder—a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lovenish Bains ◽  
Haraesh Maranna ◽  
Pawan Lal ◽  
Ronal Kori ◽  
Daljit Kaur ◽  
...  
Keyword(s):  
Case Report ◽  
Gall Bladder ◽  
Lymph Node Involvement ◽  
Chronic Cholecystitis ◽  
Large Size ◽  
Node Involvement ◽  
Uncommon Condition ◽  
Well Differentiated ◽  
Vague Abdominal Pain ◽  
Common Malignancy

Abstract Background Gall bladder cancer (GBC) is the fifth most common malignancy in the gastrointestinal system and the most common malignancy of the biliary system. GBC is a very aggressive malignancy having a 5 year survival rate of 19%. Giant Gall Bladder (GGB) is an uncommon condition that can result from cholelithiasis or chronic cholecystitis and rarely with malignancy. Case report A 65 year old lady presented with vague abdominal pain for 12 years and right abdominal lump of size 20 × 8 cms was found on examination. CT scan showed a circumferentially irregularly thickened wall (2.5 cm) of gall bladder indicative of malignancy. Per-operatively a GB of size 24 × 9 cm was noted and patient underwent radical cholecystectomy. It was surprise to find such a giant malignant GB with preserved planes. Histopathology, it was well differentiated adenocarcinoma of gall bladder of Stage II (T2a N0 M0). Discussion It is known that mucocoele of GB can attain large size, however chronic cholecystitis will lead to a shrunken gall bladder rather than an enlarged one. A malignant GB of such size and resectable is rare without any lymph node involvement or liver infiltration. Few cases of giant benign gall bladder have been reported in literature, however this appears to be the largest resectable gall bladder carcinoma reported till date as per indexed literature. Conclusion Giant GB is an uncommon finding. They are mostly benign, however malignant cases can occur. Radiological findings may suggest features of malignancy and define extent of disease. Prognosis depends on stage of disease and resectability, irrespective of size.

INCIDENTAL GALL BLADDER CARCINOMA (IGBC) IN CHOLECYSTECTOMY SPECIMENS REMOVED FOR CHOLELITHIASIS

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Dharmpal Godara ◽  
Vijay Pal Singh Dhayal
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Histopathological Examination ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Survival Outcome ◽  
Sectional Study ◽  
Gall Bladder Carcinoma ◽  
Cross Sectional ◽  
Hospital Records

Background: The present study highlights the occurrence of Incidental gallbladder carcinoma (IGBC) detected during histopathological examination in cholecystectomy specimens removed for cholelithiasis. Methods- This is a tertiary hospital based cross-sectional study of 500 cholecystectomy specimens removed during cholelithiasis. Relevant hospital records, histopathology slides and reports were reviewed, re-evaluated and studied. Results: 4(0.80%) cases of incidental gall bladder carcinoma (IGBC) were diagnosed from the histopathological evaluation (HPE) of 500 cholecystectomy specimens, constituting 0.80% of gall bladder specimens received during the study period. The age of the patients with IGBC ranged from 51-80 years. More females were affected than males with a M:F ratio of 1:3. Conclusion: Early detection of IGBC by histopathological examination would have a favourable impact on prognosis and management thereby increasing the survival outcome. Keywords: Cholelithiasis, Incidental Gall Bladder Carcinoma

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