scholarly journals A study on gender related differences in oxidative stress status

Mediscope ◽  
2018 ◽  
Vol 6 (1) ◽  
pp. 13-18
Author(s):  
MMR Sardar ◽  
MOI Ali ◽  
F Pervin ◽  
F Yeasmin ◽  
N Ahmed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxide ◽  
Alpha Tocopherol ◽  
Systematic Sampling ◽  
Female Group ◽  
Tocopherol Concentration ◽  
Medical College ◽  
Male Group ◽  
Oxidative Stress Status ◽  
The Mean

Female lives longer than male and incidence of cardiovascular disease is lower in young female. However the role of oxidative stress has been repeatedly described in various diseases but rarely healthy people. The objective of the study was to observe the gender related differences in oxidative stress status and to show significance in alteration. This cross sectional and comparative study was carried out in the Department of Physiology, Rajshahi Medical College during the period from January 2013 to June 2014. Total 45 healthy adult subjects (25 males and 20 females) were enrolled in the study. Systematic sampling technique was used to select each study subject from students, doctors and staffs of Rajshahi Medical College. Malondialdehyde (MDA), a lipid peroxide and alpha-tocopherol, an antioxidant in plasma was measured. MDA:alpha-tocopherol ratio was used as a reliable marker of oxidative stress status. The mean plasma alpha-tocopherol concentration was significantly higher (p < 0.05) and plasma MDA: alpha-tocopherol ratio was significantly lower (p < 0.05) in female group than male group. The mean plasma alpha-tocopherol concentration was significantly higher (p < 0.05) in female group aged 18-21 years than the corresponding male group. From the results of this study, it can be concluded that oxidative stress is less in female than in male indicating presence of potent compensatory response against oxidative stress in female which may be attributed to influence of female sex hormones. Mediscope Vol. 6, No. 1: Jan 2019, Page 13-18

scholarly journals The Importance of Antioxidant Status in Gastric Intestinal Metaplasia

2021 ◽  
Author(s):  
Nilay Danis ◽  
Aysegul Ertinmaz Ozkan ◽  
Fatih Karatas ◽  
Cagri Cakici ◽  
Turkan Yigitbasi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intestinal Metaplasia ◽  
Prognostic Marker ◽  
Smoking Status ◽  
Serum Levels ◽  
Control Group ◽  
Gastric Intestinal Metaplasia ◽  
Oxidative Stress Status ◽  
Cancer Types ◽  
The Mean

Background and Aim: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Patients and Methods: This was a prospective, non-randomized case-control study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT(NT/TT) ratios were statistically significantly higher in IM group compared to controls [(351.71±81.9µmol/L vs. 271.82±54.13µmol/L, p=0.000),(391.5±92.69µmol/L vs. 308.59±55.53 µmol/L, 0.000) and (0.89±0.6 vs. 0.87±0.29,  p=0.022), respectively].The mean SS to TT(SS/TT) ratio was significantly lower in IM group than control group (0.050±0.31 vs. 0.060±0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups[16.3 (3.3 – 78) vs. 18.3 (10 – 32.7), p=0.271 and 0.055 ± 0.041 vs. 0.070 ± 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT<0.062 was found as an independently prognostic marker for IM (OR, 2.38; 95%CI: 1.168 - 4.865, P=0.017). Conclusion: SS /NT ratio lower than 0.062 was found as an independently prognostic marker for IM. This ratio could help to distinguish which patients should be followed closely for gastric cancer.

scholarly journals Study of antioxidant status in malaria patients

2017 ◽  
Vol 5 (4) ◽  
pp. 1649
Author(s):  
Amit G. Tyagi ◽  
Rupal A. Tyagi ◽  
Prema Ram Choudhary ◽  
Jaidev Singh Shekhawat
Keyword(s):  
Oxidative Stress ◽  
Biochemical Markers ◽  
Antioxidant Status ◽  
Therapeutic Potential ◽  
Control Group ◽  
Oxygen Species ◽  
Medical College ◽  
Follow Up Study ◽  
The Mean

Background: Oxidative stress plays an important role in the development of metabolic changes in malaria patients. During infection RBCs are exposed to continual oxidative stress. The univalent reduction of oxygen results in a series of cytotoxic oxygen species such as O2-, H2O2, OH•. Objective was to determine the level of oxidative stress in patients suffering from malaria.Methods: The present study was conducted on 551 malaria patients and 211 age-sex matched controls, in department of Biochemistry, C U Shah Medical College, Surendranagar, Gujarat from April 2012 to May 2013.  In stage-I, day-1 malaria patient’s v/s control group, In stage-II, day-3 v/s day-1 after anti-malarial treatment and in Stage-III day-3 v/s day-1 after anti-malarial + antioxidant treatment.Results: The mean erythrocytic activity of SOD, CAT, GST were decreased (0.71±0.25EU, 9.9±2.4μmol/sec, and 11.7±3.9 U/gmHb% respectively), mean level of GSH and MDA were increased (42.1±6.06gm/Hb%, 10.9±2.83 respectively) significantly (P<0.001) as compared to control group. In the follow up study with anti-malarial treatment the mean levels of erythrocytic GSH and MDA (28.7±7.54gm/Hb% and 8.08±1.95nM/L) decreased significantly (P<0.001 and P<0.01 respectively), whereas mean activity of erythrocytic enzymes like SOD, CAT and GST (0.99±0.15 EU, 15.8±2.68μmol/sec and 22.5±5U/gmHb%) were increased significantly (P<0.001) as compared to day-1.Conclusions: Erythrocytic antioxidant enzymes, GSH and MDA may be considered to be reliable biochemical markers for diagnostic and therapeutic potential in malaria.

scholarly journals Proportions of maxillary anterior teeth relative to each other and to golden standard in Chitwan Medical College

2018 ◽  
Vol 8 (1) ◽  
pp. 14-18
Author(s):  
Meena Kumari Mishra ◽  
Manjeev Guragain ◽  
Smriti Narayan Thakur ◽  
Sanjeeb Chaudhary
Keyword(s):  
Female Group ◽  
Medical College ◽  
Anterior Teeth ◽  
Mean Width ◽  
Golden Standard ◽  
Attractive Face ◽  
Irreversible Hydrocolloid ◽  
The Mean ◽  
Aesthetic Dentistry ◽  
And Function

Introduction: One of the most important aspects of aesthetic dentistry while restoring or replacing maxillary anterior teeth is the creation of harmonious proportion between the widths of them. The appearance of anterior teeth is criti­cal for an attractive face and pleasing smile. The dimensional determination of maxillary anterior teeth is an important factor for both, esthetic and function. Materials and Methods: This study was conducted in 140 dentate subjects. Out of the 140 subjects, 70 (50%) were males and 70 (50%) were females. The age of the patients in this study ranged from 18 to 50 years. Maxillary impressions of selected subjects were made with an irreversible hydrocolloid impression material. The mesiodistal width of the maxillary anterior teeth was measured from the casts with a Boley gauge. Results: The mean width ratios were 0.83 for right LI/CI and 0.85 for left LI/CI, 1.12 for right CN/LI and 1.1 for left CN/LI in total population. The mean width ratios in male group were 0.83 for right LI/CI and 0.87 for left LI/CI, 1.14 for right CN/ LI and 1.1 for left CN/LI. Similarly, in female group the mean width ratios were 0.82 for right LI/CI and 0.83 for left LI/CI, 1.1 for right CN/LI and 1.1 for left CN/LI. Conclusion: In the evaluation of LI/CI, CN/LI, WLRs golden proportion was not found in left and right for both sexes.

Plasma Levels of Retinol, Carotenoids, and Tocopherols in Relation to Dietary Pattern among Pregnant Tanzanian Women

2003 ◽  
Vol 73 (5) ◽  
pp. 323-333 ◽  
Author(s):  
Mulokozi ◽  
Lietz ◽  
Svanberg ◽  
Mugyabuso ◽  
Henry ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Plasma Levels ◽  
Vegetable Consumption ◽  
Alpha Tocopherol ◽  
Leafy Vegetables ◽  
Tocopherol Concentration ◽  
Green Leafy Vegetables ◽  
The Mean ◽  
Plasma Retinol ◽  
Retinol Concentration

In Tanzania, as in other developing countries, dietary intake of nutrients in pregnant women is marginal or lower than the recommended intakes and therefore these women are at high risk for deficiencies. Our aim was to evaluate the relationship between diet and plasma levels of retinol, carotenoids, and alpha-tocopherol in the third trimester of pregnancy. Ninety pregnant women aged between 18 and 45 years were equally recruited from three villages. Seven-day food frequency data was collected by questionnaire. Plasma levels of retinol, carotenoids, and tocopherols were assessed by high-performance liquid chromatography (HPLC). Results indicated that cooked green leafy vegetables constituted the major source of provitamin A carotenoids, with low intake of yellow/orange fruits and preformed vitamin A. Lutein, lycopene, and beta-carotene were the predominant carotenoids in the plasma with mean values of 1.61, 0.84, and 0.63 mumol/L, respectively. There was no significant correlation between frequencies of vegetable consumption and either plasma retinol or carotenoids. However, increased consumption of green leafy vegetables with oil, which increases bioavailability, was correlated with high plasma retinol levels (p = 0.03). Low retinol levels (≤ 0.70 mmol/L) were present in 26% of women. The mean plasma retinol concentration was 0.89 mumol/L and 63% of the women had values below 1.05 mumol/L. The mean plasma a-tocopherol concentration was 15.4 mumol/L and women with plasma retinol concentration > 1.05 mumol/L had significantly higher mean alpha-tocopherol than women with plasma retinol concentration ≤ 0.70 mumol/L (p ≤ 0.01). Twenty-four percent of the women were anemic (hemoglobin:Hb <110 g/L) and the mean Hb value was 116.3 g/L.

scholarly journals Gender Influences on Colour processing: An event related potential (ERP) study

2018 ◽  
Vol 17 (4) ◽  
pp. 612-618 ◽  
Author(s):  
Rumaisa Abu Hasan ◽  
Faruque Reza ◽  
Tahamina Begum
Keyword(s):  
Medical Science ◽  
Electrode System ◽  
Event Related Potential ◽  
Female Group ◽  
Occipital Area ◽  
Male And Female ◽  
Male Group ◽  
The Mean ◽  
Mean Differences ◽  
Gender Influences

Background: We assessed cognitive function by using different colours. Colour has been used in different neuropsychology tests for diagnostic and therapeutic purposes.Purposes: As male and female hormones are different, it is important to investigate the effect of different colours on the male and female groups for planning their therapeutic strategy in different diseases.Methods: This prospective study was done between 2012 and 2014. We used the 128-sensor net for an event related potential (ERP) study in male and female groups (n= 22 in each group). Different colours were used as stimuli. Subjects pressed ‘button 1’ when they liked the colour and ‘button 2’ when they disliked it. Reaction time (RT) and differences in like and dislike stimuli were analysed. The values of the mean differences of like and dislike stimuli were calculated using a 10-20 electrode system of 19 electrodes. The amplitudes and latencies of the N200 and P300 ERP components were analysed.Results: No significant differences were found in the mean differences of the amplitudes and latencies of the N200 and P300 ERP components between the male and female groups across 19 electrode sites. RTs were non-significantly longer in the male group. However, colour reflected on the frontal-right occipital area in the female group and the frontal-left occipital area in the male group.Conclusion: There might be a possibility of delayed decision-making due to difficulty assessing emotion in the male group compared with the female group.Bangladesh Journal of Medical Science Vol.17(4) 2018 p.612-618

Study of lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases

2016 ◽  
Vol 5 (08) ◽  
pp. 4759
Author(s):  
Binod Mahato
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Lipid Profile ◽  
Mean Values ◽  
Enzymatic Antioxidant ◽  
Medical College ◽  
Stress Markers ◽  
Antioxidant Enzymes Activities ◽  
The Mean ◽  
And Oxidative Stress

Cardiovascular disease is one of the major causes of death in the India, therefore present study, was aimed to study the lipid profile, enzymatic antioxidant and oxidative stress in cardiovascular diseases. The study was carried out in the Department of Biochemistry and Medicine MGM Medical College and Hospital, Mumbai. 5ml. Blood sample was drawn into plain vacutainers and was utilised for estimation of lipid profile, oxidative stress markers concentration and antioxidant enzymes activities. The mean values of Total cholesterol, LDL TG, and MDA were significantly increased in CVD patients as compared to control (p<0.0001) and HDL, NO, SOD, CAT in CVD patients were significantly decreased as compared to control (p<0.0001). The present study reveals the importance of determining the lipid profile, free radicals and antioxidant status in CVD to enable the formulation of specific therapies for early intervention and better management of disease.

Does Floatation Influence Breaststroke Technique?

2010 ◽  
Vol 26 (2) ◽  
pp. 150-158 ◽  
Author(s):  
Hugues Leblanc ◽  
Ludovic Seifert ◽  
Didier Chollet
Keyword(s):  
Field Tests ◽  
Female Group ◽  
Slow Pace ◽  
Male Group ◽  
The Mean ◽  
Sprint Velocity

This study is aimed at examining the relationships between floatation parameters, assessed by field tests and the stroking characteristics of breaststroke swimmers. The floatation parameters were evaluated for 23 males and 23 females by the hydrostatic lift test, the sinking force acting at the ankle test and the maximal glide length after a push-off from the pool wall test. The swimmers performed two trials at submaximal and sprint pace, and then, from the data given by a PC-video velocity system, the duration and velocity of their propulsive, recovery and glide phases were analyzed. In the female group and at slow pace, glide duration is correlated with hydrostatic lift (r= .62) and with maximal glide length (r= .44); mean glide velocity is correlated with hydrostatic lift (r= .73). In the male group and at slow pace, the sinking force was correlated with the glide phase (r= –0.66) and with the mean glide velocity (r= –0.78). At sprint velocity, the hydrostatic lift is correlated with the glide phase in the female group (r= .52). Floatation parameters have an impact on the gliding phase of the breaststroke cycle.

scholarly journals Gender differences in patients presenting with NSTEMI in the STAR registry

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
A Meer ◽  
A Kinsara
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Epigastric Pain ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Female Group ◽  
St Segment Elevation ◽  
Male Group ◽  
The Mean

Abstract Funding Acknowledgements Type of funding sources: None. Background  In most acute coronary artery (ACS) related literature, the female gender constitutes a smaller proportion compared to the male gender. The presentation of ACS in females is frequently atypical, causing a delay in diagnosis and management. This study is based on gender-specific data in the Saudi Acute Myocardial Infarction Registry Program (STARS-1 Program). Methods  A prospective multicenter study, conducted with patients diagnosed with ACS in 50 participating hospitals. Results  In total, 762 (34.12%) patients were diagnosed with Non ST segment Elevation Myocardial infarction Of this group, only 164 (21.52%) were women. The mean age of the female group (64.52 ± 12.56 years) was older and the mean body mass index (BMI) was higher (30.58 ± 6.23) than the male group. A significantly higher proportion of the female group was diabetic or hypertensive, however, a smaller proportion was smoking. Hyperlipidemia was not significant between the two groups, although present in almost half (48%) of the female group. The history of angina/MI/stroke and revascularization was similar, except for renal impairment. The presentation was atypical compared to the male group as only 70% presented with chest pain, and the rest with shortness of breath or epigastric pain. At presentation, the female group were more tachycardiac, had higher blood pressure, and a higher incidence of being in class 11-111 Killip heart failure. Only 32% had a normal systolic function, and the majority had either mild or moderate systolic dysfunction. Guideline directed medical therapy were not different between the two groups, except for the initiation of a beta-blocker on admission. In particular, the rate of percutaneous coronary intervention (PCI) was similar. Overall, the in-hospital mortality was similar (5%), with more women diagnosed with atrial fibrillation and heart failure at follow-up. Conclusion  Women had a higher prevalence of risk factors affecting the presentation and morbidity but not mortality. Improving these risk factors and the lifestyle is a priority to improve the outcome and decrease morbidity.

scholarly journals Effect of combined treatment with Methotrexate and Non-steroidal anti-inflammatory drugs on plasma alpha-tocopherol level and Rheumatoid factor among Rheumatoid Arthritis patients

Mediscope ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 80-86
Author(s):  
Farhana Pervin ◽  
Md Anwar Habib ◽  
Nazimuddin Ahmed ◽  
Md Mijanur Rahman Sardar
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Rheumatoid Factor ◽  
Combined Treatment ◽  
Alpha Tocopherol ◽  
Qualitative Assessment ◽  
Medical College ◽  
Tocopherol Level ◽  
Anti Oxidant ◽  
Inflammatory Drugs

Background: Oxidative stress might play a significant role in the pathogenesis of Rheumatoid Arthritis. Traditional therapies of Rheumatoid Arthritis are governed by different NSAIDs which improve symptoms of Rheumatoid Arthritis. But addition of Methotrexate (MTX) to Non-steroidal anti-inflammatory drugs (NSAIDs) has been found to be extra beneficial by halting the disease process. Objectives: To evaluate the status of anti-oxidant alpha-tocopherol and rheumatoid factor before and after treatment with MTX and NSAIDs for two months in Rheumatoid Arthritis patients. Methods: This quasi-experimental study was carried out in the Department of Pharmacology and Therapeutics of Rajshahi Medical College, Rajshahi between the periods of January 2011 to December 2011. Total ten clinically diagnosed Rheumatoid Arthritis patients were enrolled in the study. Purposive sampling technique was used to select each study subject from medicine wards of Rajshahi Medical College Hospital. Alpha-tocopherol, an anti-oxidant in plasma was measured as marker of anti-oxidant defense. The patients were then treated with oral MTX at a dose of 10 mg weekly and Indomethacin 150 mg in three divided doses daily for 2 months. After 2 months of continuous aforementioned treatment, alpha-tocopherol levels were estimated again. Moreover qualitative assessment of rheumatoid factor was done. For statistical analysis, paired t-test was done. Results: After two months of treatment with Methotrexate and Indomethacin, plasma alpha-tocopherol levels were significantly higher (P<0.05) in Rheumatoid Arthritis patients. However no significant change was observed in qualitative assessment of rheumatoid factors. Conclusion: From the findings of this study, it can be concluded that the endogenous alpha-tocopherol level increases even without any supplementation of alpha-tocopherol by combined treatment with MTX and Indomethacin in Rheumatoid Arthritis patients and thereby reduces oxidative stress. So alpha-tocopherol level is a better marker for early assessment of prognosis of Rheumatoid arthritis than Rheumatoid factor test. Mediscope 2021;8(2): 80-86

scholarly journals Gender differences in patients presenting with NSTEMI in the STAR registry

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Meer ◽  
A Kinsara
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Epigastric Pain ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Female Group ◽  
St Segment Elevation ◽  
Male Group ◽  
The Mean

Abstract Funding Acknowledgements Type of funding sources: None. Background  In most acute coronary artery (ACS) related literature, the female gender constitutes a smaller proportion compared to the male gender. The presentation of ACS in females is frequently atypical, causing a delay in diagnosis and management. This study is based on gender-specific data in the Saudi Acute Myocardial Infarction Registry Program (STARS-1 Program). Methods  A prospective multicenter study, conducted with patients diagnosed with ACS in 50 participating hospitals. Results  In total, 762 (34.12%) patients were diagnosed with Non ST segment Elevation Myocardial infarction Of this group, only 164 (21.52%) were women. The mean age of the female group (64.52 ± 12.56 years) was older and the mean body mass index (BMI) was higher (30.58 ± 6.23) than the male group. A significantly higher proportion of the female group was diabetic or hypertensive, however, a smaller proportion was smoking. Hyperlipidemia was not significant between the two groups, although present in almost half (48%) of the female group. The history of angina/MI/stroke and revascularization was similar, except for renal impairment. The presentation was atypical compared to the male group as only 70% presented with chest pain, and the rest with shortness of breath or epigastric pain. At presentation, the female group were more tachycardiac, had higher blood pressure, and a higher incidence of being in class 11-111 Killip heart failure. Only 32% had a normal systolic function, and the majority had either mild or moderate systolic dysfunction. Guideline directed medical therapy were not different between the two groups, except for the initiation of a beta-blocker on admission. In particular, the rate of percutaneous coronary intervention (PCI) was similar. Overall, the in-hospital mortality was similar (5%), with more women diagnosed with atrial fibrillation and heart failure at follow-up. Conclusion: Women had a higher prevalence of risk factors affecting the presentation and morbidity but not mortality. Improving these risk factors and the lifestyle is a priority to improve the outcome and decrease morbidity.

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