scholarly journals Fvc, Fev1 and Fev1/Fvc % in Female SLE Patients and Their Relationship with Duration of the Disease

2014 ◽  
Vol 26 (1) ◽  
pp. 22-27
Author(s):  
Dilroze Hussain ◽  
Shelina Begum ◽  
Taskina Ali ◽  
Mohammed Nesar Uddin Ahmed ◽  
Refat Farzana
Keyword(s):  
Lung Function ◽  
Lupus Erythematosus ◽  
Autoimmune Disorder ◽  
Study Groups ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Normal Ranges ◽  
The Mean ◽  
Predicted Values ◽  
Female Subjects

Systemic Lupus Erythematosus (SLE) is an autoimmune disorder which affects multiple organs of human including lungs. To assess FVC, FEV1 and FEV1/FVC % in SLE patients and to correlate them with the duration of the disease. This cross-sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from January 2010 to December 2010. A total number of 120 female subjects were selected, among which 30 were age and BMI matched apparently healthy subjects for comparison (control) and 90 were patients of SLE ( study group) . Ages of all the patients were ranged from 20 to 50 years and they were matched in terms of age, sex and BMI. Based on the duration of the disease, patients were subdivided into B1 (1-6 months), B2 (2-5 years) and B3 (6-10 years). Controls were selected from the community and the patients from the Out Patient Department (OPD) of SLE clinic, Department of Medicine, BSMMU, Dhaka. Lung function were assessed by measuring Forced vital capacity (FVC), Forced expiratory volume in 1st second (FEV1), Forced expiratory ratio (FEV1/FVC%) with a Digital MicroDL spirometer. For statistical analysis Independent Sample ‘t’ test, One way ANOVA test and Pearson’s correlation coefficient test were performed as applicable. The mean percentage of predicted values of lung function parameters in healthy female subjects were within normal ranges. The mean percentage of predicted values of FVC, FEV1 were significantly lower in all study groups when compared to control. Again, the mean percentage of predicted values of FVC, FEV1 significantly lower in the patients of Group B3 compared to Group B2 except FVC which were non significantly lower. Moreover, these comparisons were significantly lower when compared to Group B1. The differences of the mean percentage of predicted values of FVC, FEV1 were significantly lower in Group B2 when compare to Group B1. In addition, FVC and FEV1 were positively correlated in B2 and B3 when correlated with duration of SLE. All these values were statistically non significant. In addition The mean percentage of predicted values of FEV1/ FVC% were almost similar and the differences among the groups were statistically non-significant. Pulmonary function decrease in SLE female and the reduction is inconsistently associated with duration of the disease. DOI: http://dx.doi.org/10.3329/medtoday.v26i1.21307 Medicine Today 2014 Vol.26(1): 22-27

scholarly journals Assessment of PEFR and FEF25-75 in Female SLE Patients and their Relationship with Duration of the Disease

2014 ◽  
Vol 13 (4) ◽  
pp. 415-420
Author(s):  
Dilroze Hussain ◽  
Farjana Majid ◽  
Muneera Zahir ◽  
Ohida Sultana ◽  
Shelina Begum
Keyword(s):  
Lupus Erythematosus ◽  
Medical Science ◽  
Autoimmune Disorder ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Normal Ranges ◽  
The Mean ◽  
Predicted Values ◽  
Female Subjects

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder which affects multiple organs of human including lungs. Objectives: To assess PEFR and FEF25-75 in SLE patients and to correlate them with the duration of the disease.Method: This cross-sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from January 2010 to December 2010. A total number of 120 female subjects were selected, among which 30 were age and BMI matched apparently healthy subjects for comparison (control) and 90 were patients of SLE (study group). All the patients were matched for age, sex and BMI. Based on the duration of the disease, patients were subdivided into B1 (1-6 months), B2 (2-5 years) and B3 (6-10 years). Controls were selected from the community and the patients from the Out Patient Department (OPD) of SLE clinic, Department of Medicine, BSMMU, Dhaka. (PEFR) and FEF25-75 of all the subjects were measured by a Digital MicroDL spirometer. For statistical analysis Independent Sample ‘t’ test, One way ANOVA test and Pearson’s correlation coefficient test were performed as applicable.Results: The mean percentage of predicted values of lung function parameters in healthy female subjects were within normal ranges. The mean percentage of predicted values of PEFR and FEF25-75 were significantly lower in all study groups when compared to control. Again, the mean percentage of predicted values of PEFR and FEF25-75 were significantly lower in the patients of Group B3 compared to Group B2. Moreover, these comparisons were significantly lower when compared to Group B1. The differences of the mean percentage of predicted value of PEFR, FEF25-75 were non-significantly lower in Group B2 when compare to Group B1. In addition, FEF25-75 were positively correlated with duration of SLE in group B2 but negatively correlated in B3. On the other hand PEFR was negatively correlated with duration of SLE in both B2 and B3. All these values were statistically non-significant. Conclusion: These pulmonary functions decrease in SLE female and the reduction is inconsistently associated with duration of the disease. DOI: http://dx.doi.org/10.3329/bjms.v13i4.20588 Bangladesh Journal of Medical Science Vol.13(4) 2014 p.416-420

scholarly journals FVC, FEV1 and FEV1/ FVC % in Rheumatoid Arthritic Female and their Relationships with Duration of the Disease

1970 ◽  
Vol 5 (1) ◽  
pp. 8-13
Author(s):  
Farzana Yesmin ◽  
Shelina Begum ◽  
Sultana Ferdousi
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Inflammatory Disorder ◽  
Newly Diagnosed ◽  
Cross Sectional ◽  
Normal Ranges ◽  
The Mean ◽  
Predicted Values ◽  
Student’S T ◽  
Group B

Background: Rheumatoid Arthritis (RA) is the most common inflammatory disorder mediated throughthe immune system, affecting joints and various organs including lungs. Pulmonary dysfunction inRA patients has been reported. Objective: To observe FVC, FEV1 and FEV1/ FVC % in female patientsof RA and their relationships with duration of the disease. Methods: This cross-sectional study wascarried out in the Department of Physiology, BSMMU, Dhaka, from January to December 2009 on 90RA female patients of 30-50 years age (Group B). For comparison, 30 age and BMI matched apparentlyhealthy subjects (Group A) were also studied. According to the duration of disease, RA patients weresubdivided into B1 (newly diagnosed), B2 (3-5 years ) and B3 (6-10 years ). They were selected from theOut Patient Department of Physical Medicine of Bangabandhu Sheikh Mujib Medical University,Dhaka. FVC, FEV1 and FEV1/FVC% of all the subjects were measured by a digital MicroDL spirometer.Results were expressed as percent of predicted value. For statistical analysis One-Way ANOVA,Unpaired Student's 't' test and Pearson's correlation coefficient test were performed, as required.Results: The mean percentage of predicted values of these lung function parameters in the healthyfemale subjects and newly diagnosed (B1) RA patients were within normal ranges. The mean percentageof predicted values of all the spirometric variables were significantly lower in the patients in B3compared to those in B2 (FVC p<0.01, FEV1 p<0.01), B1 (FVC p<0.05, FEV1 p<0.05, FEV1/FVC% p<0.001) and A (FVC p<0.01, FEV1 p<0.001, FEV1/FVC% p<0.001), except FEV1/FVC% in B3 vs B2 whichwas lower but nonsignificant. Again these same parameters were significantly lower in B2 in comparisonto B1 (FVC p<0.001, FEV1 p<0.001, FEV1/FVC% p< 0.001) and A (FVC p<0.001, FEV1 p<0.05, FEV1/FVC% p<0.001). In addition all the ventilatory variables had significant (p<0.001) negative correlationwith durations of disease except FVC in B1, which was significant at p<0.01 level. Conclusion: Thisstudy reveals that pulmonary functions may be lower in patients of RA and the lung function isinversely related to the duration of disease.Key Words: FVC; FEV1; Rheumatoid ArthritisDOI: 10.3329/jbsp.v5i1.5412J Bangladesh Soc Physiol. 2010 June; 5(1): 8-13

scholarly journals Pulmonary impairment after tuberculosis in a South African population

2016 ◽  
Vol 72 (1) ◽  
Author(s):  
Gibwa Cole ◽  
Duncan Miller ◽  
Tasneem Ebrahim ◽  
Tannith Dreyden ◽  
Rory Simpson ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Tuberculosis ◽  
South African ◽  
Pulmonary Rehabilitation ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Predicted Values

Background: In South Africa, pulmonary tuberculosis (PTB) remains a problem of epidemic proportions. Despite evidence demonstrating persistent lung impairment after PTB cure, few population-based South African studies have investigated this finding. Pulmonary rehabilitation post-cure is not routinely received.Objectives: To determine the effects of PTB on lung function in adults with current or past PTB. To determine any association between PTB and chronic obstructive pulmonary disease (COPD). Methods: This study was observational and cross-sectional in design. Participants (n = 55) were included if they were HIV positive on treatment, had current PTB and were on treatment, and/or had previous PTB and completed treatment or if they were healthy adult subjects with no history of PTB. A sample of convenience was used with participants coming from a similar socio-economic background and undergoing spirometry testing. Multiple regression analyses were conducted on each lung function variable.Results: Compared to normal percentage-predicted values, forced expiratory volume in 1 second (FEV1 ), forced vital capacity (FVC) and FEV1 :FVC were significantly reduced in those with current PTB by 23.39%, 15.99% and 6.4%, respectively. Both FEV1 and FVC were significantly reduced in those with past PTB by 11.76% and 10.79%, respectively. There was no association between PTB and COPD – those with previous PTB having a reduced FEV1 :FVC (4.88% less than the norm), which was just short of significance (p = 0.059).Conclusions: Lung function is reduced both during and after treatment for PTB and these deficits may persist. This has implications regarding the need for pulmonary rehabilitation even after medical cure.Keywords: Lung function, pulmonary, tuberculosis

scholarly journals PEFR and FEF25-75 in Rheumatoid Arthritic Female and their Relationships with Duration of the Disease

1970 ◽  
Vol 6 (1) ◽  
pp. 58-63
Author(s):  
Farzana Yesmin ◽  
Shelina Begum ◽  
Sultana Ferdousi
Keyword(s):  
Rheumatoid Arthritis ◽  
Lung Function ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Newly Diagnosed ◽  
Female Patients ◽  
Normal Ranges ◽  
Duration Of Disease ◽  
The Mean ◽  
Predicted Values

Background: Rheumatoid Arthritis (RA) is a chronic, progressive multisystemic inflammatory disorder of unknown etiology affecting approximately 1% of the population. Pulmonary involvement is a frequent extraarticular manifestation in rheumatoid arthritis. Objective: To observe PEFR, FEF25-75 in female patients of RA in order to find out their relationships with duration of the disease. Methods: This cross-sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, between January and December 2009 on 90 RA female patients of 30-50 years age (Group B). For comparison, 30 age and BMI matched apparently healthy subjects (Group A) were also studied. According to the duration of disease, RA patients were subdivided into B1 (newly diagnosed), B2 (3-5 years) and B3 (6- 10 years). They were selected from the Out Patient Department of Physical Medicine of Bangabandhu Sheikh Mujib Medical University, Dhaka. PEFR, FEF25-75 of all the subjects were measured by a digital MicroDL spirometer. Results were expressed as percentage of predicted value. For statistical analysis One-Way ANOVA, Unpaired Student's 't' test and Pearson's correlation coefficient test were performed. Results: The mean percentage of predicted values of these lung function parameters in the healthy female subjects and newly diagnosed (B1) RA patients were within normal ranges. The mean percentage of predicted values of both the spirometric variables were significantly lower in B3 compared to those in B2 (PEFR p<0.001, FEF25-75 p<0.001), B1 (PEFR p<0.05, FEF25-75 p<0.02) and A (PEFR p<0.05, FEF25-75 p<0.01). Again the same parameters were significantly lower in B2 in comparison to those of B1 (PEFR p<0.001, FEF25-75 p<0.05) and A (PEFR p<0.001, FEF25-75 p<0.05). In addition both the ventilatory variables had significant (p<0.001) negative correlation with durations of disease. Conclusion: This study reveals that pulmonary functions may be lower in patients with RA and their lung function is inversely related to the duration of disease. Key Words: PEFR; FEF25-75; Rheumatoid Arthritis DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8086 J Bangladesh Soc Physiol. 2011 June; 6(1): 58-63

scholarly journals POS0733 REAL-LIFE PHYSICAL ACTIVITY IN SLE PATIENTS: ASSOCIATIONS WITH FATIGUE AND QUALITY OF SLEEP

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 617.1-617
Author(s):  
H. Wohland ◽  
N. Leuchten ◽  
M. Aringer
Keyword(s):  
Physical Activity ◽  
Sleep Quality ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Real Life ◽  
Survey Study ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Fatigue Score ◽  
The Mean

Background:Fatigue is among the top complaints of patients with systemic lupus erythematosus (SLE), but only in part associated with SLE disease activity. Physical activity can help to reduce fatigue and should therefore be recommended to SLE patients. Vice versa, fatigue may arguably lead to reduced physical activity.Objectives:To investigate the extent of physical activity and the perception of fatigue and sleep quality in patients with SLE.Methods:Starting in February 2019, SLE patients were invited to participate in a cross-sectional survey study of fatigue and physical exercise during their routine outpatient clinic visits. Participants filled out a ten-page paper questionnaire focused on physical activity. To evaluate fatigue, we primarily used a 10 cm visual analogue scale (0-100 mm, with 100 meaning most fatigued), but also the FACIT fatigue score (range 0-52). Sleep quality was estimated using grades from 1 (excellent) to 6 (extremely poor).Results:93 SLE patients took part in the study. All patients fulfilled the European League Against Rheumatism/ American College of Rheumatology (EULAR/ACR) 2019 classification criteria for SLE. 91% of the patients were female. Their mean (SD) age was 45.5 (14.3) years and their mean disease duration 12.1 (9.4) years. The mean BMI was 25.2 (5.6). Of all patients, 7.5% had a diagnosis of (secondary) fibromyalgia. The mean fatigue VAS was 32 (27) mm and the mean FACIT fatigue score 35.7 (10.3). As expected, fatigue by VAS and FACIT was correlated (Spearman r=-0.61, p<0.0001). The mean SLEDAI was 1 (1) with a range of 0 to 6. Median glucocorticoid doses were 2 mg prednisolone equivalent, with a range from 0 to 10 mg.Out of 66 patients in payed jobs, 64 (97%) reported details on their working space. One person (2%) worked in a predominanty standing position, 37 (58%) worked in essentially sedentary jobs and 26 (40%) were in positions where they were mildly physically active in part. The mean fatigue VAS was 31 (24) mm for patients with partly active jobs and 27 (30) mm for those in sedentary jobs. Sleep was graded 2.9 (0.9) by those with active and 3.1 (1.3) by those with sedentary jobs.Half of the patients (51%) reported more than one physical recreational activity. 44 (47%) were walking and for five persons (5%) this was the only form of activity. Cycling was reported by 19 patients (20%), 18 of whom also practiced other activities. For transport, 52 (56%) in part chose active modes, such as walking and cycling. Patients who reported any of the above activities showed a mean fatigue VAS of 28 (25) mm, compared to 36 (28) mm in the patient group without a reported activity. Sleep quality was very similar: 3.1 (1.2) and 3.2 (1.1) for more active and more passive patients, respectively.65 (70%) patients regularly practiced sports. Of these, 39 (60%) practiced one kind of sport, 15 (23%) two, 7 (11%) three, and 2 (3%) each four and five kinds of sports. Fatigue VAS of patients practicing sports was 27 (25) mm versus 43 (28) in those who did not (p=0.0075). Sleep quality was 2.9 (1.1) in the sports cohort and 3.5 (1.1) in the no-sports cohort (p=0.0244).Conclusion:A majority of SLE patients in remission or low to moderate disease activity regularly practiced sports, and those doing so reported lesser fatigue and better sleep quality. The absolute values on the fatigue VAS were in a moderate range that made fatigue as the main cause of not performing sports rather unlikely for most patients.Disclosure of Interests:Helena Wohland: None declared, Nicolai Leuchten Speakers bureau: AbbVie, Janssen, Novartis, Roche, UCB, Consultant of: AbbVie, Janssen, Novartis, Roche, Martin Aringer Speakers bureau: AbbVie, Astra Zeneca, BMS, Boehringer Ingelheim, Chugai, Gilead, GSK, HEXAL, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi, UCB, Consultant of: AbbVie, Astra Zeneca, BMS, Boehringer Ingelheim, GSK, Lilly, MSD, Roche, Sanofi, UCB

scholarly journals TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dr. Hitesh Kumar Solanki ◽  
Dr. Omnath P Yadav ◽  
Dr. Anita J Gojiya
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Group I ◽  
Significant Difference ◽  
History Of ◽  
Young Smokers ◽  
The Mean ◽  
Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung   function and serum lipids in asymptomatic smokers   and comparable non   smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and     3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

scholarly journals Correlation between Duration of Oral Contraceptives and Hypercoagulability in Bangladeshi Women

2017 ◽  
Vol 26 (Number 1) ◽  
pp. 21-26
Author(s):  
Samsunnahar ◽  
Q S Akhter ◽  
N Akhter ◽  
K Sultana ◽  
Md. Atiquzzaman ◽  
...  
Keyword(s):  
Oral Contraceptives ◽  
Oral Contraceptive Pill ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Prolonged Duration ◽  
Group A ◽  
The Mean ◽  
Student’S T

This study was done to assess the hypercoagulability and the risk of thromboembolism in women taking oral contraceptive pill for prolonged period of time. This cross sectional study was done in the department of Physiology, Dhaka Medical College, Dhaka from Jan 2012 to Dec 2012. Ninety female subjects with the age range from 25-45 years, were taken as a study population. Among them, 60 women taking oral contraceptives for prolonged period of time ( > 1 years) were included for the study group and age matched 30 women of OCP nonusers were taken as a control. Study subjects were divided into two groups according to their duration of oral pill use: group BI ( 1 to 5 years users) were 30 women and group B2 ( >5 to 10 years users) were 30 women. Prothrombin time and activated partial thromboplastin time were estimated in all groups. Statistical analysis was done by unpaired Student's ? t' test and Pearson's Correlation Coefficient test. In this study, the mean (*SD) PT levels in group B1 & B2 were shortened than that of group A which were statistically highly significant (P < 0.001). Within the study groups, PT levels were positively correlated (r=+0.027) with the group B1 and negatively correlated (r= -0.163) with the group B2. But both the relationships were statistically non significant. The mean (+SD) AM' level in group B1 was shortened than that of group A but the result was not statistically significant. The mean (*SD) AM' level in group B2 was shortened than that of group A but the result was statistically highly significant (P<0.001). Within the study groups, APPT levels were negatively correlated with the group B1 (r= -0.268) and also group B2 (r= -0.122). But both the relationships were statistically non significant. My present study revealed that prolonged duration of OCP use ( at least for 5 years) increases the risk of hypercoagulable state and thromboembolism in women.

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

2009 ◽  
Vol 28 (12) ◽  
pp. 739-745 ◽  
Author(s):  
Davood Attaran ◽  
Shahrzad M Lari ◽  
Mohammad Khajehdaluee ◽  
Hossein Ayatollahi ◽  
Mohammad Towhidi ◽  
...  
Keyword(s):  
Lung Function ◽  
Sulfur Mustard ◽  
Chronic Obstructive ◽  
Case Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
The Mean ◽  
Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

scholarly journals Associations between blood eosinophils and decline in lung function among adults with and without asthma

2018 ◽  
Vol 51 (4) ◽  
pp. 1702536 ◽  
Author(s):  
Robert J. Hancox ◽  
Ian D. Pavord ◽  
Malcolm R. Sears
Keyword(s):  
Lung Function ◽  
Vital Capacity ◽  
Airflow Obstruction ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Lung Function Decline ◽  
Characteristic Features ◽  
Predicted Values ◽  
Blood Eosinophils ◽  
Eosinophil Counts

Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but the association between them is unclear. We assessed associations between blood eosinophils and lung function decline in a population-based cohort of young adults.We used linear mixed models to analyse associations between blood eosinophils and spirometry at 21, 26, 32 and 38 years adjusting for sex, smoking, asthma and spirometry at age 18 years. We further analysed associations between mean eosinophil counts and changes in spirometry from ages 21 to 38 years.Higher eosinophils were associated with lower forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratios and lower FEV1 % predicted values for both pre- and post-bronchodilator spirometry (all p-values ≤0.048). Although eosinophil counts were higher in participants with asthma, the associations between eosinophils and spirometry were similar among participants without asthma or wheeze. Participants with mean eosinophil counts >0.4×109 cells·L−1 between 21 and 38 years had greater declines in FEV1/FVC ratios (difference 1.8%, 95% CI 0.7–2.9%; p=0.001) and FEV1 values (difference 3.4% pred, 95% CI 1.5–5.4% pred); p=0.001) than those with lower counts.Blood eosinophils are associated with airflow obstruction and enhanced decline in lung function, independently of asthma and smoking. Eosinophilia is a risk factor for airflow obstruction even in those without symptoms.

scholarly journals Impact of chronic khat (Catha edulis Forsk) chewing on pulmonary function test and oxygen saturation in humans: A comparative study

2019 ◽  
Vol 7 ◽  
pp. 205031211882461 ◽  
Author(s):  
Gashaw Garedew Woldeamanuel ◽  
Teshome Gensa Geta
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Oxygen Saturation ◽  
Vital Capacity ◽  
Forced Expiratory Volume ◽  
Mean Values ◽  
Khat Chewing ◽  
Significant Difference ◽  
The Mean

Background: Chronic consumption of khat affects many organ systems and leads to various health disturbances in the chewers. Few studies examined the acute effects of khat ingestion on lung function parameters. However, studies which assessed the long-term effects of khat chewing on pulmonary function parameters and oxygen saturation are lacking. Objective: The aim of this study was to assess the impact of chronic Khat chewing on pulmonary function parameters and oxygen saturation among chronic Khat chewers in Wolkite, Ethiopia. Methods: A community-based comparative cross-sectional study was conducted in Wolkite, Ethiopia from 1 June 2018 to 15 August 2018. A total of 324 participants, 162 khat chewers and 162 non-chewers were included in the study. The data were collected through face-to-face interview by trained data collectors. British Medical Research Council respiratory questionnaire was used to assess respiratory symptoms. A spirometer was used to assess various lung function parameters. Moreover, oxygen saturation of hemoglobin was measured using pulse oximeter. Data were entered into CSPro version 6.2 and analyzed using SPSS version 23. Results: This study showed statistically significant (p < 0.05) reduction in the mean values of forced vital capacity, forced expiratory volume in first second and maximum ventilation volume among khat chewers as compared to non-chewers. There was no significant difference in the mean values of other lung function parameters between the two groups. Similarly, there was no significant difference (p = 0.642) in mean oxygen saturation of hemoglobin (SaO2) across the two groups. Conclusion: It is evident from this study that long-term khat consumption is associated with decreased mean forced vital capacity, forced expiratory volume in first second and maximum ventilation volume. Hence, there is a need for further study to strengthen the current findings and to explore the mechanisms of khat chewing effect on lung function parameters.

Sign in / Sign up

Export Citation Format

Share Document