scholarly journals New Drugs for Acute Heart Failure

2012 ◽  
Vol 7 (1) ◽  
pp. 35-38
Author(s):  
Mohammad Salman ◽  
Syed Allahsan ◽  
Manzoor Mahmood ◽  
Md Khairul Anam ◽  
Shahed Mohammad Anwar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Acute Heart Failure ◽  
Health Problem ◽  
Standard Therapy ◽  
New Drugs ◽  
European Medicines Agency ◽  
Major Health Problem ◽  
Major Health ◽  
Long Time

Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year. Standard therapy has not changed for long time and includes diuretics and variable use of vasodilators or inotropes. Recently Nesiritide and Levosimendan are two drugs for the treatment of acute heart failure which have been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMEA), respectively. There was little concern that Nesiritide can worsen the renal failure but recent trials had abolished this concern. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10208 UHJ 2011; 7(1): 35-38

scholarly journals Diagnosis dan Tatalaksana Terkini Gagal Jantung Akut

e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Lifi Saroinsong ◽  
Edmond L. Jim ◽  
Starry H. Rampengan
Keyword(s):  
Heart Failure ◽  
Electrical Stimulation ◽  
Literature Review ◽  
Acute Heart Failure ◽  
Neuromuscular Electrical Stimulation ◽  
Rapid Onset ◽  
Major Health Problem ◽  
Major Health ◽  
Multiple Biomarkers ◽  
Review Study

Abstract: Acute heart failure (AHF) is an emergency condition with rapid onset that requires immediate treatment. Many factors play a role in the incidence of AHF thus providing various of clinical manifestation. Prevalence and mortality of AHF is still a major health problem in Asia with the highest prevalence rate. This study intended to determine the tests needed to establish a diagnosis and recent treatment needed for AHF. This was a literature review study. The results showed the development of diagnosis and management of AHF based on the class of recommendation and levels of evidence updated by ESC 2016 and ACC/AHA/HFSA 2017. Furthermore, 4 journals discussed the development of troponin as biomarkers, multiple biomarkers, miRNA, and Lung Ultrasound (LUS). The development in AHF management was using tolvaptan, serelaxin, and neuromuscular electrical stimulation (NMES). In conclusion, diagnosis through anamnesis, physical examination, and supporting AHF can be done by understanding the causes of fluid retention and decreased cardiac output of the patient, therefore, it can provide pharmacological and non-pharmacological treatment appropriately.Keywords: diagnosis, treatment, acute heart failure Abstrak: Gagal jantung akut (GJA) merupakan kondisi darurat dengan tipe serangan yang cepat sehingga membutuhkan penanganan segera. Banyak faktor yang berperan dalam kejadian GJA sehingga memberikan gambaran klinis yang beragam. Prevalensi dan mortalitas GJA di dunia terus mengalami peningkatan dan masih merupakan masalah kesehatan utama di Asia. Penelitian ini bertujuan untuk mengetahui pemeriksaan yang diperlukan untuk menegakkan diagnosis GJA dan perkembangan tatalaksana terkini GJA. Jenis penelitian ialah literature review. Hasil penelitian mendapatkan perkembangan diagnosis dan tatalaksana GJA berdasarkan kelas rekomendasi dan tingkatan bukti yang diperbaharui oleh ESC 2016 dan ACC/AHA/HFSA 2017. Selain itu, 4 jurnal membahas perkembangan penggunaan biomarker troponin, biomarker multipel, miRNA, serta USG Paru. Perkembangan tatalaksana GJA menggunakan tolvaptan, serelaksin, dan neuromuscular electrical stimulation (NMES). Simpulan penelitian ini ialah penegakan diagnosis lewat anamnesis, pemeriksaan fisik dan penunjang GJA dapat dilakukan dengan memahami penyebab retensi cairan dan penurunan curah jantung pasien sehingga dapat memberikan tatalaksana farmakologis dan non-farmakologis dengan tepat.Kata kunci: diagnosis, tatalaksana, gagal jantung akut 

Development of an Overexertion Injury Surveillance System

1985 ◽  
Vol 29 (8) ◽  
pp. 794-798
Author(s):  
Gary D. Herrin ◽  
Charles K. Anderson ◽  
Majid Jaraiedi
Keyword(s):  
Health Problem ◽  
Surveillance System ◽  
Occupational Injuries ◽  
Injury Surveillance ◽  
Injury Surveillance System ◽  
Major Health Problem ◽  
Major Health ◽  
Minor Injury ◽  
Reporting Systems ◽  
Long Time

The frequency and severity of occupational injuries have been recognized as a major health problem within many industries for a long time. Conventional injury/illness reporting systems such as OSHA, Worman's Compensation, etc., offer no guidance for the concerned professional to identify root causes of these injuries or suggest ways to minimize consequences. The study reported on injuries at the dispensary visit level which would permit incidents to be correlated with physical job stresses across five industries. This paper compares the experiences between and within plants and shows that minor injury experiences can be used to predict more severe cases.

Prevention and Treatment of Early Childhood Caries (ECC)

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Jeffrey .
Keyword(s):  
Early Childhood ◽  
Health Problem ◽  
Early Childhood Caries ◽  
Health Providers ◽  
Missing Teeth ◽  
Optimal Basis ◽  
Major Health Problem ◽  
Major Health ◽  
Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

scholarly journals An unusual precipitant of acute heart failure—ANCA-associated vasculitis in a patient with ischaemic cardiomyopathy: a case report

2020 ◽  
Author(s):  
Krishna Prasad ◽  
Pruthvi C Revaiah ◽  
Krishna Santosh Vemuri ◽  
Parag Barwad
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Acute Heart Failure ◽  
Acute Decompensated Heart Failure ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Left Ventricular ◽  
Alveolar Haemorrhage ◽  
Coronary Syndrome ◽  
Anca Associated Vasculitis ◽  
Renal Vasculitis

Abstract Background Antineutrophil cytoplasmic antibody (ANCA)-associated pulmonary renal vasculitis is an uncommon disease entity. Its presentation as acute heart failure for the first time in a patient with established coronary artery disease (CAD) is even rarer. We present here a case of such an association and an approach to managing this clinical situation. Case summary A 60-year-old male patient presented to the emergency room with recent-onset dyspnoea New York Heart Association Class IV. He was having hypertension, uncontrolled diabetes mellitus, chronic kidney disease (CKD), and CAD. He also underwent a percutaneous coronary intervention to left anterior descending in the past for acute coronary syndrome and had moderate left ventricular dysfunction. He was being managed as a case of acute decompensated heart failure (ADHF) and was mechanically ventilated. Suddenly his ventilator requirement increased and endotracheal aspirate contained blood. The chest radiograph showed bilateral hilar infiltrates. Simultaneously he also had recurrent episodes of ventricular tachycardia (VT) requiring direct current (DC) cardioversion. Blood investigations showed deranged renal function and severe hyperkalaemia, but no evidence of coagulopathy. High-resolution computed tomography chest showed features of diffuse alveolar haemorrhage. Further investigations revealed high titres of c-ANCA and raised inflammatory biomarkers. A diagnosis of ANCA-associated vasculitis presenting as acute on CKD with dyselectrolytaemia (hyperkalaemia) leading to VT was made. Apart from standard management for associated illness, he was treated with plasma exchange, steroids, and cyclophosphamide to which he responded and was later on discharged. Discussion Antineutrophil cytoplasmic antibody-related pulmonary renal vasculitis can lead to rapidly progressing renal failure and may present as ADHF in a patient with existent CAD. The associated VT storm in our patient can be attributed to hyperkalaemia secondary to acute renal failure. A multidisciplinary approach is required for the successful management of such a complex clinical scenario.

scholarly journals Acute Cholecystitis Caused by Ceftriaxone Stones in an Adult

2009 ◽  
Vol 2009 ◽  
pp. 1-2 ◽  
Author(s):  
Christian D. Becker ◽  
Robert A. Fischer
Keyword(s):  
Adult Patient ◽  
Acute Cholecystitis ◽  
Health Problem ◽  
Medical Literature ◽  
Early Recognition ◽  
Gallstone Formation ◽  
Sludge Formation ◽  
Major Health Problem ◽  
Major Health ◽  
First Case

Acute cholecystitis is a major health problem. There are multiple etiologies to be considered and early recognition of the condition is important to optimize management and outcome. We report the first case in the medical literature of symptomatic acute cholecystitis triggered by ceftriaxone-associated gallbladder sludge formation and, importantly, solid ceftriaxone gallstone formation in an adult patient with underlying mineral and pigment cholecystolithiasis, necessitating cholecystectomy. This case serves as a reminder for physicians to keep this uncommon cause of cholecystolithiasis and cholecystitis in mind in patients who receive prolonged ceftriaxone therapy. These patients should be cautioned to promptly report to their physicians any signs or symptoms of cholecystitis in order to ensure timely and appropriate evaluation.

Abstract 15507: Trajectories of Point of Care B-type Natriuretic Peptide (bnp) and Its Role as a Predictor of All-cause Mortality Among Hiv and Non-hiv Heart Failure Patients in Uganda

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Samson Okello ◽  
Fardous C Abeya
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Point Of Care ◽  
Antiplatelet Agents ◽  
Infected People ◽  
Serial Measurement ◽  
All Cause Mortality ◽  
Hiv Serostatus

Introduction: The usefulness of serial measurement of BNP to reduce hospitalization or mortality in patients with HIV and heartfailure is unknown. Hypothesis: We sought to describe changes in B-type natriuretic peptide (BNP) and estimate the effect of HIV on BNP over a week of observation in an acute heart failure cohort of 40 HIV-infected adults (≥18 years) on antiretroviral therapy (ART) and 175 HIV-uninfected hospitalized patients in Uganda. Methods: We measured BNP using i-STAT BNP (Abbott point of care, Princeton, New Jersey) and compared changes by HIV serostatus, and evaluated BNP as a predictor of all-cause mortality at 30 days from hospitalization using multilevel mixed and competitive risk regression models respectively. Results: Overall HIV-infected participants had a higher mean BNP than HIV-uninfected counterparts. After initial declines in BNP in both groups between day 0 and day 3, BNP moderately increased among the HIV-infected on day 7 and continued to decline in the HIV-uninfected group. Each 1 pg/mL increase in baseline BNP from 400 pg/mL increased the risk of all-cause mortality within 30 days by 1% (adjusted standardized hazard ratio (aSHR) 1.01, 95%CI 1.01, 1.01). Other predictors of increased 30-day all-cause mortality included smoking (aSHR 1.99, 95%CI 1.04, 3.84), hypotension (aSHR 1.69, 95%CI 1.26, 2.26) and renal failure stage 3 (aSHR 2.06, 95%CI 1.34, 3.18), and renal failure stage 5 (aSHR 2.02, 95%CI 1.30, 3.13). We found a lower risk of 30-day all-cause mortality of 38% (95%CI 20%, 73%) for those receiving loop diuretics and 74% (95%CI 56%, 99%) for antiplatelet agents. Conclusions: Over a week of observation, HIV-infected people hospitalized with acute heart failure in Uganda have higher BNP levels than HIV-uninfected counterparts. Increases in BNP above the upper bound of the normal predicted heightened risk of all-cause mortality within 30 days of hospitalization.

scholarly journals A case of abdominal tuberculosis: a challenging diagnosis

2019 ◽  
Vol 7 (6) ◽  
pp. 2497
Author(s):  
Siraveni Thirupathi ◽  
Chinnaiyan P. ◽  
Sujeetha Chandrababu
Keyword(s):  
Developing Countries ◽  
Small Bowel ◽  
Abdominal Tuberculosis ◽  
Human Race ◽  
Major Health Problem ◽  
Major Health ◽  
Extra Pulmonary Tuberculosis ◽  
It Impacts ◽  
Long Time ◽  
Extra Pulmonary

Tuberculosis continues to intimidate the human race since traditional for an extremely long time not only due to its effects as a medical ailment, but also it impacts as a social and economic burden. Tuberculosis is a major health problem in developing countries. Abdominal tuberculosis is most common extra pulmonary tuberculosis. Tuberculosis can suspect in endemic countries like India, and can have various presentations and complications, it can mislead the diagnosis. Here, this case it involves small bowel, large bowel and peritoneum with different presentation.

scholarly journals A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

2021 ◽  
Vol 11 (4) ◽  
pp. 102-105
Author(s):  
Lalita Sharma ◽  
Sudama Singh Yadav
Keyword(s):  
Fungal Infection ◽  
Health Problem ◽  
Skin Diseases ◽  
Modern Science ◽  
Treatment Modalities ◽  
Major Health Problem ◽  
Psychological Burden ◽  
Major Health ◽  
Almost All ◽  
Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

scholarly journals Prognostic value of biomarkers and co-morbidities in patients with acute heart failure: One-year follow-up study

2017 ◽  
Vol 145 (3-4) ◽  
pp. 118-123
Author(s):  
Dejan Petrovic ◽  
Marina Deljanin-Ilic ◽  
Sanja Stojanovic
Keyword(s):  
Heart Failure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Acute Heart Failure ◽  
Troponin I ◽  
Prognostic Significance ◽  
Systolic Pressure ◽  
High Sensitivity ◽  
Clinical Group ◽  
One Year

Introduction/Objective. Clinical risk stratification of patients hospitalized due to acute heart failure (AHF) applying B-type natriuretic peptide (BNP), troponin I (TnI), and high-sensitivity C-reactive protein (hsCRP) biochemical markers can contribute to early diagnosis of AHF and lower mortality rates. The aim of this study was to investigate the prognostic significance of biomarkers (BNP, TnI, and hsCRP) and co-morbidities concerning one-year mortality in patients with AHF. Methods. Clinical group comprised 124 consecutive unselected patients, age 60?80 years, treated at the Coronary Care Unit of the Niska Banja Institute, Nis. The patients were monitored for one year after the discharge. During the first 24 hours after admission, BNP, TnI, and hsCRP were measured in fasting serum. Results. Total one-year mortality was 29.8%. The levels of serum BNP were significantly higher in the group of non-survivors compared to the group of survivors (1353.8 ?} 507.8 vs. 718.4 ?} 387.6 pg/mL, p < 0.001). We identified several clinical and biochemical prognostic risk factors by univariate and multivariate analysis. Independent predictors of one-year mortality were the following: BNP, TnI, depression, hypotension, chronic renal failure, ejection fraction, and right-ventricle systolic pressure. Conclusion. The presence of BNP and TnI biomarkers and several co-morbidities such as depression or chronic renal failure have significant influence on one-year mortality in patients with AHF.

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