scholarly journals A study on platelet count and their indices as a marker of neonatal sepsis

2021 ◽  
Vol 4 (1) ◽  
pp. 72-78
Author(s):  
Dr. Hajra Tabassum
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis

scholarly journals Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

2017 ◽  
Vol 4 (8) ◽  
pp. 511-518
Author(s):  
Dr. Dilipkumar Choudhary ◽  
◽  
Dr. Ajay Kumar Tiwari ◽  
Dr.Subhash Narang ◽  
Dr. Jatin Chhabra ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Prognostic Indicator ◽  
Platelet Indices

A Study of Platelet Count and Platelet Indices in Neonatal Sepsis

2017 ◽  
Vol 6 (3 (part-1)) ◽  
pp. 523-526
Author(s):  
Majumder Ankur ◽  
◽  
P Shashikala ◽  
Nandyal Sonam S. ◽  
Gowda Kavita U. ◽  
...  
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Platelet Indices

scholarly journals PILOT VALIDATION OF EARLY PREDICTORS FOR NEONATAL SEPSIS

2019 ◽  
Vol 8 (4) ◽  
pp. 58-65 ◽  
Author(s):  
R. Kh. Gizatullin ◽  
P. I. Mironov ◽  
A. U. Lekmanov
Keyword(s):  
Platelet Count ◽  
Body Mass ◽  
Neutrophil Count ◽  
Total Protein ◽  
Neonatal Sepsis ◽  
Information Value ◽  
Total Protein Content ◽  
Discrimination Power ◽  
Early Predictors ◽  
Laboratory Variables

Purpose: pilot development of the system estimating the risk for sepsis in newborns and determining its discrimination power.Methods. Design: a retrospective observational single-center study. 124 newborns with sepsis are included; 34 of them died. Kullback’s measure was used to estimate the information value of the examined clinical and laboratory variables. Disease outcome (whether survived or dead) was the response function. The discrimination power was determined using ROC-analysis.Results. The information value of the examined clinical and laboratory variables in the newborns was analyzed as related to the risk for sepsis. Early neonatal sepsis predictors include platelet count, total protein content, body mass and neutrophil count. Discrimination power of the mentioned predictors was calculated.Result. Determination of the risk for sepsis in a newborn based on the estimation of platelet count, neutrophil count, total protein and body mass is of moderate value.

scholarly journals Evaluation of platelet and its indices as a marker of neonatal sepsis: a prospective case control study

2018 ◽  
Vol 5 (5) ◽  
pp. 1898 ◽  
Author(s):  
Ratana Ram Choudhary ◽  
Mohan Makwana ◽  
Harish Kumar Mourya ◽  
Jagdish Dabi ◽  
Kartika Gulati
Keyword(s):  
Platelet Count ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Neonatal Morbidity ◽  
Signs And Symptoms ◽  
Control Group ◽  
Case Group ◽  
Platelet Indices ◽  
Sepsis Screen ◽  
Sepsis Screening

Background: Neonatal sepsis is major cause of neonatal morbidity and mortality worldwide. Blood culture and sepsis screening are currently used method, but their utility is limited due to delayed reporting and increased cost. Platelet indices are one such set of parameters which can be helpful in the future diagnosis of neonatal sepsis. This study was aimed to evaluate the significance of platelet indices either alone or in combination with existing sepsis screen as a marker of neonatal sepsis.Methods: Neonates admitted in the neonatal unit of Hospital and showing signs and symptoms of sepsis, and/or born to mothers with risk factor for sepsis were included in this study. Investigations sent for all these neonates included blood culture, sepsis screen (CRP, micro ESR, TLC, ANC, IT ratio) and platelet indices (Platelet count, MPV, PDW).Results: In present study, 81.12% neonates in case group had platelet count less than 1.5lacs/mm3 while in control group 20.91% neonates only had the same. This difference was statistically significant, (p<0.0001). Similarly, 70.91% neonates in case group had MPV more than >10.8 fl whereas in control group only 26.53% neonates had the same, with difference was statistically significant, (p<0.0001) Similarly, 65.81% neonates in case group and 34.69% in control group had PDW more than 19.1fl and this difference was statistically significant, (p=0.0001).Conclusions: High PDW, high MPV and low platelet count are more associated with neonatal sepsis. So, platelet and its indices may be used as a sensitive marker to identify septic babies and it may be combined with existing sepsis screen to specifically exclude non-septic case.

scholarly journals Organism Specific Response of Platelet Count in Neonatal Sepsis

2014 ◽  
Vol 4 (2) ◽  
pp. 79-83
Author(s):  
Biplob Kumar Raha ◽  
Md Abdul Baki ◽  
Tahmina Begum ◽  
Nazmun Nahar
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Specific Response ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Prolonged Duration ◽  
Fungal Sepsis ◽  
Culture Positive

Background: Neonatal sepsis is one of the major causes of neonatal morbidity and mortality, particularly in developing countries and it is caused by Gram positive bacteria, Gram negative bacteria and fungi. Thrombocytopenia has been used as an early but nonspecific marker for sepsis. About 75% of culture positive neonates have thrombocytopenia. The severity and duration of thrombocytopenia varies in different types of organism. So, the objectives of this study were to examine platelet counts and platelet indices in neonates with culture proven sepsis and to determine if there was an organism specific platelet response.Methods: This cross- sectional prospective study was carried out in the special care baby unit (SCABU) under department of Paediatrics and Neonatology, BIRDEM General Hospital, Dhaka from November 2008 to September 2009.Results: Total 120 newborn babies with culture positive sepsis were included in this study. Gram positive bacteria was found in 06 (5%), Gram negative bacteria was found in 58(48.3%) and fungi was found in 56 (46.7%) neonates. Thrombocytopenia was found in 95% of culture positive neonates. When compared with neonates with Gram positive sepsis, those with Gram-negative or fungal sepsis had a significantly lower platelet count, platelet nadir and prolonged duration of thrombocytopenia (p=<0.05). Fungal sepsis was also associated with prolonged duration of thrombocytopenia when compared with that of Gram negative sepsis (p=0.03).Conclusion: Neonatal sepsis is frequently associated with thrombocytopenia. However, Gram negative and fungal sepsis is associated with a lower platelet count, platelet nadir and prolonged duration of thrombocytopenia compared with that of Gram positive sepsis.Birdem Med J 2014; 4(2): 79-83

scholarly journals Hematological scoring system as an early diagnostic tool for neonatal sepsis

2016 ◽  
Vol 55 (6) ◽  
pp. 315
Author(s):  
Fathia Meirina ◽  
Bidasari Lubis ◽  
Tiangsa Sembiring ◽  
Nelly Rosdiana ◽  
Olga Siregar
Keyword(s):  
Platelet Count ◽  
Blood Culture ◽  
Diagnostic Tool ◽  
Neonatal Sepsis ◽  
Scoring System ◽  
Leucocyte Count ◽  
Degenerative Changes ◽  
Total Leucocyte Count ◽  
Diagnostic Study ◽  
Early Diagnostic

Background Sepsis was the leading cause of death in babies by30%-50% in developing countries. Early diagnosis of neonatalsepsis is still a difficult problem because of clinical features are notspecific. Blood culture is the gold standard, but it takes several daysand is expensive. The hematological scoring system (HSS) consistsof hematologic parameters (leucocyte count, polymorphonuclear(PMN) cells, degenerative changes, and platelet count) for earlydiagnosis of neonatal sepsis.Objective To measure HSS as an early diagnostic tool for neonatalsepsis.Methods A cross sectional study was conducted in March toJune 2013. Samples were collected by consecutive sampling.Fourty neonates suspected sepsis in neonatology unit H. AdamMalik Hospital, Medan, North Sumatera, underwent routineblood count, blood culture, and peripheral blood smear. Eachhematologic parameters were analysed using the HSS of Rodwellet al. The hematologic parameters were total leucocyte count, totalPMN cells, total PMN immature, I:T PMN ratio, I:M PMN ratio,degenerative changes, and platelet count. The total value revealedHSS score. Diagnostic study parameters were calculated.Results Ten of fourty neonates had sepsis based on blood culture􀁕􀁈􀁖􀁘􀁏􀁗􀁖􀀑􀀃􀀷􀁋􀁈􀀃􀀫􀀶􀀶􀀃􀁖􀁆􀁒􀁕􀁈􀀃􀂕􀀗􀀃􀁋􀁄􀁇􀀃􀁖􀁈􀁑􀁖􀁌􀁗􀁌􀁙􀁌􀁗􀁜􀀃􀀛􀀓􀀈􀀏􀀃􀁖􀁓􀁈􀁆􀁌􀁉􀁌􀁆􀁌􀁗􀁜􀀃􀀜􀀓􀀈􀀏􀀃with positive predictive value (PPV) 73%, negative predictivevalue (NPV) 93%, ROC curve showed cut off point 0.902 (95%CI 0.803 to 1.0).Conclusion 􀀶􀁆􀁒􀁕􀁈􀀃􀀫􀀶􀀶􀀃􀂕􀀗􀀃􀁆􀁒􀁘􀁏􀁇􀀃􀁅􀁈􀀃􀁘􀁖􀁈􀁇􀀃􀁄􀁖􀀃􀁄􀁑􀀃􀁈􀁄􀁕􀁏􀁜􀀃􀁇􀁌􀁄􀁊􀁑􀁒􀁖􀁗􀁌􀁆􀀃tool for neonatal sepsis.

scholarly journals Frequency of thrombocytopenia and its association with mortality among neonates having probable or culture proven sepsis.

2020 ◽  
Vol 27 (12) ◽  
pp. 2739-2743
Author(s):  
Shakeel Ahmad ◽  
Nusrat Hussain ◽  
Tayyaba Rafique ◽  
Rabia Saleem
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Final Analysis ◽  
P Value ◽  
Test Results ◽  
Chi Square ◽  
Platelet Counts ◽  
Chi Square Test ◽  
Medical University ◽  
Study Setting

Objectives: To determine frequency of thrombocytopenia and its association with mortality among neonates having probable or culture proven sepsis. Study Design: Descriptive Analytical study. Setting: Multicentre study done at Neonatology Unit of Teaching Hospital Dera Ghazi Khan and Nishtar Medical University, Multan. Period: February 2019 to July 2019. Material & Methods: Three hundred neonates with culture proven sepsis were enrolled. Platelet counts along with frequency of thrombocytopenia (<150000/mm3) and mortality among all the neonates were recorded. Mortality among different groups according to platelet counts was compared adopting chi-square test. Results: Out of 300 neonates considered in the final analysis, 164 (54.7%) were male. Overall, median platelet count was 213.0mm3. TCP was present in 78 (26.0%) cases. Among 146 culture proven sepsis cases, 88 (61.8%) had gram positive while 58 (38.2%) had gram negative pathogens. Cases having thrombocytopenia had significantly higher mortality (n=26/78, 33.3%) as compared with those who had normal or increased platelet count (n=25/222, 11.3%) representing a significant p value (<0.00001). Conclusion: Thrombocytopenia is a common complication of culture proven and probable neonatal sepsis. Mortality is significantly high in neonatal sepsis along with thrombocytopenia.

scholarly journals Thrombocytopenia and thrombocytosis as a predictor of neonatal sepsis: a hospital-based cross-sectional study

2021 ◽  
Author(s):  
N. Shivaramakrishna Babji ◽  
Ajay Jayasheel ◽  
Nagapraveen Veerapu
Keyword(s):  
Platelet Count ◽  
Neonatal Sepsis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Gram Positive ◽  
Cross Sectional ◽  
Gram Negative ◽  
Early Marker ◽  
Significant Difference ◽  
Culture Positive

Background: Hematological changes in sepsis can aid in the early diagnosis of sepsis even before the culture reports are obtained. Of the various hematological parameters, the platelet count can be an early marker for sepsis. This study was carried out to evaluate the role of thrombocytopenia and thrombocytosis as a marker of sepsis in neonates.Methods: A cross-sectional study was carried out at neonatal intensive care unit (NICU) at a tertiary care center from1st January 2014 to 30th September 2014. During this period,623 neonates had features suggestive of sepsis, of which 190 turned to be having culture-positive sepsis. One hundred and ninety neonates aged between 0 to 28 days of life admitted in NICU with culture-positive sepsis were included in the study. The newborns were categorized based on platelet count and type of organism cultured. Chi square test was used to test statistical significance. P<0.05 was considered statistically significant.Results: Among 190 participants, 50% had gram-positive organisms in culture, 37.9% had gram-negative sepsis, and 12.1% had fungal sepsis. The prevalence of thrombocytopenia among the participants was 39.47%. There was a statistically significant difference across the type of organism in sepsis (p<0.05). The difference in outcome across the platelet count status was insignificant, with a p=0.391. Conclusions: The most common organism causing neonatal sepsis was gram-positive organisms, followed by gram-negative organisms and fungus. Thrombocytopenia was present in all forms of neonatal sepsis irrespective of the causation. Hence, thrombocytopenia can be considered as an early marker of neonatal sepsis.

scholarly journals Modified hematological sepsis score: an easy and cost effective measure to combat neonatal septicemia

2020 ◽  
Vol 8 (2) ◽  
pp. 517
Author(s):  
Pearl Mary Varughese
Keyword(s):  
Platelet Count ◽  
Blood Culture ◽  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Heart Diseases ◽  
Cost Effective ◽  
Individual Performance ◽  
Blood Parameters ◽  
Simple Method ◽  
Effective Measure

Background: Early diagnosis of neonatal sepsis continues to be a problem because of subtle and non-specific clinical features. Blood culture is the gold standard, but it takes several days and is expensive. The hematological scoring system (HSS) consisting of different blood parameters could be an effective and simple method to help diagnose and treat neonatal sepsis. Aim of the present study was undertaken to highlight the importance of HSS in the early diagnosis and evaluation of neonatal septicaemia.Methods: This was a prospective study done in a peripheral hospital in Kerala. The inclusion criteria involved all inborn babies above 34weeks gestation. Exclusion criteria involved babies with congenital anomalies, congenital heart diseases, pathological jaundice, birth weight less than 2kg and babies requiring NICU admission, 550 babies were included in the study. Cord CRP and 48 hours CRP was taken. At 48 hours, blood samples were also taken for Total count (TC), Absolute Neutrophil Count (ANC), Platelet count, and peripheral smear. Blood culture was taken for babies suspected to have sepsis and started on antibiotics. The screening parameters were assessed for individual performance and in combination.Results: Individually, though parameters like TC, ANC, 48 hrs CRP and platelet count had excellent sensitivity (100%) and NPV (100%), their specificity was low 65%-82%. Degenerative changes showed sensitivity 94.1%, specificity 91% and NPV 99.8%. HSS score >5 and >6 had better specificity and NPV.Conclusions: HSS scoring can be used to safely exclude neonatal sepsis, thus avoiding unnecessary antibiotic exposure in newborns and undue worry for parents.

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