scholarly journals Endocrine Risk Factors for COVID-19 in Context of Aging

2021 ◽  
pp. S153-S159
Author(s):  
L MÁČOVÁ ◽  
M BIČÍKOVÁ ◽  
R HAMPL
Keyword(s):  
Risk Factors ◽  
Metabolic Diseases ◽  
Innate And Adaptive Immunity ◽  
Aged People ◽  
Autoimmune Processes ◽  
Intimate Link ◽  
The Common ◽  
Susceptible Group ◽  
Is Failure

Aged people are the most susceptible group to COVID-19 infection. Immunosenescence characterized by impairment of immune function with inflamm-aging contributes to pathophysiological alterations, among which endocrine and metabolic diseases are not exception. Diabetes, obesity along with impairment of disorders of thyroid functions are the most frequent ones, the common feature of which is failure of immune system including autoimmune processes. In the minireview we discussed how COVID-19 and aging impact innate and adaptive immunity, diabetes and selected neuroendocrine processes. Mentioned is also beneficial effect of vitamin D for attenuation of these diseases and related epigenetic issues. Particular attention is devoted to the role of ACE2 protein in the light of its intimate link with renin-angiotensin regulating system.

scholarly journals Erectile dysfunction – overview from a cardiovascular perspective

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 347-353 ◽  
Author(s):  
Frederic Baumann ◽  
Deborah Hehli ◽  
Vladimir Makaloski ◽  
Martin Schumacher ◽  
Heinz Schönhofen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Erectile Dysfunction ◽  
Cardiovascular Risk ◽  
Endovascular Therapy ◽  
Minimal Invasive ◽  
Male Population ◽  
Ageing Male ◽  
The Common ◽  
Diagnostics And Therapy

Abstract. Erectile dysfunction (ED) is an evolving health problem with growing incidence in the ageing male population with potentially predictive value for cardiovascular and other chronic diseases. ED shares the common cardiovascular risk factors. The aetiology of ED is numerous including neurogenic, psychogenic, arteriogenic, and venogenic reasons. The origin of arteriogenic ED is frequently atherosclerosis. Patients not adequately responding to conservative measures including oral medication are often referred to further vascular diagnostics and therapy. At present, the refinements in endovascular therapy allow for minimal-invasive revascularization of erection-related arteries. The role of endovascular therapy in the complex framework of the multifactorial causes of ED requires further scientific scrutiny.

Steatohepatitic Hepatocellular Carcinoma, a Morphologic Indicator of Associated Metabolic Risk Factors: A Study From India

2013 ◽  
Vol 137 (7) ◽  
pp. 961-966 ◽  
Author(s):  
Deepali Jain ◽  
Nabeen C. Nayak ◽  
Vinay Kumaran ◽  
Sanjiv Saigal
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Metabolic Diseases ◽  
Liver Parenchyma ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Nonalcoholic Fatty Liver ◽  
Persistent Viral Infection ◽  
Common Risk Factors ◽  
The Common

Context.—The common risk factors for hepatocellular carcinoma (HCC) include persistent viral infection with either hepatitis B or C virus, alcohol abuse, hemochromatosis, and metabolic syndrome. Steatohepatitic (SH) HCC has been recently recognized as a special morphologic variant of HCC associated with metabolic risk factors. Objective.—To assess the SH pattern in HCC cases of various etiologies in Indian patients and to further correlate this morphology with the presence of metabolic risk factors. Design.—A total of 101 cases of HCC with various etiologies in explanted livers from adults were included in the study. Morphologic examination was performed to identify SH lesions within the tumor and in the nontumorous liver parenchyma. Correlation of nontumor and tumor SH morphology with clinically identifiable metabolic risk factors and with non-SH type of HCC was performed. Results.—The SH variant of HCC was identified in 19 livers (18.8%). Most SH-HCC cases were associated with metabolic risk factors such as obesity, diabetes, hypertension, and hyperlipidemias. Comparison of SH-HCC with non–SH-HCC was statistically significant in terms of presence of metabolic risk factors. Conclusions.—Steatohepatitic morphology in HCC is frequent in nonalcoholic fatty liver disease–associated cirrhosis (P = .009) and is significantly associated with metabolic risk factors (P = .03). By recognizing SH pattern, one may predict associated metabolic diseases and determine the prognosis both in pretransplant and posttransplant patients.

scholarly journals Az idült májbetegségek progressziójához vezető folyamatok

2016 ◽  
Vol 157 (8) ◽  
pp. 290-297 ◽  
Author(s):  
Anna Egresi ◽  
Gabriella Lengyel ◽  
Anikó Somogyi ◽  
Anna Blázovics ◽  
Krisztina Hagymási
Keyword(s):  
Disease Progression ◽  
Metabolic Diseases ◽  
Treatment Options ◽  
Liver Steatosis ◽  
Intestinal Flora ◽  
Underlying Disease ◽  
Number Of Factors ◽  
Toxic Agents ◽  
Autoimmune Processes

As the result of various effects (viruses, metabolic diseases, nutritional factors, toxic agents, autoimmune processes) abnormal liver function, liver steatosis and connective tissue remodeling may develop. Progression of this process is complex including various pathways and a number of factors. The authors summarize the factors involved in the progression of chronic liver disease. They describe the role of cells and the produced inflammatory mediators and cytokines, as well as the relationship between the disease and the intestinal flora. They emphasize the role of oxidative stress, mitochondrial dysfunction and cell death in disease progression. Insulin resistance and micro-elements (iron, copper) in relation to liver damage are also discussed, and genetic and epigenetic aspects underlying disease progression are summarized. Discovery of novel treatment options, assessment of the effectiveness of treatment, as well as the success and proper timing of liver transplantation may depend on a better understanding of the process of disease progression. Orv. Hetil., 2016, 157(8), 290–297.

scholarly journals The Important Role of the Radiologist in Determining the Indications for the Surgical Treatment of Neuroblastoma with Vascular Image-Defined Risk Factors: A Case Report

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 279
Author(s):  
Patrycja Sosnowska-Sienkiewicz ◽  
Przemysław Mańkowski ◽  
Anna Wojas ◽  
Katarzyna Jończyk-Potoczna ◽  
Danuta Januszkiewicz-Lewandowska
Keyword(s):  
Risk Factors ◽  
Risk Group ◽  
Tumor Resection ◽  
Celiac Trunk ◽  
Staging System ◽  
Preoperative Imaging ◽  
Tumor Removal ◽  
Neuroblastoma Tumor ◽  
The Common

The International Neuroblastoma Risk Group Staging System (INRGSS) is based on the age of patients and preoperative imaging, with attention paid to whether the primary tumor is affected by one or more of specific image-defined risk factors (IDRFs). This publication presents a 2.5-year-old boy with neuroblastoma who had an accidental ligation of the celiac trunk during tumor resection. The consequences of this complication were pancreatic and spleen ischemia and necrosis, ischemia, and perforation of the common bile duct, gallbladder, stomach, and duodenum. The aim of this publication was to highlight the great role of the radiologist in determining the indications for neuroblastoma tumor removal, especially with current vascular IDRFs, and to show how the radiologist’s insightful approach can save the patient from irreversible complications.

scholarly journals Visfatin Connection: Present and Future in Osteoarthritis and Osteoporosis

2019 ◽  
Vol 8 (8) ◽  
pp. 1178 ◽  
Author(s):  
Eloi Franco-Trepat ◽  
María Guillán-Fresco ◽  
Ana Alonso-Pérez ◽  
Alberto Jorge-Mora ◽  
Vera Francisco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Developed Countries ◽  
Toll Like Receptor 4 ◽  
Permanent Disability ◽  
Potential Biomarker ◽  
Pathologic Features ◽  
The Common ◽  
Shared Risk ◽  
Similar Risk

Musculoskeletal pathologies (MSPs) such as osteoarthritis (OA) and osteoporosis (OP), are a set of disorders that cause severe pain, motion difficulties, and even permanent disability. In developed countries, the current incidence of MSPs reaches about one in four adults and keeps escalating as a consequence of aging and sedentarism. Interestingly, OA and OP have been closely related to similar risk factors, including aging, metabolic alterations, and inflammation. Visfatin, an adipokine with an inflammatory and catabolic profile, has been associated with several OA and OP metabolic risk factors, such as obesity, insulin resistance, and type II diabetes. Furthermore, visfatin has been associated with the innate immune receptor toll-like receptor 4 (TLR4), which plays a key role in cartilage and bone inflammatory and catabolic responses. Moreover, visfatin has been related to several OA and OP pathologic features. The aim of this work is to bring together basic and clinical data regarding the common role of visfatin in these pathologies and their major shared risk factors. Finally, we discuss the pitfalls of visfatin as a potential biomarker and therapeutic target in both pathologies.

Modifiable Risk Factors for Dementia: The Role of Gut Microbiota

2021 ◽  
Vol 18 ◽  
Author(s):  
Cristian Cabrera ◽  
Paloma Vicens ◽  
Margarita Torrente
Keyword(s):  
Risk Factors ◽  
Gut Microbiota ◽  
Physical Inactivity ◽  
Metabolic Diseases ◽  
Clinical Implications ◽  
Low Grade ◽  
Modifiable Risk Factors ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

: Dementia is a syndrome resulting from chronic or progressive brain disease. Around 40% of worldwide dementia can be prevented or delayed by modifying 12 risk factors: low educational attainment in early life, mid-life hypertension, mid-life obesity, hearing loss, traumatic brain injury, excessive alcohol consumption, smoking, depression, physical inactivity, social isolation, diabetes mellitus, and air pollution. There is growing evidence that gastrointestinal tract microbiota may significantly contribute to dementia pathogenesis. In particular, gut dysbiosis can trigger metabolic diseases and the progression of low-grade systemic inflammation, being involved in much of the major modifiable risk factors. In this review, we focus on studies that have evaluated the association between modifiable risk factors for dementia and the role of gut microbiota. We also suggest clinical implications for researchers in dementia-gut microbiota related fields.

scholarly journals Heart, lipids and hormones

2017 ◽  
Vol 6 (4) ◽  
pp. R59-R69 ◽  
Author(s):  
Peter Wolf ◽  
Yvonne Winhofer ◽  
Martin Krššák ◽  
Michael Krebs
Keyword(s):  
Risk Factors ◽  
Metabolic Diseases ◽  
Heart Function ◽  
Cardiac Performance ◽  
Lipid Deposition ◽  
Hormonal Changes ◽  
Endocrine Diseases ◽  
Fat Depots ◽  
And Function

Cardiovascular disease is the leading cause of death in general population. Besides well-known risk factors such as hypertension, impaired glucose tolerance and dyslipidemia, growing evidence suggests that hormonal changes in various endocrine diseases also impact the cardiac morphology and function. Recent studies highlight the importance of ectopic intracellular myocardial and pericardial lipid deposition, since even slight changes of these fat depots are associated with alterations in cardiac performance. In this review, we overview the effects of hormones, including insulin, thyroid hormones, growth hormone and cortisol, on heart function, focusing on their impact on myocardial lipid metabolism, cardiac substrate utilization and ectopic lipid deposition, in order to highlight the important role of even subtle hormonal changes for heart function in various endocrine and metabolic diseases.

Role of acquired and hereditary thrombotic risk factors in patients with ischemic colitis

2001 ◽  
Vol 120 (5) ◽  
pp. A282-A282
Author(s):  
I KOUTROUBAKIS ◽  
A SFIRIDAKI ◽  
A THEODOROPOULOU ◽  
A LIVADIOTAKI ◽  
P DIMOULIOS ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Colitis ◽  
Thrombotic Risk

Psychological Resilience Provides No Independent Protection From Suicidal Risk

Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Danica W. Y. Liu ◽  
A. Kate Fairweather-Schmidt ◽  
Richard Burns ◽  
Rachel M. Roberts ◽  
Kaarin J. Anstey
Keyword(s):  
Risk Factors ◽  
Well Being ◽  
Current Status ◽  
Psychological Resilience ◽  
Cross Sectional ◽  
Life Project ◽  
Resilience Factors ◽  
First Time

Abstract. Background: Little is known about the role of resilience in the likelihood of suicidal ideation (SI) over time. Aims: We examined the association between resilience and SI in a young-adult cohort over 4 years. Our objectives were to determine whether resilience was associated with SI at follow-up or, conversely, whether SI was associated with lowered resilience at follow-up. Method: Participants were selected from the Personality and Total Health (PATH) Through Life Project from Canberra and Queanbeyan, Australia, aged 28–32 years at the first time point and 32–36 at the second. Multinomial, linear, and binary regression analyses explored the association between resilience and SI over two time points. Models were adjusted for suicidality risk factors. Results: While unadjusted analyses identified associations between resilience and SI, these effects were fully explained by the inclusion of other suicidality risk factors. Conclusion: Despite strong cross-sectional associations, resilience and SI appear to be unrelated in a longitudinal context, once risk/resilience factors are controlled for. As independent indicators of psychological well-being, suicidality and resilience are essential if current status is to be captured. However, the addition of other factors (e.g., support, mastery) makes this association tenuous. Consequently, resilience per se may not be protective of SI.

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