scholarly journals Pharmacological Correction of Long-Term Effects of Acute Severe Poisoning with Sodium Thiopental under Chronic Light Desynchronosis

Biomeditsina ◽  
2021 ◽  
Vol 17 (3) ◽  
pp. 23-28
Author(s):  
E. G. Batotsyrenova ◽  
V. A. Kashuro ◽  
A. V. Sharabanov
Keyword(s):  
Factor Analysis ◽  
Pituitary Gland ◽  
Rangifer Tarandus ◽  
The Body ◽  
Long Term Effects ◽  
Glutathione S Transferase ◽  
Diene Conjugates ◽  
Sodium Thiopental ◽  
Glucose 6 Phosphate Dehydrogenase

We experimentally studied the possibility of using a peptide extract from the pituitary gland of a reindeer (Rangifer tarandus) to correct the functional state of the body under the combined effect of acute severe poisoning with sodium thiopental in rats, at a dose of LD50 under long-term light desynchronosis. The research was conducted using the statistical method of two-factor analysis of variance. It was found that, under constant light, a peptide extract from the pituitary gland of a reindeer affects such parameters as diene conjugates concentration, the activity of glutathione-S-transferase and glucose-6-phosphate dehydrogenase. Under prolonged darkness, the extract under study affected the activity of glutathione-S-transferase, glutathione peroxidase and glucose-6-phosphate dehydrogenase.

scholarly journals Human Body Burden of Heavy Metals and Health Consequences of Pb Exposure in Guiyu, an E-Waste Recycling Town in China

2021 ◽  
Vol 18 (23) ◽  
pp. 12428
Author(s):  
Wenlong Huang ◽  
Xiaoling Shi ◽  
Kusheng Wu
Keyword(s):  
Heavy Metals ◽  
Body Burden ◽  
Local Environment ◽  
Waste Recycling ◽  
The Body ◽  
Health Consequences ◽  
Long Term Effects ◽  
Adaptive Immune ◽  
Pb Exposure

Guiyu accommodates millions of tons of e-waste from overseas and domestic sources each year and is notorious for its e-waste dismantling industry. As a consequence, Guiyu has been described as “the world’s most toxic place” and “junk town”. Informal e-waste recycling activities have caused severe pollution to the local environment and are associated with extensive health problems to the residents. This review provides updated insights on the body burden of heavy metals derived from e-waste and health outcomes resulted from lead (Pb) exposure. The review identified that Guiyu has been highly contaminated by heavy metals, especially Pb. Excessive exposure to Pb has been associated with multi-system and long-term effects in neonates and children, covering nervous, cardiovascular, adaptive immune, and hematologic systems as well as chromosome and DNA damage. Our review indicates strong associations that emphasize the need to develop strong regulations for prevention of exposure and health consequences in Guiyu and similar sites around the world.

Environments, Past and Present

2020 ◽  
Author(s):  
Angela Duckworth ◽  
Keyword(s):  
Allostatic Load ◽  
Acute Stress ◽  
The Body ◽  
Physiological Changes ◽  
Long Term Effects ◽  
Flight Response ◽  
Fight Or Flight Response ◽  
The Brain ◽  
Fight Or Flight

For more than a century, scientists have known that acute stress activates the fight-or-flight response. When your life is on the line, your body reacts instantly: your heart races, your breath quickens, and a cascade of hormones sets off physiological changes that collectively improve your odds of survival. More recently, scientists have come to understand that the fight-or-flight response takes a toll on the brain and the body—particularly when stress is chronic rather than acute. Systems designed to handle transient threats also react to stress that occurs again and again, for weeks, months, or years. It turns out that poverty, abuse, and other forms of adversity repeatedly activate the fight-or-flight response, leading to long-term effects on the immune system and brain, which in turn increase the risk for an array of illnesses, including asthma, diabetes, arthritis, depression, and cardiovascular disease. Pioneering neuroscientist Bruce McEwen called this burden of chronic stress “allostatic load.”

Who We Are: The Foundational Forces

2021 ◽  
pp. 65-80
Author(s):  
Sandro Galea
Keyword(s):  
Social Stigma ◽  
The United States ◽  
The Body ◽  
Long Term Effects ◽  
Obesity Epidemic ◽  
Race Politics ◽  
The Social ◽  
To Come ◽  
The Many

This chapter examines the foundational forces that shape health. Even without a pandemic, the United States is faced with public health threats that are shaped by foundational forces. From the political and economic roots of the obesity epidemic, to the social stigma that informs the opioid crisis, to the many structural drivers of climate change, the social, economic, political, and demographic foundations of health are central to the challenges that must be addressed, nationally and globally, in the years to come. Engaging with these forces helped inform the response to COVID-19; they can help in addressing these other challenges as well. And just as a virus can have long-term effects on the body, the pandemic reshaped the societal foundations, with lasting implications for the economy, culture, attitudes towards core issues like race, politics, and more. Whether the experience of the pandemic leads to significant long-term benefits will depend on whether Americans retain the hard lessons of that moment and apply them to foundational forces.

Causes and Consequences of Broad-Scale Changes in the Distribution of Migratory Caribou (Rangifer tarandus) of Southern Hudson Bay

ARCTIC ◽  
2015 ◽  
Vol 68 (4) ◽  
pp. 472 ◽  
Author(s):  
Erica J. Newton ◽  
Kenneth F. Abraham ◽  
James A. Schaefer ◽  
Bruce A. Pond ◽  
Glen S. Brown ◽  
...  
Keyword(s):  
Body Size ◽  
Anthropogenic Disturbance ◽  
Rangifer Tarandus ◽  
The Body ◽  
Dietary Quality ◽  
Hudson Bay ◽  
Substantial Change ◽  
Term Data ◽  
Broad Scale

Understanding the factors driving changes in species distributions is fundamental to conservation, but for wide-ranging species this is often complicated by the need for broad-scale observations across space and time. In the last three decades, the location of summer concentrations of migratory caribou (Rangifer tarandus) in southern Hudson Bay (SHB), Canada, has shifted south and east as much as 500 km. We used long-term data (1987 – 2011) to test two hypotheses that could explain the distribution shift: forage depletion and anthropogenic disturbance. Over time and space, we compared the body size of live-captured adult female caribou, dietary quality from fecal nitrogen in July, the location of VHF- and GPS-collared female caribou in July, distribution of all-terrain vehicle (ATV) tracks and caribou tracks in August, and the proximity of collared caribou to sections of the coast with higher ATV activity in spring and summer. The forage depletion hypothesis was supported by greater body size and dietary quality in caribou of the eastern portion of SHB than in western SHB animals in 2009 – 11. The anthropogenic disturbance hypothesis was supported by the negative correlation of the distributions of ATV tracks and caribou tracks on the coast in 2010 and the fact that caribou avoided areas with ATV activity by 10 – 14 km. In 1987, collared caribou were observed largely along the coast in western SHB in mid-July, while in 2009 – 11, they were inland in western SHB and along the coast in eastern SHB. While these locations demonstrate a substantial change in summer distri­bution over three decades, we were unable to differentiate between forage depletion and anthropogenic disturbance as a single causal factor of the distribution shift.

scholarly journals Penyuluhan dan Deteksi Dini Anemia menuju Generasi Berkualitas pada Mahasiswa Kebidanan

2020 ◽  
Vol 1 (1) ◽  
pp. 72-84
Author(s):  
Marlynda Happy Nurmalita Sari ◽  
Dina Dewi Anggraini
Keyword(s):  
Early Detection ◽  
Adolescent Girls ◽  
Perinatal Death ◽  
Work Productivity ◽  
Signs And Symptoms ◽  
The Body ◽  
Long Term Effects ◽  
Adolescent Learning ◽  
Diploma Program

Background: The prevalence of anemia in adolescent girls in Indonesia is still high at 57.1%. As a result of anemia is adolescent learning achievement can decrease, work productivity decreases and body immunity decreases so that the body is easily infected. Long-term effects of anemia in adolescent girls can occur complications of pregnancy and even the risk of maternal and perinatal death. Purpose of this studi is provide counseling and early detection of anemia to Midwifery students as an effort to make them aware in preventing and overcoming anemia. Methods: The target of this activity is 132 students of the Blora Midwifery Diploma Program. This activity is carried out by providing information or knowledge in the form of counseling to students about anemia and followed by history and physical examination. Only students who showed signs and symptoms of anemia who were tested for HB levels were 30 students. Results: Early detection of 30 students there were 53.3% who were not anemic and 46.7% were anemic. Most of the students' menstruation period is 6-7 days which is 73.3%. While the results of counseling some students already understand about anemia. Conclusion: Of the 132 students only 30 showed signs and symptoms of anemia. Hb examination results are almost the same between respondents who are anemic and not anemic. It is hoped that the results of community service activities can be used as an illustration of the incidence of anemia in Midwifery students so that efforts can be made to prevent and manage anemia. Provide motivation and awareness to students to consume nutritious and iron-containing foods or to consume extra blood tablets.

scholarly journals HIGH-POWERED POLICE MOTORCYCLE: MUSCLE DISCOMFORT AMONG MALAYSIAN TRAFFIC POLICE RIDERS

2020 ◽  
Vol 20 (Special1) ◽  
pp. 255-259
Author(s):  
Nur Athirah D ◽  
Karmegam K ◽  
Irniza R ◽  
Shamsul Bahri MT ◽  
Vivien H ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
The Body ◽  
Long Term Effects ◽  
Contributing Factors ◽  
Cross Sectional ◽  
Traffic Police ◽  
Body Regions ◽  
Lower Back ◽  
Left And Right

Discomfort due to riding a motorcycle is an issue that need to be addressed as it has long-term effects of musculoskeletal disorders on motorcyclists especially among occupational motorcyclist. Thus, this study was conducted to analyse the rating of muscle discomfort and correlation with the risk factors among traffic police riders. A cross-sectional study was carried out among 137 male traffic police riders (high-powered motorcycle) with the age between 20 to 39 years old. The 100-mm visual analogue scale questionnaire included ratings of perceived discomfort scales for 20 specific body regions was used in the study. The results indicate that the lower back (left and right) were the highest mean of discomfort which were 56.6 mm and 55.9 mm respectively. This followed with right (48.5±36.2 mm) and left (48.4±30.3 mm) upper back, and right hand (47.0±33.0 mm). The mean of overall discomfort ratings for all regions were more than 20 mm.  Besides, there is a strong positive significant correlation between duration of ridings (hours) and overall discomfort ratings (p<0.01, r=0.785) and moderate positive correlation between year of traffic police motorcycle riding experience and overall discomfort ratings (p<0.01, r=0.410). As a conclusion, cumulative riding hours, riding experience and no support of the back area of the body in motorcycle seat, are the most concern in this study as this are the contributing factors to the muscle discomfort among traffic police riders while riding high-powered motorcycle. Thus, this study suggested an additional feature is needed in current motorcycle design in order to enhance comforts of traffic police riders. Also, it will improve the condition of traffic police riders’ discomfort and indirectly also improve their work and health performance as well as productivity.

scholarly journals The Efficacy of a Peptide Product from the Pituitary Gland of Rangifer tarandus as an Antioxidant Agent Under the Combined Effects of Light Desynchronosis and Depriming Toxicant

2021 ◽  
Vol 66 (7-8) ◽  
pp. 20-29
Author(s):  
E. G. Batotsyrenova ◽  
V. A. Kashuro ◽  
A. V. Sharabanov ◽  
V. K. Kozlov ◽  
A. L. Kovalenko
Keyword(s):  
Pituitary Gland ◽  
Rangifer Tarandus ◽  
Reduced Glutathione ◽  
Oxidative Status ◽  
Combined Effect ◽  
Combined Effects ◽  
Antioxidant Protection ◽  
Chemical Factor ◽  
Sodium Thiopental ◽  
Peptide Product

The possibility of using methods for determining the oxidative status of an organism (enzymatic and non-enzymatic links of the cellular antioxidant system) to assess the antioxidant properties of peptides of the pituitary gland of the reindeer (Rangifer tarandus) were investigated in an experimental study conducted with a combined effect of factors of different nature on rats: a physical factor — prolonged light desynchronosis (different light modes) and a chemical factor - acute severe poisoning with depriving toxicant (sodium thiopental, LD50). The pharmacological correction of the oxidative status of cells in the animals of the experimental subgroups was carried out with the peptide product of the pituitary gland, intranasally injecting the surviving rats with the bioproduct at a dose of 100 µg/kg, once in the first half of the objective day for 14 days after poisoning with sodium thiopental. The surviving animals of the control groups were similarly injected with saline. The effectiveness of the correction of the disruptions of the cellular oxidative status with the peptide product of the pituitary gland was tested 30 days after the onset of the combined effect of stress factors on rats. It was found that the use of this bioactive peptide product in experimental animals exposed to different light modes and a chemical factor contributed to a decrease in the initially increased indicators of lipid peroxidation in rat erythrocytes and an increase in the initially reduced indicators of the enzymatic link of antioxidant protection. The activity of superoxide dismutase, glutathione peroxidase, glutathione transferase, as well as glucose-6-phosphate dehydrogenase increased after pharmacological correction. The concentration of reduced glutathione also increased in erythrocytes. The maximum changes were observed in the experimental subgroup of rats exposed to the combined effects of constant illumination and depriming toxicant. It was also found that the revealed positive changes in the indicators of the enzymatic link of antioxidant protection in animals of the experimental subgroups are associated with the maintenance of a sufficient concentration of reduced glutathione in red blood cells, which contributed to the maintenance of the cellular redox balance, when the conditions of the external lighting regime are violated.

The Effects and Benefits of Singing Individually and in a Group

2018 ◽  
pp. 918-934
Author(s):  
Töres Theorell
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Lung Function ◽  
The Body ◽  
Tnf Alpha ◽  
Long Term Effects ◽  
Regenerative Activity ◽  
The Brain ◽  
Regular Practice

This chapter is devoted to the biology of singing. Immediate effects have been extensively scientifically studied. Breathing and its synchronization with heart rate variability has been an important theme. Endocrine (endorphins, oxytocin, cortisol, testosterone) and immunological (TNF alpha, fibrinogen, immunoglobulines) reactions have also been studied during singing. In collective singing, cohesiveness is a major factor. Singing in a group during a choir rehearsal has stronger stimulation effects on oxytocin secretion than chatting in the same group. High levels of oxtytocin coincide with strong feelings of cohesiveness. In addition, oxytocin dampens anxiety and pain. Long-term effects of singing training and regular practice have been less extensively studied but there is evidence that singing training may influence such things as the brain´s development, the ability to synchronize heart and lung function, and the level of regenerative activity in the body.

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