scholarly journals Plasma Cell Gingivitis as a Predisposing Factor for Plaque-Induced Periodontitis: A Case Report

2021 ◽  
pp. 71-74
Author(s):  
Vilma Alejandra Umanzor Bonilla ◽  
Claudette Arambú ◽  
Hugo Romero ◽  
Juan Jose Guifarro
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Benign Lesion ◽  
Unknown Etiology ◽  
Histopathological Study ◽  
Predisposing Factor ◽  
Gingival Bleeding ◽  
Gingival Enlargement

Plasma cell gingivitis is a benign lesion of unknown etiology characterized by massive infiltration of plasma cells into the connective tissue of the gingiva. Clinically it presents as a gingival enlargement with erythema and some areas with the presence of desquamation, it is usually asymptomatic, but on some occasions the patient may present pain and gingival bleeding. Diagnosis requires clinical-pathological correlation. Based on the foregoing, we present a case report of a 25-year-old female patient diagnosed with plasma cell gingivitis with idiopathic etiology based on the clinical and histopathological study.

scholarly journals Clinico-Pathological Profile and Outcomes of 45 Cases of Plasma Cell Gingivitis

2021 ◽  
Vol 10 (4) ◽  
pp. 830
Author(s):  
Stefania Leuci ◽  
Noemi Coppola ◽  
Nicola Adamo ◽  
Maria Eleonora Bizzoca ◽  
Daniela Russo ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Clinical Phenotype ◽  
Case Series ◽  
Unknown Etiology ◽  
Cell Infiltrate ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Plasma cell gingivitis (PCG) is an infrequent inflammatory disease of the gingiva of unknown etiology, characterized by a dense polyclonal proliferation of plasma cells in the connective tissue. The aim of this study was to present a case series of patients affected by PCG, analyzing demographic, clinical, histopathological, and therapeutic data. A group of 36 females and 9 males with a mean age of 60.3 years was evaluated. Clinically, 25 cases were bullous, a clinical phenotype never reported to date, 4 erythematous, 4 keratotic, 4 verruciform, and 3 ulcerative. On histological examination, pure polyclonal plasma cell infiltrate was detected in 20 specimens, while in 25 specimens it was associated with a mixed infiltrate. The first-line therapy consisted of oral hygiene and topical corticosteroids in all patients. In 25 patients, doxycycline and sulfasalazine were added; in 10 of these patients, the disease persisted, and it was necessary to resort to systemic steroids. This study presented the clinico-pathological profile and outcomes of a case series of PCG. This could be an aid for clinicians to be aware of the heterogeneous clinical phenotype and of the possible pure bullous phenotype of PCG. Further studies are needed to improve the knowledge about this disorder.

scholarly journals Immunoglobulin G4-related periodontitis: case report and review of the literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jinmei Zhang ◽  
Lei Zhao ◽  
Jieyu Zhou ◽  
Wei Dong ◽  
Yafei Wu
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Plasma Cells ◽  
Alveolar Bone ◽  
Systemic Disease ◽  
Unknown Etiology ◽  
High Power Field ◽  
Obliterative Phlebitis ◽  
Immunoglobulin G4 ◽  
Gingival Enlargement

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory systemic disease of unknown etiology that can affect one or multiple organs. The disease can mimic many infectious and inflammatory diseases, mainly causing organ enlargement or hyperplasia. Its diagnosis primarily relies on clinical, serologic, and histological features (lymphoplasmacytic infiltrates, storiform fibrosis, and obliterative phlebitis of IgG4 + plasma cells). Here, we report a rare case of IgG4-related periodontitis, and review the relevant literatures. Case presentation A 38-year-old Chinese man visited the Department of Periodontics with gingival enlargement, loose teeth, and tooth loss. The patient had very poor oral hygiene and a large amount of calculus. Gingivae were edematous with deep periodontal pockets and attachment loss. Panoramic radiography showed alveolar bone loss. Serologic examination showed that IgG was 23.70 g/L and IgG4 concentration was 2.800 g/L. There was significant lymphoplasmacytic infiltration, a storiform pattern of fibrosis, and mitotic figures with hematoxylin and eosin staining; immunohistochemical staining showed 10 scattered IgG4-positive plasma cells in a high-power field. The patient was diagnosed as IgG4-related periodontitis. He received a course of corticosteroids with periodontal therapy, and the enlargement was significantly improved without recurrence. Conclusion IgG4-RD in the oral and maxillofacial region mainly involves salivary glands, but this rare case was characterized by enlarged gingivae. The differential diagnosis of IgG4-RD should be based on the clinical features and serologic (IgG4) and histopathological examinations. Corticosteroid therapy is effective for most IgG4-RD patients. Taken together, we hope this case report and the literature review can help dentists to improve their understanding of the IgG4-RD.

Refractory eosinophilic fasciitis successfully treated with infliximab: A case report

2021 ◽  
pp. 239719832110043
Author(s):  
Paulina Śmigielska ◽  
Justyna Czarny ◽  
Jacek Kowalski ◽  
Aleksandra Wilkowska ◽  
Roman J. Nowicki
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Treatment Failure ◽  
Immunosuppressive Drugs ◽  
Unknown Etiology ◽  
High Dose ◽  
Eosinophilic Fasciitis ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

Eosinophilic fasciitis is a rare connective tissue disease of unknown etiology. Therapeutic options include high-dose corticosteroids and other immunosuppressive drugs. We present a typical eosinophilic fasciitis case, which did not respond to first-line treatment, but improved remarkably after infliximab administration. This report demonstrates that in case of initial treatment failure, infliximab might be a relatively safe and effective way of eosinophilic fasciitis management.

scholarly journals Abdominal localization of unicentric form of Castleman disease: A case report

2017 ◽  
Vol 74 (4) ◽  
pp. 367-370
Author(s):  
Bosko Milev ◽  
Borka Milev ◽  
Zoran Kostic ◽  
Darko Mirkovic ◽  
Nenad Perisic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Mr Enterography ◽  
Unknown Etiology ◽  
Cell Type ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Golden Standard

Introduction. Castleman disease is a rare disease of the unknown etiology, occuring in two clinical forms: unicentric or multicentric. It is characterized by the hyperplasia of lymph glands. In literature the four pathohistological forms were described: hyaline vascular type, plasma cell type, mixed type and a recently recognized plasmablastic type. The most frequent changes are localized in the mediastinum, while the abdominal localization is with significatly rare occurrence, and that was the motive for presentation of this case. Case report. In a 41-year old male magnetic resonance (MR) enterography showed a change in the ileocecal area without the presence of subjective symptoms of digestive tract and without loss of body mass. Due to the suspicion of stromal tumor, surgical intervention was indicated. Pathohistological findings showed Castleman lymphadenopathia reactiva mesenterii (plasma cell type) which was in the unicentric form. There were present only anaemia and the increased value of sedimentation from the laboratory analyses. Conclusion. Abdominal localization of unicentric plasma cell form occurs rarely and the surgical method of treatment presents the golden standard as it was shown in the presented case.

scholarly journals Geographic Stomatitis with Multiple Areas Involvement of Oral Cavity: A Case Report and Review of Literatures

2021 ◽  
Vol 10 ◽  
pp. 2107
Author(s):  
Farid Abbasi ◽  
Aliyeh Sehatpour ◽  
Seyed Masoud Sajedi ◽  
Parisa Bahadori ◽  
Mohadeseh Nouri
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Benign Lesion ◽  
Ventral Surface ◽  
Unknown Etiology ◽  
Clinical Appearance ◽  
Clinicopathologic Findings ◽  
Characteristic Features ◽  
Rule Out

Background: Geographic stomatitis is an uncommon migratory benign lesion of oral mucosa with unknown etiology. It can affect all the areas of the oral mucosa, but the dorsum and lateral borders of the tongue are the most commonly involved areas called geographic tongue. The clinical appearance of this condition is the oval or circular erythematous areas with irregular elevated keratotic borders. These characteristic features of geographic stomatitis are diagnostic for all clinicians when appearing on the dorsum of the tongue, despite other affected areas of oral mucosa that can confuse clinicians. This condition may be associated with some diseases such as psoriasis, Reiter’s syndrome, and atopic conditions, so the clinicians should rule out these diseases and diagnose the geographic stomatitis. Case Report: A 17-year-old male attended to our department for a routine dentistry checkup. During the intraoral examination, we found multiple erythematous areas surrounded by a thin white border on different surfaces of his oral cavity. His extraoral examinations were completely normal. Conclusion: Due to the rarity of this lesion on the other sites of oral mucosa rather than dorsum and lateral borders of the tongue such as labial mucosa, buccal mucosa, the floor of the mouth, ventral surface of the tongue, and palate, it is necessary to report, study and evaluate each case of this condition that clinicopathologic findings have confirmed this diagnosis, to treat and advice these patients on the best approach. [GMJ.2021;10:e2071]

scholarly journals Epulis gravidarum with histological features of plasma cell granuloma associated to herbal toothpaste: A case report

2021 ◽  
Author(s):  
Dewi Zakiawati ◽  
Irna Sufiawati
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Plasma Cell Granuloma ◽  
Histological Features ◽  
Hormonal Imbalance ◽  
Gingival Enlargement

Hormonal imbalance during the pregnancy may predispose a localized gingival enlargement called epulis gravidarum. This paper aims to elaborate on a case of epulis gravidarum with histological features of plasma cell granuloma. Theoretically, they present in different histological features. However, in this case, the histological examinations showed both entities.

PLASMA CELL GRANULOMA IN BUCCAL MUCOSA: A CASE REPORT AND REVIEW OF DIFFERENT CASE REPORTS ON PLASMA CELL GRANULOMA IN ORAL CAVITY

2021 ◽  
pp. 9-10
Author(s):  
Pranay Bhandari ◽  
Pratiksha pawar ◽  
Ameya Bihani ◽  
Roopal Rathi
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Plasma Cell ◽  
Buccal Mucosa ◽  
Squamous Epithelium ◽  
Case Reports ◽  
Treatment Plan ◽  
Benign Lesion ◽  
Chief Complaint ◽  
Plasma Cell Granuloma

Introduction: 3 Plasma cell granuloma mainly occurs in lungs but can occur in any other organ or soft tissue . It occurs very rarely in oral cavity. We have also reviewed different articles describing plasma cell granuloma in oral cavity. We search the articles in google scholar and pubmed with keywords plasma cell granuloma in oral cavity, buccal mucosa, gingiva, tongue. A Case report: 39 year old male came with a chief complaint of growth on left buccal mucosa. HPE discovered parakeratinized stratied squamous epithelium, showing focal ulceration and underlying dense connective tissue stroma. On the basis of clinicopathological ndings the diagnosis of plasma cell granuloma was made. Discussion: Plasma cell granuloma is a benign lesion but its exact aetiology, behaviour and prognosis is not completely known. We can give emphasis on frozen histopathology intraoperatively to avoid unnecessarily extensive and potentially destructive surgery as the treatment plan.

A RARE CASE PRESENTATION OF PRIMARY PLASMA CELL LEUKEMIA WITH REVIEW OF LITERATURE, A CASE REPORT

2021 ◽  
pp. 21-22
Author(s):  
Gaurav Sharma ◽  
Smita Sharma
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Peripheral Blood ◽  
Plasma Cells ◽  
Plasma Cell Leukemia ◽  
Rare Entity ◽  
Cell Leukemia ◽  
Case Presentation ◽  
Blood Examination ◽  
Primary Plasma Cell Leukemia

Introduction: Primary Plasma Cell Leukemia (pPCL) is Plasma cell dyscrasia subtype which is rare and aggressive. It carries very poor prognosis. It has unique clinical and laboratory prole. Its rst clinical presentation is leukemia. Peripheral blood examination shows circulating mature looking yet clonal, plasma cells. On molecular and cytogenetic examinations, many aberrations are seen which are unique and make it a distinct entity different from traditional Multiple Myeloma (MM). Case presentation: 37 yr old Indian female presented with difculty in breathing for last 3 months and was initially evaluated for cardiac function & COVID-19 screening. Peripheral blood examination revealed circulating plasma cells. Bone marrow apirate conrmed the initial diagnosis of pPCL. She received BIODRONATE + Inj. BORTEZOMIB + Inj. CYCLOPHOSPHAMIDE + Tab Dexa and was advised for PETscan and skeletal survey. But due to nancial constraints, family decided to go for complete systemic workup in next phase of chemotherapy cycle. She was discharged with advise to be in close follow up and to complete her treatment cycles. Discussion: pPCL needs to be diagnosed promptly to formulate optimal intensive therapy. This atypical presentation with shortness of breath of rare entity of pPCLin such young age emphasizes the need for quick and thorough initial workup. Conclusion: Because of rarity of this disease, there is paucity of literature from India and especially the impact of the standard therapies in resource poor countries. Our case report highlights these challenges for conclusive management of this rare entity

Multiple Eccrine Syringofibroadenoma of Mascaro of the Lower Extremity

2016 ◽  
Vol 106 (6) ◽  
pp. 433-438
Author(s):  
Danae L. Lowell ◽  
Nichol L. Salvo ◽  
William J. Weily ◽  
Michael Swiatek ◽  
Hannah Sahli
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lower Extremity ◽  
Benign Lesion ◽  
Unknown Etiology ◽  
Secretory Differentiation

Eccrine syringofibroadenoma (ESFA) is a rare benign lesion of ductal and secretory differentiation exhibiting multiple cutaneous polymorphic presentations with an unknown etiology. We present a case of ESFA that uniquely exhibited large, thick, verrucous-like hyperplastic growths as well as superficial shiny mosaic plaques and deep ulcerations in three different anatomical locations in the same patient. The diagnosis of ESFA was confirmed histologically after biopsies were performed on all of the affected areas. In addition to a case report and literature review, we also present classification, clinical, and histologic aspects of ESFA.

scholarly journals Plasma cell gingivitis - an unusual case of simultaneus disease occurence in two siblings

2019 ◽  
Vol 76 (1) ◽  
pp. 81-85
Author(s):  
Milanko Djuric ◽  
Tanja Veljovic ◽  
Ivana Gusic ◽  
Jelena Mirnic ◽  
Nada Vuckovic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Inflammatory Reaction ◽  
Unusual Case ◽  
Plasma Cells ◽  
Clinical Manifestations ◽  
Chewing Gum ◽  
Systemic Diseases ◽  
Disease Etiology ◽  
Clinical Appearance

Introduction. Plasma cell gingivitis (PCG) is a relatively rare disease that usually occurs on the anterior maxillary and mandibular gingiva. It manifests as extreme redness, swelling and gum tissue enlargement with propensity for bleeding, accompanied by extensive infiltration of plasma cells in the lamina propria. While the disease etiology remains unclear, its presentation is mostly attributed to nonspecific inflammatory reaction to certain foodstuffs or ingredients in oral hygiene products. Case report. A 9-year-old boy and 11-year-old girl were brought for exam by their mother because of fiery red lesions on the gingiva. The lesions had the same clinical features and identical localization and were concomitantly present in both siblings. After excluding other oral or systemic diseases with similar clinical manifestations, a diagnosis of PCG was established (most likely due to chewing gum). Conclusion. While beeing a purely benign, the PCG clinical appearance may mask much more detrimental conditions. Consequently, each such lesion requires due attention. To date, familial tendency for the development of such a condition has not been reported.

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